Details for: PDK3

Gene ID: 5165

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PDK3

Ensembl ID: ENSG00000067992

Description: pyruvate dehydrogenase kinase 3

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pancreatic A cell CL0000171
    CSI 25.61
    rCSI 26.83%
    PRS 84.5
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 18.95
    rCSI 11.19%
    PRS 94.7
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 18.38
    rCSI 30.85%
    PRS 64.08
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 15.88
    rCSI 38.59%
    PRS 62.1
  • L6b glutamatergic cortical neuron CL4023038
    CSI 12.62
    rCSI 39.44%
    PRS 65.75
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 9.52
    rCSI 34.27%
    PRS 62.05
  • pancreatic PP cell CL0002275
    CSI 8.55
    rCSI 34.02%
    PRS 87.88
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 6.8
    rCSI 40.07%
    PRS 64.76
  • astrocyte of the cerebral cortex CL0002605
    CSI 6.24
    rCSI 13.99%
    PRS 64.89
  • mucosal invariant T cell CL0000940
    CSI 6.03
    rCSI 4.87%
    PRS 89.65
  • retinal bipolar neuron CL0000748
    CSI 5.15
    rCSI 9.65%
    PRS 70.24
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 4.76
    rCSI 4.86%
    PRS 90.37
  • parietal epithelial cell CL1000452
    CSI 4.52
    rCSI 12.07%
    PRS 73.59
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 4.5
    rCSI 5.43%
    PRS 88.5
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 4.02
    rCSI 5%
    PRS 61.96
  • stem cell CL0000034
    CSI 4.01
    rCSI 3.87%
    PRS 75.27
  • tracheobronchial smooth muscle cell CL0019019
    CSI 4.01
    rCSI 7.06%
    PRS 86.32
  • melanocyte CL0000148
    CSI 3.9
    rCSI 2.89%
    PRS 75.35
  • neural crest cell CL0011012
    CSI 3.84
    rCSI 3.03%
    PRS 70.92
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 3.52
    rCSI 13.29%
    PRS 64.69
  • type B pancreatic cell CL0000169
    CSI 3.31
    rCSI 7.33%
    PRS 80.88
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 3.23
    rCSI 4.57%
    PRS 78.41
  • double negative thymocyte CL0002489
    CSI 3.23
    rCSI 2.24%
    PRS 91.96
  • alveolar macrophage CL0000583
    CSI 3.21
    rCSI 5.28%
    PRS 85.05
  • conjunctival epithelial cell CL1000432
    CSI 3.17
    rCSI 4.85%
    PRS 81.7
  • class switched memory B cell CL0000972
    CSI 3.05
    rCSI 2.28%
    PRS 92.09
  • interneuron CL0000099
    CSI 2.95
    rCSI 5.92%
    PRS 72.3
  • unswitched memory B cell CL0000970
    CSI 2.92
    rCSI 2.45%
    PRS 92.86
  • elicited macrophage CL0000861
    CSI 2.89
    rCSI 2.65%
    PRS 88.64
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.86
    rCSI 3.68%
    PRS 65.26
  • choroid plexus epithelial cell CL0000706
    CSI 2.81
    rCSI 4.61%
    PRS 71.36
  • vascular leptomeningeal cell CL4023051
    CSI 2.81
    rCSI 4.93%
    PRS 75.94
  • hepatic stellate cell CL0000632
    CSI 2.79
    rCSI 10.45%
    PRS 74.37
  • Mueller cell CL0000636
    CSI 2.79
    rCSI 6.36%
    PRS 73.27
  • group 3 innate lymphoid cell CL0001071
    CSI 2.78
    rCSI 2.09%
    PRS 86.97
  • chondrocyte CL0000138
    CSI 2.77
    rCSI 4.41%
    PRS 74.94
  • Kupffer cell CL0000091
    CSI 2.74
    rCSI 6.27%
    PRS 82.35
  • contractile cell CL0000183
    CSI 2.74
    rCSI 8.08%
    PRS 80.57
  • rod bipolar cell CL0000751
    CSI 2.67
    rCSI 4.81%
    PRS 75.03
  • alpha-beta T cell CL0000789
    CSI 2.64
    rCSI 3.09%
    PRS 93.33
  • inhibitory interneuron CL0000498
    CSI 2.61
    rCSI 6.02%
    PRS 69.86
  • pulmonary ionocyte CL0017000
    CSI 2.6
    rCSI 3.16%
    PRS 87.47
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 2.55
    rCSI 7.31%
    PRS 95.55
  • pro-B cell CL0000826
    CSI 2.54
    rCSI 2.11%
    PRS 83.81
  • acinar cell CL0000622
    CSI 2.48
    rCSI 3.64%
    PRS 90.05
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 2.45
    rCSI 2.83%
    PRS 73.81
  • glioblast CL0000030
    CSI 2.42
    rCSI 3.87%
    PRS 73.22
