Details for: PEX13

Gene ID: 5194

Symbol: PEX13

Ensembl ID: ENSG00000162928

Description: peroxisomal biogenesis factor 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.6636
    Cell Significance Index: -23.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.4957
    Cell Significance Index: -22.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.4709
    Cell Significance Index: -23.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.7160
    Cell Significance Index: -21.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.6127
    Cell Significance Index: -25.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.9745
    Cell Significance Index: -20.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.9115
    Cell Significance Index: -24.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4887
    Cell Significance Index: -22.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3152
    Cell Significance Index: -24.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.7562
    Cell Significance Index: -17.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.0117
    Cell Significance Index: -8.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7961
    Cell Significance Index: 145.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4092
    Cell Significance Index: 32.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0050
    Cell Significance Index: 138.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2711
    Cell Significance Index: 252.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0554
    Cell Significance Index: 28.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0188
    Cell Significance Index: 61.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8796
    Cell Significance Index: 143.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8302
    Cell Significance Index: 7.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8126
    Cell Significance Index: 163.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8072
    Cell Significance Index: 21.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6290
    Cell Significance Index: 113.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6261
    Cell Significance Index: 76.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6226
    Cell Significance Index: 28.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5881
    Cell Significance Index: 12.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4771
    Cell Significance Index: 13.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3711
    Cell Significance Index: 36.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3687
    Cell Significance Index: 17.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3434
    Cell Significance Index: 123.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3412
    Cell Significance Index: 26.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3364
    Cell Significance Index: 43.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3286
    Cell Significance Index: 5.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3234
    Cell Significance Index: 176.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3041
    Cell Significance Index: 14.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2863
    Cell Significance Index: 8.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2825
    Cell Significance Index: 19.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2713
    Cell Significance Index: 119.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2684
    Cell Significance Index: 15.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2600
    Cell Significance Index: 35.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2583
    Cell Significance Index: 19.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2562
    Cell Significance Index: 48.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2278
    Cell Significance Index: 14.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2178
    Cell Significance Index: 13.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1838
    Cell Significance Index: 8.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1664
    Cell Significance Index: 4.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1629
    Cell Significance Index: 147.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1089
    Cell Significance Index: 4.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1087
    Cell Significance Index: 75.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0986
    Cell Significance Index: 12.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0783
    Cell Significance Index: 2.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0615
    Cell Significance Index: 10.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0524
    Cell Significance Index: 1.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0488
    Cell Significance Index: 1.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0220
    Cell Significance Index: 1.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0118
    Cell Significance Index: 22.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0062
    Cell Significance Index: 3.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0024
    Cell Significance Index: 1.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0013
    Cell Significance Index: -1.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0052
    Cell Significance Index: -3.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0093
    Cell Significance Index: -6.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0107
    Cell Significance Index: -14.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0216
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0257
    Cell Significance Index: -19.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0322
    Cell Significance Index: -4.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0327
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0375
    Cell Significance Index: -21.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0453
    Cell Significance Index: -28.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0478
    Cell Significance Index: -4.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0494
    Cell Significance Index: -1.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0668
    Cell Significance Index: -19.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0718
    Cell Significance Index: -1.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0877
    Cell Significance Index: -10.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0941
    Cell Significance Index: -3.2700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1201
    Cell Significance Index: -1.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1208
    Cell Significance Index: -14.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1236
    Cell Significance Index: -14.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1320
    Cell Significance Index: -27.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1524
    Cell Significance Index: -4.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1685
    Cell Significance Index: -3.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1706
    Cell Significance Index: -3.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1760
    Cell Significance Index: -2.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1795
    Cell Significance Index: -11.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1813
    Cell Significance Index: -3.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2107
    Cell Significance Index: -3.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2175
    Cell Significance Index: -22.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2460
    Cell Significance Index: -5.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2461
    Cell Significance Index: -7.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2523
    Cell Significance Index: -13.1400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2551
    Cell Significance Index: -2.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2569
    Cell Significance Index: -20.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2924
    Cell Significance Index: -3.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2957
    Cell Significance Index: -1.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3016
    Cell Significance Index: -7.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3482
    Cell Significance Index: -5.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3989
    Cell Significance Index: -10.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4086
    Cell Significance Index: -11.6600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4180
    Cell Significance Index: -5.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4220
    Cell Significance Index: -25.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4248
    Cell Significance Index: -13.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PEX13 is a protein-coding gene that belongs to the peroxisomal biogenesis factor family. It is significantly expressed in various cell types, including germ cells, epithelial cells, and neurons. The gene's product, PEX13, is thought to play a role in the import of peroxisomal proteins into the peroxisomal matrix, a process that is essential for the proper functioning of peroxisomes. **Pathways and Functions:** PEX13 is involved in several cellular pathways, including: 1. **Fatty acid alpha-oxidation**: PEX13 is required for the import of peroxisomal proteins involved in fatty acid oxidation, a crucial process for energy production. 2. **Protein modification**: PEX13 is involved in the modification of peroxisomal proteins, which is essential for their proper functioning and stability. 3. **Reactive oxygen species (ROS) detoxification**: PEX13 is involved in the detoxification of ROS, which is crucial for maintaining cellular homeostasis. 4. **Microtubule-based peroxisome localization**: PEX13 is required for the localization of peroxisomes to microtubules, a process that is essential for their proper distribution and function. **Clinical Significance:** Dysregulation of PEX13 has been implicated in various diseases, including: 1. **Peroxisomal disorders**: Mutations in the PEX13 gene have been associated with peroxisomal disorders, such as Zellweger spectrum disorders and neonatal adrenoleukodystrophy. 2. **Immune system regulation**: PEX13 has been shown to play a role in the regulation of the immune system, particularly in the context of autoimmunity and inflammation. 3. **Neurological disorders**: PEX13 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PEX13 is a crucial gene involved in the biogenesis and function of peroxisomes, which are essential for various cellular processes, including fatty acid oxidation, protein modification, and ROS detoxification. Dysregulation of PEX13 has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and immune system regulation. Further research is needed to fully elucidate the role of PEX13 in human disease and to explore potential therapeutic strategies for its dysregulation.

