Details for: SIRT7

Gene ID: 51547

Symbol: SIRT7

Ensembl ID: ENSG00000187531

Description: sirtuin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 134.4304
    Cell Significance Index: -20.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.2986
    Cell Significance Index: -22.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.3137
    Cell Significance Index: -25.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.0083
    Cell Significance Index: -21.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.5499
    Cell Significance Index: -24.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.9407
    Cell Significance Index: -24.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.9172
    Cell Significance Index: -21.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.9707
    Cell Significance Index: -23.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.4990
    Cell Significance Index: -17.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3716
    Cell Significance Index: -19.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1327
    Cell Significance Index: -24.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9667
    Cell Significance Index: -10.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4586
    Cell Significance Index: 19.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4235
    Cell Significance Index: 21.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3813
    Cell Significance Index: 62.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2220
    Cell Significance Index: 73.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2130
    Cell Significance Index: 78.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1455
    Cell Significance Index: 33.0100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0806
    Cell Significance Index: 117.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0542
    Cell Significance Index: 54.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0008
    Cell Significance Index: 27.9700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9225
    Cell Significance Index: 14.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8460
    Cell Significance Index: 763.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6958
    Cell Significance Index: 18.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6776
    Cell Significance Index: 122.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6684
    Cell Significance Index: 66.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6173
    Cell Significance Index: 42.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5604
    Cell Significance Index: 15.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5384
    Cell Significance Index: 66.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4960
    Cell Significance Index: 99.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4334
    Cell Significance Index: 86.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4206
    Cell Significance Index: 19.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3918
    Cell Significance Index: 213.9800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3735
    Cell Significance Index: 17.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3578
    Cell Significance Index: 68.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3540
    Cell Significance Index: 3.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2722
    Cell Significance Index: 120.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2547
    Cell Significance Index: 8.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2453
    Cell Significance Index: 33.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2290
    Cell Significance Index: 17.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2187
    Cell Significance Index: 25.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2039
    Cell Significance Index: 33.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1818
    Cell Significance Index: 12.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1633
    Cell Significance Index: 58.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1488
    Cell Significance Index: 3.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1228
    Cell Significance Index: 2.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1076
    Cell Significance Index: 74.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0957
    Cell Significance Index: 2.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0906
    Cell Significance Index: 1.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0635
    Cell Significance Index: 8.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0335
    Cell Significance Index: 4.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0019
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0037
    Cell Significance Index: -6.8500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -4.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0097
    Cell Significance Index: -14.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.7000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0152
    Cell Significance Index: -11.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0190
    Cell Significance Index: -3.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0202
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0274
    Cell Significance Index: -20.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0328
    Cell Significance Index: -14.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0373
    Cell Significance Index: -21.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0411
    Cell Significance Index: -4.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0445
    Cell Significance Index: -27.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0519
    Cell Significance Index: -7.5400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0611
    Cell Significance Index: -0.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0684
    Cell Significance Index: -19.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0694
    Cell Significance Index: -7.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0817
    Cell Significance Index: -4.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1167
    Cell Significance Index: -13.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1242
    Cell Significance Index: -2.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1243
    Cell Significance Index: -9.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1254
    Cell Significance Index: -26.4200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1383
    Cell Significance Index: -2.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1911
    Cell Significance Index: -12.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1921
    Cell Significance Index: -12.1100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2011
    Cell Significance Index: -1.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2060
    Cell Significance Index: -12.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2286
    Cell Significance Index: -23.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2717
    Cell Significance Index: -9.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2725
    Cell Significance Index: -15.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2743
    Cell Significance Index: -7.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2822
    Cell Significance Index: -7.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2846
    Cell Significance Index: -12.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2848
    Cell Significance Index: -22.5600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3415
    Cell Significance Index: -12.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3830
    Cell Significance Index: -10.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4011
    Cell Significance Index: -24.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4272
    Cell Significance Index: -9.8700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4533
    Cell Significance Index: -7.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4639
    Cell Significance Index: -5.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4811
    Cell Significance Index: -14.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4909
    Cell Significance Index: -10.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4915
    Cell Significance Index: -12.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5193
    Cell Significance Index: -16.5400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5259
    Cell Significance Index: -4.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5284
    Cell Significance Index: -15.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5361
    Cell Significance Index: -14.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SIRT7 is a relatively large protein, consisting of 504 amino acids, with a molecular weight of approximately 60 kDa. It is characterized by its ability to bind to NAD+, which serves as a cofactor for its deacetylase activity. SIRT7 is predominantly localized to the nucleolus, where it interacts with various components of the nucleolar machinery, including histone deacetylases and RNA polymerase I. The protein exhibits a high degree of specificity for certain substrates, including histones, transcription factors, and metabolic enzymes. **Pathways and Functions:** SIRT7 is involved in a wide range of cellular processes, including: 1. **DNA Damage Response:** SIRT7 has been shown to regulate the activity of DNA repair enzymes, such as PARP1 and MRE11, and modulate the expression of genes involved in DNA repair and replication. 2. **Epigenetic Regulation:** SIRT7 interacts with histone deacetylases and regulates the acetylation status of histones, which is essential for chromatin remodeling and gene expression. 3. **Metabolism:** SIRT7 has been implicated in the regulation of gluconeogenesis, fatty acid metabolism, and amino acid synthesis. 4. **Transcriptional Control:** SIRT7 modulates the activity of transcription factors, such as HIF1α and NF-κB, and regulates the expression of genes involved in various cellular processes. 5. **Nucleolar Function:** SIRT7 plays a critical role in maintaining the structure and function of the nucleolus, where it interacts with components of the nucleolar machinery, including RNA polymerase I and histone deacetylases. **Clinical Significance:** Dysregulation of SIRT7 has been implicated in various diseases, including: 1. **Cancer:** SIRT7 has been shown to be overexpressed in certain types of cancer, including breast and colon cancer, where it promotes tumor growth and metastasis. 2. **Aging:** SIRT7 has been implicated in the regulation of aging-related processes, including telomere shortening and epigenetic changes. 3. **Metabolic Disorders:** SIRT7 has been linked to metabolic disorders, including diabetes and obesity, where it regulates glucose and lipid metabolism. 4. **Neurodegenerative Diseases:** SIRT7 has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's, where it regulates the activity of transcription factors and modulates the expression of genes involved in neuronal function. **Conclusion:** SIRT7 is a multifunctional protein that plays a critical role in maintaining cellular homeostasis, particularly in the context of DNA damage response, epigenetic regulation, and metabolism. Its dysregulation has been implicated in various diseases, including cancer, aging, metabolic disorders, and neurodegenerative diseases. Further research is needed to elucidate the mechanisms by which SIRT7 regulates cellular processes and to explore its potential therapeutic applications.

