Details for: PIK3C3

Gene ID: 5289

Symbol: PIK3C3

Ensembl ID: ENSG00000078142

Description: phosphatidylinositol 3-kinase catalytic subunit type 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 276.8327
    Cell Significance Index: -43.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.2570
    Cell Significance Index: -42.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.4368
    Cell Significance Index: -45.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.8354
    Cell Significance Index: -36.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 81.4565
    Cell Significance Index: -41.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.8426
    Cell Significance Index: -36.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.8083
    Cell Significance Index: -44.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.2080
    Cell Significance Index: -40.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5115
    Cell Significance Index: -41.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.3861
    Cell Significance Index: -44.9300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2127
    Cell Significance Index: -24.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2381
    Cell Significance Index: 448.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8280
    Cell Significance Index: 69.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.8044
    Cell Significance Index: 79.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6734
    Cell Significance Index: 165.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5249
    Cell Significance Index: 85.5700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3339
    Cell Significance Index: 16.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2276
    Cell Significance Index: 440.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1876
    Cell Significance Index: 235.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0553
    Cell Significance Index: 64.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8947
    Cell Significance Index: 23.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8523
    Cell Significance Index: 20.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8433
    Cell Significance Index: 56.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8261
    Cell Significance Index: 134.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8240
    Cell Significance Index: 63.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7749
    Cell Significance Index: 84.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7563
    Cell Significance Index: 14.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7311
    Cell Significance Index: 9.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7080
    Cell Significance Index: 20.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7054
    Cell Significance Index: 127.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5072
    Cell Significance Index: 30.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4859
    Cell Significance Index: 336.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3390
    Cell Significance Index: 41.6800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2875
    Cell Significance Index: 7.3900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2159
    Cell Significance Index: 3.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2121
    Cell Significance Index: 399.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2048
    Cell Significance Index: 111.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1762
    Cell Significance Index: 77.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1677
    Cell Significance Index: 106.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1659
    Cell Significance Index: 22.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1474
    Cell Significance Index: 66.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1467
    Cell Significance Index: 225.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1414
    Cell Significance Index: 4.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1203
    Cell Significance Index: 221.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0932
    Cell Significance Index: 2.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0881
    Cell Significance Index: 5.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0823
    Cell Significance Index: 2.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0641
    Cell Significance Index: 87.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0442
    Cell Significance Index: 8.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0058
    Cell Significance Index: 1.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0034
    Cell Significance Index: 0.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0031
    Cell Significance Index: 2.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0172
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0203
    Cell Significance Index: -15.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0206
    Cell Significance Index: -12.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0260
    Cell Significance Index: -19.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0383
    Cell Significance Index: -1.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0543
    Cell Significance Index: -41.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0550
    Cell Significance Index: -31.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0784
    Cell Significance Index: -8.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0912
    Cell Significance Index: -4.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0940
    Cell Significance Index: -11.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0993
    Cell Significance Index: -6.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1057
    Cell Significance Index: -4.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1076
    Cell Significance Index: -13.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1148
