Details for: SERPINI2

Gene ID: 5276

Symbol: SERPINI2

Ensembl ID: ENSG00000114204

Description: serpin family I member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 146.0142
    Cell Significance Index: 73.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.7268
    Cell Significance Index: -7.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.3737
    Cell Significance Index: 405.3200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.7757
    Cell Significance Index: 24.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6215
    Cell Significance Index: 17.3700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4645
    Cell Significance Index: 28.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2913
    Cell Significance Index: 33.2500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.2347
    Cell Significance Index: 3.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2176
    Cell Significance Index: 8.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1688
    Cell Significance Index: 5.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1528
    Cell Significance Index: 6.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1464
    Cell Significance Index: 27.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1265
    Cell Significance Index: 36.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1167
    Cell Significance Index: 5.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1131
    Cell Significance Index: 22.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0864
    Cell Significance Index: 2.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0682
    Cell Significance Index: 42.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0518
    Cell Significance Index: 46.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0352
    Cell Significance Index: 12.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0089
    Cell Significance Index: 0.5000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.0051
    Cell Significance Index: 0.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0001
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -7.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0061
    Cell Significance Index: -4.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0085
    Cell Significance Index: -1.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0107
    Cell Significance Index: -6.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0137
    Cell Significance Index: -2.2300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0146
    Cell Significance Index: -0.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0151
    Cell Significance Index: -6.8600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0156
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0187
    Cell Significance Index: -3.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0192
    Cell Significance Index: -2.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0235
    Cell Significance Index: -4.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0249
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0314
    Cell Significance Index: -3.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0326
    Cell Significance Index: -2.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0349
    Cell Significance Index: -5.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0426
    Cell Significance Index: -4.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0460
    Cell Significance Index: -3.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0463
    Cell Significance Index: -1.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0504
    Cell Significance Index: -6.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0537
    Cell Significance Index: -0.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0617
    Cell Significance Index: -6.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0633
    Cell Significance Index: -3.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0662
    Cell Significance Index: -7.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0709
    Cell Significance Index: -4.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0727
    Cell Significance Index: -7.5700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0743
    Cell Significance Index: -1.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0816
    Cell Significance Index: -5.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0879
    Cell Significance Index: -2.0300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1195
    Cell Significance Index: -0.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1219
    Cell Significance Index: -2.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1221
    Cell Significance Index: -3.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1249
    Cell Significance Index: -2.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1280
    Cell Significance Index: -3.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1297
    Cell Significance Index: -7.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1495
    Cell Significance Index: -3.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1567
    Cell Significance Index: -5.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1579
    Cell Significance Index: -4.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1601
    Cell Significance Index: -7.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1726
    Cell Significance Index: -5.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1738
    Cell Significance Index: -4.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1739
    Cell Significance Index: -5.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1920
    Cell Significance Index: -2.7500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1927
    Cell Significance Index: -1.2100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2018
    Cell Significance Index: -2.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2149
    Cell Significance Index: -10.0200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2226
    Cell Significance Index: -8.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2505
    Cell Significance Index: -6.7000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.2545
    Cell Significance Index: -2.4900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2595
    Cell Significance Index: -2.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2655
    Cell Significance Index: -6.9800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2656
    Cell Significance Index: -2.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2658
    Cell Significance Index: -5.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2749
    Cell Significance Index: -7.8800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2798
    Cell Significance Index: -2.4200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2799
    Cell Significance Index: -5.9400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.2809
    Cell Significance Index: -2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2819
    Cell Significance Index: -14.2500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2829
    Cell Significance Index: -3.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2830
    Cell Significance Index: -11.6000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2843
    Cell Significance Index: -7.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2846
    Cell Significance Index: -7.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2862
    Cell Significance Index: -7.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2869
    Cell Significance Index: -7.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2949
    Cell Significance Index: -7.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2950
    Cell Significance Index: -8.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3067
    Cell Significance Index: -6.4200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3070
    Cell Significance Index: -9.7100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3143
    Cell Significance Index: -4.1900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3157
    Cell Significance Index: -6.8200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3186
    Cell Significance Index: -4.3000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3211
    Cell Significance Index: -8.1800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3235
    Cell Significance Index: -4.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serpin Family Member:** SERPINI2 belongs to the serpin family, a group of proteins that inhibit serine-type endopeptidases, which are involved in various cellular processes. 2. **Tissue-Specific Expression:** SERPINI2 is expressed in epithelial cells, neurons, and astrocytes across multiple organs, suggesting its involvement in maintaining tissue homeostasis. 3. **Inhibition of Endopeptidase Activity:** SERPINI2 inhibits serine-type endopeptidases, which are involved in cell signaling, differentiation, and survival pathways. 4. **Regulation of Cell Signaling:** SERPINI2 modulates cell signaling pathways, including those involved in inflammation, immune responses, and tissue repair. **Pathways and Functions:** 1. **Negative Regulation of Endopeptidase Activity:** SERPINI2 inhibits serine-type endopeptidases, which are involved in cell signaling, differentiation, and survival pathways. 2. **Protein Binding:** SERPINI2 binds to serine-type endopeptidases, modulating their activity and preventing excessive proteolysis. 3. **Extracellular Exosome and Extracellular Space:** SERPINI2 is involved in regulating the extracellular exosome and extracellular space, which is essential for maintaining tissue homeostasis. 4. **Protein Binding:** SERPINI2 binds to proteins involved in cell signaling, differentiation, and survival pathways, modulating their activity. **Clinical Significance:** 1. **Disease Association:** Alterations in SERPINI2 expression have been associated with various diseases, including pancreatic cancer, Alzheimer's disease, and inflammatory disorders. 2. **Tissue Homeostasis:** SERPINI2 plays a crucial role in maintaining tissue homeostasis, and its dysregulation can lead to tissue damage and disease. 3. **Therapeutic Potential:** SERPINI2 may serve as a therapeutic target for diseases characterized by excessive proteolysis, such as cancer and inflammatory disorders. 4. **Cancer Therapy:** SERPINI2 may be involved in cancer progression, and its inhibition could be a potential therapeutic strategy for cancer treatment. In conclusion, SERPINI2 is a critical serpin gene involved in regulating endopeptidase activity and maintaining tissue homeostasis. Its dysregulation has been associated with various diseases, and its therapeutic potential offers new avenues for the treatment of diseases characterized by excessive proteolysis. Further research is necessary to fully understand the role of SERPINI2 in human physiology and disease.

