Details for: CDK12

Gene ID: 51755

Symbol: CDK12

Ensembl ID: ENSG00000167258

Description: cyclin dependent kinase 12

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 318.6212
    Cell Significance Index: -49.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 193.7366
    Cell Significance Index: -49.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.9733
    Cell Significance Index: -56.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 115.1488
    Cell Significance Index: -46.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.0271
    Cell Significance Index: -53.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.7081
    Cell Significance Index: -56.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.1965
    Cell Significance Index: -46.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 42.9212
    Cell Significance Index: -52.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.5494
    Cell Significance Index: -52.3700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.9571
    Cell Significance Index: -45.9400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.7277
    Cell Significance Index: -54.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2904
    Cell Significance Index: -24.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5386
    Cell Significance Index: 503.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.5342
    Cell Significance Index: 175.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9420
    Cell Significance Index: 192.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9100
    Cell Significance Index: 51.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8582
    Cell Significance Index: 372.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7942
    Cell Significance Index: 24.4800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4725
    Cell Significance Index: 42.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.3481
    Cell Significance Index: 75.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3346
    Cell Significance Index: 478.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3039
    Cell Significance Index: 59.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1990
    Cell Significance Index: 130.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0960
    Cell Significance Index: 197.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0714
    Cell Significance Index: 174.2600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0653
    Cell Significance Index: 26.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0578
    Cell Significance Index: 81.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0571
    Cell Significance Index: 129.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0437
    Cell Significance Index: 28.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.9346
    Cell Significance Index: 26.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8377
    Cell Significance Index: 16.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8261
    Cell Significance Index: 113.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7674
    Cell Significance Index: 49.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7047
    Cell Significance Index: 31.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7017
    Cell Significance Index: 383.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6796
    Cell Significance Index: 470.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6333
    Cell Significance Index: 32.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6021
    Cell Significance Index: 22.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4357
    Cell Significance Index: 192.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4240
    Cell Significance Index: 26.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2979
    Cell Significance Index: 20.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2893
    Cell Significance Index: 15.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2801
    Cell Significance Index: 7.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2621
    Cell Significance Index: 12.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2433
    Cell Significance Index: 8.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2257
    Cell Significance Index: 425.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2036
    Cell Significance Index: 9.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1817
    Cell Significance Index: 34.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1407
    Cell Significance Index: 16.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1330
    Cell Significance Index: 84.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1310
    Cell Significance Index: 16.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1278
    Cell Significance Index: 3.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1055
    Cell Significance Index: 162.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1050
    Cell Significance Index: 193.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0785
    Cell Significance Index: 8.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0728
    Cell Significance Index: 5.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0615
    Cell Significance Index: 27.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0452
    Cell Significance Index: 7.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0410
    Cell Significance Index: 55.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0229
    Cell Significance Index: -14.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0265
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0486
    Cell Significance Index: -36.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0596
    Cell Significance Index: -3.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0632
    Cell Significance Index: -35.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0723
    Cell Significance Index: -1.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1202
    Cell Significance Index: -2.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1362
    Cell Significance Index: -13.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1569
    Cell Significance Index: -33.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1642
    Cell Significance Index: -47.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1745
    Cell Significance Index: -25.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2276
    Cell Significance Index: -3.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2634
    Cell Significance Index: -7.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2718
    Cell Significance Index: -20.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2876
    Cell Significance Index: -15.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3000
    Cell Significance Index: -5.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3150
    Cell Significance Index: -36.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3221
    Cell Significance Index: -6.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3261
    Cell Significance Index: -7.8200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3263
    Cell Significance Index: -37.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3502
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3758
    Cell Significance Index: -39.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3969
    Cell Significance Index: -3.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4731
    Cell Significance Index: -10.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5320
    Cell Significance Index: -12.2900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5415
    Cell Significance Index: -14.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5887
    Cell Significance Index: -16.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6004
    Cell Significance Index: -20.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6114
    Cell Significance Index: -48.4200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6321
    Cell Significance Index: -7.8400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6412
    Cell Significance Index: -13.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7758
    Cell Significance Index: -47.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8653
    Cell Significance Index: -27.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8951
    Cell Significance Index: -13.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9077
    Cell Significance Index: -19.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9328
    Cell Significance Index: -17.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9803
    Cell Significance Index: -28.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9868
    Cell Significance Index: -31.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0009
    Cell Significance Index: -25.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Phosphorylation-dependent activation**: CDK12 is activated through phosphorylation, which is essential for its ability to phosphorylate and activate RNAPII. 2. **Specificity for RNAPII**: CDK12 exhibits specificity for RNAPII, demonstrating its unique role in regulating transcriptional elongation. 3. **Involvement in cell cycle regulation**: CDK12 is essential for the regulation of the cell cycle, particularly during the G2/M phase, where it phosphorylates and activates key cell cycle regulators. 4. **Interactions with other transcriptional regulators**: CDK12 interacts with various transcriptional regulators, including TP53, to modulate gene expression and DNA repair. **Pathways and Functions:** 1. **Transcriptional elongation**: CDK12 regulates the phosphorylation and activation of RNAPII, thereby controlling transcriptional elongation and gene expression. 2. **Cell cycle regulation**: CDK12 phosphorylates and activates key cell cycle regulators, ensuring proper cell cycle progression and preventing aberrant cell proliferation. 3. **DNA repair**: CDK12 interacts with TP53 to regulate the transcription of DNA repair genes, maintaining genome stability. 4. **Gene expression regulation**: CDK12 modulates gene expression through its interactions with transcriptional regulators, influencing cellular processes such as differentiation, proliferation, and apoptosis. **Clinical Significance:** 1. **Cancer association**: Aberrant CDK12 expression has been linked to various cancers, including breast, lung, and colon cancer, highlighting its potential as a therapeutic target. 2. **Neurological disorders**: CDK12 dysregulation has been implicated in neurological disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), underscoring its role in neurodegenerative diseases. 3. **Immunological disorders**: CDK12 plays a crucial role in regulating immune responses, and its dysregulation may contribute to immunological disorders, such as autoimmune diseases and immunodeficiency syndromes. 4. **Personalized medicine**: CDK12's involvement in various diseases and its potential as a therapeutic target make it an attractive candidate for personalized medicine approaches. In conclusion, CDK12 is a multifaceted enzyme that plays a crucial role in regulating transcriptional elongation, cell cycle progression, and DNA repair. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying CDK12's functions and its potential as a therapeutic target.

