Details for: TRIAP1

Gene ID: 51499

Symbol: TRIAP1

Ensembl ID: ENSG00000170855

Description: TP53 regulated inhibitor of apoptosis 1

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Metabolism of proteins
    (R-HSA-392499)
  • Mitochondrial protein degradation
    (R-HSA-9837999)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Tp53 regulates transcription of cell death genes
    (R-HSA-5633008)
  • Tp53 regulates transcription of genes involved in cytochrome c release
    (R-HSA-6803204)
  • Transcriptional regulation by tp53
    (R-HSA-3700989)
  • Apoptotic process
    (GO:0006915)
  • Cellular response to uv
    (GO:0034644)
  • Dna damage response, signal transduction by p53 class mediator
    (GO:0030330)
  • Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    (GO:0006977)
  • Intermembrane lipid transfer
    (GO:0120009)
  • Mitochondrial intermembrane space
    (GO:0005758)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043154)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:1902166)
  • Negative regulation of release of cytochrome c from mitochondria
    (GO:0090201)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • P53 binding
    (GO:0002039)
  • Phosphatidic acid transfer activity
    (GO:1990050)
  • Phospholipid translocation
    (GO:0045332)
  • Phospholipid transport
    (GO:0015914)
  • Positive regulation of phospholipid transport
    (GO:2001140)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Regulation of membrane lipid distribution
    (GO:0097035)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 122.0224
    Cell Significance Index: -18.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.8084
    Cell Significance Index: -15.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.9325
    Cell Significance Index: -22.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.2944
    Cell Significance Index: -22.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.1272
    Cell Significance Index: -22.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9705
    Cell Significance Index: -23.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.3456
    Cell Significance Index: -14.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9065
    Cell Significance Index: -15.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2513
    Cell Significance Index: 366.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9492
    Cell Significance Index: 117.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9408
    Cell Significance Index: 226.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.9990
    Cell Significance Index: 10.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9818
    Cell Significance Index: 69.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8905
    Cell Significance Index: 7.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8834
    Cell Significance Index: 23.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7827
    Cell Significance Index: 27.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7166
    Cell Significance Index: 15.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6694
    Cell Significance Index: 43.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6575
    Cell Significance Index: 359.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6553
    Cell Significance Index: 45.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5869
    Cell Significance Index: 259.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5381
    Cell Significance Index: 25.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5154
    Cell Significance Index: 66.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4939
    Cell Significance Index: 23.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4643
    Cell Significance Index: 63.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4630
    Cell Significance Index: 5.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4418
    Cell Significance Index: 52.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4206
    Cell Significance Index: 11.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4097
    Cell Significance Index: 5.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3786
    Cell Significance Index: 11.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3715
    Cell Significance Index: 27.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.3656
    Cell Significance Index: 37.3500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3643
    Cell Significance Index: 5.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3642
    Cell Significance Index: 18.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3302
    Cell Significance Index: 40.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3000
    Cell Significance Index: 2.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2977
    Cell Significance Index: 53.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2849
    Cell Significance Index: 56.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2796
    Cell Significance Index: 7.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2737
    Cell Significance Index: 5.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1854
    Cell Significance Index: 23.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1808
    Cell Significance Index: 34.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1573
    Cell Significance Index: 4.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1372
    Cell Significance Index: 6.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0778
    Cell Significance Index: 1.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0560
    Cell Significance Index: 11.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0550
    Cell Significance Index: 1.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0403
    Cell Significance Index: 3.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0323
    Cell Significance Index: 0.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0244
    Cell Significance Index: 7.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0196
    Cell Significance Index: 14.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0161
    Cell Significance Index: 2.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0106
    Cell Significance Index: 0.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0110
    Cell Significance Index: -8.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0111
    Cell Significance Index: -20.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0173
    Cell Significance Index: -31.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0206
    Cell Significance Index: -0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0210
    Cell Significance Index: -32.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0232
    Cell Significance Index: -31.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0251
    Cell Significance Index: -18.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0285
    Cell Significance Index: -19.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0305
    Cell Significance Index: -19.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0336
    Cell Significance Index: -1.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0341
