Details for: NCKIPSD

Gene ID: 51517

Symbol: NCKIPSD

Ensembl ID: ENSG00000213672

Description: NCK interacting protein with SH3 domain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 86.0200
    Cell Significance Index: -13.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.5003
    Cell Significance Index: -13.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 29.7592
    Cell Significance Index: -14.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.0857
    Cell Significance Index: -11.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.9928
    Cell Significance Index: -11.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1034
    Cell Significance Index: -13.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7371
    Cell Significance Index: -12.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5073
    Cell Significance Index: -13.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5633
    Cell Significance Index: -5.6100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4843
    Cell Significance Index: 24.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9078
    Cell Significance Index: 89.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9028
    Cell Significance Index: 146.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8285
    Cell Significance Index: 22.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7711
    Cell Significance Index: 89.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7092
    Cell Significance Index: 640.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6727
    Cell Significance Index: 134.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6047
    Cell Significance Index: 36.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5751
    Cell Significance Index: 62.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.5432
    Cell Significance Index: 8.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4145
    Cell Significance Index: 8.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3457
    Cell Significance Index: 9.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3446
    Cell Significance Index: 17.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2840
    Cell Significance Index: 19.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2817
    Cell Significance Index: 101.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2791
    Cell Significance Index: 55.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2074
    Cell Significance Index: 9.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1369
    Cell Significance Index: 94.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1139
    Cell Significance Index: 2.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1093
    Cell Significance Index: 59.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0858
    Cell Significance Index: 1.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0788
    Cell Significance Index: 1.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0771
    Cell Significance Index: 10.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0711
    Cell Significance Index: 1.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0662
    Cell Significance Index: 4.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0652
    Cell Significance Index: 3.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0558
    Cell Significance Index: 10.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0513
    Cell Significance Index: 9.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0506
    Cell Significance Index: 2.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0497
    Cell Significance Index: 21.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0421
    Cell Significance Index: 2.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0400
    Cell Significance Index: 5.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0259
    Cell Significance Index: 1.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0258
    Cell Significance Index: 0.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0219
    Cell Significance Index: 2.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0170
    Cell Significance Index: 1.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0168
    Cell Significance Index: 30.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0150
    Cell Significance Index: 23.0300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0147
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0131
    Cell Significance Index: 24.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0035
    Cell Significance Index: 1.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0010
    Cell Significance Index: -1.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0023
    Cell Significance Index: -0.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0043
    Cell Significance Index: -2.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0069
    Cell Significance Index: -0.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0137
    Cell Significance Index: -10.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0153
    Cell Significance Index: -11.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0166
    Cell Significance Index: -2.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0219
    Cell Significance Index: -12.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0225
    Cell Significance Index: -2.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0237
    Cell Significance Index: -14.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0294
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0334
    Cell Significance Index: -5.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0393
    Cell Significance Index: -11.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0499
    Cell Significance Index: -5.7200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0512
    Cell Significance Index: -1.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0558
    Cell Significance Index: -7.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0583
    Cell Significance Index: -1.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0597
    Cell Significance Index: -2.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0630
    Cell Significance Index: -3.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0635
    Cell Significance Index: -2.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0650
    Cell Significance Index: -1.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0683
    Cell Significance Index: -14.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0841
    Cell Significance Index: -5.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1082
    Cell Significance Index: -2.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1179
    Cell Significance Index: -12.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1201
    Cell Significance Index: -8.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1211
    Cell Significance Index: -5.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1255
    Cell Significance Index: -1.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1258
    Cell Significance Index: -7.0600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1391
    Cell Significance Index: -1.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1484
    Cell Significance Index: -11.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1649
    Cell Significance Index: -3.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1689
    Cell Significance Index: -4.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1702
    Cell Significance Index: -10.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1807
    Cell Significance Index: -3.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1837
    Cell Significance Index: -9.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1974
    Cell Significance Index: -6.8600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2115
    Cell Significance Index: -1.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2256
    Cell Significance Index: -13.8300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2282
    Cell Significance Index: -1.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2342
    Cell Significance Index: -7.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2436
    Cell Significance Index: -4.1800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2482
    Cell Significance Index: -3.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2539
    Cell Significance Index: -6.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2550
    Cell Significance Index: -8.3500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2642
    Cell Significance Index: -3.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2649
    Cell Significance Index: -9.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2709
    Cell Significance Index: -4.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Summary of NCKIPSD Gene** The NCKIPSD gene, also known as SPN90_HUMAN, encodes a protein that belongs to the NCK-interacting protein family. This gene is involved in various cellular processes, including cytoskeletal organization, endocytosis, and immune system function. NCKIPSD is expressed in multiple cell types, including hematopoietic cells, smooth muscle cells, and epithelial cells. The gene's expression patterns and functional roles suggest its importance in maintaining cellular homeostasis and responding to environmental stimuli. **Key Characteristics of NCKIPSD Gene** 1. **Domain Structure**: The NCKIPSD protein contains a SH3 (Src Homology 3) domain, which is a characteristic feature of many proteins involved in cytoskeletal organization and signal transduction. 2. **Cellular Localization**: NCKIPSD is expressed in various cell types, including hematopoietic cells, smooth muscle cells, and epithelial cells, suggesting its role in maintaining tissue homeostasis. 3. **Protein-Protein Interactions**: NCKIPSD interacts with other proteins, such as the Arp2/3 complex, Cop9 signalosome, and Rho GTPases, which are involved in cytoskeletal reorganization and cell signaling. 4. **Signaling Pathways**: NCKIPSD is involved in various signaling pathways, including those regulated by Rho GTPases, which play a crucial role in cell migration, endocytosis, and immune system function. **Pathways and Functions of NCKIPSD Gene** 1. **Cytoskeletal Organization**: NCKIPSD is involved in regulating actin dynamics, which is essential for maintaining cellular shape and structure. 2. **Endocytosis**: NCKIPSD is required for the formation of phagocytic cups, which is a critical step in the process of phagocytosis. 3. **Immune System Function**: NCKIPSD is expressed in immune cells, such as T cells and macrophages, and is involved in regulating immune responses to pathogens. 4. **Neurotransmission**: NCKIPSD is also expressed in neurons and is involved in regulating synaptic plasticity and neuronal development. **Clinical Significance of NCKIPSD Gene** 1. **Infectious Diseases**: NCKIPSD is involved in the regulation of phagocytosis, which is critical for responding to infections. Alterations in NCKIPSD expression or function may contribute to the development of infectious diseases. 2. **Cancer**: NCKIPSD has been implicated in the regulation of cellular migration and invasion, which are critical processes in cancer progression. 3. **Neurological Disorders**: NCKIPSD is expressed in neurons and is involved in regulating synaptic plasticity and neuronal development. Alterations in NCKIPSD expression or function may contribute to the development of neurological disorders, such as Alzheimer's disease. 4. **Immunodeficiency Diseases**: NCKIPSD is involved in regulating immune responses to pathogens. Alterations in NCKIPSD expression or function may contribute to the development of immunodeficiency diseases. In conclusion, the NCKIPSD gene is a critical regulator of cytoskeletal organization, endocytosis, and immune system function. Its expression patterns and functional roles suggest its importance in maintaining cellular homeostasis and responding to environmental stimuli. Further research is needed to fully understand the clinical significance of NCKIPSD and its role in various diseases.

