Details for: GALNT7

Gene ID: 51809

Symbol: GALNT7

Ensembl ID: ENSG00000109586

Description: polypeptide N-acetylgalactosaminyltransferase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 276.5112
    Cell Significance Index: -43.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.4364
    Cell Significance Index: -40.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.6515
    Cell Significance Index: -44.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.3185
    Cell Significance Index: -34.2600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 65.8585
    Cell Significance Index: -44.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.1144
    Cell Significance Index: -34.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.3297
    Cell Significance Index: -43.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.0852
    Cell Significance Index: -43.0900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.0236
    Cell Significance Index: -36.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.0693
    Cell Significance Index: -43.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.5109
    Cell Significance Index: 197.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.2980
    Cell Significance Index: 87.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2703
    Cell Significance Index: 2049.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.2499
    Cell Significance Index: 99.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.9402
    Cell Significance Index: 211.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8897
    Cell Significance Index: 379.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6632
    Cell Significance Index: 270.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4566
    Cell Significance Index: 31.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4518
    Cell Significance Index: 24.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1877
    Cell Significance Index: 61.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9814
    Cell Significance Index: 63.3200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.9782
    Cell Significance Index: 6.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9354
    Cell Significance Index: 335.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9145
    Cell Significance Index: 499.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8481
    Cell Significance Index: 18.5700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7528
    Cell Significance Index: 21.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7141
    Cell Significance Index: 70.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6014
    Cell Significance Index: 27.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5219
    Cell Significance Index: 360.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5021
    Cell Significance Index: 90.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3484
    Cell Significance Index: 8.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2934
    Cell Significance Index: 8.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2433
    Cell Significance Index: 8.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2172
    Cell Significance Index: 408.8800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2145
    Cell Significance Index: 2.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2025
    Cell Significance Index: 12.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1995
    Cell Significance Index: 24.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1966
    Cell Significance Index: 33.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1806
    Cell Significance Index: 114.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1636
    Cell Significance Index: 31.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1603
    Cell Significance Index: 31.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1506
    Cell Significance Index: 4.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1483
    Cell Significance Index: 9.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1368
    Cell Significance Index: 6.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0492
    Cell Significance Index: 75.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0168
    Cell Significance Index: 7.6200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0125
    Cell Significance Index: 0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0041
    Cell Significance Index: 7.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0053
    Cell Significance Index: -2.3600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0258
    Cell Significance Index: -35.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0311
    Cell Significance Index: -19.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0324
    Cell Significance Index: -23.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0348
    Cell Significance Index: -5.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0392
    Cell Significance Index: -5.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0399
    Cell Significance Index: -29.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0425
    Cell Significance Index: -32.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0446
    Cell Significance Index: -0.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0589
    Cell Significance Index: -33.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1155
    Cell Significance Index: -14.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1270
    Cell Significance Index: -36.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1334
    Cell Significance Index: -28.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1406
    Cell Significance Index: -10.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1739
    Cell Significance Index: -13.3500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1751
    Cell Significance Index: -1.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1796
    Cell Significance Index: -2.4500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1880
    Cell Significance Index: -21.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2010
    Cell Significance Index: -23.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2030
    Cell Significance Index: -20.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2055
    Cell Significance Index: -9.6600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.2253
    Cell Significance Index: -1.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2294
    Cell Significance Index: -5.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2380
    Cell Significance Index: -27.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2386
    Cell Significance Index: -6.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2501
    Cell Significance Index: -29.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2563
    Cell Significance Index: -33.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2598
    Cell Significance Index: -6.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2773
    Cell Significance Index: -8.8800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2826
    Cell Significance Index: -4.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3603
    Cell Significance Index: -24.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3607
    Cell Significance Index: -18.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3608
    Cell Significance Index: -9.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3629
    Cell Significance Index: -37.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3945
    Cell Significance Index: -10.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4015
    Cell Significance Index: -28.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4215
    Cell Significance Index: -25.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4622
    Cell Significance Index: -13.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4720
    Cell Significance Index: -6.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4832
    Cell Significance Index: -38.2700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4905
    Cell Significance Index: -10.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4955
    Cell Significance Index: -10.7400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5021
    Cell Significance Index: -3.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5087
    Cell Significance Index: -35.1800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5844
    Cell Significance Index: -6.0500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6273
    Cell Significance Index: -8.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6415
    Cell Significance Index: -32.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6561
    Cell Significance Index: -22.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6565
    Cell Significance Index: -34.4700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7214
    Cell Significance Index: -8.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7401
    Cell Significance Index: -14.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** GALNT7 is a polypeptide N-acetylgalactosaminyltransferase (P-NAGT) that catalyzes the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine residues on target proteins, resulting in the formation of O-glycans. 2. **Subcellular localization:** GALNT7 is primarily localized to the Golgi apparatus, where it interacts with other glycosyltransferases to form O-glycans. 3. **Cellular expression:** GALNT7 is expressed in a wide range of cell types, including hematopoietic cells, smooth muscle fibers, epithelial cells, and immune cells. 4. **Protein sequence:** The GALNT7 protein consists of 462 amino acids and contains multiple repeats of the N-acetylgalactosaminyltransferase domain. **Pathways and Functions:** 1. **O-glycosylation:** GALNT7 is involved in the formation of O-glycans, which play a crucial role in protein-protein interactions, cell signaling, and cell adhesion. 2. **Immune responses:** GALNT7 is expressed in immune cells, including T cells and B cells, where it contributes to the formation of O-glycans on surface proteins, influencing immune cell function and signaling. 3. **Epithelial function:** GALNT7 is expressed in epithelial cells, where it helps maintain the integrity of the epithelial barrier and regulates cell signaling and differentiation. 4. **Cellular differentiation:** GALNT7 is involved in the regulation of cellular differentiation, particularly in hematopoietic cells, where it influences the development of immune cells. **Clinical Significance:** Dysregulation of GALNT7 has been implicated in various diseases, including: 1. **Immune disorders:** Alterations in GALNT7 expression and function have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** GALNT7 has been implicated in cancer progression, particularly in colon and breast cancer, where it contributes to the formation of O-glycans on tumor-associated proteins. 3. **Neurological disorders:** GALNT7 has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, where it influences the formation of O-glycans on neuronal proteins. In conclusion, GALNT7 is a crucial enzyme involved in the post-translational modification of proteins, with significant implications for immune function, epithelial function, and cellular differentiation. Further research is needed to fully elucidate the mechanisms by which GALNT7 regulates these processes and to explore its potential therapeutic applications in various diseases.