  • colon epithelial cell CL0011108
    CSI 2.41
    rCSI 2.52%
    PRS 79.04
  • CD14-positive monocyte CL0001054
    CSI 2.36
    rCSI 2.94%
    PRS 89.8
  • cerebral cortex neuron CL0010012
    CSI 2.35
    rCSI 9.57%
    PRS 73.59
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 2.3
    rCSI 1.77%
    PRS 84.47
  • mature T cell CL0002419
    CSI 2.28
    rCSI 1.77%
    PRS 93.49
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 2.26
    rCSI 7.07%
    PRS 68.09
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.23
    rCSI 2.66%
    PRS 64.22
  • enteroendocrine cell CL0000164
    CSI 2.19
    rCSI 2.99%
    PRS 81.1
  • direct pathway medium spiny neuron CL4023026
    CSI 2.17
    rCSI 51.99%
    PRS 62.17
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.14
    rCSI 51.75%
    PRS 62.75
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 2.14
    rCSI 1.95%
    PRS 92
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.01
    rCSI 5.25%
    PRS 82.74
  • adipocyte CL0000136
    CSI 1.98
    rCSI 2.54%
    PRS 71.98
  • renal interstitial pericyte CL1001318
    CSI 1.94
    rCSI 5.33%
    PRS 76.89
  • neuron CL0000540
    CSI 1.93
    rCSI 5.14%
    PRS 69.06
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 1.89
    rCSI 1.28%
    PRS 92.8
  • lung secretory cell CL1000272
    CSI 1.83
    rCSI 4.53%
    PRS 81.64
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 1.82
    rCSI 2.17%
    PRS 94.46
  • amacrine cell CL0000561
    CSI 1.81
    rCSI 5.24%
    PRS 71.31
  • granulocyte CL0000094
    CSI 1.8
    rCSI 2.75%
    PRS 88.07
  • regular atrial cardiac myocyte CL0002129
    CSI 1.78
    rCSI 5.73%
    PRS 78.34
  • T-helper 17 cell CL0000899
    CSI 1.78
    rCSI 1.41%
    PRS 95.84
  • cerebral cortex endothelial cell CL1001602
    CSI 1.75
    rCSI 3.03%
    PRS 73.46
  • cardiac muscle cell CL0000746
    CSI 1.74
    rCSI 2.5%
    PRS 71.58
  • endocardial cell CL0002350
    CSI 1.71
    rCSI 8.17%
    PRS 77.93
  • kidney connecting tubule epithelial cell CL1000768
    CSI 1.68
    rCSI 4.27%
    PRS 72.27
  • ON midget ganglion cell CL4033046
    CSI 1.67
    rCSI 34.06%
    PRS 71.52
  • pulmonary artery endothelial cell CL1001568
    CSI 1.64
    rCSI 2.23%
    PRS 89.42
  • GABAergic neuron CL0000617
    CSI 1.56
    rCSI 5.22%
    PRS 65.64
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.54
    rCSI 2.47%
    PRS 65.62
  • retinal ganglion cell CL0000740
    CSI 1.39
    rCSI 3.08%
    PRS 67.73
  • extravillous trophoblast CL0008036
    CSI 1.39
    rCSI 1.72%
    PRS 79.73
  • OFF midget ganglion cell CL4033047
    CSI 1.37
    rCSI 27.89%
    PRS 72.63
  • enteroendocrine cell of small intestine CL0009006
    CSI 1.35
    rCSI 2.98%
    PRS 88.27
  • neural progenitor cell CL0011020
    CSI 1.35
    rCSI 5.95%
    PRS 70.18
  • blood vessel smooth muscle cell CL0019018
    CSI 1.3
    rCSI 10.56%
    PRS 76.12
  • intermediate monocyte CL0002393
    CSI 1.29
    rCSI 1.95%
    PRS 86.51
  • glutamatergic neuron CL0000679
    CSI 1.26
    rCSI 2.59%
    PRS 68.97
  • fibroblast of cardiac tissue CL0002548
    CSI 1.21
    rCSI 5.8%
    PRS 81.57
  • ON parasol ganglion cell CL4033052
    CSI 1.19
    rCSI 16.92%
    PRS 72.89
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 1.19
    rCSI 3.91%
    PRS 67.51
  • glial cell CL0000125
    CSI 1.14
    rCSI 4.33%
    PRS 72.94
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.12
    rCSI 2.91%
    PRS 77.12
  • retinal cone cell CL0000573
    CSI 1.11
    rCSI 1.79%
    PRS 71.97
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.09
    rCSI 1.92%
    PRS 63.54
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.04
    rCSI 2.49%
    PRS 68.55
  • GABAergic amacrine cell CL4030027
    CSI 0.81
    rCSI 2.78%
    PRS 67.83
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.47
    rCSI 2.38%
    PRS 92.01
  • medium spiny neuron CL1001474
    CSI 0.38
    rCSI 3.3%