    Cell Significance Index: -24.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1269
    Cell Significance Index: -36.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1302
    Cell Significance Index: -13.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1327
    Cell Significance Index: -19.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1473
    Cell Significance Index: -17.1700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1647
    Cell Significance Index: -2.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1895
    Cell Significance Index: -9.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1898
    Cell Significance Index: -8.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2138
    Cell Significance Index: -27.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2426
    Cell Significance Index: -5.1900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2482
    Cell Significance Index: -3.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2676
    Cell Significance Index: -27.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2745
    Cell Significance Index: -6.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3004
    Cell Significance Index: -15.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3154
    Cell Significance Index: -36.0000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3320
    Cell Significance Index: -7.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3394
    Cell Significance Index: -7.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3585
    Cell Significance Index: -26.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3836
    Cell Significance Index: -27.1300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3946
    Cell Significance Index: -4.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3977
    Cell Significance Index: -6.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4455
    Cell Significance Index: -7.4600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4597
    Cell Significance Index: -9.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4628
    Cell Significance Index: -12.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4629
    Cell Significance Index: -36.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5297
    Cell Significance Index: -7.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5773
    Cell Significance Index: -20.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5809
    Cell Significance Index: -18.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6019
    Cell Significance Index: -7.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6116
    Cell Significance Index: -12.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6268
    Cell Significance Index: -20.5200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6411
    Cell Significance Index: -5.2300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6529
    Cell Significance Index: -8.2400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6565
    Cell Significance Index: -9.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6745
    Cell Significance Index: -18.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **PI3K Complex Component**: PIK3C3 is a catalytic subunit of the PI3K complex, which is composed of three subunits (PIK3CA, PIK3CB, and PIK3CC). The PIK3C3 subunit is responsible for the synthesis of PI3P, a key lipid molecule that regulates various cellular processes. 2. **Autophagy and Immune Response**: PIK3C3 is involved in the regulation of autophagy, a cellular process that involves the degradation and recycling of damaged or dysfunctional cellular components. Autophagy is critical for maintaining immune homeostasis and preventing disease. 3. **Cell Signaling and Metabolism**: PIK3C3 regulates cell signaling pathways, including insulin signaling, insulin-like growth factor 1 (IGF-1) signaling, and Rho GTPase signaling, which are involved in various cellular processes, including metabolism, cell growth, and differentiation. 4. **Signaling by Receptor Tyrosine Kinases**: PIK3C3 is also involved in signaling by receptor tyrosine kinases (RTKs), which are critical for regulating cell growth, differentiation, and survival. **Pathways and Functions:** 1. **Autophagy**: PIK3C3 regulates autophagy by promoting the formation of autophagosomes and autolysosomes, which are involved in the degradation and recycling of damaged or dysfunctional cellular components. 2. **Immune Response**: PIK3C3 is involved in regulating immune cell function, including the activation and proliferation of T cells, B cells, and macrophages. 3. **Cell Signaling**: PIK3C3 regulates various cell signaling pathways, including insulin signaling, IGF-1 signaling, and Rho GTPase signaling, which are involved in various cellular processes, including metabolism, cell growth, and differentiation. 4. **Metabolism**: PIK3C3 regulates metabolism by promoting the synthesis of phosphatidylinositol 3-phosphate (PI3P), a key lipid molecule that regulates membrane trafficking and autophagy. **Clinical Significance:** 1. **Cancer**: PIK3C3 is overexpressed in various types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis and resistance to chemotherapy. 2. **Autoimmune Diseases**: PIK3C3 is involved in regulating immune cell function and is associated with autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological Disorders**: PIK3C3 is involved in regulating neuronal function and is associated with neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Infectious Diseases**: PIK3C3 is involved in regulating immune cell function and is associated with infectious diseases, such as HIV and influenza. In conclusion, PIK3C3 is a crucial regulator of cellular processes and immune response, and its dysregulation is associated with various diseases, including cancer, autoimmune diseases, neurological disorders, and infectious diseases. Further research is needed to fully understand the role of PIK3C3 in maintaining cellular homeostasis and immune function.

