Details for: CXXC5

Gene ID: 51523

Symbol: CXXC5

Ensembl ID: ENSG00000171604

Description: CXXC finger protein 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 259.1529
    Cell Significance Index: -40.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.6091
    Cell Significance Index: -34.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.1954
    Cell Significance Index: -35.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.3483
    Cell Significance Index: -41.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.6960
    Cell Significance Index: -35.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.9461
    Cell Significance Index: -44.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.0022
    Cell Significance Index: -37.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1571
    Cell Significance Index: -37.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4773
    Cell Significance Index: -45.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.7075
    Cell Significance Index: 665.1400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.9090
    Cell Significance Index: 39.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.5349
    Cell Significance Index: 157.5900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.7767
    Cell Significance Index: 29.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.2788
    Cell Significance Index: 172.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.1754
    Cell Significance Index: 46.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5362
    Cell Significance Index: 99.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4366
    Cell Significance Index: 784.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3714
    Cell Significance Index: 149.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2711
    Cell Significance Index: 254.9900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2533
    Cell Significance Index: 203.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2016
    Cell Significance Index: 72.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8974
    Cell Significance Index: 41.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8454
    Cell Significance Index: 167.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8452
    Cell Significance Index: 144.3200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.8307
    Cell Significance Index: 6.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7356
    Cell Significance Index: 86.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6889
    Cell Significance Index: 47.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5740
    Cell Significance Index: 32.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5296
    Cell Significance Index: 33.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5018
    Cell Significance Index: 37.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3782
    Cell Significance Index: 37.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3356
    Cell Significance Index: 120.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2442
    Cell Significance Index: 6.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2309
    Cell Significance Index: 43.9400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1605
    Cell Significance Index: 2.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1580
    Cell Significance Index: 7.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1495
    Cell Significance Index: 94.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1235
    Cell Significance Index: 8.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1207
    Cell Significance Index: 227.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1013
    Cell Significance Index: 70.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0982
    Cell Significance Index: 71.9900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0642
    Cell Significance Index: 0.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0416
    Cell Significance Index: 1.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0333
    Cell Significance Index: 45.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0288
    Cell Significance Index: 5.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0284
    Cell Significance Index: 3.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0177
    Cell Significance Index: 27.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0126
    Cell Significance Index: 0.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0031
    Cell Significance Index: 1.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0054
    Cell Significance Index: -0.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0200
    Cell Significance Index: -14.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0271
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0311
    Cell Significance Index: -19.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0326
    Cell Significance Index: -14.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0441
    Cell Significance Index: -33.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0546
    Cell Significance Index: -30.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0693
    Cell Significance Index: -7.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0961
    Cell Significance Index: -2.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0980
    Cell Significance Index: -12.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1075
    Cell Significance Index: -22.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1212
    Cell Significance Index: -34.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1411
    Cell Significance Index: -16.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1425
    Cell Significance Index: -20.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1507
    Cell Significance Index: -3.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1858
    Cell Significance Index: -14.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2088
    Cell Significance Index: -5.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2216
    Cell Significance Index: -17.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2889
    Cell Significance Index: -17.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3282
    Cell Significance Index: -15.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3380
    Cell Significance Index: -38.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3512
    Cell Significance Index: -8.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3553
    Cell Significance Index: -11.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3692
    Cell Significance Index: -10.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3894
    Cell Significance Index: -40.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4280
    Cell Significance Index: -12.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4572
    Cell Significance Index: -9.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4655
    Cell Significance Index: -13.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5765
    Cell Significance Index: -14.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5789
    Cell Significance Index: -7.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5825
    Cell Significance Index: -30.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5982
    Cell Significance Index: -42.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6110
    Cell Significance Index: -17.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7002
    Cell Significance Index: -42.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7071
    Cell Significance Index: -7.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7242
    Cell Significance Index: -12.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7338
    Cell Significance Index: -20.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7689
    Cell Significance Index: -10.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8159
    Cell Significance Index: -41.2300
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.8276
    Cell Significance Index: -7.2900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8740
    Cell Significance Index: -12.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9288
    Cell Significance Index: -29.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9472
    Cell Significance Index: -15.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9719
    Cell Significance Index: -42.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9765
    Cell Significance Index: -34.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9881
    Cell Significance Index: -32.3500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0033
    Cell Significance Index: -17.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0136
    Cell Significance Index: -37.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0321
    Cell Significance Index: -20.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CXXC5 is a small, cytoplasmic protein that belongs to the CXXC family of zinc finger proteins. The CXXC motif in CXXC5 is composed of three cysteine residues, which bind to zinc ions, allowing the protein to interact with DNA and other proteins. This motif is essential for the protein's function, as it enables CXXC5 to regulate gene expression and participate in various cellular processes. **Pathways and Functions:** CXXC5 has been implicated in multiple signaling pathways and cellular processes, including: 1. **DNA-binding transcription factor binding**: CXXC5 interacts with transcription factors, such as NF-κB, to regulate gene expression. 2. **Esr-mediated signaling**: CXXC5 is involved in the regulation of estrogen-dependent gene expression, which is critical in various physiological and pathological processes. 3. **Methyl-CpG binding**: CXXC5 binds to methylated DNA, which is essential for the regulation of gene expression and DNA repair. 4. **Negative regulation of transcription by RNA polymerase II**: CXXC5 inhibits the activity of RNA polymerase II, a key enzyme in transcription. 5. **Zinc ion binding**: CXXC5's CXXC motif binds to zinc ions, which are essential for protein function and stability. **Clinical Significance:** CXXC5 has been identified in various disease contexts, including: 1. **Cancer**: CXXC5 has been implicated in the regulation of gene expression in cancer cells, including the promotion of oncogenesis. 2. **Inflammatory diseases**: CXXC5 has been shown to regulate the activity of immune cells, including T cells and mast cells, which are involved in inflammatory diseases. 3. **Neurological disorders**: CXXC5 has been implicated in the regulation of gene expression in neurons, which is essential for maintaining neural function and preventing neurodegenerative diseases. In conclusion, CXXC5 is a multifunctional protein that plays a critical role in various cellular processes, including gene regulation, DNA repair, and immune function. Its dysregulation has been implicated in various disease contexts, highlighting the importance of further research into the functions and significance of CXXC5. **Recommendations:** Further studies are needed to elucidate the mechanisms by which CXXC5 regulates gene expression and participates in various cellular processes. Additionally, the clinical significance of CXXC5 in human health and disease should be further investigated, including the development of diagnostic and therapeutic strategies for diseases associated with CXXC5 dysregulation. **Future Directions:** Future studies should focus on the following areas: 1. **Elucidating the mechanisms of CXXC5 regulation**: Further research is needed to understand the molecular mechanisms by which CXXC5 regulates gene expression and participates in various cellular processes. 2. **Investigating the clinical significance of CXXC5 in human health and disease**: The clinical significance of CXXC5 in various disease contexts should be further investigated, including the development of diagnostic and therapeutic strategies. 3. **Developing therapeutic strategies for CXXC5-related diseases**: The development of therapeutic strategies for diseases associated with CXXC5 dysregulation, such as cancer and inflammatory diseases, should be further investigated.

