Details for: GTSE1

Gene ID: 51512

Symbol: GTSE1

Ensembl ID: ENSG00000075218

Description: G2 and S-phase expressed 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.5941
    Cell Significance Index: -7.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.1154
    Cell Significance Index: -7.5400
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 4.9396
    Cell Significance Index: 3.7700
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 1.4121
    Cell Significance Index: 17.5400
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.1963
    Cell Significance Index: 6.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8260
    Cell Significance Index: 134.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8196
    Cell Significance Index: 8.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7368
    Cell Significance Index: 86.8900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6445
    Cell Significance Index: 70.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6181
    Cell Significance Index: 21.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5660
    Cell Significance Index: 31.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5365
    Cell Significance Index: 102.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5105
    Cell Significance Index: 14.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4684
    Cell Significance Index: 92.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4344
    Cell Significance Index: 50.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3898
    Cell Significance Index: 8.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.3483
    Cell Significance Index: -0.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3342
    Cell Significance Index: 301.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3338
    Cell Significance Index: 23.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2434
    Cell Significance Index: 6.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2324
    Cell Significance Index: 12.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2250
    Cell Significance Index: 6.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2204
    Cell Significance Index: 5.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1984
    Cell Significance Index: 6.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1951
    Cell Significance Index: 5.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1757
    Cell Significance Index: 17.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1414
    Cell Significance Index: 77.2100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1245
    Cell Significance Index: 0.2800
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0990
    Cell Significance Index: 0.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0906
    Cell Significance Index: 1.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0708
    Cell Significance Index: 1.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0607
    Cell Significance Index: 37.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0549
    Cell Significance Index: 1.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0472
    Cell Significance Index: 2.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0424
    Cell Significance Index: 1.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0418
    Cell Significance Index: 18.4800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0252
    Cell Significance Index: 0.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0247
    Cell Significance Index: 0.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0097
    Cell Significance Index: 0.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0047
    Cell Significance Index: 0.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0036
    Cell Significance Index: 6.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0027
    Cell Significance Index: 0.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0018
    Cell Significance Index: 0.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0003
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0023
    Cell Significance Index: -1.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0026
    Cell Significance Index: -4.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0068
    Cell Significance Index: -2.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0089
    Cell Significance Index: -1.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0099
    Cell Significance Index: -6.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0108
    Cell Significance Index: -7.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0146
    Cell Significance Index: -1.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0162
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0187
    Cell Significance Index: -3.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0227
    Cell Significance Index: -6.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0246
    Cell Significance Index: -2.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0254
    Cell Significance Index: -3.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0338
    Cell Significance Index: -0.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0341
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0385
    Cell Significance Index: -4.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0388
    Cell Significance Index: -4.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0488
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0491
    Cell Significance Index: -5.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0571
    Cell Significance Index: -7.3800
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0603
    Cell Significance Index: -0.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0634
    Cell Significance Index: -4.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0716
    Cell Significance Index: -1.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0741
    Cell Significance Index: -7.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0756
    Cell Significance Index: -1.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0789
    Cell Significance Index: -4.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0856
    Cell Significance Index: -6.5700
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0902
    Cell Significance Index: -0.5400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0971
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0988
    Cell Significance Index: -2.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1004
    Cell Significance Index: -7.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1008
    Cell Significance Index: -5.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1068
    Cell Significance Index: -6.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1112
    Cell Significance Index: -8.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1133
    Cell Significance Index: -7.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1245
    Cell Significance Index: -5.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1410
    Cell Significance Index: -3.4200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1484
    Cell Significance Index: -1.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1553
    Cell Significance Index: -4.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1557
    Cell Significance Index: -7.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1561
    Cell Significance Index: -8.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1621
    Cell Significance Index: -7.1700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.1678
    Cell Significance Index: -1.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1822
    Cell Significance Index: -5.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1849
    Cell Significance Index: -7.0000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1877
    Cell Significance Index: -4.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2107
    Cell Significance Index: -7.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2191
    Cell Significance Index: -2.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2248
    Cell Significance Index: -7.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2259
    Cell Significance Index: -3.8000
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: -0.2268
    Cell Significance Index: -0.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2295
    Cell Significance Index: -7.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GTSE1 is a protein that is expressed in both the nucleus and cytoplasm, and its expression is tightly regulated during the cell cycle. It is highly expressed in cells undergoing rapid proliferation, such as hematopoietic cells and epithelial cells. GTSE1 has been shown to interact with various proteins, including microtubules, tubulin, and p53, which are essential for regulating the cell cycle. GTSE1's expression is also influenced by DNA damage, and it has been implicated in the regulation of cell cycle checkpoints. **Pathways and Functions:** GTSE1 is involved in several cell cycle-related pathways, including: 1. **Cell cycle checkpoints:** GTSE1 plays a crucial role in regulating the G2/M checkpoint, which is a critical phase in the cell cycle where the cell prepares to enter mitosis. 2. **Mitotic spindle formation:** GTSE1 interacts with microtubules and tubulin to regulate the formation of the mitotic spindle, which is essential for cell division. 3. **DNA damage response:** GTSE1 is involved in the regulation of the DNA damage response, which is a critical mechanism for maintaining genome stability. 4. **Signal transduction by p53 class mediator:** GTSE1 interacts with p53, a tumor suppressor protein, to regulate cell cycle arrest in response to DNA damage. **Clinical Significance:** GTSE1's expression has been linked to various diseases, including cancer. Its dysregulation has been implicated in the development of tumors, and it is being investigated as a potential therapeutic target. GTSE1's role in regulating cell cycle checkpoints and DNA damage response makes it an attractive target for cancer therapy. Additionally, GTSE1's expression has been linked to various other diseases, including neurodegenerative disorders and cardiovascular disease. In conclusion, GTSE1 is a protein that plays a critical role in regulating cell cycle progression, particularly during the G2/M checkpoint. Its expression is tightly regulated during the cell cycle, and it interacts with various proteins to regulate cell cycle-related pathways. GTSE1's dysregulation has been implicated in various diseases, including cancer, and it is being investigated as a potential therapeutic target. Further research is needed to fully understand the role of GTSE1 in human disease and to explore its therapeutic potential.