Genular Protein ID: 794429027

Symbol: SPI2_HUMAN

Name: Serpin I2

UniProtKB Accession Codes:

O75830

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9624529

Title: Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells.

PubMed ID: 9624529

DOI: 10.1002/(sici)1098-2264(199807)22:3<179::aid-gcc3>3.3.co;2-u

PubMed ID: 10097100

Title: Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells.

PubMed ID: 10097100

DOI: 10.1073/pnas.96.7.3700

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 405
  • Mass: 46145
  • Checksum: 5BA18C60E4FDE9A4
  • Sequence:
    • MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ 
LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK 
EQYLHGNKEF FQSAIKLVDF QDAKACAEMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV 
NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS 
YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD 
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL 
AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSL

Genular Protein ID: 1814981569

Symbol: B4DDY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDY9

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 413
  • Mass: 46994
  • Checksum: BCBA74F931E174BB
  • Sequence:
    • MDTIFLWSLL LLFFGSQASR CSAQKNTEFA VDLYQEVSLS HKDNIIFSPL GITLVLEMVQ 
LGAKGKAQQQ IRQTLKQQET SAGEEFFVLK SFFSAISEKK QEFTFNLANA LYLQEGFTVK 
EQYLHGNKEF FQSAIKLVDF QDAKACAGMI STWVERKTDG KIKDMFSGEE FGPLTRLVLV 
NAIYFKGDWK QKFRKEDTQL INFTKKNGST VKIPMMKALL RTKYGYFSES SLNYQVLELS 
YKGDEFSLII ILPAEGMDIE EVEKLITAQQ ILKWLSEMQE EEVEISLPRF KVEQKVDFKD 
VLYSLNITEI FSGGCDLSGI TDSSEVYVSQ VTQKVFFEIN EDGSEAATST GIHIPVIMSL 
AQSQFIANHP FLFIMKHNPT ESILFMGRVT NPDTQEIKGR DLDSLWMKST ASE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.