    PRS 69.9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [PDK3](/details-gene/5165) (Pyruvate Dehydrogenase Kinase 3) is a protein-coding gene located on the X chromosome that encodes a mitochondrial kinase. Its primary function is the regulation of cellular metabolism by phosphorylating and inactivating the pyruvate dehydrogenase (PDH) complex. This action serves as a critical gatekeeper, controlling the flux of pyruvate into the tricarboxylic acid (TCA) cycle for oxidative phosphorylation. **Overall**, expression data indicate that [PDK3](/details-gene/5165) is a significant gene in a diverse array of metabolically active cells, including endocrine cells of the pancreas such as [pancreatic A cells](/details-cell/CL0000171), various neuronal subtypes including [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011), and specific lymphocyte populations like [central memory CD4-positive, alpha-beta T cells](/details-cell/CL0000904). Its involvement in hypoxia-inducible factor signaling suggests a key role in metabolic adaptation under low-oxygen conditions, a process with significant implications in both normal physiology and diseases like cancer ([Link](https://doi.org/10.1074/jbc.m803508200)). ## Cellular Roles and Expression Landscape The expression profile of [PDK3](/details-gene/5165) highlights its importance in cells and tissues with high or specialized metabolic demands. **Overall**, its significance is most pronounced in three distinct biological systems: 1. **Endocrine and Metabolic Regulation:** The highest significance score for [PDK3](/details-gene/5165) is observed in [pancreatic A cells](/details-cell/CL0000171) (CSI: 25.61), which are responsible for glucagon secretion. Its notable presence also in [pancreatic PP cells](/details-cell/CL0002275) suggests a crucial role in the fine-tuning of glucose and energy homeostasis within the islet of Langerhans. 2. **Nervous System Energetics:** [PDK3](/details-gene/5165) is highly significant across a wide range of neuronal subtypes. This includes both excitatory glutamatergic neurons (e.g., [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040), [L6b glutamatergic cortical neuron](/details-cell/CL4023038)) and inhibitory GABAergic interneurons (e.g., [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011)). This widespread expression pattern in the central nervous system is consistent with a fundamental role in managing the high energy expenditure required for neuronal activity, synaptic transmission, and maintenance of ion gradients. 3. **Immune Cell Metabolism:** The gene is a key marker in specific lymphocyte populations, most notably [central memory CD4-positive, alpha-beta T cells](/details-cell/CL0000904) (CSI: 18.95). It is also significant in developing [double-positive, alpha-beta thymocytes](/details-cell/CL0000809) and antigen-presenting cells like [CD1c-positive myeloid dendritic cells](/details-cell/CL0002399). This pattern suggests that [PDK3](/details-gene/5165)-mediated metabolic regulation is important for T cell development, the establishment of long-term immunological memory, and immune surveillance. ## Pathways and Molecular Function The molecular functions of [PDK3](/details-gene/5165) are centered on its role as a serine/threonine protein kinase located within the [mitochondrial matrix](/details-go/GO:0005759). Its specific activity, `[Pyruvate dehydrogenase (acetyl-transferring) kinase activity](/details-go/GO:0004740)`, directly contributes to the `[Regulation of acetyl-coa biosynthetic process from pyruvate](/details-go/GO:0010510)`, a key control point in cellular metabolism. This is a central feature of the Reactome pathway `[Regulation of pyruvate dehydrogenase (pdh) complex](/details-reactome/R-HSA-204174)`. Beyond this core function, [PDK3](/details-gene/5165) is embedded in broader regulatory networks. It is a component of the `[Hypoxia-inducible factor-1alpha signaling pathway](/details-go/GO:0097411)`, indicating that its expression is