Details for: MAP3K20

Gene ID: 51776

Symbol: MAP3K20

Ensembl ID: ENSG00000091436

Description: mitogen-activated protein kinase kinase kinase 20

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 122.8312
    Cell Significance Index: -50.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.6743
    Cell Significance Index: -45.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 91.1738
    Cell Significance Index: -37.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 85.0724
    Cell Significance Index: -43.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.7958
    Cell Significance Index: -37.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2081
    Cell Significance Index: -24.5300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 8.5996
    Cell Significance Index: 209.8300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 7.1030
    Cell Significance Index: 114.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.8297
    Cell Significance Index: 149.8500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.4332
    Cell Significance Index: 65.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.2137
    Cell Significance Index: 323.3500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.1853
    Cell Significance Index: 40.1100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.9130
    Cell Significance Index: 13.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.5567
    Cell Significance Index: 49.9000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.5123
    Cell Significance Index: 13.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.4264
    Cell Significance Index: 16.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1422
    Cell Significance Index: 294.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.7106
    Cell Significance Index: 39.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5648
    Cell Significance Index: 310.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1179
    Cell Significance Index: 75.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0040
    Cell Significance Index: 56.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9488
    Cell Significance Index: 103.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8818
    Cell Significance Index: 52.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.8765
    Cell Significance Index: 397.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8570
    Cell Significance Index: 23.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8093
    Cell Significance Index: 94.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7496
    Cell Significance Index: 19.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6701
    Cell Significance Index: 19.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6412
    Cell Significance Index: 578.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4973
    Cell Significance Index: 63.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4823
    Cell Significance Index: 91.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4451
    Cell Significance Index: 12.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3580
    Cell Significance Index: 24.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3541
    Cell Significance Index: 156.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3397
    Cell Significance Index: 7.1100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3391
    Cell Significance Index: 4.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3132
    Cell Significance Index: 589.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3075
    Cell Significance Index: 19.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2652
    Cell Significance Index: 53.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2416
    Cell Significance Index: 14.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2166
    Cell Significance Index: 24.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1945
    Cell Significance Index: 69.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1648
    Cell Significance Index: 12.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1455
    Cell Significance Index: 92.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1444
    Cell Significance Index: 3.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1441
    Cell Significance Index: 78.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1374
    Cell Significance Index: 16.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1331
    Cell Significance Index: 92.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1291
    Cell Significance Index: 12.7800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1205
    Cell Significance Index: 6.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1096
    Cell Significance Index: 5.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0739
    Cell Significance Index: 7.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0424
    Cell Significance Index: 78.1600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0320
    Cell Significance Index: 0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0315
    Cell Significance Index: 5.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0281
    Cell Significance Index: 43.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0238
    Cell Significance Index: 1.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0151
    Cell Significance Index: 1.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0106
    Cell Significance Index: 14.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0067
    Cell Significance Index: 1.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0079
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0476
    Cell Significance Index: -1.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0482
    Cell Significance Index: -5.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0518
    Cell Significance Index: -1.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0549
    Cell Significance Index: -40.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0557
    Cell Significance Index: -41.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0576
    Cell Significance Index: -8.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0747
    Cell Significance Index: -1.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0825
    Cell Significance Index: -1.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0840
    Cell Significance Index: -47.3700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0845
    Cell Significance Index: -0.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0963
    Cell Significance Index: -9.8400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1076
    Cell Significance Index: -1.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1141
    Cell Significance Index: -32.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1709
    Cell Significance Index: -7.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2435
    Cell Significance Index: -51.3000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2468
    Cell Significance Index: -5.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2782
    Cell Significance Index: -8.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2949
    Cell Significance Index: -15.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3128
    Cell Significance Index: -4.8400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4347
    Cell Significance Index: -6.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4427
    Cell Significance Index: -27.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4904
    Cell Significance Index: -6.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5131
    Cell Significance Index: -40.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5206
    Cell Significance Index: -5.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5600
    Cell Significance Index: -19.4600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5781
    Cell Significance Index: -10.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6365
    Cell Significance Index: -15.9100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6476
    Cell Significance Index: -11.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6713
    Cell Significance Index: -42.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6782
    Cell Significance Index: -30.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7483
    Cell Significance Index: -38.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7637
    Cell Significance Index: -10.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8171
    Cell Significance Index: -42.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8311
    Cell Significance Index: -18.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8578
    Cell Significance Index: -8.8800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8633
    Cell Significance Index: -22.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9223
    Cell Significance Index: -24.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9285
    Cell Significance Index: -30.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MAP3K20 exhibits several key characteristics that distinguish it from other kinases: 1. **Serine/threonine kinase activity**: MAP3K20 possesses the ability to phosphorylate and activate downstream targets, thereby modulating cellular responses. 2. **Multifunctional nature**: This gene is involved in various signaling pathways, including the MAPK, JNK, and p38 cascades, as well as DNA damage checkpoint signaling and inflammatory response. 3. **Cell-type specific expression**: MAP3K20 is highly expressed in embryonic stem cells, smooth muscle fibers, and immune cells, suggesting its importance in these cell types. 4. **Regulation of apoptosis and programmed cell death**: MAP3K20 has been implicated in the regulation of apoptotic processes, including pyroptotic inflammatory response and positive regulation of apoptotic process. **Pathways and Functions** MAP3K20 is involved in numerous signaling pathways, including: 1. **MAPK cascade**: This gene is a key component of the MAPK signaling pathway, which regulates various cellular processes, including cell growth, differentiation, and survival. 2. **JNK cascade**: MAP3K20 is also involved in the JNK signaling pathway, which is activated in response to cellular stressors, such as UV radiation and heat shock. 3. **p38MAPK cascade**: This gene is a component of the p38MAPK signaling pathway, which regulates cellular responses to stressors, including inflammation and cell death. 4. **DNA damage checkpoint signaling**: MAP3K20 plays a role in the regulation of mitotic DNA damage checkpoint, which ensures the accurate transmission of genetic information during cell division. 5. **Inflammatory response**: This gene has been implicated in the regulation of inflammatory responses, including pyroptotic inflammatory response. **Clinical Significance** The clinical significance of MAP3K20 is multifaceted: 1. **Cancer therapy**: MAP3K20 has been identified as a tumor suppressor gene in human cervical cancer, suggesting its potential as a therapeutic target in cancer treatment. 2. **Neurological disorders**: The gene's involvement in stress-activated signaling pathways has led to its consideration as a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Immune system disorders**: MAP3K20's role in immune cell function has led to its consideration as a potential therapeutic target for autoimmune disorders, such as rheumatoid arthritis and lupus. 4. **Cardiovascular disease**: The gene's involvement in cellular stress responses has led to its consideration as a potential therapeutic target for cardiovascular disease, including atherosclerosis and heart failure. In conclusion, MAP3K20 is a multifunctional gene that plays a critical role in various cellular processes, including cell death, differentiation, and response to environmental stressors. Its involvement in multiple signaling pathways underscores its potential as a therapeutic target in diseases characterized by dysregulated cellular responses. Further research is needed to fully elucidate the mechanisms by which MAP3K20 regulates cellular responses and to explore its therapeutic potential in various disease states.

