Details for: TM7SF3
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 20.52rCSI 49.87%PRS 41.96
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CSI 17.46rCSI 17.43%PRS 54.82
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CSI 12.12rCSI 37.87%PRS 44.98
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CSI 11.97rCSI 11.31%PRS 61.18
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CSI 10.38rCSI 8.39%PRS 63
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CSI 9.62rCSI 18.71%PRS 64.52
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CSI 9.22rCSI 11.48%PRS 41.41
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CSI 9.07rCSI 21.52%PRS 65.25
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CSI 8.76rCSI 6.49%PRS 54.18
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CSI 8.3rCSI 5.52%PRS 64.66
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CSI 8.09rCSI 11.83%PRS 66.19
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CSI 7.39rCSI 43.52%PRS 44.66
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CSI 7.29rCSI 26.22%PRS 41.74
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CSI 7.07rCSI 16.96%PRS 71.97
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CSI 6.88rCSI 16.39%PRS 62.53
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CSI 6.85rCSI 35.36%PRS 82.97
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CSI 6.42rCSI 25%PRS 81.55
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CSI 5.92rCSI 7.08%PRS 43.12
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CSI 5.87rCSI 5.66%PRS 61.62
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CSI 5.79rCSI 8.35%PRS 71.1
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CSI 5.73rCSI 7.62%PRS 68.01
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CSI 5.59rCSI 7.98%PRS 63.86
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CSI 5.26rCSI 8.08%PRS 57.49
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CSI 5.14rCSI 11.49%PRS 69.33
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CSI 5.07rCSI 3.93%PRS 63.42
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CSI 4.99rCSI 14.46%PRS 63
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CSI 4.76rCSI 11.62%PRS 55.1
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CSI 4.75rCSI 12.4%PRS 65.27
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CSI 4.67rCSI 4.96%PRS 71.91
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CSI 4.66rCSI 12.3%PRS 70.37
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CSI 4.58rCSI 10.56%PRS 50.67
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CSI 4.39rCSI 14.72%PRS 46.78
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CSI 4.37rCSI 17.11%PRS 38.25
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CSI 4.27rCSI 7.53%PRS 58.48
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CSI 4.24rCSI 4.55%PRS 60.94
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CSI 4.14rCSI 6.67%PRS 51.12
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CSI 4.12rCSI 6.33%PRS 70.56
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CSI 4.04rCSI 3.28%PRS 62.06
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CSI 3.71rCSI 6.55%PRS 42.4
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CSI 3.65rCSI 12.33%PRS 65.51
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CSI 3.65rCSI 2.74%PRS 67.05
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CSI 3.51rCSI 21.95%PRS 53.43
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CSI 3.47rCSI 2.64%PRS 74.6
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CSI 3.42rCSI 10.15%PRS 71.54
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CSI 3.34rCSI 3.43%PRS 77.93
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CSI 3.33rCSI 4.05%PRS 69.05
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CSI 3.32rCSI 14.36%PRS 74.16
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CSI 3.2rCSI 5.7%PRS 74.9
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CSI 3.14rCSI 3.9%PRS 63.3
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CSI 3.1rCSI 3.05%PRS 77.2
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CSI 3.09rCSI 3.97%PRS 58.71
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CSI 3.01rCSI 2.09%PRS 72.75
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CSI 2.98rCSI 2.62%PRS 67.1
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CSI 2.98rCSI 3.11%PRS 61.8
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CSI 2.97rCSI 5.57%PRS 49.93
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CSI 2.91rCSI 4.03%PRS 62.65
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CSI 2.91rCSI 7.51%PRS 56.57
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CSI 2.87rCSI 6.57%PRS 61.44
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CSI 2.87rCSI 2.27%PRS 48.38
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CSI 2.86rCSI 6.52%PRS 53.39
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CSI 2.82rCSI 2.38%PRS 78.51
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CSI 2.82rCSI 5.66%PRS 50.61