induced under low-oxygen conditions to shift cellular metabolism away from aerobic respiration and toward glycolysis. This metabolic switch, known as the Warburg effect, is critical in physiology and pathology, particularly in cancer where it promotes survival and drug resistance ([Link](https://doi.org/10.1158/0008-5472.can-12-0979)). Furthermore, its involvement in the `[Peroxisome proliferator activated receptor signaling pathway](/details-go/GO:0035357)` and `[Cellular response to fatty acid](/details-go/GO:0071398)` suggests that its activity is coordinated with lipid metabolism, allowing cells to flexibly adapt their energy source based on nutrient availability ([Link](https://doi.org/10.1016/j.jmb.2007.06.091)). This multifaceted regulation aligns with its high expression in metabolically plastic cells like memory T cells and pancreatic cells. ## Research Directions The functional annotations and expression profile of [PDK3](/details-gene/5165) suggest several avenues for future investigation, particularly concerning its role in immunology and cancer biology. **Proposed Testable Hypotheses:** 1. **Immunology:** The high significance of [PDK3](/details-gene/5165) in [central memory CD4-positive, alpha-beta T cells](/details-cell/CL0000904) suggests a non-redundant role in establishing the metabolic phenotype required for long-term survival and recall. We hypothesize that **[PDK3](/details-gene/5165) is essential for the formation and maintenance of T cell memory by enforcing a state of metabolic quiescence and flexibility, allowing these cells to persist and rapidly reactivate upon secondary antigen encounter.** 2. **Oncology:** Given its established link to the HIF-1alpha pathway and metabolic reprogramming in cancer ([Link](https://doi.org/10.1074/jbc.m803508200)), we hypothesize that **inhibition of [PDK3](/details-gene/5165) in solid tumors will reverse the Warburg effect, thereby increasing oxidative stress and re-sensitizing cancer cells to conventional pro-oxidant chemotherapies and radiation.** 3. **Neurobiology:** The prominent expression of [PDK3](/details-gene/5165) in diverse neuronal populations suggests it may function as a neuroprotective factor. We hypothesize that **[PDK3](/details-gene/5165) activity allows neurons to dynamically regulate mitochondrial activity to mitigate excitotoxicity and oxidative damage during periods of high metabolic stress or nutrient limitation.** **Suggested Experimental Approach (Hypothesis 1):** To test the role of [PDK3](/details-gene/5165) in T cell memory, a T cell-specific conditional knockout mouse model (*Pdk3fl/fl;Cd4-Cre*) should be generated. Following a viral infection (e.g., with Lymphocytic Choriomeningitis Virus), the formation, persistence, and metabolic profile of memory CD4+ and CD8+ T cells should be compared between knockout and wild-type animals. Key readouts would include: (1) quantification of memory T cell populations at various time points post-infection via flow cytometry; (2) metabolic analysis of isolated memory T cells using a Seahorse XF Analyzer to measure rates of glycolysis and oxidative phosphorylation; and (3) assessment of protective immunity via a secondary challenge with the same pathogen. **Therapeutic Potential:** As a protein kinase, [PDK3](/details-gene/5165) is a highly druggable target. Its role in promoting the Warburg effect and conferring drug resistance makes it a compelling target for cancer therapy. A therapeutic strategy would involve the development of potent and specific small molecule **inhibitors** of [PDK3](/details-gene/5165). Such a drug could force cancer cells to rely more on oxidative phosphorylation, increasing their production of reactive oxygen species and rendering them more susceptible to apoptosis-inducing agents. This approach could be particularly effective in hypoxic tumors where [PDK3](/details-gene/5165) is often upregulated, potentially overcoming a major mechanism of therapeutic resistance.

