Details for: PDK1

Gene ID: 5163

Symbol: PDK1

Ensembl ID: ENSG00000152256

Description: pyruvate dehydrogenase kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 130.3801
    Cell Significance Index: -20.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 79.5211
    Cell Significance Index: -20.1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 55.3954
    Cell Significance Index: -22.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.6359
    Cell Significance Index: -22.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.5715
    Cell Significance Index: -18.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.9025
    Cell Significance Index: -20.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4392
    Cell Significance Index: -22.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4600
    Cell Significance Index: -16.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3623
    Cell Significance Index: -21.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.3903
    Cell Significance Index: -7.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.3814
    Cell Significance Index: 90.6100
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.6231
    Cell Significance Index: 1.1600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.5810
    Cell Significance Index: 19.6100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.3218
    Cell Significance Index: 2.9800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1806
    Cell Significance Index: 9.1000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.0553
    Cell Significance Index: 17.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0144
    Cell Significance Index: 100.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8648
    Cell Significance Index: 173.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7422
    Cell Significance Index: 147.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6010
    Cell Significance Index: 215.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.5880
    Cell Significance Index: 8.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5182
    Cell Significance Index: 84.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5042
    Cell Significance Index: 26.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4978
    Cell Significance Index: 54.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4469
    Cell Significance Index: 26.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4208
    Cell Significance Index: 23.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3823
    Cell Significance Index: 588.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3113
    Cell Significance Index: 16.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2871
    Cell Significance Index: 259.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2822
    Cell Significance Index: 383.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2802
    Cell Significance Index: 7.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2622
    Cell Significance Index: 20.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2491
    Cell Significance Index: 459.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2106
    Cell Significance Index: 14.5700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2003
    Cell Significance Index: 9.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1995
    Cell Significance Index: 375.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1827
    Cell Significance Index: 126.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1621
    Cell Significance Index: 88.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1617
    Cell Significance Index: 7.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1556
    Cell Significance Index: 98.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1527
    Cell Significance Index: 1.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1517
    Cell Significance Index: 28.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1408
    Cell Significance Index: 3.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1311
    Cell Significance Index: 59.5000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1249
    Cell Significance Index: 55.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1248
    Cell Significance Index: 3.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1177
    Cell Significance Index: 7.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0864
    Cell Significance Index: 3.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0478
    Cell Significance Index: 1.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0477
    Cell Significance Index: 5.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0381
    Cell Significance Index: 2.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0285
    Cell Significance Index: 3.9200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0278
    Cell Significance Index: 0.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0169
    Cell Significance Index: 2.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0042
    Cell Significance Index: 0.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0037
    Cell Significance Index: 0.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0152
    Cell Significance Index: -0.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0173
    Cell Significance Index: -2.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0207
    Cell Significance Index: -15.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0209
    Cell Significance Index: -15.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0249
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0250
    Cell Significance Index: -18.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0317
    Cell Significance Index: -17.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0368
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0374
    Cell Significance Index: -23.3800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0412
    Cell Significance Index: -0.3400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0421
    Cell Significance Index: -0.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0447
    Cell Significance Index: -4.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0544
    Cell Significance Index: -15.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0641
    Cell Significance Index: -7.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0686
    Cell Significance Index: -4.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0750
    Cell Significance Index: -9.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0950
    Cell Significance Index: -6.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1057
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1093
    Cell Significance Index: -23.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1108
    Cell Significance Index: -2.3600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1135
    Cell Significance Index: -1.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1168
    Cell Significance Index: -15.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1296
    Cell Significance Index: -8.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1311
    Cell Significance Index: -2.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1516
    Cell Significance Index: -17.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1568
    Cell Significance Index: -7.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1637
    Cell Significance Index: -1.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1826
    Cell Significance Index: -3.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2173
    Cell Significance Index: -6.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2384
    Cell Significance Index: -17.7700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2385
    Cell Significance Index: -3.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2564
    Cell Significance Index: -20.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2615
    Cell Significance Index: -5.7300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2760
    Cell Significance Index: -16.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2880
    Cell Significance Index: -7.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3062
    Cell Significance Index: -10.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3079
    Cell Significance Index: -16.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3155
    Cell Significance Index: -5.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3167
    Cell Significance Index: -5.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3233
    Cell Significance Index: -8.8000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3296
    Cell Significance Index: -4.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3683
    Cell Significance Index: -8.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3764
    Cell Significance Index: -2.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDK1 is a mitochondrial enzyme that belongs to the kinase family. It is specifically expressed in various cell types, including lens epithelial cells, corneal endothelial cells, and granulosa cells. PDK1 is characterized by its ability to phosphorylate and regulate the activity of the pyruvate dehydrogenase complex (PDC), which is a crucial enzyme in the conversion of pyruvate to acetyl-CoA. This process is essential for the production of energy in the form of ATP. **Pathways and Functions:** PDK1 is involved in several key metabolic pathways, including: 1. **Glucose Metabolic Process:** PDK1 regulates the conversion of pyruvate to acetyl-CoA, which is a critical step in glucose metabolism. 2. **Pyruvate Metabolism:** PDK1 modulates the activity of the pyruvate dehydrogenase complex (PDC), which is responsible for the conversion of pyruvate to acetyl-CoA. 3. **Mitochondrial Matrix:** PDK1 is localized to the mitochondrial matrix, where it regulates the activity of the PDC. 4. **Signaling by Nuclear Receptors:** PDK1 is also involved in signaling pathways regulated by nuclear receptors, such as retinoic acid. 5. **Intrinsic Apoptotic Signaling Pathway:** PDK1 modulates the activity of the PDC, which is also involved in the regulation of apoptosis. **Clinical Significance:** Dysregulation of PDK1 has been implicated in various diseases, including: 1. **Diabetes:** PDK1 plays a critical role in glucose metabolism, and its dysregulation can contribute to the development of diabetes. 2. **Cancer:** PDK1 is involved in signaling pathways that regulate cell proliferation and survival, making it a potential target for cancer therapy. 3. **Neurological Disorders:** PDK1 is also involved in the regulation of energy metabolism in the brain, and its dysregulation has been implicated in neurological disorders such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular Disease:** PDK1 modulates the activity of the PDC, which is also involved in the regulation of energy metabolism in the heart, making it a potential target for cardiovascular disease therapy. In conclusion, PDK1 is a crucial enzyme that plays a pivotal role in regulating metabolic pathways, particularly in the conversion of pyruvate to acetyl-CoA. Its dysregulation has been implicated in various diseases, and further research is needed to fully understand its role in human health and disease.