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CSI 2.79rCSI 3.51%PRS 73.42
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CSI 2.76rCSI 3.97%PRS 72.32
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CSI 2.75rCSI 2.87%PRS 59.57
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CSI 2.67rCSI 3.71%PRS 60.2
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CSI 2.65rCSI 1.57%PRS 78.88
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CSI 2.64rCSI 5.36%PRS 41
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CSI 2.63rCSI 5.82%PRS 47.76
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CSI 2.63rCSI 62.95%PRS 42.39
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CSI 2.6rCSI 7.4%PRS 59.7
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CSI 2.55rCSI 4.14%PRS 58.18
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CSI 2.54rCSI 3.46%PRS 73.36
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CSI 2.52rCSI 3.24%PRS 66.27
-
CSI 2.48rCSI 2.06%PRS 63.77
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CSI 2.45rCSI 10.8%PRS 52.01
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CSI 2.45rCSI 4.11%PRS 43.34
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CSI 2.44rCSI 3.93%PRS 45.39
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CSI 2.43rCSI 3.83%PRS 63.87
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CSI 2.38rCSI 2.75%PRS 54.69
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CSI 2.37rCSI 57.26%PRS 43.29
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CSI 2.36rCSI 4.24%PRS 54.64
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CSI 2.34rCSI 5.25%PRS 44.09
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CSI 2.34rCSI 8.77%PRS 53.64
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CSI 2.33rCSI 4.18%PRS 60.69
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CSI 2.33rCSI 1.79%PRS 62.04
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CSI 2.32rCSI 3.7%PRS 54.23
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CSI 2.3rCSI 3.13%PRS 53.36
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CSI 2.29rCSI 13.72%PRS 68.9
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CSI 2.28rCSI 5.36%PRS 66.36
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CSI 2.28rCSI 10.91%PRS 60.27
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CSI 2.27rCSI 5.75%PRS 69.51
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CSI 2.27rCSI 1.53%PRS 74.69
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CSI 2.25rCSI 1.75%PRS 79.32
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CSI 2.21rCSI 2.32%PRS 65.21
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CSI 2.18rCSI 2.52%PRS 51.61
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CSI 2.18rCSI 9.67%PRS 61.06
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CSI 2.17rCSI 1.96%PRS 58.43
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CSI 2.16rCSI 3.26%PRS 65.71
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CSI 2.12rCSI 5.64%PRS 73.04
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CSI 0.2rCSI 4.7%PRS 80.5%
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CSI 0.2rCSI 4.8%PRS 52.5%
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CSI 0.3rCSI 3.2%PRS 82.0%
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CSI 0.3rCSI 3.3%PRS 76.4%
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CSI 0.3rCSI 1.9%PRS 70.8%
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CSI 0.4rCSI 2.2%PRS 74.1%
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CSI 0.5rCSI 3.3%PRS 87.1%
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CSI 0.5rCSI 2.0%PRS 44.1%
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CSI 0.6rCSI 1.6%PRS 51.3%
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CSI 0.6rCSI 3.4%PRS 81.0%
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CSI 0.7rCSI 2.2%PRS 47.5%
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CSI 0.8rCSI 1.5%PRS 72.0%
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CSI 0.8rCSI 1.9%PRS 79.2%
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CSI 0.8rCSI 2.1%PRS 59.1%
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CSI 0.8rCSI 5.9%PRS 48.4%
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CSI 0.8rCSI 1.2%PRS 57.8%
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CSI 0.8rCSI 1.8%PRS 59.5%
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CSI 0.9rCSI 3.7%PRS 58.1%
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CSI 0.9rCSI 7.9%PRS 49.0%
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CSI 1.0rCSI 1.5%PRS 59.7%
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CSI 1.0rCSI 2.7%PRS 52.6%
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CSI 1.0rCSI 1.2%PRS 70.4%
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CSI 1.0rCSI 1.4%PRS 55.1%
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CSI 1.1rCSI 8.6%PRS 70.2%
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CSI 1.2rCSI 3.8%PRS 48.7%