Genular Protein ID: 1162573211

Symbol: SPN90_HUMAN

Name: NCK-interacting protein with SH3 domain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10648423

Title: Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11)(p21;q23).

PubMed ID: 10648423

PubMed ID: 10619843

Title: The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein.

PubMed ID: 10619843

DOI: 10.1093/emboj/19.1.48

PubMed ID: 11241789

Title: Genomic organization, tissue expression and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia.

PubMed ID: 11241789

DOI: 10.1002/gcc.1102

PubMed ID: 11278500

Title: SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adapter protein that is developmentally regulated during cardiac myocyte differentiation.

PubMed ID: 11278500

DOI: 10.1074/jbc.m009411200

PubMed ID: 11509578

Title: mDia-interacting protein acts downstream of rho-mDia and modifies src activation and stress fiber formation.

PubMed ID: 11509578

DOI: 10.1074/jbc.m107026200

PubMed ID: 15095401

Title: Identification of FHOD1-binding proteins and mechanisms of FHOD1-regulated actin dynamics.

PubMed ID: 15095401

DOI: 10.1002/jcb.20031

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22419821

Title: Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis.

PubMed ID: 22419821

DOI: 10.1091/mbc.e11-11-0934

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 722
  • Mass: 78960
  • Checksum: 7683046B94647332
  • Sequence:
  • MYRALYAFRS AEPNALAFAA GETFLVLERS SAHWWLAARA RSGETGYVPP AYLRRLQGLE 
    QDVLQAIDRA IEAVHNTAMR DGGKYSLEQR GVLQKLIHHR KETLSRRGPS ASSVAVMTSS 
    TSDHHLDAAA ARQPNGVCRA GFERQHSLPS SEHLGADGGL YQIPLPSSQI PPQPRRAAPT 
    TPPPPVKRRD REALMASGSG GHNTMPSGGN SVSSGSSVSS TSLDTLYTSS SPSEPGSSCS 
    PTPPPVPRRG THTTVSQVQP PPSKASAPEP PAEEEVATGT TSASDDLEAL GTLSLGTTEE 
    KAAAEAAVPR TIGAELMELV RRNTGLSHEL CRVAIGIIVG HIQASVPASS PVMEQVLLSL 
    VEGKDLSMAL PSGQVCHDQQ RLEVIFADLA RRKDDAQQRS WALYEDEGVI RCYLEELLHI 
    LTDADPEVCK KMCKRNEFES VLALVAYYQM EHRASLRLLL LKCFGAMCSL DAAIISTLVS 
    SVLPVELARD MQTDTQDHQK LCYSALILAM VFSMGEAVPY AHYEHLGTPF AQFLLNIVED 
    GLPLDTTEQL PDLCVNLLLA LNLHLPAADQ NVIMAALSKH ANVKIFSEKL LLLLNRGDDP 
    VRIFKHEPQP PHSVLKFLQD VFGSPATAAI FYHTDMMALI DITVRHIADL SPGDKLRMEY 
    LSLMHAIVRT TPYLQHRHRL PDLQAILRRI LNEEETSPQC QMDRMIVREM CKEFLVLGEA 
    PS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.