Details for: TM7SF3

Gene ID: 51768

Symbol: TM7SF3

Ensembl ID: ENSG00000064115

Description: transmembrane 7 superfamily member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 255.0384
    Cell Significance Index: -39.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.1681
    Cell Significance Index: -36.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 98.1313
    Cell Significance Index: -46.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 90.0415
    Cell Significance Index: -36.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 82.7979
    Cell Significance Index: -42.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 69.1631
    Cell Significance Index: -46.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.3140
    Cell Significance Index: -36.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.3030
    Cell Significance Index: -44.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.9686
    Cell Significance Index: -37.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.5774
    Cell Significance Index: -45.6900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3348
    Cell Significance Index: -20.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.3102
    Cell Significance Index: 31.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0963
    Cell Significance Index: 420.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6750
    Cell Significance Index: 46.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.5177
    Cell Significance Index: 25.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3734
    Cell Significance Index: 272.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2320
    Cell Significance Index: 33.5400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1221
    Cell Significance Index: 182.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1099
    Cell Significance Index: 29.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1082
    Cell Significance Index: 57.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9557
    Cell Significance Index: 172.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9186
    Cell Significance Index: 42.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7686
    Cell Significance Index: 275.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6919
    Cell Significance Index: 85.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6645
    Cell Significance Index: 362.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5148
    Cell Significance Index: 28.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5053
    Cell Significance Index: 31.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4723
    Cell Significance Index: 326.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4625
    Cell Significance Index: 11.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4313
    Cell Significance Index: 27.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3729
    Cell Significance Index: 14.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3706
    Cell Significance Index: 163.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3612
    Cell Significance Index: 326.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3571
    Cell Significance Index: 24.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3570
    Cell Significance Index: 60.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3055
    Cell Significance Index: 13.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2566
    Cell Significance Index: 18.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2381
    Cell Significance Index: 6.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1955
    Cell Significance Index: 15.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1944
    Cell Significance Index: 19.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1614
    Cell Significance Index: 10.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1545
    Cell Significance Index: 19.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1346
    Cell Significance Index: 25.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1253
    Cell Significance Index: 235.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0622
    Cell Significance Index: 28.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0452
    Cell Significance Index: 83.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0284
    Cell Significance Index: 43.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0281
    Cell Significance Index: 17.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0130
    Cell Significance Index: 1.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0052
    Cell Significance Index: 7.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0088
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0165
    Cell Significance Index: -12.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0194
    Cell Significance Index: -0.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0225
    Cell Significance Index: -16.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0271
    Cell Significance Index: -16.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0352
    Cell Significance Index: -5.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0432
    Cell Significance Index: -4.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0496
    Cell Significance Index: -27.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0607
    Cell Significance Index: -1.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0642
    Cell Significance Index: -7.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0676
    Cell Significance Index: -8.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0912
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1068
    Cell Significance Index: -22.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1127
    Cell Significance Index: -12.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1198
    Cell Significance Index: -3.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1277
    Cell Significance Index: -36.7500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1341
    Cell Significance Index: -1.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1362
    Cell Significance Index: -15.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1363
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1442
    Cell Significance Index: -16.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1625
    Cell Significance Index: -4.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2015
    Cell Significance Index: -15.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2581
    Cell Significance Index: -6.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2594
    Cell Significance Index: -13.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2660
    Cell Significance Index: -8.5200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2866
    Cell Significance Index: -4.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2968
    Cell Significance Index: -13.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3396
    Cell Significance Index: -9.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3722
    Cell Significance Index: -38.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3757
    Cell Significance Index: -8.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3792
    Cell Significance Index: -17.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4499
    Cell Significance Index: -35.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5266
    Cell Significance Index: -11.2200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.5666
    Cell Significance Index: -9.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5994
    Cell Significance Index: -5.5200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6200
    Cell Significance Index: -18.2100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.6207
    Cell Significance Index: -4.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6385
    Cell Significance Index: -33.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6826
    Cell Significance Index: -34.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7423
    Cell Significance Index: -45.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7429
    Cell Significance Index: -23.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7458
    Cell Significance Index: -19.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7581
    Cell Significance Index: -24.8200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7791
    Cell Significance Index: -17.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7909
    Cell Significance Index: -17.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8386
    Cell Significance Index: -14.0400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8396
    Cell Significance Index: -17.8200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8676
    Cell Significance Index: -13.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8916
    Cell Significance Index: -15.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Structure:** TM7SF3 is a transmembrane protein, comprising a hydrophobic transmembrane domain and an extracellular domain, which allows it to interact with other molecules and regulate cellular processes. 2. **Expression Patterns:** TM7SF3 is expressed in a wide range of cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, smooth muscle fibers, and immune cells like CD8-alpha-beta-positive alpha-beta intraepithelial T cells. 3. **Functional Diversity:** TM7SF3 is involved in various cellular processes, including negative regulation of programmed cell death, positive regulation of insulin secretion, and response to unfolded proteins. **Pathways and Functions:** 1. **Cellular Response to Unfolded Proteins:** TM7SF3 is involved in the cellular response to unfolded proteins, which is crucial for maintaining protein homeostasis and preventing cell death. 2. **Extracellular Exosome:** TM7SF3 is also involved in the formation and regulation of extracellular exosomes, which play a key role in intercellular communication and cell signaling. 3. **Molecular Function:** TM7SF3 is a negative regulator of programmed cell death and a positive regulator of insulin secretion, highlighting its role in maintaining cellular homeostasis and regulating metabolic processes. 4. **Plasma Membrane:** TM7SF3 is a plasma membrane protein, allowing it to interact with other molecules and regulate cellular processes. **Clinical Significance:** 1. **Cancer Research:** TM7SF3 expression has been implicated in various cancers, including colorectal, breast, and lung cancers. Further studies are needed to understand its role in cancer development and progression. 2. **Immune Regulation:** TM7SF3's involvement in immune cell function and regulation makes it a potential target for immunotherapy in cancer and autoimmune diseases. 3. **Metabolic Disorders:** TM7SF3's role in insulin secretion and glucose metabolism suggests its potential as a therapeutic target for metabolic disorders, such as diabetes and insulin resistance. 4. **Neurological Disorders:** TM7SF3's expression in neurons and its involvement in cellular response to unfolded proteins make it a potential target for neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, TM7SF3 is a multifunctional protein with diverse roles in cellular regulation, immune function, and metabolic processes. Further studies are needed to fully understand its implications in human health and disease, and to explore its potential as a therapeutic target in various clinical applications.

