Details for: PPME1

Gene ID: 51400

Symbol: PPME1

Ensembl ID: ENSG00000214517

Description: protein phosphatase methylesterase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 201.8705
    Cell Significance Index: -31.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.8237
    Cell Significance Index: -39.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 99.4301
    Cell Significance Index: -40.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.9856
    Cell Significance Index: -41.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.9894
    Cell Significance Index: -32.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.6111
    Cell Significance Index: -32.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.4901
    Cell Significance Index: -36.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0806
    Cell Significance Index: -37.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4706
    Cell Significance Index: -32.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.4028
    Cell Significance Index: -41.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7898
    Cell Significance Index: -14.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9322
    Cell Significance Index: 387.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1618
    Cell Significance Index: 114.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1419
    Cell Significance Index: 15.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0933
    Cell Significance Index: 177.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0244
    Cell Significance Index: 45.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0014
    Cell Significance Index: 37.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9782
    Cell Significance Index: 883.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9224
    Cell Significance Index: 183.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9102
    Cell Significance Index: 326.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8142
    Cell Significance Index: 20.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7373
    Cell Significance Index: 38.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7028
    Cell Significance Index: 76.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6692
    Cell Significance Index: 45.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5957
    Cell Significance Index: 412.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5948
    Cell Significance Index: 45.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5865
    Cell Significance Index: 7.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5487
    Cell Significance Index: 30.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5375
    Cell Significance Index: 15.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5321
    Cell Significance Index: 95.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5001
    Cell Significance Index: 22.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4705
    Cell Significance Index: 13.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4631
    Cell Significance Index: 28.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4556
    Cell Significance Index: 23.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4496
    Cell Significance Index: 9.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4293
    Cell Significance Index: 12.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4257
    Cell Significance Index: 232.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4212
    Cell Significance Index: 51.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4010
    Cell Significance Index: 177.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3459
    Cell Significance Index: 3.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2875
    Cell Significance Index: 39.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2269
    Cell Significance Index: 43.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2104
    Cell Significance Index: 95.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1686
    Cell Significance Index: 7.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1352
    Cell Significance Index: 3.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1212
    Cell Significance Index: 186.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1136
    Cell Significance Index: 213.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0825
    Cell Significance Index: 112.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0823
    Cell Significance Index: 151.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0484
    Cell Significance Index: 0.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0476
    Cell Significance Index: 3.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0456
    Cell Significance Index: 28.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0452
    Cell Significance Index: 1.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0398
    Cell Significance Index: 0.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0095
    Cell Significance Index: 0.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0075
    Cell Significance Index: 1.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0069
    Cell Significance Index: 0.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0153
    Cell Significance Index: -2.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0212
    Cell Significance Index: -15.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0314
    Cell Significance Index: -17.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0328
    Cell Significance Index: -2.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0428
    Cell Significance Index: -32.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0591
    Cell Significance Index: -7.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0696
    Cell Significance Index: -7.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0862
    Cell Significance Index: -4.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0972
    Cell Significance Index: -20.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1093
    Cell Significance Index: -11.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1148
    Cell Significance Index: -11.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1165
    Cell Significance Index: -13.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1179
    Cell Significance Index: -33.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1317
    Cell Significance Index: -17.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1831
    Cell Significance Index: -3.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1906
    Cell Significance Index: -22.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1948
    Cell Significance Index: -22.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2172
    Cell Significance Index: -14.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3025
    Cell Significance Index: -7.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3269
    Cell Significance Index: -6.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3418
    Cell Significance Index: -5.7200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3938
    Cell Significance Index: -31.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4373
    Cell Significance Index: -22.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4399
    Cell Significance Index: -14.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.4576
    Cell Significance Index: -6.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4727
    Cell Significance Index: -28.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4803
    Cell Significance Index: -16.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5201
    Cell Significance Index: -14.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5405
    Cell Significance Index: -7.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5729
    Cell Significance Index: -12.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5822
    Cell Significance Index: -19.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5885
    Cell Significance Index: -7.0200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5903
    Cell Significance Index: -18.8000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5964
    Cell Significance Index: -13.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6305
    Cell Significance Index: -16.9000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6686
    Cell Significance Index: -13.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7043
    Cell Significance Index: -14.1400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7197
    Cell Significance Index: -17.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7410
    Cell Significance Index: -15.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8067
    Cell Significance Index: -23.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PPME1 is characterized by its ability to catalyze the demethylation of proteins, specifically those bearing methyl groups in their C-terminal region. This activity is crucial for the regulation of protein function and stability. PPME1 is also known to interact with various proteins, including protein phosphatase 2A, protein kinase, and cyclin A/B1/B2, which highlights its involvement in cell cycle regulation and protein phosphatase activity. **Pathways and Functions** PPME1 is involved in several key cellular pathways, including: 1. **Cell Cycle Regulation**: PPME1 plays a crucial role in the regulation of the cell cycle, particularly during the G2/M transition. It interacts with cyclin A/B1/B2, which are essential regulators of the cell cycle. 2. **Protein Demethylation**: PPME1 is responsible for the demethylation of proteins, which is essential for the regulation of protein function and stability. 3. **Protein Phosphatase Activity**: PPME1 is involved in protein phosphatase activity, which is crucial for the regulation of various cellular processes. 4. **LncRNA Binding**: PPME1 interacts with long non-coding RNAs (lncRNAs), which are essential regulators of gene expression. 5. **Mitotic G2-G2/M Phases**: PPME1 is involved in the regulation of the mitotic G2-G2/M phases, which is essential for the proper completion of mitosis. **Clinical Significance** The clinical significance of PPME1 is an area of active research, and several studies have highlighted its potential role in various diseases. For example: 1. **Cancer**: PPME1 has been implicated in the regulation of cell cycle and protein phosphatase activity, which is essential for the development and progression of cancer. 2. **Autoimmune Diseases**: PPME1 has been shown to interact with lncRNAs, which are essential regulators of gene expression in autoimmune diseases. 3. **Neurological Disorders**: PPME1 has been implicated in the regulation of protein demethylation, which is essential for the proper functioning of proteins in neurological disorders. In conclusion, PPME1 is a multifaceted gene with diverse expression patterns and functions. Its involvement in various cellular pathways, including cell cycle regulation, protein demethylation, and protein phosphatase activity, highlights its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the clinical significance of PPME1 and its potential role in various diseases.