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CSI 1.2rCSI 2.9%PRS 51.0%
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CSI 1.2rCSI 1.7%PRS 51.3%
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CSI 1.2rCSI 1.1%PRS 66.5%
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CSI 1.2rCSI 1.3%PRS 58.0%
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CSI 1.3rCSI 4.5%PRS 90.3%
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CSI 1.3rCSI 3.3%PRS 65.1%
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CSI 1.3rCSI 5.0%PRS 76.1%
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CSI 1.3rCSI 1.4%PRS 67.2%
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CSI 1.4rCSI 3.8%PRS 57.2%
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CSI 1.4rCSI 1.7%PRS 72.4%
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CSI 1.4rCSI 2.1%PRS 73.1%
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CSI 1.4rCSI 1.7%PRS 64.0%
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CSI 1.5rCSI 6.9%PRS 61.7%
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CSI 1.5rCSI 2.1%PRS 57.5%
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CSI 1.5rCSI 1.9%PRS 44.6%
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CSI 1.5rCSI 6.0%PRS 56.1%
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CSI 1.5rCSI 2.3%PRS 62.2%
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CSI 1.5rCSI 2.4%PRS 65.8%
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CSI 1.5rCSI 2.3%PRS 70.9%
-
CSI 1.5rCSI 2.1%PRS 63.3%
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CSI 1.6rCSI 2.1%PRS 61.8%
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CSI 1.6rCSI 3.9%PRS 48.9%
-
CSI 1.6rCSI 2.3%PRS 57.9%
-
CSI 1.6rCSI 2.6%PRS 72.6%
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CSI 1.7rCSI 5.3%PRS 58.8%
-
CSI 1.7rCSI 3.9%PRS 58.0%
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CSI 1.7rCSI 1.5%PRS 49.4%
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CSI 1.7rCSI 3.1%PRS 53.5%
-
CSI 1.7rCSI 3.4%PRS 59.3%
-
CSI 1.7rCSI 3.8%PRS 65.8%
-
CSI 1.8rCSI 4.6%PRS 61.4%
-
CSI 1.8rCSI 2.6%PRS 66.9%
-
CSI 1.8rCSI 1.7%PRS 52.2%
-
CSI 1.8rCSI 2.8%PRS 69.1%
-
CSI 1.9rCSI 4.9%PRS 50.9%
-
CSI 1.9rCSI 4.7%PRS 60.0%
-
CSI 1.9rCSI 3.1%PRS 50.8%
-
CSI 1.9rCSI 7.7%PRS 60.4%
-
CSI 1.9rCSI 7.5%PRS 66.5%
-
CSI 1.9rCSI 3.3%PRS 84.1%
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CSI 2.0rCSI 3.4%PRS 51.8%
-
CSI 2.0rCSI 1.6%PRS 65.9%
-
CSI 2.0rCSI 1.6%PRS 68.3%
-
CSI 2.0rCSI 2.0%PRS 64.2%
-
CSI 2.0rCSI 7.7%PRS 52.5%
-
CSI 2.0rCSI 1.7%PRS 60.8%
-
CSI 2.0rCSI 2.2%PRS 65.3%
-
CSI 2.1rCSI 1.5%PRS 64.4%
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CSI 2.1rCSI 5.6%PRS 73.0%
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CSI 2.2rCSI 3.3%PRS 65.7%
-
CSI 2.2rCSI 2.0%PRS 58.4%
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CSI 2.2rCSI 9.7%PRS 61.1%
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CSI 2.2rCSI 2.5%PRS 51.6%
-
CSI 2.2rCSI 2.3%PRS 65.2%
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CSI 2.3rCSI 1.8%PRS 79.3%
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CSI 2.3rCSI 1.5%PRS 74.7%
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CSI 2.3rCSI 5.8%PRS 69.5%
-
CSI 2.3rCSI 10.9%PRS 60.3%
-
CSI 2.3rCSI 5.4%PRS 66.4%
-
CSI 2.3rCSI 13.7%PRS 68.9%
-
CSI 2.3rCSI 3.1%PRS 53.4%
-
CSI 2.3rCSI 3.7%PRS 54.2%
-
CSI 2.3rCSI 1.8%PRS 62.0%
-
CSI 2.3rCSI 4.2%PRS 60.7%
-
CSI 2.3rCSI 8.8%PRS 53.6%
-
CSI 2.3rCSI 5.3%PRS 44.1%
-
CSI 2.4rCSI 4.2%PRS 54.6%
-
CSI 2.4rCSI 57.3%PRS 43.3%
-
CSI 2.4rCSI 2.8%PRS 54.7%
-
CSI 2.4rCSI 3.8%PRS 63.9%
-
CSI 2.4rCSI 3.9%PRS 45.4%
-
CSI 2.5rCSI 4.1%PRS 43.3%
-
CSI 2.5rCSI 10.8%PRS 52.0%
-
CSI 2.5rCSI 2.1%PRS 63.8%
-
CSI 2.5rCSI 3.2%PRS 66.3%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 2912745657
Symbol: TM7S3_HUMAN
Name: Transmembrane 7 superfamily member 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10828615
Title: Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3.
PubMed ID: 10828615
DOI: 10.1159/000015514
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21853325
Title: An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.
PubMed ID: 21853325
PubMed ID: 27740623
Title: TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.
PubMed ID: 27740623
DOI: 10.1038/cdd.2016.108
Sequence Information:
- Length: 570
- Mass: 64166
- Checksum: CC296D7C22AD894C
- Sequence:
MGFLQLLVVA VLASEHRVAG AAEVFGNSSE GLIEFSVGKF RYFELNRPFP EEAILHDISS NVTFLIFQIH SQYQNTTVSF SPTLLSNSSE TGTASGLVFI LRPEQSTCTW YLGTSGIQPV QNMAILLSYS ERDPVPGGCN LEFDLDIDPN IYLEYNFFET TIKFAPANLG YARGVDPPPC DAGTDQDSRW RLQYDVYQYF LPENDLTEEM LLKHLQRMVS VPQVKASALK VVTLTANDKT SVSFSSLPGQ GVIYNVIVWD PFLNTSAAYI PAHTYACSFE AGEGSCASLG RVSSKVFFTL FALLGFFICF FGHRFWKTEL FFIGFIIMGF FFYILITRLT PIKYDVNLIL TAVTGSVGGM FLVAVWWRFG ILSICMLCVG LVLGFLISSV TFFTPLGNLK IFHDDGVFWV TFSCIAILIP VVFMGCLRIL NILTCGVIGS YSVVLAIDSY WSTSLSYITL NVLKRALNKD FHRAFTNVPF QTNDFIILAV WGMLAVSGIT LQIRRERGRP FFPPHPYKLW KQERERRVTN ILDPSYHIPP LRERLYGRLT QIKGLFQKEQ PAGERTPLLL