Genular Protein ID: 2904860212

Symbol: PDK1_HUMAN

Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

UniProtKB Accession Codes:

Q15118 B2R6T1 B7Z937 D3DPD8 E9PD65 Q308M4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7499431

Title: Diversity of the pyruvate dehydrogenase kinase gene family in humans.

PubMed ID: 7499431

DOI: 10.1074/jbc.270.48.28989

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18541534

Title: Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.

PubMed ID: 18541534

DOI: 10.1074/jbc.m801765200

PubMed ID: 21763680

Title: Overexpression of pyruvate dehydrogenase kinase 3 increases drug resistance and early recurrence in colon cancer.

PubMed ID: 21763680

DOI: 10.1016/j.ajpath.2011.05.050

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22195962

Title: Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.

PubMed ID: 22195962

DOI: 10.1016/j.molcel.2011.10.015

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27505672

Title: Mitochondrial Akt regulation of hypoxic tumor reprogramming.

PubMed ID: 27505672

DOI: 10.1016/j.ccell.2016.07.004

PubMed ID: 17683942

Title: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

PubMed ID: 17683942

DOI: 10.1016/j.str.2007.07.001

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 436
  • Mass: 49244
  • Checksum: D14CD594E0EA45A2
  • Sequence:
    • MRLARLLRGA ALAGPGPGLR AAGFSRSFSS DSGSSPASER GVPGQVDFYA RFSPSPLSMK 
QFLDFGSVNA CEKTSFMFLR QELPVRLANI MKEISLLPDN LLRTPSVQLV QSWYIQSLQE 
LLDFKDKSAE DAKAIYDFTD TVIRIRNRHN DVIPTMAQGV IEYKESFGVD PVTSQNVQYF 
LDRFYMSRIS IRMLLNQHSL LFGGKGKGSP SHRKHIGSIN PNCNVLEVIK DGYENARRLC 
DLYYINSPEL ELEELNAKSP GQPIQVVYVP SHLYHMVFEL FKNAMRATME HHANRGVYPP 
IQVHVTLGNE DLTVKMSDRG GGVPLRKIDR LFNYMYSTAP RPRVETSRAV PLAGFGYGLP 
ISRLYAQYFQ GDLKLYSLEG YGTDAVIYIK ALSTDSIERL PVYNKAAWKH YNTNHEADDW 
CVPSREPKDM TTFRSA

Genular Protein ID: 4114871463

Symbol: B7Z7N6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7N6

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 360
  • Mass: 41303
  • Checksum: 4B86ADECF096D0F5
  • Sequence:
    • MFLRQELPVR LANIMKEISL LPDNLLRTPS VQLVQSWYIQ SLQELLDFKD KSAEDAKAIY 
DFTDTVIRIR NRHNDVIPTM AQGVIEYKES FGVDPVTSQN VQYFLDRFYM SRISIRMLLN 
QHSLLFGGKG KGSPSHRKHI GSINPNCNVL EVIKDGYENA RRLCDLYYIN SPELELEELN 
AKSPGQPIQV VYVPSHLYHM VFELFKNAMR ATMEHHANRG VYPPIQVHVT LGNEDLTVKM 
SDRGGGVPLR KIDRLFNYMY STAPRPRVET SRAVPLAGFG YGLPISRLYA QYFQGDLKLY 
SLEGYGTDAV IYIKALSTDS IERLPVYNKA AWKHYNTNHE ADDWCVPSRE PKDMTTFRSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.