Details for: CALML5

Gene ID: 51806

Symbol: CALML5

Ensembl ID: ENSG00000178372

Description: calmodulin like 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 12.0785
    Cell Significance Index: 67.2300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 11.3833
    Cell Significance Index: 25.6600
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 10.5370
    Cell Significance Index: 12.1300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 9.3113
    Cell Significance Index: 194.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.9476
    Cell Significance Index: 323.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3073
    Cell Significance Index: 168.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2264
    Cell Significance Index: 542.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9667
    Cell Significance Index: 68.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3181
    Cell Significance Index: 14.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0152
    Cell Significance Index: -0.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0473
    Cell Significance Index: -32.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0498
    Cell Significance Index: -0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0530
    Cell Significance Index: -40.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0652
    Cell Significance Index: -35.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1012
    Cell Significance Index: -45.9200
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1137
    Cell Significance Index: -1.0100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1492
    Cell Significance Index: -26.9000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1582
    Cell Significance Index: -1.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2022
    Cell Significance Index: -24.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2036
    Cell Significance Index: -40.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2756
    Cell Significance Index: -7.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3360
    Cell Significance Index: -25.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4126
    Cell Significance Index: -47.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4794
    Cell Significance Index: -8.8600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.5309
    Cell Significance Index: -6.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5379
    Cell Significance Index: -19.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5521
    Cell Significance Index: -28.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5929
    Cell Significance Index: -37.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5986
    Cell Significance Index: -10.3200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.6065
    Cell Significance Index: -10.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6780
    Cell Significance Index: -10.4900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7319
    Cell Significance Index: -18.2800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.7840
    Cell Significance Index: -11.1600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.7969
    Cell Significance Index: -9.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.8040
    Cell Significance Index: -9.3800
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.8249
    Cell Significance Index: -8.8700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.8340
    Cell Significance Index: -8.8600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.8692
    Cell Significance Index: -8.6000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.8800
    Cell Significance Index: -7.0000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.9043
    Cell Significance Index: -7.3300
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.9314
    Cell Significance Index: -8.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0141
    Cell Significance Index: -35.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.0423
    Cell Significance Index: -9.8800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -1.0558
    Cell Significance Index: -8.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.0815
    Cell Significance Index: -56.1800
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -1.1368
    Cell Significance Index: -7.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2538
    Cell Significance Index: -35.9400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -1.3481
    Cell Significance Index: -18.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.3932
    Cell Significance Index: -37.2000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -1.4064
    Cell Significance Index: -9.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4443
    Cell Significance Index: -38.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.4707
    Cell Significance Index: -40.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.4740
    Cell Significance Index: -38.7600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -1.6174
    Cell Significance Index: -10.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.7053
    Cell Significance Index: -37.3400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -1.7408
    Cell Significance Index: -21.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.7638
    Cell Significance Index: -40.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.7910
    Cell Significance Index: -45.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.8867
    Cell Significance Index: -33.3400
  • Cell Name: monocyte (CL0000576)
    Fold Change: -1.9684
    Cell Significance Index: -22.6500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.9945
    Cell Significance Index: -65.3000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.9949
    Cell Significance Index: -25.6900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -2.0049
    Cell Significance Index: -39.2000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -2.0153
    Cell Significance Index: -14.4700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -2.1233
    Cell Significance Index: -30.1700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -2.1356
    Cell Significance Index: -20.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -2.1463
    Cell Significance Index: -35.9200
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -2.1558
    Cell Significance Index: -16.4500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -2.2921
    Cell Significance Index: -39.1800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -2.3916
    Cell Significance Index: -40.6200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -2.4376
    Cell Significance Index: -39.4800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -2.4666
    Cell Significance Index: -34.2100
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -2.4891
    Cell Significance Index: -11.4600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -2.5275
    Cell Significance Index: -32.0100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -2.5893
    Cell Significance Index: -22.2500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -2.5898
    Cell Significance Index: -30.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -2.6017
    Cell Significance Index: -38.4100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -2.6506
    Cell Significance Index: -27.9600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -2.6878
    Cell Significance Index: -37.7500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -2.6926
    Cell Significance Index: -35.7800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -2.6942
    Cell Significance Index: -33.8400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -2.7021
    Cell Significance Index: -36.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -2.7040
    Cell Significance Index: -36.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -2.7211
    Cell Significance Index: -35.2100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -2.7220
    Cell Significance Index: -37.0300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -2.7482
    Cell Significance Index: -39.9000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -2.8371
    Cell Significance Index: -45.0100
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -2.8379
    Cell Significance Index: -56.5900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -2.8483
    Cell Significance Index: -39.0600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -2.8783
    Cell Significance Index: -29.6900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -2.8835
    Cell Significance Index: -36.3100
  • Cell Name: T cell (CL0000084)
    Fold Change: -2.8891
    Cell Significance Index: -34.1100
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -2.9000
    Cell Significance Index: -37.1400
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -2.9115
    Cell Significance Index: -31.9600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -2.9172
    Cell Significance Index: -36.8600
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -2.9264
    Cell Significance Index: -44.5200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -2.9412
    Cell Significance Index: -35.0000
  • Cell Name: pericyte (CL0000669)
    Fold Change: -2.9413
    Cell Significance Index: -35.2700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.9577
    Cell Significance Index: -35.3700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -2.9642
    Cell Significance Index: -36.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CALML5 exhibits several key characteristics that highlight its importance in cellular processes. These include: 1. **Calcium-binding properties:** CALML5 contains a calcium-binding domain, which allows it to interact with calcium ions and modulate downstream signaling pathways. 2. **Microtubule organization:** CALML5 has been implicated in the regulation of microtubule dynamics, which is essential for maintaining cellular organization and structure. 3. **Protein binding:** CALML5 can interact with various proteins, including those involved in immune responses, cell differentiation, and signal transduction. 4. **Signaling pathways:** CALML5 is involved in multiple signaling pathways, including those related to immune responses, cell differentiation, and development. **Pathways and Functions:** CALML5 is involved in several key pathways and functions, including: 1. **Immune response:** CALML5 plays a role in regulating immune responses, particularly in the context of innate immunity, where it interacts with neutrophils and modulates their degranulation. 2. **Cell differentiation:** CALML5 is involved in the differentiation of keratinocytes in the interfollicular epidermis of mammalian skin, highlighting its role in epidermal development. 3. **Signal transduction:** CALML5 can interact with various signaling molecules, modulating the activity of downstream effectors and influencing cellular responses. 4. **Cell organization:** CALML5 regulates microtubule dynamics, which is essential for maintaining cellular organization and structure. **Clinical Significance:** The clinical significance of CALML5 is an area of ongoing research. However, the following implications are already apparent: 1. **Immune-related disorders:** Dysregulation of CALML5 may contribute to immune-related disorders, such as autoimmune diseases and inflammatory conditions. 2. **Cancer:** CALML5 may play a role in cancer development and progression, particularly in the context of epithelial-to-mesenchymal transition (EMT). 3. **Neurological disorders:** CALML5 may be involved in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where calcium dysregulation is a hallmark. 4. **Regenerative medicine:** CALML5 may have potential applications in regenerative medicine, where its role in cell differentiation and organization could be exploited to promote tissue repair and regeneration. In conclusion, CALML5 is a multifaceted protein that plays a critical role in immune response, cell differentiation, and signal transduction. Further research is needed to fully elucidate its clinical significance and potential therapeutic applications.

