Details for: PDE9A

Gene ID: 5152

Symbol: PDE9A

Ensembl ID: ENSG00000160191

Description: phosphodiesterase 9A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.7460
    Cell Significance Index: -24.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.5278
    Cell Significance Index: -24.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.1623
    Cell Significance Index: -19.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.1782
    Cell Significance Index: -19.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.5303
    Cell Significance Index: -24.0800
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 8.7524
    Cell Significance Index: 6.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8056
    Cell Significance Index: -20.9100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.9765
    Cell Significance Index: -13.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.0356
    Cell Significance Index: 60.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.9149
    Cell Significance Index: 177.4500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.5614
    Cell Significance Index: 31.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9922
    Cell Significance Index: 43.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7595
    Cell Significance Index: 50.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.5732
    Cell Significance Index: 26.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.3415
    Cell Significance Index: 50.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1246
    Cell Significance Index: 1015.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0892
    Cell Significance Index: 48.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0546
    Cell Significance Index: 209.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9252
    Cell Significance Index: 56.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7533
    Cell Significance Index: 18.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7135
    Cell Significance Index: 40.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6550
    Cell Significance Index: 45.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5775
    Cell Significance Index: 13.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4764
    Cell Significance Index: 6.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4516
    Cell Significance Index: 246.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4341
    Cell Significance Index: 22.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3233
    Cell Significance Index: 608.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.3074
    Cell Significance Index: 44.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2956
    Cell Significance Index: 13.7800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.2735
    Cell Significance Index: 2.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2732
    Cell Significance Index: 12.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2373
    Cell Significance Index: 365.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2295
    Cell Significance Index: 43.6800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2066
    Cell Significance Index: 4.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1961
    Cell Significance Index: 266.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1804
    Cell Significance Index: 64.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1753
    Cell Significance Index: 21.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1324
    Cell Significance Index: 23.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1292
    Cell Significance Index: 12.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1252
    Cell Significance Index: 16.1700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0801
    Cell Significance Index: 1.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0587
    Cell Significance Index: 108.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0461
    Cell Significance Index: 1.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0458
    Cell Significance Index: 1.6100
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0249
    Cell Significance Index: 0.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0237
    Cell Significance Index: 0.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0187
    Cell Significance Index: 3.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0091
    Cell Significance Index: 6.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0061
    Cell Significance Index: 3.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0203
    Cell Significance Index: -15.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0253
    Cell Significance Index: -19.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0262
    Cell Significance Index: -0.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0294
    Cell Significance Index: -4.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0330
    Cell Significance Index: -14.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0369
    Cell Significance Index: -20.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0376
    Cell Significance Index: -16.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0390
    Cell Significance Index: -24.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0626
    Cell Significance Index: -18.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0672
    Cell Significance Index: -1.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0709
    Cell Significance Index: -7.2400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0724
    Cell Significance Index: -0.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0735
    Cell Significance Index: -8.5600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0826
    Cell Significance Index: -0.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0886
    Cell Significance Index: -11.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1012
    Cell Significance Index: -11.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1059
    Cell Significance Index: -12.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1127
    Cell Significance Index: -23.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1133
    Cell Significance Index: -19.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1532
    Cell Significance Index: -4.1700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1645
    Cell Significance Index: -8.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1770
    Cell Significance Index: -18.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2035
    Cell Significance Index: -16.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2173
    Cell Significance Index: -11.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2269
    Cell Significance Index: -6.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2297
    Cell Significance Index: -14.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2440
    Cell Significance Index: -16.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2441
    Cell Significance Index: -18.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2522
    Cell Significance Index: -17.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2611
    Cell Significance Index: -6.6700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2799
    Cell Significance Index: -5.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2859
    Cell Significance Index: -4.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3051
    Cell Significance Index: -5.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3105
    Cell Significance Index: -20.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3219
    Cell Significance Index: -24.7000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3283
    Cell Significance Index: -2.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3291
    Cell Significance Index: -8.2100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3328
    Cell Significance Index: -11.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3440
    Cell Significance Index: -21.6800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3512
    Cell Significance Index: -4.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3638
    Cell Significance Index: -11.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3784
    Cell Significance Index: -3.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.3787
    Cell Significance Index: -4.5900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3790
    Cell Significance Index: -2.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3860
    Cell Significance Index: -6.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3991
    Cell Significance Index: -7.7900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.4050
    Cell Significance Index: -5.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4276
    Cell Significance Index: -8.9500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4320
    Cell Significance Index: -11.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4325
    Cell Significance Index: -15.1500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4366
    Cell Significance Index: -6.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDE9A is a type of phosphodiesterase that specifically hydrolyzes cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), two key secondary messengers in cellular signaling pathways. The enzyme is highly specific, with a preference for cGMP as a substrate. PDE9A is also known to be involved in the regulation of cellular proliferation, differentiation, and survival, particularly in neural precursor cells. **Pathways and Functions:** PDE9A is implicated in various signaling pathways, including: 1. **Camp-mediated signaling:** PDE9A regulates the cAMP pathway by degrading cAMP, thereby modulating the activity of downstream effectors. 2. **Cgmp catabolic process:** PDE9A is responsible for the degradation of cGMP, which plays a crucial role in various cellular processes, including smooth muscle relaxation and neurotransmission. 3. **Cgmp effects:** PDE9A modulates the activity of cGMP-dependent protein kinases (PKG), which are involved in the regulation of various cellular processes, including cardiac hypertrophy and synaptic plasticity. 4. **Nitric oxide stimulates guanylate cyclase:** PDE9A is involved in the regulation of nitric oxide (NO)-stimulated guanylate cyclase activity, which is essential for the production of cGMP. **Clinical Significance:** PDE9A has been implicated in various diseases, including: 1. **Hemostasis disorders:** PDE9A is involved in the regulation of platelet homeostasis and thrombosis, making it a potential target for the treatment of bleeding disorders. 2. **Cardiac hypertrophy:** PDE9A is overexpressed in cardiac hypertrophy, suggesting its potential role as a therapeutic target for the treatment of this condition. 3. **Neurological disorders:** PDE9A is involved in the regulation of neural precursor cell proliferation and synaptic plasticity, making it a potential target for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 4. **Cancer:** PDE9A has been implicated in the regulation of cancer cell growth and survival, suggesting its potential role as a therapeutic target for cancer treatment. In conclusion, PDE9A is a multifunctional enzyme that plays a crucial role in various cellular processes, including signaling pathways, cellular proliferation, and differentiation. Its dysregulation has been implicated in various diseases, making it a potential target for the development of new therapeutic strategies. **Significantly expressed cells:** * Secondary lens fiber * Colon epithelial cell * Lens epithelial cell * Near-projecting glutamatergic cortical neuron * Cerebellar granule cell precursor * CNS interneuron * Renal principal cell * Chandelier pvalb GABAergic cortical interneuron * Neuron associated cell (sensu Vertebrata) * Cardiac neuron **Proteins:** * PDE9A_HUMAN * A0A0S2Z4A3_HUMAN * A0A0S2Z475_HUMAN **References:** * [Insert references to relevant scientific studies and reviews on PDE9A] Note: This article is a comprehensive review of the gene PDE9A, and it is not intended to be a primary research article. The references provided are not real, and you should use a reliable academic search engine to find relevant studies on PDE9A.

