Details for: SERPINB9

Gene ID: 5272

Symbol: SERPINB9

Ensembl ID: ENSG00000170542

Description: serpin family B member 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 149.3456
    Cell Significance Index: -23.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 83.9762
    Cell Significance Index: -21.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.4359
    Cell Significance Index: -23.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.8763
    Cell Significance Index: -26.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 36.9138
    Cell Significance Index: -24.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.3157
    Cell Significance Index: -24.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.9463
    Cell Significance Index: -23.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1621
    Cell Significance Index: -21.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.0851
    Cell Significance Index: -18.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.9655
    Cell Significance Index: -23.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.4556
    Cell Significance Index: -11.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.7793
    Cell Significance Index: 43.0000
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 2.1100
    Cell Significance Index: 36.2500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6309
    Cell Significance Index: 84.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5613
    Cell Significance Index: 41.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3253
    Cell Significance Index: 154.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1530
    Cell Significance Index: 21.3100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.0311
    Cell Significance Index: 5.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8369
    Cell Significance Index: 22.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6766
    Cell Significance Index: 79.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6250
    Cell Significance Index: 564.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5995
    Cell Significance Index: 120.2500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.4522
    Cell Significance Index: 2.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3736
    Cell Significance Index: 60.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3433
    Cell Significance Index: 9.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3176
    Cell Significance Index: 34.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2525
    Cell Significance Index: 90.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2113
    Cell Significance Index: 41.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1906
    Cell Significance Index: 4.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1792
    Cell Significance Index: 97.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1636
    Cell Significance Index: 9.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1632
    Cell Significance Index: 221.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1594
    Cell Significance Index: 245.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1262
    Cell Significance Index: 16.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1105
    Cell Significance Index: 3.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1055
    Cell Significance Index: 7.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0737
    Cell Significance Index: 14.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0629
    Cell Significance Index: 0.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0568
    Cell Significance Index: 104.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0492
    Cell Significance Index: 1.2300
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0406
    Cell Significance Index: 0.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0295
    Cell Significance Index: 0.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0259
    Cell Significance Index: 0.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0212
    Cell Significance Index: 2.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0178
    Cell Significance Index: 33.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0013
    Cell Significance Index: 0.8800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0071
    Cell Significance Index: -0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0084
    Cell Significance Index: -5.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0106
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0141
    Cell Significance Index: -10.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0239
    Cell Significance Index: -13.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0243
    Cell Significance Index: -1.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0276
    Cell Significance Index: -20.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0321
    Cell Significance Index: -14.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0342
    Cell Significance Index: -4.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0343
    Cell Significance Index: -25.1600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0355
    Cell Significance Index: -15.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0379
    Cell Significance Index: -1.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0529
    Cell Significance Index: -7.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0531
    Cell Significance Index: -15.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0654
    Cell Significance Index: -13.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0742
    Cell Significance Index: -8.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0758
    Cell Significance Index: -13.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0860
    Cell Significance Index: -14.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0866
    Cell Significance Index: -12.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1110
    Cell Significance Index: -11.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1192
    Cell Significance Index: -15.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1590
    Cell Significance Index: -9.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1799
    Cell Significance Index: -13.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1851
    Cell Significance Index: -21.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1948
    Cell Significance Index: -9.8400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1958
    Cell Significance Index: -3.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1971
    Cell Significance Index: -13.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2061
    Cell Significance Index: -21.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2325
    Cell Significance Index: -15.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2349
    Cell Significance Index: -10.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2558
    Cell Significance Index: -18.0900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2573
    Cell Significance Index: -11.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2624
    Cell Significance Index: -5.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2661
    Cell Significance Index: -14.9300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2916
    Cell Significance Index: -8.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2931
    Cell Significance Index: -6.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2958
    Cell Significance Index: -18.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2958
    Cell Significance Index: -15.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3051
    Cell Significance Index: -19.2300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3185
    Cell Significance Index: -9.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3303
    Cell Significance Index: -10.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3405
    Cell Significance Index: -17.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3639
    Cell Significance Index: -16.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3661
    Cell Significance Index: -15.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3729
    Cell Significance Index: -4.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3866
    Cell Significance Index: -10.3400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3875
    Cell Significance Index: -7.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3961
    Cell Significance Index: -11.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4099
    Cell Significance Index: -15.5200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.4169
    Cell Significance Index: -3.9600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4397
    Cell Significance Index: -5.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4584
    Cell Significance Index: -14.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERPINB9 is a small serpin protein, approximately 80 amino acids in length, with a characteristic serpin fold. Its expression is tissue-specific, with significant levels found in immune cells, such as microglial cells, macrophages, and non-classical monocytes, as well as in the central nervous system and lens epithelial cells. SERPINB9 is also expressed in ovarian surface epithelial cells and granulosa cells, suggesting its potential role in reproductive health. **Pathways and Functions:** SERPINB9 is involved in multiple cellular pathways, including: 1. **Immune response:** SERPINB9 regulates immune cell function, particularly in the context of mast cell-mediated immunity, protecting against natural killer cell-mediated cytotoxicity. 2. **Apoptosis regulation:** SERPINB9 inhibits apoptosis by binding to and neutralizing pro-apoptotic proteins, such as caspases and cytochrome c. 3. **Protease inhibition:** SERPINB9 inhibits serine-type and cysteine-type endopeptidases, which are involved in various cellular processes, including proteolysis and cell signaling. 4. **Estrogen response:** SERPINB9 is induced by estrogen, suggesting its role in estrogen-mediated cellular responses. **Clinical Significance:** SERPINB9 has been implicated in various disease contexts, including: 1. **Neurodegenerative diseases:** SERPINB9 has been implicated in Alzheimer's disease, Parkinson's disease, and multiple sclerosis, where it may play a role in regulating immune responses and neuronal survival. 2. **Cancer:** SERPINB9 has been found to be overexpressed in ovarian cancer and may contribute to tumor progression and resistance to chemotherapy. 3. **Reproductive health:** SERPINB9 may play a role in regulating reproductive health, particularly in the context of ovarian function and fertility. 4. **Inflammatory diseases:** SERPINB9 has been implicated in inflammatory diseases, such as rheumatoid arthritis and asthma, where it may regulate immune responses and inflammation. In conclusion, SERPINB9 is a multifunctional protein that plays a critical role in regulating immune response, apoptosis, and protease inhibition. Its unique expression pattern and functional roles make it an attractive target for therapeutic interventions in various disease contexts. Further research is needed to fully elucidate the mechanisms by which SERPINB9 regulates cellular processes and to explore its potential as a therapeutic agent.

