Details for: LCMT1

Gene ID: 51451

Symbol: LCMT1

Ensembl ID: ENSG00000205629

Description: leucine carboxyl methyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 226.2365
    Cell Significance Index: -35.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.2405
    Cell Significance Index: -29.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.9657
    Cell Significance Index: -39.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 82.7309
    Cell Significance Index: -33.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.6413
    Cell Significance Index: -37.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 58.4332
    Cell Significance Index: -39.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.3132
    Cell Significance Index: -33.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.5972
    Cell Significance Index: -37.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3999
    Cell Significance Index: -27.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7211
    Cell Significance Index: -38.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.6253
    Cell Significance Index: -14.5000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6440
    Cell Significance Index: 69.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.6058
    Cell Significance Index: 69.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1902
    Cell Significance Index: 255.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5528
    Cell Significance Index: 311.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.2467
    Cell Significance Index: 31.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8113
    Cell Significance Index: 111.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8093
    Cell Significance Index: 290.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7510
    Cell Significance Index: 122.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7406
    Cell Significance Index: 51.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6990
    Cell Significance Index: 36.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6469
    Cell Significance Index: 353.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6254
    Cell Significance Index: 124.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5352
    Cell Significance Index: 370.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5295
    Cell Significance Index: 24.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5242
    Cell Significance Index: 94.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5232
    Cell Significance Index: 18.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4972
    Cell Significance Index: 23.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4822
    Cell Significance Index: 59.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4768
    Cell Significance Index: 12.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4721
    Cell Significance Index: 61.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4518
    Cell Significance Index: 23.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3394
    Cell Significance Index: 40.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2998
    Cell Significance Index: 132.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2872
    Cell Significance Index: 28.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2776
    Cell Significance Index: 21.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2707
    Cell Significance Index: 51.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2236
    Cell Significance Index: 9.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2188
    Cell Significance Index: 4.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2130
    Cell Significance Index: 13.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2106
    Cell Significance Index: 15.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2080
    Cell Significance Index: 7.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2029
    Cell Significance Index: 5.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1987
    Cell Significance Index: 5.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1917
    Cell Significance Index: 10.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1879
    Cell Significance Index: 5.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1814
    Cell Significance Index: 3.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1559
    Cell Significance Index: 10.4800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1415
    Cell Significance Index: 24.1600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1272
    Cell Significance Index: 8.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0940
    Cell Significance Index: 4.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0889
    Cell Significance Index: 167.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0709
    Cell Significance Index: 64.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0708
    Cell Significance Index: 5.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0563
    Cell Significance Index: 7.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0471
    Cell Significance Index: 72.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0377
    Cell Significance Index: 69.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0153
    Cell Significance Index: 20.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0128
    Cell Significance Index: 0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0094
    Cell Significance Index: 5.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0159
    Cell Significance Index: -0.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0234
    Cell Significance Index: -1.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0242
    Cell Significance Index: -17.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0349
    Cell Significance Index: -5.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0426
    Cell Significance Index: -31.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0452
    Cell Significance Index: -4.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0599
    Cell Significance Index: -1.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0607
    Cell Significance Index: -34.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0669
    Cell Significance Index: -41.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1152
    Cell Significance Index: -33.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1486
    Cell Significance Index: -2.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1603
    Cell Significance Index: -4.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1888
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1948
    Cell Significance Index: -41.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2025
    Cell Significance Index: -23.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2145
    Cell Significance Index: -1.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2604
    Cell Significance Index: -7.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2871
    Cell Significance Index: -29.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2886
    Cell Significance Index: -6.3200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3006
    Cell Significance Index: -2.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3640
    Cell Significance Index: -8.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3955
    Cell Significance Index: -31.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4204
    Cell Significance Index: -6.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4484
    Cell Significance Index: -10.3600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4660
    Cell Significance Index: -5.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4706
    Cell Significance Index: -5.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4815
    Cell Significance Index: -6.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4840
    Cell Significance Index: -25.2100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.5033
    Cell Significance Index: -7.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5423
    Cell Significance Index: -11.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5774
    Cell Significance Index: -35.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5843
    Cell Significance Index: -15.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6205
    Cell Significance Index: -12.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6277
    Cell Significance Index: -19.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6765
    Cell Significance Index: -22.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6922
    Cell Significance Index: -10.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6971
    Cell Significance Index: -14.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Methylation Activity:** LCMT1 is a S-adenosylmethionine-dependent methyltransferase, which catalyzes the methylation of proteins, specifically the C-terminal leucine residue. This modification can regulate protein-protein interactions, protein stability, and cellular signaling pathways. 2. **Cell Cycle Regulation:** LCMT1 is involved in the regulation of the cell cycle, particularly in the G2/M transition phase. This phase is crucial for the proper segregation of chromosomes and the maintenance of genomic stability. 3. **Immune Response:** LCMT1 is expressed in immune cells, such as CD8-alpha-beta-positive T cells and mucosal type mast cells, suggesting its involvement in immune function and the regulation of immune responses. 4. **Tissue-Specific Expression:** LCMT1 is significantly expressed in various cell types, including hematopoietic cells, smooth muscle cells, and goblet cells, highlighting its role in maintaining tissue homeostasis. **Pathways and Functions:** 1. **C-terminal Protein Methylation:** LCMT1 is involved in the methylation of proteins, which can regulate protein-protein interactions, protein stability, and cellular signaling pathways. 2. **Cell Cycle Regulation:** LCMT1 is involved in the regulation of the cell cycle, particularly in the G2/M transition phase, which is crucial for the proper segregation of chromosomes and the maintenance of genomic stability. 3. **Regulation of Apoptotic Process:** LCMT1 may play a role in regulating the apoptotic process by modulating protein-protein interactions and protein stability. 4. **Regulation of Glucose Metabolic Process:** LCMT1 may be involved in the regulation of glucose metabolism by modulating protein-protein interactions and protein stability. 5. **Regulation of Mitotic Cell Cycle Spindle Assembly Checkpoint:** LCMT1 may play a role in regulating the spindle assembly checkpoint, which is crucial for maintaining genomic stability during mitosis. **Clinical Significance:** 1. **Cancer:** Alterations in LCMT1 expression or function may contribute to cancer development and progression, as it plays a role in regulating cell cycle progression and apoptosis. 2. **Immune-Mediated Diseases:** LCMT1 may play a role in regulating immune responses, and alterations in its expression or function may contribute to immune-mediated diseases, such as autoimmune disorders. 3. **Neurological Disorders:** LCMT1 may be involved in regulating protein-protein interactions and protein stability in the nervous system, and alterations in its expression or function may contribute to neurological disorders, such as Alzheimer's disease. 4. **Gastrointestinal Disorders:** LCMT1 may play a role in regulating glucose metabolism and protein-protein interactions in the gastrointestinal tract, and alterations in its expression or function may contribute to gastrointestinal disorders, such as diabetes and inflammatory bowel disease. In conclusion, LCMT1 is a multifaceted gene involved in protein modification, cell cycle regulation, and immune response. Its significance in various cellular processes highlights its importance in maintaining tissue homeostasis and immune function. Further research is needed to elucidate the clinical significance of LCMT1 and its role in various diseases.

