Details for: HACD3

Gene ID: 51495

Symbol: HACD3

Ensembl ID: ENSG00000074696

Description: 3-hydroxyacyl-CoA dehydratase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 147.1651
    Cell Significance Index: -69.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 136.8099
    Cell Significance Index: -55.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 58.2984
    Cell Significance Index: -55.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.9150
    Cell Significance Index: -64.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.2827
    Cell Significance Index: -46.9400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.1298
    Cell Significance Index: -22.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.9275
    Cell Significance Index: 204.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.1371
    Cell Significance Index: 310.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.0923
    Cell Significance Index: 107.4600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.9418
    Cell Significance Index: 27.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3185
    Cell Significance Index: 130.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0089
    Cell Significance Index: 362.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8630
    Cell Significance Index: 373.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7506
    Cell Significance Index: 347.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6224
    Cell Significance Index: 42.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6085
    Cell Significance Index: 84.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5652
    Cell Significance Index: 561.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4753
    Cell Significance Index: 88.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4679
    Cell Significance Index: 801.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4048
    Cell Significance Index: 172.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2635
    Cell Significance Index: 173.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9704
    Cell Significance Index: 27.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9572
    Cell Significance Index: 60.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9375
    Cell Significance Index: 648.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8143
    Cell Significance Index: 11.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8119
    Cell Significance Index: 17.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7279
    Cell Significance Index: 50.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7206
    Cell Significance Index: 33.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7181
    Cell Significance Index: 92.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5936
    Cell Significance Index: 44.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5579
    Cell Significance Index: 246.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5351
    Cell Significance Index: 11.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5174
    Cell Significance Index: 11.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5025
    Cell Significance Index: 33.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4762
    Cell Significance Index: 29.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3519
    Cell Significance Index: 10.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3434
    Cell Significance Index: 55.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3405
    Cell Significance Index: 24.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2743
    Cell Significance Index: 3.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1217
    Cell Significance Index: 6.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1202
    Cell Significance Index: 226.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1201
    Cell Significance Index: 22.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1125
    Cell Significance Index: 5.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0934
    Cell Significance Index: 68.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0933
    Cell Significance Index: 0.7400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0358
    Cell Significance Index: 55.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0308
    Cell Significance Index: 3.9700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0262
    Cell Significance Index: 0.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0192
    Cell Significance Index: 26.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0146
    Cell Significance Index: 0.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0117
    Cell Significance Index: 21.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0053
    Cell Significance Index: 0.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0179
    Cell Significance Index: -0.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0179
    Cell Significance Index: -0.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0286
    Cell Significance Index: -4.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0401
    Cell Significance Index: -1.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0492
    Cell Significance Index: -1.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0608
    Cell Significance Index: -27.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0657
    Cell Significance Index: -48.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1072
    Cell Significance Index: -60.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1078
    Cell Significance Index: -11.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1094
    Cell Significance Index: -2.3300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1106
    Cell Significance Index: -3.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1200
    Cell Significance Index: -14.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1203
    Cell Significance Index: -9.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1253
    Cell Significance Index: -14.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1337
    Cell Significance Index: -83.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1732
    Cell Significance Index: -20.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1786
    Cell Significance Index: -7.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1987
    Cell Significance Index: -57.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2031
    Cell Significance Index: -10.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2047
    Cell Significance Index: -2.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2106
    Cell Significance Index: -30.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2659
    Cell Significance Index: -10.0700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3210
    Cell Significance Index: -3.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3396
    Cell Significance Index: -21.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3409
    Cell Significance Index: -71.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3818
    Cell Significance Index: -4.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5787
    Cell Significance Index: -60.2600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.5916
    Cell Significance Index: -3.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7385
    Cell Significance Index: -58.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7793
    Cell Significance Index: -22.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7877
    Cell Significance Index: -23.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8087
    Cell Significance Index: -33.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8165
    Cell Significance Index: -20.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9065
    Cell Significance Index: -19.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9095
    Cell Significance Index: -29.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9691
    Cell Significance Index: -22.3900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9867
    Cell Significance Index: -19.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9893
    Cell Significance Index: -25.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9905
    Cell Significance Index: -29.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1158
    Cell Significance Index: -68.4100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1566
    Cell Significance Index: -22.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2497
    Cell Significance Index: -39.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2599
    Cell Significance Index: -41.2500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.2769
    Cell Significance Index: -10.5400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -1.2851
    Cell Significance Index: -8.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.3933
    Cell Significance Index: -23.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HACD3 is a member of the 3-hydroxyacyl-CoA dehydratase family, which plays a crucial role in fatty acid elongation and biosynthesis. The enzyme is specifically involved in the conversion of 3-hydroxyacyl-CoA to 3-ketoacyl-CoA, a critical step in the synthesis of very-long-chain fatty acids. HACD3 is widely expressed in various cell types, including smooth muscle fibers, mucosal type mast cells, and immune cells such as CD8-alpha-beta-positive intraepithelial T cells and alpha-beta regulatory T cells. **Pathways and Functions:** HACD3 is involved in several metabolic and signaling pathways, including: 1. Fatty acid elongation and biosynthesis: HACD3 plays a crucial role in the synthesis of very-long-chain fatty acids, which are essential for various cellular processes, including membrane structure and function. 2. Canonical NF-κB signaling: HACD3 has been shown to interact with the canonical NF-κB pathway, which is involved in inflammation, immune responses, and cell survival. 3. Endoplasmic reticulum and nuclear membrane: HACD3 is localized to the endoplasmic reticulum and nuclear membrane, suggesting its involvement in protein synthesis, folding, and transport. 4. Viral replication: HACD3 has been shown to interact with viral proteins, suggesting its role in modulating viral replication and immune responses. **Clinical Significance:** The expression of HACD3 in various cell types and its involvement in metabolic and signaling pathways suggest its potential role in various diseases, including: 1. Metabolic disorders: Altered expression of HACD3 may contribute to metabolic disorders, such as fatty acid imbalances and lipid metabolism disorders. 2. Immune-related disorders: HACD3's involvement in immune responses and viral replication may contribute to immune-related disorders, such as autoimmune diseases and viral infections. 3. Cancer: HACD3's expression in cancer cells may contribute to tumor growth, metastasis, and immune evasion. In conclusion, HACD3 is an enzyme with a complex role in immunological and metabolic processes. Further research is needed to elucidate its specific functions and clinical significance, and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. Further studies are needed to characterize the specific functions of HACD3 in different cell types and disease contexts. 2. The development of specific inhibitors or modulators of HACD3 may provide novel therapeutic strategies for metabolic and immune-related disorders. 3. The expression of HACD3 in various cell types and tissues should be further investigated to understand its role in normal and diseased states. **Limitations:** 1. Limited information is available on the specific functions and clinical significance of HACD3. 2. Further research is needed to understand the specific mechanisms by which HACD3 interacts with viral proteins and modulates immune responses. 3. The expression of HACD3 in various cell types and tissues may be influenced by multiple factors, including environmental and genetic factors.

