Details for: CPSF3

Gene ID: 51692

Symbol: CPSF3

Ensembl ID: ENSG00000119203

Description: cleavage and polyadenylation specific factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.0358
    Cell Significance Index: -16.9600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.3243
    Cell Significance Index: -17.3300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.9023
    Cell Significance Index: -23.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.8269
    Cell Significance Index: -19.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.5710
    Cell Significance Index: -19.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.9812
    Cell Significance Index: -22.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3053
    Cell Significance Index: -19.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.8907
    Cell Significance Index: -23.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2669
    Cell Significance Index: -7.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5012
    Cell Significance Index: 244.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2032
    Cell Significance Index: 1086.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1170
    Cell Significance Index: 15.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1014
    Cell Significance Index: 66.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0333
    Cell Significance Index: 112.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8950
    Cell Significance Index: 104.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7288
    Cell Significance Index: 144.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6055
    Cell Significance Index: 31.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5841
    Cell Significance Index: 6.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4907
    Cell Significance Index: 25.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4650
    Cell Significance Index: 93.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4099
    Cell Significance Index: 50.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3872
    Cell Significance Index: 10.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3791
    Cell Significance Index: 24.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3669
    Cell Significance Index: 43.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3560
    Cell Significance Index: 12.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3525
    Cell Significance Index: 9.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3413
    Cell Significance Index: 19.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3238
    Cell Significance Index: 58.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3208
    Cell Significance Index: 221.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2990
    Cell Significance Index: 20.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2982
    Cell Significance Index: 6.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2965
    Cell Significance Index: 161.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2470
    Cell Significance Index: 109.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2147
    Cell Significance Index: 77.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2105
    Cell Significance Index: 6.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2095
    Cell Significance Index: 14.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1779
    Cell Significance Index: 24.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1372
    Cell Significance Index: 8.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1170
    Cell Significance Index: 8.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0898
    Cell Significance Index: 1.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0832
    Cell Significance Index: 3.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0743
    Cell Significance Index: 3.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0713
    Cell Significance Index: 13.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0661
    Cell Significance Index: 6.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0656
    Cell Significance Index: 2.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0602
    Cell Significance Index: 1.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0417
    Cell Significance Index: 78.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0268
    Cell Significance Index: 0.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0255
    Cell Significance Index: 47.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0228
    Cell Significance Index: 2.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0216
    Cell Significance Index: 33.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0116
    Cell Significance Index: 0.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0083
    Cell Significance Index: 5.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0047
    Cell Significance Index: 6.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0130
    Cell Significance Index: -5.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0183
    Cell Significance Index: -2.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0199
    Cell Significance Index: -15.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0213
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0253
    Cell Significance Index: -18.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0329
    Cell Significance Index: -4.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0347
    Cell Significance Index: -0.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0367
    Cell Significance Index: -3.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0376
    Cell Significance Index: -21.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0410
    Cell Significance Index: -7.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0429
    Cell Significance Index: -26.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0544
    Cell Significance Index: -1.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0635
    Cell Significance Index: -1.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0660
    Cell Significance Index: -3.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0670
    Cell Significance Index: -19.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0859
    Cell Significance Index: -6.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0908
    Cell Significance Index: -1.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0983
    Cell Significance Index: -6.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1021
    Cell Significance Index: -1.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1068
    Cell Significance Index: -4.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1147
    Cell Significance Index: -6.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1240
    Cell Significance Index: -26.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1361
    Cell Significance Index: -15.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1440
    Cell Significance Index: -4.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1632
    Cell Significance Index: -6.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1909
    Cell Significance Index: -5.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1960
    Cell Significance Index: -13.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2020
    Cell Significance Index: -5.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2052
    Cell Significance Index: -21.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2094
    Cell Significance Index: -1.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2147
    Cell Significance Index: -5.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2321
    Cell Significance Index: -14.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2328
    Cell Significance Index: -2.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2347
    Cell Significance Index: -18.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2633
    Cell Significance Index: -2.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3291
    Cell Significance Index: -4.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3584
    Cell Significance Index: -7.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4193
    Cell Significance Index: -12.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4250
    Cell Significance Index: -9.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4421
    Cell Significance Index: -3.5300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4426
    Cell Significance Index: -8.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4566
    Cell Significance Index: -12.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4709
    Cell Significance Index: -10.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4762
    Cell Significance Index: -7.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4763
    Cell Significance Index: -15.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CPSF3 is a 54-kDa protein that belongs to the cleavage and polyadenylation specificity factor family. It is primarily expressed in the nucleus, where it plays a crucial role in the regulation of RNA processing. CPSF3 exhibits a high degree of specificity in its interactions with RNA, allowing it to accurately recognize and process specific sequences. Its ability to bind to RNA and facilitate the cleavage and polyadenylation of pre-mRNA makes it an essential component of the RNA processing machinery. **Pathways and Functions:** CPSF3 is involved in several key pathways, including: 1. **Co-transcriptional mRNA 3'-end processing:** CPSF3 collaborates with other proteins to regulate the 3'-end processing of pre-mRNA, resulting in the production of mature mRNA. 2. **Cleavage and polyadenylation pathway:** CPSF3 is a key component of the cleavage and polyadenylation specificity factor complex, which ensures accurate and efficient processing of RNA. 3. **Gene expression (transcription):** CPSF3 regulates gene expression by controlling the processing of pre-mRNA into mature mRNA. 4. **Metabolism of RNA:** CPSF3 is involved in the regulation of RNA metabolism, including the degradation of aberrant RNA and the transport of mature mRNA to the cytoplasm. **Clinical Significance:** Dysregulation of CPSF3 has been implicated in various diseases, including: 1. **Cancer:** CPSF3 mutations have been associated with certain types of cancer, including leukemia and lymphoma. 2. **Neurological disorders:** CPSF3 mutations have been linked to neurological disorders, such as autism and schizophrenia. 3. **Immune system dysregulation:** CPSF3 plays a crucial role in the regulation of immune cell development and function, and dysregulation of CPSF3 has been implicated in immune system dysregulation. In conclusion, CPSF3 is a critical protein that plays a pivotal role in RNA processing and regulation of gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of CPSF3 in human health and disease.

