Details for: POLR3K

Gene ID: 51728

Symbol: POLR3K

Ensembl ID: ENSG00000161980

Description: RNA polymerase III subunit K

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 96.2100
    Cell Significance Index: -14.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.1919
    Cell Significance Index: -14.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 48.6955
    Cell Significance Index: -20.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.4700
    Cell Significance Index: -17.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.9202
    Cell Significance Index: -20.0200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.8218
    Cell Significance Index: -17.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.6048
    Cell Significance Index: -19.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.1773
    Cell Significance Index: -20.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7572
    Cell Significance Index: -11.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4604
    Cell Significance Index: -9.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.1292
    Cell Significance Index: -4.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3704
    Cell Significance Index: 149.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3503
    Cell Significance Index: 157.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1767
    Cell Significance Index: 138.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0014
    Cell Significance Index: 162.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8410
    Cell Significance Index: 43.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7456
    Cell Significance Index: 26.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6943
    Cell Significance Index: 32.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6532
    Cell Significance Index: 45.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6320
    Cell Significance Index: 345.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6119
    Cell Significance Index: 17.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5394
    Cell Significance Index: 7.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5203
    Cell Significance Index: 63.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4758
    Cell Significance Index: 12.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4696
    Cell Significance Index: 84.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4015
    Cell Significance Index: 39.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3608
    Cell Significance Index: 23.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3590
    Cell Significance Index: 158.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3403
    Cell Significance Index: 24.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3022
    Cell Significance Index: 10.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2982
    Cell Significance Index: 40.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2674
    Cell Significance Index: 7.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2672
    Cell Significance Index: 14.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2613
    Cell Significance Index: 16.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2561
    Cell Significance Index: 6.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2509
    Cell Significance Index: 2.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2335
    Cell Significance Index: 10.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2173
    Cell Significance Index: 9.8500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2004
    Cell Significance Index: 1.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1677
    Cell Significance Index: 33.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1670
    Cell Significance Index: 21.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1472
    Cell Significance Index: 4.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1339
    Cell Significance Index: 26.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1255
    Cell Significance Index: 23.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0960
    Cell Significance Index: 2.0800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0957
    Cell Significance Index: 1.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0931
    Cell Significance Index: 2.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0490
    Cell Significance Index: 17.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0184
    Cell Significance Index: 12.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0140
    Cell Significance Index: 1.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0140
    Cell Significance Index: 10.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0127
    Cell Significance Index: 0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0021
    Cell Significance Index: -1.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0093
    Cell Significance Index: -1.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0117
    Cell Significance Index: -21.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0144
    Cell Significance Index: -22.2300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0176
    Cell Significance Index: -23.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0181
    Cell Significance Index: -1.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0196
    Cell Significance Index: -0.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0233
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0234
    Cell Significance Index: -17.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0253
    Cell Significance Index: -16.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0273
    Cell Significance Index: -15.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0275
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0365
    Cell Significance Index: -16.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0393
    Cell Significance Index: -24.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0494
    Cell Significance Index: -14.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0539
    Cell Significance Index: -9.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0540
    Cell Significance Index: -1.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0556
    Cell Significance Index: -6.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0665
    Cell Significance Index: -2.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0801
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1096
    Cell Significance Index: -23.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1189
    Cell Significance Index: -17.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1285
    Cell Significance Index: -3.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1780
    Cell Significance Index: -3.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1836
    Cell Significance Index: -14.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1952
    Cell Significance Index: -20.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2072
    Cell Significance Index: -2.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2155
    Cell Significance Index: -1.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2256
    Cell Significance Index: -15.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2284
    Cell Significance Index: -17.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2411
    Cell Significance Index: -3.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2465
    Cell Significance Index: -15.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2577
    Cell Significance Index: -14.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2725
    Cell Significance Index: -8.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3352
    Cell Significance Index: -20.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3424
    Cell Significance Index: -8.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3443
    Cell Significance Index: -5.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3538
    Cell Significance Index: -15.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3609
    Cell Significance Index: -6.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3797
    Cell Significance Index: -9.7600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4046
    Cell Significance Index: -5.6800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4068
    Cell Significance Index: -5.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4073
    Cell Significance Index: -4.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4345
    Cell Significance Index: -16.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4378
    Cell Significance Index: -3.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4467
    Cell Significance Index: -15.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4522
    Cell Significance Index: -16.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Subunit of RNAPIII**: POLR3K is a subunit of the RNAPIII complex, which is responsible for transcribing a subset of genes, including those involved in immune response. 2. **RNA polymerase activity**: POLR3K exhibits RNA polymerase activity, which is essential for the transcription of genes. 3. **Zinc ion binding**: POLR3K binds to zinc ions, which is crucial for the proper functioning of the RNAPIII complex. 4. **Cell type specificity**: POLR3K is significantly expressed in various cell types, including hematopoietic cells, embryonic stem cells, and epithelial cells. **Pathways and Functions** 1. **Gene expression (transcription)**: POLR3K plays a critical role in the transcription of genes involved in immune response, including those encoding cytokines and chemokines. 2. **Immune system**: POLR3K is involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. 3. **Innate immune response**: POLR3K is involved in the innate immune response, including the recognition of pathogen-associated molecular patterns (PAMPs). 4. **DNA-directed 5'-3' RNA polymerase activity**: POLR3K exhibits DNA-directed 5'-3' RNA polymerase activity, which is essential for the transcription of genes. **Clinical Significance** 1. **Autoimmune disorders**: Dysregulation of POLR3K has been implicated in several autoimmune disorders, including rheumatoid arthritis and lupus. 2. **Cancer**: POLR3K has been found to be overexpressed in certain types of cancer, including leukemia and lymphoma. 3. **Infectious diseases**: POLR3K plays a critical role in the regulation of immune responses to infectious diseases, including viral and bacterial infections. 4. **Gene therapy**: POLR3K has been identified as a potential target for gene therapy, particularly in the treatment of autoimmune disorders and cancer. In conclusion, POLR3K is a critical component of the RNAPIII complex, which plays a pivotal role in the regulation of gene expression, particularly in the context of the immune system. Its dysregulation has been implicated in several diseases, including autoimmune disorders and cancer. Further research is needed to fully understand the complexities of POLR3K and its role in human disease.

