Details for: RAB6B

Gene ID: 51560

Symbol: RAB6B

Ensembl ID: ENSG00000154917

Description: RAB6B, member RAS oncogene family

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 136.8091
    Cell Significance Index: -21.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 107.4737
    Cell Significance Index: -27.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.1200
    Cell Significance Index: -26.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.2278
    Cell Significance Index: -24.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.9031
    Cell Significance Index: -27.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0599
    Cell Significance Index: 413.2100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8748
    Cell Significance Index: 53.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5188
    Cell Significance Index: 93.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1946
    Cell Significance Index: 428.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9589
    Cell Significance Index: 64.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9065
    Cell Significance Index: 55.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7744
    Cell Significance Index: 90.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6872
    Cell Significance Index: 16.4800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.6829
    Cell Significance Index: 9.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6623
    Cell Significance Index: 41.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6197
    Cell Significance Index: 27.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5873
    Cell Significance Index: 22.2400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5670
    Cell Significance Index: 25.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4959
    Cell Significance Index: 94.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4809
    Cell Significance Index: 5.9700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4480
    Cell Significance Index: 5.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4236
    Cell Significance Index: 22.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4211
    Cell Significance Index: 61.2100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3772
    Cell Significance Index: 12.0800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3307
    Cell Significance Index: 5.4500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2805
    Cell Significance Index: 2.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2354
    Cell Significance Index: 212.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2140
    Cell Significance Index: 21.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1032
    Cell Significance Index: 16.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0586
    Cell Significance Index: 32.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0169
    Cell Significance Index: 1.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0095
    Cell Significance Index: 1.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0093
    Cell Significance Index: 0.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0006
    Cell Significance Index: 1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0070
    Cell Significance Index: -10.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0097
    Cell Significance Index: -0.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0111
    Cell Significance Index: -0.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0122
    Cell Significance Index: -7.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0202
    Cell Significance Index: -0.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0296
    Cell Significance Index: -0.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0346
    Cell Significance Index: -26.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0356
    Cell Significance Index: -26.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0393
    Cell Significance Index: -2.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0410
    Cell Significance Index: -18.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0435
    Cell Significance Index: -24.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0493
    Cell Significance Index: -22.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0506
    Cell Significance Index: -31.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0540
    Cell Significance Index: -1.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0708
    Cell Significance Index: -12.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0737
    Cell Significance Index: -21.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0981
    Cell Significance Index: -6.7800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1037
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1082
    Cell Significance Index: -18.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1118
    Cell Significance Index: -22.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1125
    Cell Significance Index: -1.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1172
    Cell Significance Index: -11.9700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1216
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1414
    Cell Significance Index: -29.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1418
    Cell Significance Index: -8.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1443
    Cell Significance Index: -18.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1511
    Cell Significance Index: -18.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1586
    Cell Significance Index: -21.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1664
    Cell Significance Index: -19.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1700
    Cell Significance Index: -9.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1836
    Cell Significance Index: -2.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1894
    Cell Significance Index: -24.2800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1957
    Cell Significance Index: -3.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2201
    Cell Significance Index: -25.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2308
    Cell Significance Index: -7.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2336
    Cell Significance Index: -4.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2437
    Cell Significance Index: -5.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2512
    Cell Significance Index: -5.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2599
    Cell Significance Index: -27.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2747
    Cell Significance Index: -21.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2886
    Cell Significance Index: -9.4500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2995
    Cell Significance Index: -2.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3070
    Cell Significance Index: -22.8800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3171
    Cell Significance Index: -6.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3185
    Cell Significance Index: -3.4700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3472
    Cell Significance Index: -4.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3636
    Cell Significance Index: -18.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3736
    Cell Significance Index: -10.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3785
    Cell Significance Index: -26.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3905
    Cell Significance Index: -8.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3931
    Cell Significance Index: -25.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3939
    Cell Significance Index: -8.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4053
    Cell Significance Index: -19.0500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4606
    Cell Significance Index: -11.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4653
    Cell Significance Index: -16.3000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4791
    Cell Significance Index: -6.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4862
    Cell Significance Index: -10.3600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4946
    Cell Significance Index: -11.9800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5015
    Cell Significance Index: -6.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5211
    Cell Significance Index: -7.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5442
    Cell Significance Index: -14.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5491
    Cell Significance Index: -11.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5503
    Cell Significance Index: -6.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RAB6B shares several key characteristics with other RAB proteins, including: 1. **GTPase activity**: RAB6B possesses GTPase activity, which enables it to hydrolyze GTP to GDP, regulating its active state and interactions with downstream effectors. 2. **Rab GEF and GAP exchange**: RAB6B can exchange GDP for GTP through the action of a GEF (guanine nucleotide exchange factor) or exchange GDP for GTP through the action of a GAP (GTPase-activating protein). 3. **Geranylgeranylation**: RAB6B undergoes geranylgeranylation, a post-translational modification that anchors the protein to the Golgi membrane. 4. **Regulation of trafficking**: RAB6B regulates various forms of trafficking, including retrograde and anterograde transport, to maintain cellular homeostasis and function. **Pathways and Functions** RAB6B is involved in several key pathways, including: 1. **Copi-independent golgi-to-ER retrograde traffic**: RAB6B regulates the transport of proteins from the Golgi apparatus to the endoplasmic reticulum (ER) through copi-independent mechanisms. 2. **Cytoplasmic vesicle formation**: RAB6B is involved in the formation and movement of cytoplasmic vesicles, which are essential for protein transport and cellular homeostasis. 3. **Intra-golgi and retrograde golgi-to-ER traffic**: RAB6B regulates the movement of proteins within the Golgi apparatus and between the Golgi and ER. 4. **Intra-golgi and retrograde vesicle-mediated transport**: RAB6B regulates the transport of proteins within the Golgi apparatus and between the Golgi and ER through vesicle-mediated mechanisms. **Clinical Significance** RAB6B's involvement in various cellular processes has significant implications for human disease. Abnormal expression or function of RAB6B has been linked to: 1. **Hematological disorders**: RAB6B is highly expressed in hematopoietic cells, and alterations in its expression or function may contribute to hematological disorders, such as leukemia or lymphoma. 2. **Neurodegenerative diseases**: RAB6B is expressed in neurons and has been implicated in neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. 3. **Cancer**: RAB6B has been shown to be overexpressed in certain types of cancer, including breast cancer or colon cancer, and may contribute to tumorigenesis. In conclusion, RAB6B plays a critical role in regulating various cellular processes, particularly in the endomembrane system. Its involvement in hematopoietic cells, neurons, and certain epithelial cells highlights its importance in maintaining cellular homeostasis and function. Further research on RAB6B's role in human disease may lead to the development of novel therapeutic strategies for treating various disorders.