Genular Protein ID: 2533867062

Symbol: PK3C3_HUMAN

Name: Phosphatidylinositol 3-kinase catalytic subunit type 3

UniProtKB Accession Codes:

Q8NEB9 Q15134

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 1 EMBL 3 EMDB 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PIR 1 PIRSF 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 1 Rhea 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7628435

Title: A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

PubMed ID: 7628435

DOI: 10.1002/j.1460-2075.1995.tb07340.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14617358

Title: Human VPS34 and p150 are Rab7 interacting partners.

PubMed ID: 14617358

DOI: 10.1034/j.1600-0854.2003.00133.x

PubMed ID: 16417406

Title: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

PubMed ID: 16417406

DOI: 10.1371/journal.pbio.0040038

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19050071

Title: Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

PubMed ID: 19050071

DOI: 10.1073/pnas.0810452105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20643123

Title: A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

PubMed ID: 20643123

DOI: 10.1016/j.yexcr.2010.07.008

PubMed ID: 19270696

Title: Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages.

PubMed ID: 19270696

DOI: 10.1038/ncb1846

PubMed ID: 20208530

Title: PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.

PubMed ID: 20208530

DOI: 10.1038/ncb2036

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22493499

Title: Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex.

PubMed ID: 22493499

DOI: 10.1074/jbc.m112.367060

PubMed ID: 23954414

Title: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

PubMed ID: 23954414

DOI: 10.1016/j.cell.2013.07.035

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23878393

Title: Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.

PubMed ID: 23878393

DOI: 10.1128/mcb.00079-13

PubMed ID: 25490155

Title: Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex.

PubMed ID: 25490155

DOI: 10.7554/elife.05115

PubMed ID: 31806350

Title: The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1.

PubMed ID: 31806350

DOI: 10.1016/j.molcel.2019.10.035

PubMed ID: 32690950

Title: STEEP mediates STING ER exit and activation of signaling.

PubMed ID: 32690950

DOI: 10.1038/s41590-020-0730-5

PubMed ID: 32929276

Title:

PubMed ID: 32929276

DOI: 10.1038/s41590-020-0803-5

PubMed ID: 34320401

Title: Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication.

PubMed ID: 34320401

DOI: 10.1016/j.celrep.2021.109479

PubMed ID: 33473107

Title: Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.

PubMed ID: 33473107

DOI: 10.1038/s41467-020-20780-2

PubMed ID: 33637724

Title: VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism.

PubMed ID: 33637724

DOI: 10.1038/s41467-021-21715-1

Sequence Information:

  • Length: 887
  • Mass: 101549
  • Checksum: 1C03D97338E44976
  • Sequence:
    • MGEAEKFHYI YSCDLDINVQ LKIGSLEGKR EQKSYKAVLE DPMLKFSGLY QETCSDLYVT 
CQVFAEGKPL ALPVRTSYKA FSTRWNWNEW LKLPVKYPDL PRNAQVALTI WDVYGPGKAV 
PVGGTTVSLF GKYGMFRQGM HDLKVWPNVE ADGSEPTKTP GRTSSTLSED QMSRLAKLTK 
AHRQGHMVKV DWLDRLTFRE IEMINESEKR SSNFMYLMVE FRCVKCDDKE YGIVYYEKDG 
DESSPILTSF ELVKVPDPQM SMENLVESKH HKLARSLRSG PSDHDLKPNA ATRDQLNIIV 
SYPPTKQLTY EEQDLVWKFR YYLTNQEKAL TKFLKCVNWD LPQEAKQALE LLGKWKPMDV 
EDSLELLSSH YTNPTVRRYA VARLRQADDE DLLMYLLQLV QALKYENFDD IKNGLEPTKK 
DSQSSVSENV SNSGINSAEI DSSQIITSPL PSVSSPPPAS KTKEVPDGEN LEQDLCTFLI 
SRACKNSTLA NYLYWYVIVE CEDQDTQQRD PKTHEMYLNV MRRFSQALLK GDKSVRVMRS 
LLAAQQTFVD RLVHLMKAVQ RESGNRKKKN ERLQALLGDN EKMNLSDVEL IPLPLEPQVK 
IRGIIPETAT LFKSALMPAQ LFFKTEDGGK YPVIFKHGDD LRQDQLILQI ISLMDKLLRK 
ENLDLKLTPY KVLATSTKHG FMQFIQSVPV AEVLDTEGSI QNFFRKYAPS ENGPNGISAE 
VMDTYVKSCA GYCVITYILG VGDRHLDNLL LTKTGKLFHI DFGYILGRDP KPLPPPMKLN 
KEMVEGMGGT QSEQYQEFRK QCYTAFLHLR RYSNLILNLF SLMVDANIPD IALEPDKTVK 
KVQDKFRLDL SDEEAVHYMQ SLIDESVHAL FAAVVEQIHK FAQYWRK

