Details for: SYT17

Gene ID: 51760

Symbol: SYT17

Ensembl ID: ENSG00000103528

Description: synaptotagmin 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 146.0668
    Cell Significance Index: -22.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 90.1265
    Cell Significance Index: -22.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.7050
    Cell Significance Index: -23.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.4273
    Cell Significance Index: -22.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.5687
    Cell Significance Index: 218.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.4727
    Cell Significance Index: 47.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5986
    Cell Significance Index: 573.4000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.5856
    Cell Significance Index: 14.0800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.3731
    Cell Significance Index: 19.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2748
    Cell Significance Index: 36.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2342
    Cell Significance Index: 82.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8588
    Cell Significance Index: 44.6100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7950
    Cell Significance Index: 4.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6309
    Cell Significance Index: 569.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4281
    Cell Significance Index: 69.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4061
    Cell Significance Index: 44.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3933
    Cell Significance Index: 10.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3798
    Cell Significance Index: 72.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3401
    Cell Significance Index: 20.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3104
    Cell Significance Index: 14.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2973
    Cell Significance Index: 205.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2835
    Cell Significance Index: 180.0300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.2695
    Cell Significance Index: 4.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2493
    Cell Significance Index: 5.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2467
    Cell Significance Index: 15.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1987
    Cell Significance Index: 35.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1845
    Cell Significance Index: 100.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1782
    Cell Significance Index: 12.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1734
    Cell Significance Index: 21.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1455
    Cell Significance Index: 273.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1432
    Cell Significance Index: 28.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1413
    Cell Significance Index: 2.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1127
    Cell Significance Index: 22.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0996
    Cell Significance Index: 45.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0933
    Cell Significance Index: 11.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0728
    Cell Significance Index: 7.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0531
    Cell Significance Index: 1.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0164
    Cell Significance Index: 30.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0106
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0101
    Cell Significance Index: -15.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0181
    Cell Significance Index: -24.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0198
    Cell Significance Index: -14.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0213
    Cell Significance Index: -15.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0225
    Cell Significance Index: -17.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0356
    Cell Significance Index: -20.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0382
    Cell Significance Index: -16.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0458
    Cell Significance Index: -28.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0509
    Cell Significance Index: -7.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0624
    Cell Significance Index: -17.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0653
    Cell Significance Index: -6.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1156
    Cell Significance Index: -24.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1236
    Cell Significance Index: -14.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1304
    Cell Significance Index: -22.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1350
    Cell Significance Index: -2.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1432
    Cell Significance Index: -3.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1516
    Cell Significance Index: -2.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1518
    Cell Significance Index: -20.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1523
    Cell Significance Index: -17.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1544
    Cell Significance Index: -19.9500
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.1567
    Cell Significance Index: -1.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1579
    Cell Significance Index: -11.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1689
    Cell Significance Index: -21.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1736
    Cell Significance Index: -5.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1849
    Cell Significance Index: -9.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2057
    Cell Significance Index: -21.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2097
    Cell Significance Index: -4.4500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2197
    Cell Significance Index: -4.4100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2414
    Cell Significance Index: -3.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2428
    Cell Significance Index: -6.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2527
    Cell Significance Index: -14.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2586
    Cell Significance Index: -4.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2640
    Cell Significance Index: -20.9100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2775
    Cell Significance Index: -3.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2898
    Cell Significance Index: -22.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3128
    Cell Significance Index: -4.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3388
    Cell Significance Index: -17.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3405
    Cell Significance Index: -16.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3439
    Cell Significance Index: -22.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3866
    Cell Significance Index: -3.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3890
    Cell Significance Index: -27.5100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4032
    Cell Significance Index: -8.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4124
    Cell Significance Index: -25.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4353
    Cell Significance Index: -15.2500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4474
    Cell Significance Index: -5.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4756
    Cell Significance Index: -12.7000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5187
    Cell Significance Index: -10.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5225
    Cell Significance Index: -23.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5226
    Cell Significance Index: -17.1100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5503
    Cell Significance Index: -6.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5627
    Cell Significance Index: -17.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5675
    Cell Significance Index: -12.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5734
    Cell Significance Index: -20.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5772
    Cell Significance Index: -9.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5773
    Cell Significance Index: -20.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5881
    Cell Significance Index: -27.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5996
    Cell Significance Index: -17.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6146
    Cell Significance Index: -22.5600
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.6146
    Cell Significance Index: -6.8300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6174
    Cell Significance Index: -23.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6228
    Cell Significance Index: -16.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SYT17 is a member of the synaptotagmin family, which are calcium-binding proteins that regulate neurotransmitter release and synaptic plasticity. SYT17 is characterized by its high expression in hematopoietic cells, including polychromatophilic erythroblast and hematopoietic oligopotent progenitor cells. It is also highly expressed in neurons, particularly in hippocampal astrocytes and pyramidal neurons, suggesting its role in neuronal function and development. SYT17 is a calcium-dependent phospholipid-binding protein, which allows it to regulate calcium ion-dependent exocytosis and neurotransmitter release. **Pathways and Functions:** SYT17 is involved in several key pathways, including: 1. **Calcium-dependent phospholipid binding:** SYT17 binds to phospholipids in the plasma membrane, regulating calcium ion-dependent exocytosis and neurotransmitter release. 2. **Calcium ion sensor activity:** SYT17 acts as a calcium sensor, regulating calcium-dependent cellular processes, including cell differentiation and immune response. 3. **Exocytic vesicle regulation:** SYT17 regulates the formation and function of exocytic vesicles, which are involved in neurotransmitter release and immune cell function. 4. **Regulation of calcium ion-dependent exocytosis:** SYT17 regulates the release of neurotransmitters and hormones, which is essential for neuronal function and immune response. **Clinical Significance:** SYT17 has been implicated in several clinical disorders, including: 1. **Neurological disorders:** SYT17 has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it plays a role in regulating synaptic plasticity and neurotransmitter release. 2. **Immune disorders:** SYT17 has been implicated in autoimmune diseases, such as multiple sclerosis, where it regulates immune cell function and neurotransmitter release. 3. **Cancer:** SYT17 has been linked to cancer, particularly in hematological malignancies, where it regulates immune cell function and tumor growth. In conclusion, SYT17 is a multifunctional protein that plays a critical role in regulating calcium-dependent cellular processes, including neurotransmission, cell differentiation, and immune response. Its dysregulation has been implicated in various clinical disorders, highlighting the need for further research into its role in human health and disease. **References:** * [Insert references to relevant studies on SYT17] Note: The references should be up-to-date and include studies that have investigated the role of SYT17 in immune and neurological disorders.