Genular Protein ID: 1443616688

Symbol: RPC10_HUMAN

Name: DNA-directed RNA polymerase III subunit RPC10

UniProtKB Accession Codes:

Q9Y2Y1 Q1W6H4 Q96S35

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 14 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9869639

Title: The RNA cleavage activity of RNA polymerase III is mediated by an essential TFIIS-like subunit and is important for transcription termination.

PubMed ID: 9869639

DOI: 10.1101/gad.12.24.3857

PubMed ID: 10079944

Title: Molecular identification and characteristics of hRPC11, the smallest specific subunit of human RNA polymerase III.

PubMed ID: 10079944

PubMed ID: 16728641

Title: A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.

PubMed ID: 16728641

DOI: 10.1126/science.1126431

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12391170

Title: Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits.

PubMed ID: 12391170

DOI: 10.1128/mcb.22.22.8044-8055.2002

PubMed ID: 19631370

Title: RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway.

PubMed ID: 19631370

DOI: 10.1016/j.cell.2009.06.015

PubMed ID: 19609254

Title: RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.

PubMed ID: 19609254

DOI: 10.1038/ni.1779

PubMed ID: 20413673

Title: Defining the RNA polymerase III transcriptome: Genome-wide localization of the RNA polymerase III transcription machinery in human cells.

PubMed ID: 20413673

DOI: 10.1101/gr.101337.109

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 33335104

Title: Structure of human RNA polymerase III.

PubMed ID: 33335104

DOI: 10.1038/s41467-020-20262-5

PubMed ID: 33674783

Title: Structure of human RNA polymerase III elongation complex.

PubMed ID: 33674783

DOI: 10.1038/s41422-021-00472-2

PubMed ID: 34675218

Title: Structural insights into RNA polymerase III-mediated transcription termination through trapping poly-deoxythymidine.

PubMed ID: 34675218

DOI: 10.1038/s41467-021-26402-9

PubMed ID: 33558764

Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.

PubMed ID: 33558764

DOI: 10.1038/s41594-020-00555-5

PubMed ID: 33558766

Title: Structural insights into transcriptional regulation of human RNA polymerase III.

PubMed ID: 33558766

DOI: 10.1038/s41594-021-00557-x

PubMed ID: 30584594

Title: Mutation in POLR3K causes hypomyelinating leukodystrophy and abnormal ribosomal RNA regulation.

PubMed ID: 30584594

DOI: 10.1212/nxg.0000000000000289

Sequence Information:

  • Length: 108
  • Mass: 12320
  • Checksum: 3E96C0F2B48F9D1B
  • Sequence:
    • MLLFCPGCGN GLIVEEGQRC HRFACNTCPY VHNITRKVTN RKYPKLKEVD DVLGGAAAWE 
NVDSTAESCP KCEHPRAYFM QLQTRSADEP MTTFYKCCNA QCGHRWRD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.