Genular Protein ID: 3863776553

Symbol: SIR7_HUMAN

Name: NAD-dependent protein deacetylase sirtuin-7

UniProtKB Accession Codes:

Q9NRC8 A8K2K0 B3KSU8 Q3MIK4 Q9NSZ6 Q9NUS6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 40 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 Rhea 20 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10873683

Title: Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins.

PubMed ID: 10873683

DOI: 10.1006/bbrc.2000.3000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11953824

Title: Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.

PubMed ID: 11953824

DOI: 10.1038/sj.bjc.6600156

PubMed ID: 12454780

Title:

PubMed ID: 12454780

DOI: 10.1038/sj.bjc.6600636

PubMed ID: 12454781

Title: 'SIRT8' expressed in thyroid cancer is actually SIRT7.

PubMed ID: 12454781

DOI: 10.1038/sj.bjc.6600635

PubMed ID: 16079181

Title: Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

PubMed ID: 16079181

DOI: 10.1091/mbc.e05-01-0033

PubMed ID: 16618798

Title: Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.

PubMed ID: 16618798

DOI: 10.1101/gad.1399706

PubMed ID: 19174463

Title: Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis.

PubMed ID: 19174463

DOI: 10.1242/jcs.042382

PubMed ID: 22586326

Title: Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

PubMed ID: 22586326

DOI: 10.1074/mcp.a111.015156

PubMed ID: 22722849

Title: SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation.

PubMed ID: 22722849

DOI: 10.1038/nature11043

PubMed ID: 24207024

Title: Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.

PubMed ID: 24207024

DOI: 10.1016/j.molcel.2013.10.010

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26907567

Title: SIRT7 is activated by DNA and deacetylates histone H3 in the chromatin context.

PubMed ID: 26907567

DOI: 10.1021/acschembio.5b01084

PubMed ID: 26867678

Title: SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing.