Genular Protein ID: 1615489827

Symbol: RAB6B_HUMAN

Name: Ras-related protein Rab-6B

UniProtKB Accession Codes:

Q9NRW1 B2R5Z9 B7Z337 D3DND3 Q92929

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 Rhea 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10893188

Title: The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus.

PubMed ID: 10893188

DOI: 10.1242/jcs.113.15.2725

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9030196

Title: RAB GTPases expressed in human melanoma cells.

PubMed ID: 9030196

DOI: 10.1016/s0167-4889(96)00169-3

PubMed ID: 17707369

Title: A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells.

PubMed ID: 17707369

DOI: 10.1016/j.yexcr.2007.05.032

PubMed ID: 18044744

Title: Rab6 family proteins interact with the dynein light chain protein DYNLRB1.

PubMed ID: 18044744

DOI: 10.1002/cm.20254

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21822290

Title: Modulation of Rab GTPase function by a protein phosphocholine transferase.

PubMed ID: 21822290

DOI: 10.1038/nature10335

PubMed ID: 23737971

Title: A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6.

PubMed ID: 23737971

DOI: 10.1371/journal.pone.0064149

PubMed ID: 26209634

Title: Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.

PubMed ID: 26209634

DOI: 10.1074/jbc.m115.669242

PubMed ID: 25492866

Title: Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth.

PubMed ID: 25492866

DOI: 10.1074/jbc.m114.608174

PubMed ID: 16790928

Title: The structure of human neuronal Rab6B in the active and inactive form.

PubMed ID: 16790928

DOI: 10.1107/s0907444906015319

Sequence Information:

  • Length: 208
  • Mass: 23462
  • Checksum: E81C831996E2446D
  • Sequence:
    • MSAGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR 
TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNLNS FQQTSKWIDD VRTERGSDVI 
IMLVGNKTDL ADKRQITIEE GEQRAKELSV MFIETSAKTG YNVKQLFRRV ASALPGMENV 
QEKSKEGMID IKLDKPQEPP ASEGGCSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.