Genular Protein ID: 3916503826

Symbol: M3K20_HUMAN

Name: Human cervical cancer suppressor gene 4 protein

UniProtKB Accession Codes:

Q9NYL2 B3KPG2 Q53SX1 Q580W8 Q59GY5 Q86YW8 Q9HCC4 Q9HCC5 Q9HDD2 Q9NYE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 16 Ensembl 4 ExpressionAtlas 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 Rhea 8 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10924358

Title: Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif.

PubMed ID: 10924358

DOI: 10.1006/bbrc.2000.3236

PubMed ID: 11042189

Title: Identification and characterization of a novel MAP kinase kinase kinase, MLTK.

PubMed ID: 11042189

DOI: 10.1074/jbc.m008595200

PubMed ID: 11549352

Title: Tissue distribution and functional expression of a cDNA encoding a novel mixed lineage kinase.

PubMed ID: 11549352

DOI: 10.1006/jmcc.2001.1437

PubMed ID: 11836244

Title: MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest.

PubMed ID: 11836244

DOI: 10.1074/jbc.m111994200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12220515

Title: Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest.

PubMed ID: 12220515

DOI: 10.1016/s0006-291x(02)02123-x

PubMed ID: 12535642

Title: A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle.

PubMed ID: 12535642

DOI: 10.1016/s0006-291x(02)02980-7

PubMed ID: 14521931

Title: Effect of C-terminal truncations on MLK7 catalytic activity and JNK activation.

PubMed ID: 14521931

DOI: 10.1016/j.bbrc.2003.09.075

PubMed ID: 12761180

Title: Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.

PubMed ID: 12761180

DOI: 10.1093/jb/mvg022

PubMed ID: 15172994

Title: A novel role for mixed-lineage kinase-like mitogen-activated protein triple kinase alpha in neoplastic cell transformation and tumor development.

PubMed ID: 15172994

DOI: 10.1158/0008-5472.can-04-0201

PubMed ID: 15342622

Title: The stress kinase MRK contributes to regulation of DNA damage checkpoints through a p38gamma-independent pathway.

PubMed ID: 15342622

DOI: 10.1074/jbc.m409961200

PubMed ID: 15350844

Title: Transgenic mice with cardiac-specific over-expression of MLK7 have increased mortality when exposed to chronic beta-adrenergic stimulation.

PubMed ID: 15350844

DOI: 10.1016/j.yjmcc.2004.06.004

PubMed ID: 15684425

Title: Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha.

PubMed ID: 15684425

DOI: 10.1074/jbc.m410521200

PubMed ID: 15737997

Title: Complete inhibition of anisomycin and UV radiation but not cytokine induced JNK and p38 activation by an aryl-substituted dihydropyrrolopyrazole quinoline and mixed lineage kinase 7 small interfering RNA.

PubMed ID: 15737997

DOI: 10.1074/jbc.m413059200

PubMed ID: 18331592

Title: ZAK: a MAP3Kinase that transduces Shiga toxin- and ricin-induced proinflammatory cytokine expression.