Genular Protein ID: 2831286306

Symbol: CPSF3_HUMAN

Name: Cleavage and polyadenylation specificity factor subunit 3

UniProtKB Accession Codes:

Q9UKF6 O14769 Q53RS2 Q96F36

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 9 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14749727

Title: Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.

PubMed ID: 14749727

DOI: 10.1038/sj.emboj.7600070

PubMed ID: 15037765

Title: Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.

PubMed ID: 15037765

DOI: 10.1261/rna.5214404

PubMed ID: 17923699

Title: Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complex.

PubMed ID: 17923699

DOI: 10.1128/mcb.01186-07

PubMed ID: 18688255

Title: Conserved motifs in both CPSF73 and CPSF100 are required to assemble the active endonuclease for histone mRNA 3'-end maturation.

PubMed ID: 18688255

DOI: 10.1038/embor.2008.146

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19217410

Title: Molecular architecture of the human pre-mRNA 3' processing complex.

PubMed ID: 19217410

DOI: 10.1016/j.molcel.2008.12.028

PubMed ID: 21102410

Title: The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA.

PubMed ID: 21102410

DOI: 10.1038/emboj.2010.287

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30507380

Title: Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.

PubMed ID: 30507380

DOI: 10.7554/elife.39865

PubMed ID: 17128255

Title: Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.

PubMed ID: 17128255

DOI: 10.1038/nature05363

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 35121750

Title: Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene.

PubMed ID: 35121750

DOI: 10.1038/s41467-022-28330-8

Sequence Information:

  • Length: 684
  • Mass: 77486
  • Checksum: F8AA24EA6FB78377
  • Sequence:
    • MSAIPAEESD QLLIRPLGAG QEVGRSCIIL EFKGRKIMLD CGIHPGLEGM DALPYIDLID 
PAEIDLLLIS HFHLDHCGAL PWFLQKTSFK GRTFMTHATK AIYRWLLSDY VKVSNISADD 
MLYTETDLEE SMDKIETINF HEVKEVAGIK FWCYHAGHVL GAAMFMIEIA GVKLLYTGDF 
SRQEDRHLMA AEIPNIKPDI LIIESTYGTH IHEKREEREA RFCNTVHDIV NRGGRGLIPV 
FALGRAQELL LILDEYWQNH PELHDIPIYY ASSLAKKCMA VYQTYVNAMN DKIRKQININ 
NPFVFKHISN LKSMDHFDDI GPSVVMASPG MMQSGLSREL FESWCTDKRN GVIIAGYCVE 
GTLAKHIMSE PEEITTMSGQ KLPLKMSVDY ISFSAHTDYQ QTSEFIRALK PPHVILVHGE 
QNEMARLKAA LIREYEDNDE VHIEVHNPRN TEAVTLNFRG EKLAKVMGFL ADKKPEQGQR 
VSGILVKRNF NYHILSPCDL SNYTDLAMST VKQTQAIPYT GPFNLLCYQL QKLTGDVEEL 
EIQEKPALKV FKNITVIQEP GMVVLEWLAN PSNDMYADTV TTVILEVQSN PKIRKGAVQK 
VSKKLEMHVY SKRLEIMLQD IFGEDCVSVK DDSILSVTVD GKTANLNLET RTVECEEGSE 
DDESLREMVE LAAQRLYEAL TPVH

Genular Protein ID: 3100869061

Symbol: G5E9W3_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E9W3

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 2 SMART 6 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 647
  • Mass: 73477
  • Checksum: 558D4F5A9C32B464
  • Sequence:
    • MLDCGIHPGL EGMDALPYID LIDPAEIDLL LISHFHLDHC GALPWFLQKT SFKGRTFMTH 
ATKAIYRWLL SDYVKVSNIS ADDMLYTETD LEESMDKIET INFHEVKEVA GIKFWCYHAG 
HVLGAAMFMI EIAGVKLLYT GDFSRQEDRH LMAAEIPNIK PDILIIESTY GTHIHEKREE 
REARFCNTVH DIVNRGGRGL IPVFALGRAQ ELLLILDEYW QNHPELHDIP IYYASSLAKK 
CMAVYQTYVN AMNDKIRKQI NINNPFVFKH ISNLKSMDHF DDIGPSVVMA SPGMMQSGLS 
RELFESWCTD KRNGVIIAGY CVEGTLAKHI MSEPEEITTM SGQKLPLKMS VDYISFSAHT 
DYQQTSEFIR ALKPPHVILV HGEQNEMARL KAALIREYED NDEVHIEVHN PRNTEAVTLN 
FRGEKLAKVM GFLADKKPEQ GQRVSGILVK RNFNYHILSP CDLSNYTDLA MSTVKQTQAI 
PYTGPFNLLC YQLQKLTGDV EELEIQEKPA LKVFKNITVI QEPGMVVLEW LANPSNDMYA 
DTVTTVILEV QSNPKIRKGA VQKVSKKLEM HVYSKRLEIM LQDIFGEDCV SVKDDSILSV 
TVDGKTANLN LETRTVECEE GSEDDESLRE MVELAAQRLY EALTPVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.