Details for: RASD1

Gene ID: 51655

Symbol: RASD1

Ensembl ID: ENSG00000108551

Description: ras related dexamethasone induced 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.5455
    Cell Significance Index: -22.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 92.2949
    Cell Significance Index: -23.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.3394
    Cell Significance Index: -22.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.7436
    Cell Significance Index: -23.1100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.0183
    Cell Significance Index: -21.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7399
    Cell Significance Index: -22.6500
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.9125
    Cell Significance Index: 18.8100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.0111
    Cell Significance Index: 24.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.7721
    Cell Significance Index: 108.1300
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 3.0116
    Cell Significance Index: 13.1100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.5208
    Cell Significance Index: 14.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.4801
    Cell Significance Index: 317.9400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.4622
    Cell Significance Index: 26.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.2370
    Cell Significance Index: 101.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7257
    Cell Significance Index: 46.2400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.7255
    Cell Significance Index: 13.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4719
    Cell Significance Index: 1329.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4339
    Cell Significance Index: 39.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3743
    Cell Significance Index: 102.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0549
    Cell Significance Index: 49.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9913
    Cell Significance Index: 28.5600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.9028
    Cell Significance Index: 9.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8959
    Cell Significance Index: 145.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8754
    Cell Significance Index: 95.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7516
    Cell Significance Index: 74.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6492
    Cell Significance Index: 30.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6086
    Cell Significance Index: 9.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5973
    Cell Significance Index: 119.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5972
    Cell Significance Index: 35.8500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4903
    Cell Significance Index: 33.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4730
    Cell Significance Index: 209.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4055
    Cell Significance Index: 28.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4026
    Cell Significance Index: 219.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3336
    Cell Significance Index: 41.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2793
    Cell Significance Index: 4.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2622
    Cell Significance Index: 49.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2185
    Cell Significance Index: 3.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2085
    Cell Significance Index: 13.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1766
    Cell Significance Index: 2.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1621
    Cell Significance Index: 58.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1577
    Cell Significance Index: 21.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1537
    Cell Significance Index: 27.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1501
    Cell Significance Index: 7.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1488
    Cell Significance Index: 16.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0966
    Cell Significance Index: 12.4800
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.0794
    Cell Significance Index: 0.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0370
    Cell Significance Index: 1.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0238
    Cell Significance Index: 2.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0161
    Cell Significance Index: 10.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0121
    Cell Significance Index: 9.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0053
    Cell Significance Index: 8.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0036
    Cell Significance Index: 0.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -9.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0072
    Cell Significance Index: -4.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.1000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.0107
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0162
    Cell Significance Index: -21.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0164
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0177
    Cell Significance Index: -11.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0188
    Cell Significance Index: -10.6300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0236
    Cell Significance Index: -0.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0238
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0347
    Cell Significance Index: -7.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0380
    Cell Significance Index: -2.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0396
    Cell Significance Index: -4.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0404
    Cell Significance Index: -18.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0404
    Cell Significance Index: -6.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0573
    Cell Significance Index: -11.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0587
    Cell Significance Index: -16.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0789
    Cell Significance Index: -1.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0843
    Cell Significance Index: -9.8300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0881
    Cell Significance Index: -0.7400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0931
    Cell Significance Index: -1.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0957
    Cell Significance Index: -5.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1026
    Cell Significance Index: -14.9200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1193
    Cell Significance Index: -3.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1494
    Cell Significance Index: -4.7900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1815
    Cell Significance Index: -2.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1923
    Cell Significance Index: -11.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1923
    Cell Significance Index: -22.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2177
    Cell Significance Index: -7.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2204
    Cell Significance Index: -22.9500
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2239
    Cell Significance Index: -3.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2364
    Cell Significance Index: -6.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2407
    Cell Significance Index: -19.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2763
    Cell Significance Index: -16.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2814
    Cell Significance Index: -9.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2835
    Cell Significance Index: -14.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2991
    Cell Significance Index: -8.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3036
    Cell Significance Index: -6.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3276
    Cell Significance Index: -20.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3476
    Cell Significance Index: -5.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3592
    Cell Significance Index: -18.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3645
    Cell Significance Index: -11.6100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3808
    Cell Significance Index: -2.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3887
    Cell Significance Index: -14.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3896
    Cell Significance Index: -6.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3908
    Cell Significance Index: -5.7700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Genetic and Expression Profile**: RASD1 is a Ras-related gene, characterized by its involvement in G-protein coupled receptor signaling pathways and its expression in a wide range of cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. 2. **Protein Structure and Function**: The RASD1 protein interacts with various cellular components, influencing transcriptional regulation, cell growth, and differentiation. Its ability to bind to G-protein beta-subunits and interact with GTPases underscores its role in signaling pathways. 3. **Regulatory Mechanisms**: RASD1 is involved in the negative regulation of DNA-templated transcription, suggesting its potential role in modulating gene expression in response to various cellular signals. **Pathways and Functions:** 1. **G-Protein Coupled Receptor Signaling Pathway**: RASD1 interacts with G-protein beta-subunits, modulating signaling pathways that regulate cellular responses to external stimuli. 2. **Nitric Oxide Mediated Signal Transduction**: RASD1's involvement in nitric oxide mediated signal transduction suggests its role in modulating cellular responses to nitric oxide, a key signaling molecule. 3. **Negative Regulation of DNA-templated Transcription**: RASD1's ability to negatively regulate transcriptional activity implies its potential role in modulating gene expression in response to cellular signals. 4. **Cell Growth and Differentiation**: RASD1's involvement in cell growth and differentiation pathways underscores its role in regulating cellular development and proliferation. **Clinical Significance:** 1. **Immune Regulation**: RASD1's role in immune regulation, particularly in hematopoietic cells, highlights its potential as a therapeutic target for immune-related disorders. 2. **Cancer**: The expression of RASD1 in various cancer types suggests its potential involvement in tumorigenesis and cancer progression. 3. **Autoimmune Diseases**: RASD1's involvement in autoimmune diseases, such as rheumatoid arthritis, underscores its potential role in modulating immune responses and tissue damage. 4. **Neurological Disorders**: The expression of RASD1 in the brain and its involvement in neurological disorders, such as Alzheimer's disease, highlights its potential role in modulating neuronal function and behavior. In conclusion, RASD1 is a multifaceted gene that plays a crucial role in immune regulation, cell growth, and differentiation. Its involvement in various signaling pathways and its expression in diverse cell types underscore its clinical significance in a range of diseases, including immune-related disorders, cancer, and neurological disorders. Further research is needed to fully elucidate the role of RASD1 in human health and disease.