Genular Protein ID: 1364831198

Symbol: PDE9A_HUMAN

Name: N/A

UniProtKB Accession Codes:

O76083 B2RBI5 B4DFI5 D3DSJ8 D3DSJ9 O75490 O75491 O95225 Q53Y40 Q5QD39 Q86SF7 Q86SI6 Q86SJ3 Q86WN3 Q86WN4 Q86WN5 Q86WN6 Q86WN7 Q86WN8 Q86WN9 Q86WP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 13 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 38 Ensembl 13 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 16 RNAct 1 Reactome 1 RefSeq 22 Rhea 1 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9624146

Title: Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase.

PubMed ID: 9624146

DOI: 10.1074/jbc.273.25.15559

PubMed ID: 9856478

Title: Identification and characterization of a novel cyclic nucleotide phosphodiesterase gene (PDE9A) that maps to 21q22.3: alternative splicing of mRNA transcripts, genomic structure and sequence.

PubMed ID: 9856478

DOI: 10.1007/s004390050838

PubMed ID: 12565835

Title: Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene.

PubMed ID: 12565835

DOI: 10.1016/s0006-291x(03)00021-4

PubMed ID: 14527714

Title: Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants.

PubMed ID: 14527714

DOI: 10.1016/s0378-1119(03)00733-9

PubMed ID: 17090334

Title: Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene.

PubMed ID: 17090334

DOI: 10.1186/1471-2199-7-39

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16150925

Title: Characterization of the first potent and selective PDE9 inhibitor using a cGMP reporter cell line.

PubMed ID: 16150925

DOI: 10.1124/mol.105.017608

PubMed ID: 22328573

Title: Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.

PubMed ID: 22328573

DOI: 10.1124/jpet.111.191353

PubMed ID: 24746902

Title: Phosphodiesterase 9: insights from protein structure and role in therapeutics.

PubMed ID: 24746902

DOI: 10.1016/j.lfs.2014.04.007

PubMed ID: 25799991

Title: Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.

PubMed ID: 25799991

DOI: 10.1038/nature14332

PubMed ID: 15210993

Title: Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding.

PubMed ID: 15210993

DOI: 10.1073/pnas.0401120101

PubMed ID: 18757755

Title: Structural basis for the catalytic mechanism of human phosphodiesterase 9.

PubMed ID: 18757755

DOI: 10.1073/pnas.0708850105

PubMed ID: 19919087

Title: Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy.

PubMed ID: 19919087

DOI: 10.1021/jm9015334

PubMed ID: 20121115

Title: Insight into binding of phosphodiesterase-9A selective inhibitors by crystal structures and mutagenesis.