    Cell Significance Index: -12.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0429
    Cell Significance Index: -26.7900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0441
    Cell Significance Index: -0.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0485
    Cell Significance Index: -1.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0514
    Cell Significance Index: -23.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0523
    Cell Significance Index: -1.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0592
    Cell Significance Index: -1.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0629
    Cell Significance Index: -0.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0741
    Cell Significance Index: -3.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0899
    Cell Significance Index: -10.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1263
    Cell Significance Index: -3.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1313
    Cell Significance Index: -27.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1476
    Cell Significance Index: -21.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2040
    Cell Significance Index: -5.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2137
    Cell Significance Index: -13.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2198
    Cell Significance Index: -17.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2261
    Cell Significance Index: -23.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2342
    Cell Significance Index: -6.0200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2454
    Cell Significance Index: -2.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2563
    Cell Significance Index: -2.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2657
    Cell Significance Index: -16.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2812
    Cell Significance Index: -18.9100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3107
    Cell Significance Index: -23.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3127
    Cell Significance Index: -9.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3137
    Cell Significance Index: -4.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3409
    Cell Significance Index: -6.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3512
    Cell Significance Index: -19.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3796
    Cell Significance Index: -8.7700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3967
    Cell Significance Index: -5.0800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3992
    Cell Significance Index: -5.6000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4203
    Cell Significance Index: -3.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4922
    Cell Significance Index: -21.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5042
    Cell Significance Index: -10.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.5134
    Cell Significance Index: -8.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5168
    Cell Significance Index: -18.9700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5239
    Cell Significance Index: -3.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRIAP1 is a 35-kDa protein that belongs to the inhibitor of apoptosis (IAP) family. It is highly expressed in various cell types, including hematopoietic cells, epithelial cells, and smooth muscle cells. TRIAP1 is characterized by its ability to inhibit apoptosis by interacting with key pro-apoptotic proteins, such as cytochrome c and caspases. Additionally, TRIAP1 has been shown to regulate phospholipid transport and membrane lipid distribution, which is essential for maintaining cellular homeostasis. **Pathways and Functions:** TRIAP1 is involved in several key pathways that regulate apoptosis and cellular homeostasis. These include: 1. **Apoptotic process:** TRIAP1 inhibits apoptosis by interacting with pro-apoptotic proteins, such as cytochrome c and caspases. 2. **DNA damage response:** TRIAP1 is regulated by TP53, which ensures that cells respond appropriately to DNA damage. 3. **Signal transduction by p53 class mediator:** TRIAP1 is involved in the regulation of transcription by RNA polymerase II, which is essential for cell growth and survival. 4. **Mitochondrial intermembrane space:** TRIAP1 regulates the release of cytochrome c from mitochondria, which is a critical step in the apoptotic process. TRIAP1's functions are critical for maintaining cellular homeostasis and preventing cancer. Its ability to regulate apoptosis, DNA damage response, and signal transduction by p53 class mediator ensures that cells respond appropriately to cellular stress. **Clinical Significance:** TRIAP1 has been implicated in various diseases, including cancer, where its dysregulation can lead to uncontrolled cell growth and apoptosis resistance. Specifically, TRIAP1 has been shown to be overexpressed in several types of cancer, including breast cancer, lung cancer, and leukemia. Additionally, TRIAP1 has been implicated in autoimmune diseases, such as lupus and rheumatoid arthritis, where its dysregulation can lead to immune system dysfunction. In conclusion, TRIAP1 is a multifunctional protein that plays a critical role in regulating apoptosis, DNA damage response, and signal transduction by p53 class mediator. Its dysregulation has been implicated in various diseases, including cancer and autoimmune diseases. Further research is needed to fully understand the molecular mechanisms of TRIAP1 and its role in human disease. **Future Directions:** 1. **Investigating the role of TRIAP1 in cancer:** Further research is needed to understand the role of TRIAP1 in cancer development and progression. 2. **Developing TRIAP1-based therapeutic strategies:** TRIAP1-based therapeutic strategies may provide new avenues for treating cancer and autoimmune diseases. 3. **Understanding the regulation of TRIAP1:** Further research is needed to understand the regulation of TRIAP1 by TP53 and other signaling pathways. By elucidating the molecular mechanisms of TRIAP1, we can gain a deeper understanding of its role in human disease and develop new therapeutic strategies for treating various diseases.

Genular Protein ID: 1876457531

Symbol: TRIA1_HUMAN

Name: TP53-regulated inhibitor of apoptosis 1

UniProtKB Accession Codes:

O43715 B2R4Z7 Q5RKS5 Q6LCA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 GO 20 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15735003

Title: p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.

PubMed ID: 15735003

DOI: 10.1158/0008-5472.can-04-3339

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23931759

Title: TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid.

PubMed ID: 23931759

DOI: 10.1016/j.cmet.2013.07.008

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26071602

Title: Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes.

PubMed ID: 26071602

DOI: 10.15252/embr.201540229

Sequence Information:

  • Length: 76
  • Mass: 8786
  • Checksum: 00B41AC399D76590
  • Sequence:
    • MNSVGEACTD MKREYDQCFN RWFAEKFLKG DSSGDPCTDL FKRYQQCVQK AIKEKEIPIE 
GLEFMGHGKE KPENSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.