Genular Protein ID: 2240733785

Symbol: PPME1_HUMAN

Name: Protein phosphatase methylesterase 1

UniProtKB Accession Codes:

Q9Y570 B3KMU6 B5MEE7 J3QT22 Q8WYG8 Q9NVT5 Q9UI18

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 11 EMDB 1 ESTHER 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10318862

Title: A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A.

PubMed ID: 10318862

DOI: 10.1074/jbc.274.20.14382

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 18394995

Title: Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

PubMed ID: 18394995

DOI: 10.1016/j.cell.2008.02.041

Sequence Information:

  • Length: 386
  • Mass: 42315
  • Checksum: 37B25324583E8578
  • Sequence:
    • MSALEKSMHL GRLPSRPPLP GSGGSQSGAK MRMGPGRKRD FSPVPWSQYF ESMEDVEVEN 
ETGKDTFRVY KSGSEGPVLL LLHGGGHSAL SWAVFTAAII SRVQCRIVAL DLRSHGETKV 
KNPEDLSAET MAKDVGNVVE AMYGDLPPPI MLIGHSMGGA IAVHTASSNL VPSLLGLCMI 
DVVEGTAMDA LNSMQNFLRG RPKTFKSLEN AIEWSVKSGQ IRNLESARVS MVGQVKQCEG 
ITSPEGSKSI VEGIIEEEEE DEEGSESISK RKKEDDMETK KDHPYTWRIE LAKTEKYWDG 
WFRGLSNLFL SCPIPKLLLL AGVDRLDKDL TIGQMQGKFQ MQVLPQCGHA VHEDAPDKVA 
EAVATFLIRH RFAEPIGGFQ CVFPGC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.