Genular Protein ID: 3898110252

Symbol: PEX13_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q92968 B2RCS1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 6 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9653144

Title: Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.

PubMed ID: 9653144

DOI: 10.1073/pnas.95.14.8087

PubMed ID: 10441330

Title: Isolation, characterization and mutation analysis of PEX13-defective Chinese hamster ovary cell mutants.

PubMed ID: 10441330

DOI: 10.1093/hmg/8.9.1673

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8858165

Title: Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor.

PubMed ID: 8858165

DOI: 10.1083/jcb.135.1.85

PubMed ID: 10704444

Title: PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.

PubMed ID: 10704444

DOI: 10.1083/jcb.148.5.931

PubMed ID: 11390669

Title: Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.

PubMed ID: 11390669

DOI: 10.1128/mcb.21.13.4413-4424.2001

PubMed ID: 19449432

Title: Zellweger syndrome caused by PEX13 deficiency: report of two novel mutations.

PubMed ID: 19449432

DOI: 10.1002/ajmg.a.32874

PubMed ID: 28765278

Title: The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.

PubMed ID: 28765278

DOI: 10.1074/jbc.m117.805044

PubMed ID: 10441568

Title: PEX13 is mutated in complementation group 13 of the peroxisome-biogenesis disorders.

PubMed ID: 10441568

DOI: 10.1086/302534

PubMed ID: 10332040

Title: Nonsense and temperature-sensitive mutations in PEX13 are the cause of complementation group H of peroxisome biogenesis disorders.

PubMed ID: 10332040

DOI: 10.1093/hmg/8.6.1077

PubMed ID: 17041890

Title: Identification of novel mutations in PEX2, PEX6, PEX10, PEX12, and PEX13 in Zellweger spectrum patients.

PubMed ID: 17041890

DOI: 10.1002/humu.9462

Sequence Information:

  • Length: 403
  • Mass: 44130
  • Checksum: 1E85BEE04366C01C
  • Sequence:
    • MASQPPPPPK PWETRRIPGA GPGPGPGPTF QSADLGPTLM TRPGQPALTR VPPPILPRPS 
QQTGSSSVNT FRPAYSSFSS GYGAYGNSFY GGYSPYSYGY NGLGYNRLRV DDLPPSRFVQ 
QAEESSRGAF QSIESIVHAF ASVSMMMDAT FSAVYNSFRA VLDVANHFSR LKIHFTKVFS 
AFALVRTIRY LYRRLQRMLG LRRGSENEDL WAESEGTVAC LGAEDRAATS AKSWPIFLFF 
AVILGGPYLI WKLLSTHSDE VTDSINWASG EDDHVVARAE YDFAAVSEEE ISFRAGDMLN 
LALKEQQPKV RGWLLASLDG QTTGLIPANY VKILGKRKGR KTVESSKVSK QQQSFTNPTL 
TKGATVADSL DEQEAAFESV FVETNKVPVA PDSIGKDGEK QDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.