Genular Protein ID: 2460956535

Symbol: GTSE1_HUMAN

Name: Protein B99 homolog

UniProtKB Accession Codes:

Q9NYZ3 B0QYM3 Q20WK2 Q53GX5 Q5R3I6 Q6DHX4 Q9BRE0 Q9UGZ9 Q9Y557

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10974554

Title: Cloning, chromosome mapping and functional characterization of a human homologue of murine Gtse-1 (B99) gene.

PubMed ID: 10974554

DOI: 10.1016/s0378-1119(00)00260-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 739
  • Mass: 78505
  • Checksum: 1FF702D67CB4AD98
  • Sequence:
    • MEGGGGRDEP SACRAGDVNM DDPKKEDILL LADEKFDFDL SLSSSSANED DEVFFGPFGH 
KERCIAASLE LNNPVPEQPP LPTSESPFAW SPLAGEKFVE VYKEAHLLAL HIESSSRNQA 
AQAAKPEDPR SQGVERFIQE SKLKINLFEK EKEMKKSPTS LKRETYYLSD SPLLGPPVGE 
PRLLASSPAL PSSGAQARLT RAPGPPHSAH ALPRESCTAH AASQAATQRK PGTKLLLPRA 
ASVRGRSIPG AAEKPKKEIP ASPSRTKIPA EKESHRDVLP DKPAPGAVNV PAAGSHLGQG 
KRAIPVPNKL GLKKTLLKAP GSTSNLARKS SSGPVWSGAS SACTSPAVGK AKSSEFASIP 
ANSSRPLSNI SKSGRMGPAM LRPALPAGPV GASSWQAKRV DVSELAAEQL TAPPSASPTQ 
PQTPEGGGQW LNSSCAWSES SQLNKTRSIR RRDSCLNSKT KVMPTPTNQF KIPKFSIGDS 
PDSSTPKLSR AQRPQSCTSV GRVTVHSTPV RRSSGPAPQS LLSAWRVSAL PTPASRRCSG 
LPPMTPKTMP RAVGSPLCVP ARRRSSEPRK NSAMRTEPTR ESNRKTDSRL VDVSPDRGSP 
PSRVPQALNF SPEESDSTFS KSTATEVARE EAKPGGDAAP SEALLVDIKL EPLAVTPDAA 
SQPLIDLPLI DFCDTPEAHV AVGSESRPLI DLMTNTPDMN KNVAKPSPVV GQLIDLSSPL 
IQLSPEADKE NVDSPLLKF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.