Genular Protein ID: 216342820

Symbol: CXXC5_HUMAN

Name: CXXC-type zinc finger protein 5

UniProtKB Accession Codes:

Q7LFL8 B3KND0 C8CBA8 Q8TB79 Q9NV51 Q9P0S8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 2 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 15 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 19557330

Title: The CXXC finger 5 protein is required for DNA damage-induced p53 activation.

PubMed ID: 19557330

DOI: 10.1007/s11427-009-0083-7

PubMed ID: 12761501

Title: Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

PubMed ID: 12761501

DOI: 10.1038/sj.onc.1206406

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 19182210

Title: Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis.

PubMed ID: 19182210

DOI: 10.1182/blood-2008-07-170035

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23303788

Title: Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.

PubMed ID: 23303788

DOI: 10.1093/nar/gks1454

PubMed ID: 29276034

Title: DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.

PubMed ID: 29276034

DOI: 10.1016/j.str.2017.11.022

Sequence Information:

  • Length: 322
  • Mass: 32977
  • Checksum: ECC19B4DE9872BC5
  • Sequence:
    • MSSLGGGSQD AGGSSSSSTN GSGGSGSSGP KAGAADKSAV VAAAAPASVA DDTPPPERRN 
KSGIISEPLN KSLRRSRPLS HYSSFGSSGG SGGGSMMGGE SADKATAAAA AASLLANGHD 
LAAAMAVDKS NPTSKHKSGA VASLLSKAER ATELAAEGQL TLQQFAQSTE MLKRVVQEHL 
PLMSEAGAGL PDMEAVAGAE ALNGQSDFPY LGAFPINPGL FIMTPAGVFL AESALHMAGL 
AEYPMQGELA SAISSGKKKR KRCGMCAPCR RRINCEQCSS CRNRKTGHQI CKFRKCEELK 
KKPSAALEKV MLPTGAAFRW FQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.