Genular Protein ID: 1549993547

Symbol: LCMT1_HUMAN

Name: Leucine carboxyl methyltransferase 1

UniProtKB Accession Codes:

Q9UIC8 A6NL89 A8K770 Q53FC5 Q96CI5 Q9H6I9 Q9NTG4 Q9Y378

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 10 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10600115

Title: Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.

PubMed ID: 10600115

DOI: 10.1021/bi991646a

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21206058

Title: The structure of human leucine carboxyl methyltransferase 1 that regulates protein phosphatase PP2A.

PubMed ID: 21206058

DOI: 10.1107/s0907444910042204

PubMed ID: 21292165

Title: The structural basis for tight control of PP2A methylation and function by LCMT-1.

PubMed ID: 21292165

DOI: 10.1016/j.molcel.2010.12.030

Sequence Information:

  • Length: 334
  • Mass: 38379
  • Checksum: C8D200118E6F353D
  • Sequence:
    • MATRQRESSI TSCCSTSSCD ADDEGVRGTC EDASLCKRFA VSIGYWHDPY IQHFVRLSKE 
RKAPEINRGY FARVHGVSQL IKAFLRKTEC HCQIVNLGAG MDTTFWRLKD EDLLPSKYFE 
VDFPMIVTRK LHSIKCKPPL SSPILELHSE DTLQMDGHIL DSKRYAVIGA DLRDLSELEE 
KLKKCNMNTQ LPTLLIAECV LVYMTPEQSA NLLKWAANSF ERAMFINYEQ VNMGDRFGQI 
MIENLRRRQC DLAGVETCKS LESQKERLLS NGWETASAVD MMELYNRLPR AEVSRIESLE 
FLDEMELLEQ LMRHYCLCWA TKGGNELGLK EITY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.