Genular Protein ID: 3217972309

Symbol: RASD1_HUMAN

Name: Dexamethasone-induced Ras-related protein 1

UniProtKB Accession Codes:

Q9Y272 B2R709 B4DFF4 Q9NYB4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10673050

Title: Cloning, expression and characterization of a novel human Ras-related protein that is regulated by glucocorticoid hormone.

PubMed ID: 10673050

DOI: 10.1016/s0167-4781(99)00197-9

PubMed ID: 10471929

Title: Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling.

PubMed ID: 10471929

DOI: 10.1038/12867

PubMed ID: 12818426

Title: Identification of a glucocorticoid response element in the 3'-flanking region of the human Dexras1 gene.

PubMed ID: 12818426

DOI: 10.1016/s0167-4781(03)00079-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12498886

Title: Nitrosopeptide mapping: a novel methodology reveals s-nitrosylation of dexras1 on a single cysteine residue.

PubMed ID: 12498886

DOI: 10.1016/s1074-5521(02)00293-4

Sequence Information:

  • Length: 281
  • Mass: 31642
  • Checksum: 06C3C4417E4A69BD
  • Sequence:
    • MKLAAMIKKM CPSDSELSIP AKNCYRMVIL GSSKVGKTAI VSRFLTGRFE DAYTPTIEDF 
HRKFYSIRGE VYQLDILDTS GNHPFPAMRR LSILTGDVFI LVFSLDNRDS FEEVQRLRQQ 
ILDTKSCLKN KTKENVDVPL VICGNKGDRD FYREVDQREI EQLVGDDPQR CAYFEISAKK 
NSSLDQMFRA LFAMAKLPSE MSPDLHRKVS VQYCDVLHKK ALRNKKLLRA GSGGGGGDPG 
DAFGIVAPFA RRPSVHSDLM YIREKASAGS QAKDKERCVI S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.