PubMed ID: 18331592

DOI: 10.1111/j.1462-5822.2008.01139.x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20559024

Title: ZAK is required for doxorubicin, a novel ribotoxic stressor, to induce SAPK activation and apoptosis in HaCaT cells.

PubMed ID: 20559024

DOI: 10.4161/cbt.10.3.12367

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21224381

Title: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation.

PubMed ID: 21224381

DOI: 10.1074/jbc.m110.185645

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27859413

Title: ZAKbeta antagonizes and ameliorates the cardiac hypertrophic and apoptotic effects induced by ZAKalpha.

PubMed ID: 27859413

DOI: 10.1002/cbf.3234

PubMed ID: 32610081

Title: Ribosome collisions trigger general stress responses to regulate cell fate.

PubMed ID: 32610081

DOI: 10.1016/j.cell.2020.06.006

PubMed ID: 32289254

Title: ZAKalpha recognizes stalled ribosomes through partially redundant sensor domains.

PubMed ID: 32289254

DOI: 10.1016/j.molcel.2020.03.021

PubMed ID: 35857590

Title: ZAKalpha-driven ribotoxic stress response activates the human NLRP1 inflammasome.

PubMed ID: 35857590

DOI: 10.1126/science.abl6324

PubMed ID: 26999302

Title: Structure of the Human Protein Kinase ZAK in Complex with Vemurafenib.

PubMed ID: 26999302

DOI: 10.1021/acschembio.6b00043

PubMed ID: 28586211

Title: Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.

PubMed ID: 28586211

DOI: 10.1021/acs.jmedchem.7b00572

PubMed ID: 31244114

Title: Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors.

PubMed ID: 31244114

DOI: 10.1021/acs.jmedchem.9b00664

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 26755636

Title: Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice.

PubMed ID: 26755636

DOI: 10.1101/gr.199430.115

PubMed ID: 27816943

Title: Recessive mutations in the kinase ZAK cause a congenital myopathy with fibre type disproportion.

PubMed ID: 27816943

DOI: 10.1093/brain/aww257

PubMed ID: 30237576

Title: Autozygome and high throughput confirmation of disease genes candidacy.

PubMed ID: 30237576

DOI: 10.1038/s41436-018-0138-x

PubMed ID: 32266845

Title: Rare missense variant p.Ala505Ser in the ZAK protein observed in a patient with split-hand/foot malformation from a non-consanguineous pedigree.

PubMed ID: 32266845

DOI: 10.1177/0300060519879293

Sequence Information:

  • Length: 800
  • Mass: 91155
  • Checksum: B2814509EC54B07A
  • Sequence:
    • MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 
SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE EMDMDHIMTW ATDVAKGMHY 
LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHNH TTHMSLVGTF PWMAPEVIQS 
LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH 
QCWEADAKKR PSFKQIISIL ESMSNDTSLP DKCNSFLHNK AEWRCEIEAT LERLKKLERD 
LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LPSFEIGAWT EDDVYCWVQQ LVRKGDSSAE 
MSVYASLFKE NNITGKRLLL LEEEDLKDMG IVSKGHIIHF KSAIEKLTHD YINLFHFPPL 
IKDSGGEPEE NEEKIVNLEL VFGFHLKPGT GPQDCKWKMY MEMDGDEIAI TYIKDVTFNT 
NLPDAEILKM TKPPFVMEKW IVGIAKSQTV ECTVTYESDV RTPKSTKHVH SIQWSRTKPQ 
DEVKAVQLAI QTLFTNSDGN PGSRSDSSAD CQWLDTLRMR QIASNTSLQR SQSNPILGSP 
FFSHFDGQDS YAAAVRRPQV PIKYQQITPV NQSRSSSPTQ YGLTKNFSSL HLNSRDSGFS 
SGNTDTSSER GRYSDRSRNK YGRGSISLNS SPRGRYSGKS QHSTPSRGRY PGKFYRVSQS 
ALNPHQSPDF KRSPRDLHQP NTIPGMPLHP ETDSRASEED SKVSEGGWTK VEYRKKPHRP 
SPAKTNKERA RGDHRGWRNF

Genular Protein ID: 3294053973

Symbol: D4Q8H0_HUMAN

Name: N/A

UniProtKB Accession Codes:

D4Q8H0

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 HOGENOM 1 InterPro 5 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 1 RefSeq 3 SAM 2 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 455
  • Mass: 51582
  • Checksum: E87DB84A4D58B752
  • Sequence:
    • MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 
SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE EMDMDHIMTW ATDVAKGMHY 
LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHNH TTHMSLVGTF PWMAPEVIQS 
LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH 
QCWEADAKKR PSFKQIISIL ESMSNDTSLP DKCNSFLHNK AEWRCEIEAT LERLKKLERD 
LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LLPLAARMSE ESYFESKTEE SNSAEMSCQI 
TATSNGEGHG MNPSLQAMML MGFGDIFSMN KAGAVMHSGM QINMQAKQNS SKTTSKRRGK 
KVNMALGFSD FDLSEGDDDD DDDGEEEDND MDNSE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.