Genular Protein ID: 1955346041

Symbol: GALT7_HUMAN

Name: N-acetylgalactosaminyltransferase 7

UniProtKB Accession Codes:

Q86SF2 B3KQU3 Q7Z5W7 Q9UJ28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 2 CCDS 1 CDD 2 CTD 1 ChEBI 14 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10544240

Title: A novel human UDP-N-acetyl-D-galactosamine;polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.

PubMed ID: 10544240

DOI: 10.1016/s0014-5793(99)01268-5

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11925450

Title: Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila.

PubMed ID: 11925450

DOI: 10.1074/jbc.m202684200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 657
  • Mass: 75389
  • Checksum: D78CB5CBDA4B02FA
  • Sequence:
    • MRLKIGFILR SLLVVGSFLG LVVLWSSLTP RPDDPSPLSR MREDRDVNDP MPNRGGNGLA 
PGEDRFKPVV PWPHVEGVEV DLESIRRINK AKNEQEHHAG GDSQKDIMQR QYLTFKPQTF 
TYHDPVLRPG ILGNFEPKEP EPPGVVGGPG EKAKPLVLGP EFKQAIQASI KEFGFNMVAS 
DMISLDRSVN DLRQEECKYW HYDENLLTSS VVIVFHNEGW STLMRTVHSV IKRTPRKYLA 
EIVLIDDFSN KEHLKEKLDE YIKLWNGLVK VFRNERREGL IQARSIGAQK AKLGQVLIYL 
DAHCEVAVNW YAPLVAPISK DRTICTVPLI DVINGNTYEI IPQGGGDEDG YARGAWDWSM 
LWKRVPLTPQ EKRLRKTKTE PYRSPAMAGG LFAIEREFFF ELGLYDPGLQ IWGGENFEIS 
YKIWQCGGKL LFVPCSRVGH IYRLEGWQGN PPPIYVGSSP TLKNYVRVVE VWWDEYKDYF 
YASRPESQAL PYGDISELKK FREDHNCKSF KWFMEEIAYD ITSHYPLPPK NVDWGEIRGF 
ETAYCIDSMG KTNGGFVELG PCHRMGGNQL FRINEANQLM QYDQCLTKGA DGSKVMITHC 
NLNEFKEWQY FKNLHRFTHI PSGKCLDRSE VLHQVFISNC DSSKTTQKWE MNNIHSV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.