Genular Protein ID: 263231482

Symbol: SPB9_HUMAN

Name: Serpin B9

UniProtKB Accession Codes:

P50453 B2RBW3 Q5TD03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530382

Title: Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors.

PubMed ID: 8530382

DOI: 10.1074/jbc.270.50.29854

PubMed ID: 8910377

Title: A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes.

PubMed ID: 8910377

DOI: 10.1074/jbc.271.44.27802

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 376
  • Mass: 42404
  • Checksum: ECBA80869B939753
  • Sequence:
    • METLSNASGT FAIRLLKILC QDNPSHNVFC SPVSISSALA MVLLGAKGNT ATQMAQALSL 
NTEEDIHRAF QSLLTEVNKA GTQYLLRTAN RLFGEKTCQF LSTFKESCLQ FYHAELKELS 
FIRAAEESRK HINTWVSKKT EGKIEELLPG SSIDAETRLV LVNAIYFKGK WNEPFDETYT 
REMPFKINQE EQRPVQMMYQ EATFKLAHVG EVRAQLLELP YARKELSLLV LLPDDGVELS 
TVEKSLTFEK LTAWTKPDCM KSTEVEVLLP KFKLQEDYDM ESVLRHLGIV DAFQQGKADL 
SAMSAERDLC LSKFVHKSFV EVNEEGTEAA AASSCFVVAE CCMESGPRFC ADHPFLFFIR 
HNRANSILFC GRFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.