Genular Protein ID: 4014809908

Symbol: A8MYT4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MYT4

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 11 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 8 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 SAM 1 SMART 2 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 824
  • Mass: 94400
  • Checksum: 32C4721A6B2576F0
  • Sequence:
    • MGEAEKFHYI YSCDLDINVQ LKIWNEWLKL PVKYPDLPRN AQVALTIWDV YGPGKAVPVG 
GTTVSLFGKY GMFRQGMHDL KVWPNVEADG SEPTKTPGRT SSTLSEDQMS RLAKLTKAHR 
QGHMVKVDWL DRLTFREIEM INESEKRSSN FMYLMVEFRC VKCDDKEYGI VYYEKDGDES 
SPILTSFELV KVPDPQMSME NLVESKHHKL ARSLRSGPSD HDLKPNAATR DQLNIIVSYP 
PTKQLTYEEQ DLVWKFRYYL TNQEKALTKF LKCVNWDLPQ EAKQALELLG KWKPMDVEDS 
LELLSSHYTN PTVRRYAVAR LRQADDEDLL MYLLQLVQAL KYENFDDIKN GLEPTKKDSQ 
SSVSENVSNS GINSAEIDSS QIITSPLPSV SSPPPASKTK EVPDGENLEQ DLCTFLISRA 
CKNSTLANYL YWYVIVECED QDTQQRDPKT HEMYLNVMRR FSQALLKGDK SVRVMRSLLA 
AQQTFVDRLV HLMKAVQRES GNRKKKNERL QALLGDNEKM NLSDVELIPL PLEPQVKIRG 
IIPETATLFK SALMPAQLFF KTEDGGKYPV IFKHGDDLRQ DQLILQIISL MDKLLRKENL 
DLKLTPYKVL ATSTKHGFMQ FIQSVPVAEV LDTEGSIQNF FRKYAPSENG PNGISAEVMD 
TYVKSCAGYC VITYILGVGD RHLDNLLLTK TGKLFHIDFG YILGRDPKPL PPPMKLNKEM 
VEGMGGTQSE QYQEFRKQCY TAFLHLRRYS NLILNLFSLM VDANIPDIAL EPDKTVKKVQ 
DKFRLDLSDE EAVHYMQSLI DESVHALFAA VVEQIHKFAQ YWRK

Genular Protein ID: 2769334646

Symbol: B4DPV9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DPV9

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 11 Gene3D 3 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PROSITE 8 PeptideAtlas 1 Pfam 3 RefSeq 1 Rhea 1 SAM 1 SMART 2 SUPFAM 3

Sequence Information:

  • Length: 824
  • Mass: 94399
  • Checksum: 764675E6535051A2
  • Sequence:
    • MGEAEKFHYI YSCDLDINVQ LKIWNEWLKL PVKYPDLPRN AQVALTIWDV YGPGKAVPVG 
GTTVSLFGKY GMFRQGMHDL KVWPNVEADG SEPTKTPGRT SSTLSEDQMS RLAKLTKAHR 
QGHMVKVDWL DRLTFREIEM INESEKRSSN FMYLMVEFRC VKCDDKEYGI VYYEKDGDES 
SPILTSFELV KVPDPQMSME NLVESKHHKL ARSLRSGPSD HNLKPNAATR DQLNIIVSYP 
PTKQLTYEEQ DLVWKFRYYL TNQEKALTKF LKCVNWDLPQ EAKQALELLG KWKPMDVEDS 
LELLSSHYTN PTVRRYAVAR LRQADDEDLL MYLLQLVQAL KYENFDDIKN GLEPTKKDSQ 
SSVSENVSNS GINSAEIDSS QIITSPLPSV SSPPPASKTK EVPDGENLEQ DLCTFLISRA 
CKNSTLANYL YWYVIVECED QDTQQRDPKT HEMYLNVMRR FSQALLKGDK SVRVMRSLLA 
AQQTFVDRLV HLMKAVQRES GNRKKKNERL QALLGDNEKM NLSDVELIPL PLEPQVKIRG 
IIPETATLFK SALMPAQLFF KTEDGGKYPV IFKHGDDLRQ DQLILQIISL MDKLLRKENL 
DLKLTPYKVL ATSTKHGFMQ FIQSVPVAEV LDTEGSIQNF FRKYAPSENG PNGISAEVMD 
TYVKSCAGYC VITYILGVGD RHLDNLLLTK TGKLFHIDFG YILGRDPKPL PPPMKLNKEM 
VEGMGGTQSE QYQEFRKQCY TAFLHLRRYS NLILNLFSLM VDANIPDIAL EPDKTVKKVQ 
DKFRLDLSDE EAVHYMQSLI DESVHALFAA VVEQIHKFAQ YWRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.