PubMed ID: 20121115

DOI: 10.1021/jm901519f

PubMed ID: 21483814

Title: Structural asymmetry of phosphodiesterase-9, potential protonation of a glutamic acid, and role of the invariant glutamine.

PubMed ID: 21483814

DOI: 10.1371/journal.pone.0018092

PubMed ID: 22985069

Title: Structure-based discovery of highly selective phosphodiesterase-9A inhibitors and implications for inhibitor design.

PubMed ID: 22985069

DOI: 10.1021/jm301189c

PubMed ID: 23025719

Title: Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.

PubMed ID: 23025719

DOI: 10.1021/jm3009635

Sequence Information:

  • Length: 593
  • Mass: 68493
  • Checksum: E2731C7C828C0994
  • Sequence:
    • MGSGSSSYRP KAIYLDIDGR IQKVIFSKYC NSSDIMDLFC IATGLPRNTT ISLLTTDDAM 
VSIDPTMPAN SERTPYKVRP VAIKQLSAGV EDKRTTSRGQ SAERPLRDRR VVGLEQPRRE 
GAFESGQVEP RPREPQGCYQ EGQRIPPERE ELIQSVLAQV AEQFSRAFKI NELKAEVANH 
LAVLEKRVEL EGLKVVEIEK CKSDIKKMRE ELAARSSRTN CPCKYSFLDN HKKLTPRRDV 
PTYPKYLLSP ETIEALRKPT FDVWLWEPNE MLSCLEHMYH DLGLVRDFSI NPVTLRRWLF 
CVHDNYRNNP FHNFRHCFCV AQMMYSMVWL CSLQEKFSQT DILILMTAAI CHDLDHPGYN 
NTYQINARTE LAVRYNDISP LENHHCAVAF QILAEPECNI FSNIPPDGFK QIRQGMITLI 
LATDMARHAE IMDSFKEKME NFDYSNEEHM TLLKMILIKC CDISNEVRPM EVAEPWVDCL 
LEEYFMQSDR EKSEGLPVAP FMDRDKVTKA TAQIGFIKFV LIPMFETVTK LFPMVEEIML 
QPLWESRDRY EELKRIDDAM KELQKKTDSL TSGATEKSRE RSRDVKNSEG DCA

Genular Protein ID: 3594017739

Symbol: A0A0S2Z475_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z475

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 7 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 3 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 465
  • Mass: 54096
  • Checksum: BDD6A8F85E591A67
  • Sequence:
    • MGSGSSSYRP KAIYLDIDGR IQKHSVQSET CGHQATLRAF KINELKAEVA NHLAVLEKRV 
ELEGLKVVEI EKCKSDIKKM REELAARSSR TNCPCKYSFL DNHKKLTPRR DVPTYPKYLL 
SPETIEALRK PTFDVWLWEP NEMLSCLEHM YHDLGLVRDF SINPVTLRRW LFCVHDNYRN 
NPFHNFRHCF CVAQMMYSMV WLCSLQEKFS QTDILILMTA AICHDLDHPG YNNTYQINAR 
TELAVRYNDI SPLENHHCAV AFQILAEPEC NIFSNIPPDG FKQIRQGMIT LILATDMARH 
AEIMDSFKEK MENFDYSNEE HMTLLKMILI KCCDISNEVR PMEVAEPWVD CLLEEYFMQS 
DREKSEGLPV APFMDRDKVT KATAQIGFIK FVLIPMFETV TKLFPMVEEI MLQPLWESRD 
RYEELKRIDD AMKELQKKTD SLTSGATEKS RERSRDVKNS EGDCA

Genular Protein ID: 591619786

Symbol: A0A0S2Z4A3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4A3

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 3 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 533
  • Mass: 61709
  • Checksum: 728ADAAACE0E4D29
  • Sequence:
    • MGSGSSSYRP KAIYLDIDGR IQKVIFSKYC NSSDIMDLFC IATGLPRNTT ISLLTTDDAM 
VSIDPTMPAN SERTPYKVRP VAIKQLSERE ELIQSVLAQV AEQFSRAFKI NELKAEVANH 
LAVLEKRVEL EGLKVVEIEK CKSDIKKMRE ELAARSSRTN CPCKYSFLDN HKKLTPRRDV 
PTYPKYLLSP ETIEALRKPT FDVWLWEPNE MLSCLEHMYH DLGLVRDFSI NPVTLRRWLF 
CVHDNYRNNP FHNFRHCFCV AQMMYSMVWL CSLQEKFSQT DILILMTAAI CHDLDHPGYN 
NTYQINARTE LAVRYNDISP LENHHCAVAF QILAEPECNI FSNIPPDGFK QIRQGMITLI 
LATDMARHAE IMDSFKEKME NFDYSNEEHM TLLKMILIKC CDISNEVRPM EVAEPWVDCL 
LEEYFMQSDR EKSEGLPVAP FMDRDKVTKA TAQIGFIKFV LIPMFETVTK LFPMVEEIML 
QPLWESRDRY EELKRIDDAM KELQKKTDSL TSGATEKSRE RSRDVKNSEG DCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.