Genular Protein ID: 2378204282

Symbol: CALL5_HUMAN

Name: Calmodulin-like protein 5

UniProtKB Accession Codes:

Q9NZT1 Q5SQI3 Q8IXU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 20 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10777582

Title: Identification and cloning of a new calmodulin-like protein from human epidermis.

PubMed ID: 10777582

DOI: 10.1074/jbc.275.17.12841

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16765896

Title: A structural and dynamic characterization of the EF-hand protein CLSP.

PubMed ID: 16765896

DOI: 10.1016/j.str.2006.04.004

PubMed ID: 17488105

Title: Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data.

PubMed ID: 17488105

DOI: 10.1021/pr0700908

Sequence Information:

  • Length: 146
  • Mass: 15893
  • Checksum: 70746291268494CC
  • Sequence:
    • MAGELTPEEE AQYKKAFSAV DTDGNGTINA QELGAALKAT GKNLSEAQLR KLISEVDSDG 
DGEISFQEFL TAAKKARAGL EDLQVAFRAF DQDGDGHITV DELRRAMAGL GQPLPQEELD 
AMIREADVDQ DGRVNYEEFA RMLAQE

Genular Protein ID: 705219930

Symbol: Q53H37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53H37

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 IntAct 1 InterPro 4 KEGG 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 146
  • Mass: 15876
  • Checksum: D074628473DE557A
  • Sequence:
    • MAGELTPEEE AQYKKAFSAV DTDGNGTINA QELGAAPKAT GKNLSEAQLR KLISEVDSDG 
DGEISFQEFL TAAKKARAGL EDLQVAFRAF DQDGDGHITV DELRRAMAGL GQPLPQEELD 
AMIREADVDQ DGRVNYEEFA RMLAQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.