Genular Protein ID: 2912745657

Symbol: TM7S3_HUMAN

Name: Transmembrane 7 superfamily member 3

UniProtKB Accession Codes:

Q9NS93 B3KMZ3 Q9NUS4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10828615

Title: Isolation and characterization of a novel gene encoding a putative seven-span transmembrane protein, TM7SF3.

PubMed ID: 10828615

DOI: 10.1159/000015514

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21853325

Title: An siRNA screen identifies transmembrane 7 superfamily member 3 (TM7SF3), a seven transmembrane orphan receptor, as an inhibitor of cytokine-induced death of pancreatic beta cells.

PubMed ID: 21853325

DOI: 10.1007/s00125-011-2277-3

PubMed ID: 27740623

Title: TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response.

PubMed ID: 27740623

DOI: 10.1038/cdd.2016.108

Sequence Information:

  • Length: 570
  • Mass: 64166
  • Checksum: CC296D7C22AD894C
  • Sequence:
    • MGFLQLLVVA VLASEHRVAG AAEVFGNSSE GLIEFSVGKF RYFELNRPFP EEAILHDISS 
NVTFLIFQIH SQYQNTTVSF SPTLLSNSSE TGTASGLVFI LRPEQSTCTW YLGTSGIQPV 
QNMAILLSYS ERDPVPGGCN LEFDLDIDPN IYLEYNFFET TIKFAPANLG YARGVDPPPC 
DAGTDQDSRW RLQYDVYQYF LPENDLTEEM LLKHLQRMVS VPQVKASALK VVTLTANDKT 
SVSFSSLPGQ GVIYNVIVWD PFLNTSAAYI PAHTYACSFE AGEGSCASLG RVSSKVFFTL 
FALLGFFICF FGHRFWKTEL FFIGFIIMGF FFYILITRLT PIKYDVNLIL TAVTGSVGGM 
FLVAVWWRFG ILSICMLCVG LVLGFLISSV TFFTPLGNLK IFHDDGVFWV TFSCIAILIP 
VVFMGCLRIL NILTCGVIGS YSVVLAIDSY WSTSLSYITL NVLKRALNKD FHRAFTNVPF 
QTNDFIILAV WGMLAVSGIT LQIRRERGRP FFPPHPYKLW KQERERRVTN ILDPSYHIPP 
LRERLYGRLT QIKGLFQKEQ PAGERTPLLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.