Genular Protein ID: 1987502637

Symbol: HACD3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10747961

Title: B-ind1, a novel mediator of Rac1 signaling cloned from sodium butyrate-treated fibroblasts.

PubMed ID: 10747961

DOI: 10.1074/jbc.m000887200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16516406

Title: Human B-ind1 gene promoter: cloning and regulation by histone deacetylase inhibitors.

PubMed ID: 16516406

DOI: 10.1016/j.gene.2006.01.022

PubMed ID: 16638134

Title: SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis.

PubMed ID: 16638134

DOI: 10.1186/1471-2407-6-105

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18554506

Title: Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis.

PubMed ID: 18554506

DOI: 10.1016/j.febslet.2008.06.007

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25687571

Title: The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.

PubMed ID: 25687571

DOI: 10.1074/mcp.m114.047159

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 362
  • Mass: 43160
  • Checksum: 1B3591E88DD85D16
  • Sequence:
  • MENQVLTPHV YWAQRHRELY LRVELSDVQN PAISITENVL HFKAQGHGAK GDNVYEFHLE 
    FLDLVKPEPV YKLTQRQVNI TVQKKVSQWW ERLTKQEKRP LFLAPDFDRW LDESDAEMEL 
    RAKEEERLNK LRLESEGSPE TLTNLRKGYL FMYNLVQFLG FSWIFVNLTV RFCILGKESF 
    YDTFHTVADM MYFCQMLAVV ETINAAIGVT TSPVLPSLIQ LLGRNFILFI IFGTMEEMQN 
    KAVVFFVFYL WSAIEIFRYS FYMLTCIDMD WKVLTWLRYT LWIPLYPLGC LAEAVSVIQS 
    IPIFNETGRF SFTLPYPVKI KVRFSFFLQI YLIMIFLGLY INFRHLYKQR RRRYGQKKKK 
    IH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.