PubMed ID: 26867678

DOI: 10.1038/ncomms10734

PubMed ID: 27436229

Title: SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.

PubMed ID: 27436229

DOI: 10.1038/ncomms12235

PubMed ID: 27997115

Title: SIRT7 is an RNA-activated protein lysine deacylase.

PubMed ID: 27997115

DOI: 10.1021/acschembio.6b00954

PubMed ID: 28147277

Title: Regulation of serine-threonine kinase Akt activation by NAD+-dependent deacetylase SIRT7.

PubMed ID: 28147277

DOI: 10.1016/j.celrep.2017.01.009

PubMed ID: 28886238

Title: SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes.

PubMed ID: 28886238

DOI: 10.1111/febs.14259

PubMed ID: 28790157

Title: SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.

PubMed ID: 28790157

DOI: 10.1101/gad.300624.117

PubMed ID: 28655758

Title: Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis.

PubMed ID: 28655758

DOI: 10.1074/jbc.m117.780130

PubMed ID: 28426094

Title: SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription.

PubMed ID: 28426094

DOI: 10.1093/nar/gkx053

PubMed ID: 30540930

Title: SIRT7-dependent deacetylation of fibrillarin controls histone H2A methylation and rRNA synthesis during the cell cycle.

PubMed ID: 30540930

DOI: 10.1016/j.celrep.2018.11.051

PubMed ID: 30420520

Title: Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis.

PubMed ID: 30420520

DOI: 10.15252/embr.201846377

PubMed ID: 29728458

Title: The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability.

PubMed ID: 29728458

DOI: 10.1074/jbc.ac118.003325

PubMed ID: 31075303

Title: SIRT7 regulates the nuclear export of NF-kappaB p65 by deacetylating Ran.

PubMed ID: 31075303

DOI: 10.1016/j.bbamcr.2019.05.001

PubMed ID: 30653310

Title: A click chemistry approach reveals the chromatin-dependent histone H3K36 deacylase nature of SIRT7.

PubMed ID: 30653310

DOI: 10.1021/jacs.8b12083

PubMed ID: 31542297

Title: Glutarylation of histone H4 lysine 91 regulates chromatin dynamics.

PubMed ID: 31542297

DOI: 10.1016/j.molcel.2019.08.018

PubMed ID: 31226208

Title: SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina.

PubMed ID: 31226208

DOI: 10.1093/nar/gkz519

PubMed ID: 35939806

Title: Potent Activation of NAD+-Dependent Deacetylase Sirt7 by Nucleosome Binding.

PubMed ID: 35939806

DOI: 10.1021/acschembio.2c00348

PubMed ID: 30944854

Title: SIRT7-mediated ATM deacetylation is essential for its deactivation and DNA damage repair.

PubMed ID: 30944854

DOI: 10.1126/sciadv.aav1118

PubMed ID: 36646384

Title: E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide.

PubMed ID: 36646384

DOI: 10.1016/j.jbc.2023.102909

PubMed ID: 27287224

Title: Crystal structure of the N-terminal domain of human SIRT7 reveals a three-helical domain architecture.

PubMed ID: 27287224

DOI: 10.1002/prot.25085

Sequence Information:

  • Length: 400
  • Mass: 44898
  • Checksum: 55D7736A864AFE6F
  • Sequence:
    • MAAGGLSRSE RKAAERVRRL REEQQRERLR QVSRILRKAA AERSAEEGRL LAESADLVTE 
LQGRSRRREG LKRRQEEVCD DPEELRGKVR ELASAVRNAK YLVVYTGAGI STAASIPDYR 
GPNGVWTLLQ KGRSVSAADL SEAEPTLTHM SITRLHEQKL VQHVVSQNCD GLHLRSGLPR 
TAISELHGNM YIEVCTSCVP NREYVRVFDV TERTALHRHQ TGRTCHKCGT QLRDTIVHFG 
ERGTLGQPLN WEAATEAASR ADTILCLGSS LKVLKKYPRL WCMTKPPSRR PKLYIVNLQW 
TPKDDWAALK LHGKCDDVMR LLMAELGLEI PAYSRWQDPI FSLATPLRAG EEGSHSRKSL 
CRSREEAPPG DRGAPLSSAP ILGGWFGRGC TKRTKRKKVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.