Details for: SERPINI2

Gene ID: 5276

Symbol: SERPINI2

Ensembl ID: ENSG00000114204

Description: serpin family I member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.96
    Marker Score: 2233
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.64
    Marker Score: 10798
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 2.83
    Marker Score: 8244.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.41
    Marker Score: 5096
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.34
    Marker Score: 2248
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.8
    Marker Score: 15243.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.65
    Marker Score: 1427
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.52
    Marker Score: 1515.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.48
    Marker Score: 665
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168694
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.23
    Marker Score: 454
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.11
    Marker Score: 780
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251797
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1
    Marker Score: 21287
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.98
    Marker Score: 2808
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.79
    Marker Score: 374
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.73
    Marker Score: 2510
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.72
    Marker Score: 472.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.71
    Marker Score: 6156
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 459
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.57
    Marker Score: 262
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.57
    Marker Score: 1073
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.52
    Marker Score: 1854
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.5
    Marker Score: 958
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.47
    Marker Score: 946
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.44
    Marker Score: 494
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.43
    Marker Score: 447
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 113
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 678
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.41
    Marker Score: 527
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.4
    Marker Score: 233
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.37
    Marker Score: 533
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.35
    Marker Score: 144
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.35
    Marker Score: 212
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.34
    Marker Score: 643
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.34
    Marker Score: 309
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.33
    Marker Score: 5117
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.32
    Marker Score: 2976
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.32
    Marker Score: 110
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.31
    Marker Score: 192
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3
    Marker Score: 132
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.28
    Marker Score: 157
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.27
    Marker Score: 162
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.26
    Marker Score: 235
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.25
    Marker Score: 312
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 104
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.23
    Marker Score: 230
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.23
    Marker Score: 143
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.22
    Marker Score: 260
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.22
    Marker Score: 213
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.21
    Marker Score: 231.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 143
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.2
    Marker Score: 313
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2
    Marker Score: 12224
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.2
    Marker Score: 222
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.19
    Marker Score: 237
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.19
    Marker Score: 187
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.17
    Marker Score: 519
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.17
    Marker Score: 48
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.17
    Marker Score: 1704
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.16
    Marker Score: 668
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.16
    Marker Score: 682
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.16
    Marker Score: 1383
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.16
    Marker Score: 4010
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.16
    Marker Score: 442
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 91

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Other Information

**Key characteristics:** * SERPINI2 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is expressed in high levels in epithelial cells of exocrine pancreas, OFF-bipolar cell, ON-bipolar cell, pancreatic acinar cell, retina horizontal cell, retinal bipolar neuron, astrocyte, colon goblet cell, and enterocyte of epithelium of large intestine. * It is a serpin, which is an enzyme that catalyzes the hydrolysis of peptide bonds in proteins. * SERPINI2 is a negative regulator of endopeptidase activity, which means that it inhibits the activity of endopeptidases, which are enzymes that break down proteins. **Pathways and functions:** * SERPINI2 is involved in the regulation of pancreatic secretion. It is a key regulator of the secretion of digestive enzymes from the pancreas, including trypsin, chymotrypsin, and elastase. * It also regulates the secretion of hormones from endocrine cells. * SERPINI2 is involved in the regulation of inflammation. It is expressed in epithelial cells of the lung and retina, where it helps to regulate the inflammatory response. * It is also expressed in macrophages, where it helps to regulate the inflammatory response. **Clinical significance:** * Mutations in SERPINI2 have been linked to the development of several human diseases, including pancreatitis, colon cancer, and lung cancer. * SERPINI2 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 794429027

Symbol: SPI2_HUMAN

Name: Serpin I2

UniProtKB Accession Codes:

O75830

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9624529

Title: Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells.

PubMed ID: 9624529

DOI: 10.1002/(sici)1098-2264(199807)22:3<179::aid-gcc3>3.3.co;2-u

PubMed ID: 10097100

Title: Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells.

PubMed ID: 10097100

DOI: 10.1073/pnas.96.7.3700

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 405
  • Mass: 46145
  • Checksum: 5BA18C60E4FDE9A4
  • Sequence:
    • MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ 
LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK 
EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV 
NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS 
YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD 
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL 
AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL

Genular Protein ID: 1814981569

Symbol: B4DDY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDY9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 6 KEGG 1 MEROPS 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 413
  • Mass: 46994
  • Checksum: BCBA74F931E174BB
  • Sequence:
    • MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ 
LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK 
EQYLHGNKEF FQSAIKLVDF QDAKACAGMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV 
NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS 
YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD 
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL 
AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSLWMKST ASE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.