Genular Protein ID: 366350980

Symbol: PDK3_HUMAN

Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial

UniProtKB Accession Codes:

Q15120 B4DXG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 4 Ensembl 3 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7499431

Title: Diversity of the pyruvate dehydrogenase kinase gene family in humans.

PubMed ID: 7499431

DOI: 10.1074/jbc.270.48.28989

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10748134

Title: Marked differences between two isoforms of human pyruvate dehydrogenase kinase.

PubMed ID: 10748134

DOI: 10.1074/jbc.m909488199

PubMed ID: 11486000

Title: Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase.

PubMed ID: 11486000

DOI: 10.1074/jbc.m103069200

PubMed ID: 11978179

Title: Interaction between the individual isoenzymes of pyruvate dehydrogenase kinase and the inner lipoyl-bearing domain of transacetylase component of pyruvate dehydrogenase complex.

PubMed ID: 11978179

DOI: 10.1042/bj20020301

PubMed ID: 16436377

Title: Characterization of testis-specific isoenzyme of human pyruvate dehydrogenase.

PubMed ID: 16436377

DOI: 10.1074/jbc.m511481200

PubMed ID: 17669420

Title: Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.

PubMed ID: 17669420

DOI: 10.1016/j.jmb.2007.06.091

PubMed ID: 18718909

Title: Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance.

PubMed ID: 18718909

DOI: 10.1074/jbc.m803508200

PubMed ID: 20715114

Title: Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex.

PubMed ID: 20715114

DOI: 10.1002/ijc.25599

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22865452

Title: Inactivation of the HIF-1alpha/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.

PubMed ID: 22865452

DOI: 10.1158/0008-5472.can-12-0979

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15861126

Title: Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.

PubMed ID: 15861126

DOI: 10.1038/sj.emboj.7600663

PubMed ID: 17532006

Title: Crystal structure of an asymmetric complex of pyruvate dehydrogenase kinase 3 with lipoyl domain 2 and its biological implications.

PubMed ID: 17532006

DOI: 10.1016/j.jmb.2007.04.083

PubMed ID: 17683942

Title: Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

PubMed ID: 17683942

DOI: 10.1016/j.str.2007.07.001

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 23297365

Title: A new locus for X-linked dominant Charcot-Marie-Tooth disease (CMTX6) is caused by mutations in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene.

PubMed ID: 23297365

DOI: 10.1093/hmg/dds557

Sequence Information:

  • Length: 406
  • Mass: 46939
  • Checksum: EF2415D3F9D8D61E
  • Sequence:
    • MRLFRWLLKQ PVPKQIERYS RFSPSPLSIK QFLDFGRDNA CEKTSYMFLR KELPVRLANT 
MREVNLLPDN LLNRPSVGLV QSWYMQSFLE LLEYENKSPE DPQVLDNFLQ VLIKVRNRHN 
DVVPTMAQGV IEYKEKFGFD PFISTNIQYF LDRFYTNRIS FRMLINQHTL LFGGDTNPVH 
PKHIGSIDPT CNVADVVKDA YETAKMLCEQ YYLVAPELEV EEFNAKAPDK PIQVVYVPSH 
LFHMLFELFK NSMRATVELY EDRKEGYPAV KTLVTLGKED LSIKISDLGG GVPLRKIDRL 
FNYMYSTAPR PSLEPTRAAP LAGFGYGLPI SRLYARYFQG DLKLYSMEGV GTDAVIYLKA 
LSSESFERLP VFNKSAWRHY KTTPEADDWS NPSSEPRDAS KYKAKQ