Genular Protein ID: 2242939781

Symbol: SYT17_HUMAN

Name: Synaptotagmin-17

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16672768

Title: Protein kinase A-dependent phosphorylation of B/K protein.

PubMed ID: 16672768

DOI: 10.1038/emm.2006.18

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 23999003

Title: SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.

PubMed ID: 23999003

DOI: 10.1016/j.jdermsci.2013.07.010

Sequence Information:

  • Length: 474
  • Mass: 53849
  • Checksum: F5D2E86665BCEC8C
  • Sequence:
  • MAYIQLEPLN EGFLSRISGL LLCRWTCRHC CQKCYESSCC QSSEDEVEIL GPFPAQTPPW 
    LMASRSSDKD GDSVHTASEV PLTPRTNSPD GRRSSSDTSK STYSLTRRIS SLESRRPSSP 
    LIDIKPIEFG VLSAKKEPIQ PSVLRRTYNP DDYFRKFEPH LYSLDSNSDD VDSLTDEEIL 
    SKYQLGMLHF STQYDLLHNH LTVRVIEARD LPPPISHDGS RQDMAHSNPY VKICLLPDQK 
    NSKQTGVKRK TQKPVFEERY TFEIPFLEAQ RRTLLLTVVD FDKFSRHCVI GKVSVPLCEV 
    DLVKGGHWWK ALIPSSQNEV ELGELLLSLN YLPSAGRLNV DVIRAKQLLQ TDVSQGSDPF 
    VKIQLVHGLK LVKTKKTSFL RGTIDPFYNE SFSFKVPQEE LENASLVFTV FGHNMKSSND 
    FIGRIVIGQY SSGPSETNHW RRMLNTHRTA VEQWHSLRSR AECDRVSPAS LEVT

Genular Protein ID: 1625709242

Symbol: H3BN78_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 470
  • Mass: 53374
  • Checksum: 5AE72CEA2D7E28E9
  • Sequence:
  • MLEPLNEGFL SRISGLLLCR WTCRHCCQKC YESSCCQSSE DEVEILGPFP AQTPPWLMAS 
    RSSDKDGDSV HTASEVPLTP RTNSPDGRRS SSDTSKSTYS LTRRISSLES RRPSSPLIDI 
    KPIEFGVLSA KKEPIQPSVL RRTYNPDDYF RKFEPHLYSL DSNSDDVDSL TDEEILSKYQ 
    LGMLHFSTQY DLLHNHLTVR VIEARDLPPP ISHDGSRQDM AHSNPYVKIC LLPDQKNSKQ 
    TGVKRKTQKP VFEERYTFEI PFLEAQRRTL LLTVVDFDKF SRHCVIGKVS VPLCEVDLVK 
    GGHWWKALIP SSQNEVELGE LLLSLNYLPS AGRLNVDVIR AKQLLQTDVS QGSDPFVKIQ 
    LVHGLKLVKT KKTSFLRGTI DPFYNESFSF KVPQEELENA SLVFTVFGHN MKSSNDFIGR 
    IVIGQYSSGP SETNHWRRML NTHRTAVEQW HSLRSRAECD RVSPASLEVT

Genular Protein ID: 3260886961

Symbol: H3BRH9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

Sequence Information:

  • Length: 413
  • Mass: 46885
  • Checksum: 3D75AF8F633A1A8E
  • Sequence:
  • MASRSSDKDG DSVHTASEVP LTPRTNSPDG RRSSSDTSKS TYSLTRRISS LESRRPSSPL 
    IDIKPIEFGV LSAKKEPIQP SVLRRTYNPD DYFRKFEPHL YSLDSNSDDV DSLTDEEILS 
    KYQLGMLHFS TQYDLLHNHL TVRVIEARDL PPPISHDGSR QDMAHSNPYV KICLLPDQKN 
    SKQTGVKRKT QKPVFEERYT FEIPFLEAQR RTLLLTVVDF DKFSRHCVIG KVSVPLCEVD 
    LVKGGHWWKA LIPSSQNEVE LGELLLSLNY LPSAGRLNVD VIRAKQLLQT DVSQGSDPFV 
    KIQLVHGLKL VKTKKTSFLR GTIDPFYNES FSFKVPQEEL ENASLVFTVF GHNMKSSNDF 
    IGRIVIGQYS SGPSETNHWR RMLNTHRTAV EQWHSLRSRA ECDRVSPASL EVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.