Genular Protein ID: 4022844923

Symbol: CDK12_HUMAN

Name: Cyclin-dependent kinase 12

UniProtKB Accession Codes:

Q9NYV4 A7E2B2 B4DYX4 B9EIQ6 O94978

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CPTC 1 CTD 1 CarbonylDB 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 4 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 37 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 9 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11683387

Title: CrkRS: a novel conserved Cdc2-related protein kinase that colocalises with SC35 speckles.

PubMed ID: 11683387

DOI: 10.1242/jcs.114.14.2591

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19651820

Title: CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.

PubMed ID: 19651820

DOI: 10.1093/carcin/bgp187

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20952539

Title: CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1.

PubMed ID: 20952539

DOI: 10.1101/gad.1968210

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21097718

Title: Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing.

PubMed ID: 21097718

DOI: 10.1158/0008-5472.can-10-1749

PubMed ID: 22012619

Title: The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.

PubMed ID: 22012619

DOI: 10.1101/gad.16962311

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34696162

Title: HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation.

PubMed ID: 34696162

DOI: 10.3390/vaccines9101054

PubMed ID: 24662513

Title: The structure and substrate specificity of human Cdk12/Cyclin K.

PubMed ID: 24662513

DOI: 10.1038/ncomms4505

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1490
  • Mass: 164155
  • Checksum: D6B04B998ECDE58E
  • Sequence:
    • MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA 
ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR 
DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH 
KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA 
SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR 
SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP 
AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES 
KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK 
VKLDENSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP 
TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN 
SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGDD DMDSPKETLP SKPVKKEKEQ 
RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG 
KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ 
LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM 
KQLMEGLEYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW 
YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW 
PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL 
KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK 
NSSPAPPQPA PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI 
HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQTTLEAS 
STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAACPPHIL 
PPEKRPPEPP GPPPPPPPPP LVEGDLSSAP QELNPAVTAA LLQLLSQPEA EPPGHLPHEH 
QALRPMEYST RPRPNRTYGN TDGPETGFSA IDTDERNSGP ALTESLVQTL VKNRTFSGSL 
SHLGESSSYQ GTGSVQFPGD QDLRFARVPL ALHPVVGQPF LKAEGSSNSV VHAETKLQNY 
GELGPGTTGA SSSGAGLHWG GPTQSSAYGK LYRGPTRVPP RGGRGRGVPY

Genular Protein ID: 103535497

Symbol: H0YLT2_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YLT2

Database IDs:

ARBA 15 Bgee 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 EC 2 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 4 Rhea 6 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 1262
  • Mass: 140047
  • Checksum: F705FBB541D6C09D
  • Sequence:
    • MPNSERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLVS KHKRHKSKHS KDMGLVTPEA 
ASLGTVIKPL VEYDDISSDS DTFSDDMAFK LDRRENDERR GSDRSDRLHK HRHHQHRRSR 
DLLKAKQTEK EKSQEVSSKS GSMKDRISGS SKRSNEETDD YGKAQVAKSS SKESRSSKLH 
KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS SKQDDSPSGA 
SYGQDYDLSP SRSHTSSNYD SYKKSPGSTS RRQSVSPPYK EPSAYQSSTR SPSPYSRRQR 
SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP 
AYSRHSSSHS KKKRSSSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES 
KGSPVFLPRK ENSSVEAKDS GLESKKLPRS VKLEKSAPDT ELVNVTHLNT EVKNSSDTGK 
VKLDENSEKH LVKDLKAQGT RDSKPIALKE EIVTPKETET SEKETPPPLP TIASPPPPLP 
TTTPPPQTPP LPPLPPIPAL PQQPPLPPSQ PAFSQVPASS TSTLPPSTHS KTSAVSSQAN 
SQPPVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLPGDD DMDSPKETLP SKPVKKEKEQ 
RTRHLLTDLP LPPELPGGDL SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG 
KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ 
LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM 
KQLMEGLEYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW 
YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW 
PDVIKLPYFN TMKPKKQYRR RLREEFSFIP SAALDLLDHM LTLDPSKRCT AEQTLQSDFL 
KDVELSKMAP PDLPHWQDCH ELWSKKRRRQ RQSGVVVEEP PPSKTSRKET TSGTSTEPVK 
NSSPAPPQPA PGKVESGAGD AIGLADITQQ LNQSELAVLL NLLQSQTDLS IPQMAQLLNI 
HSNPEMQQQL EALNQSISAL TEATSQQQDS ETMAPEESLK EAPSAPVILP SAEQTTLEAS 
STPADMQNIL AVLLSQLMKT QEPAGSLEEN NSDKNSGPQG PRRTPTMPQE EAAGRSNGGN 
AL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.