PIK3CB | ENSG00000051382 | NCBI 5291

Details for: PIK3CB

Gene ID: 5291

Symbol: PIK3CB

Ensembl ID: ENSG00000051382

Description: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Cell-cell communication
(R-HSA-1500931)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signal transduction
(R-HSA-186763)
Downstream tcr signaling
(R-HSA-202424)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-HSA-9027276)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Gpvi-mediated activation cascade
(R-HSA-114604)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Interleukin-2 family signaling
(R-HSA-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Interleukin receptor shc signaling
(R-HSA-912526)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nephrin family interactions
(R-HSA-373753)
Nervous system development
(R-HSA-9675108)
Phospholipid metabolism
(R-HSA-1483257)
Pi3k/akt activation
(R-HSA-198203)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pi metabolism
(R-HSA-1483255)
Pip3 activates akt signaling
(R-HSA-1257604)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of signaling by cbl
(R-HSA-912631)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Ret signaling
(R-HSA-8853659)
Role of lat2/ntal/lab on calcium mobilization
(R-HSA-2730905)
Role of phospholipids in phagocytosis
(R-HSA-2029485)
Signaling by alk
(R-HSA-201556)
Signaling by alk fusions and activated point mutants
(R-HSA-9725370)
Signaling by alk in cancer
(R-HSA-9700206)
Signaling by csf1 (m-csf) in myeloid cells
(R-HSA-9680350)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by interleukins
(R-HSA-449147)
Signaling by ltk
(R-HSA-9842663)
Signaling by ltk in cancer
(R-HSA-9842640)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfra extracellular domain mutants
(R-HSA-9673770)
Signaling by pdgfra transmembrane, juxtamembrane and kinase domain mutants
(R-HSA-9673767)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Synthesis of pips at the plasma membrane
(R-HSA-1660499)
Tcr signaling
(R-HSA-202403)
Tie2 signaling
(R-HSA-210993)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
1-phosphatidylinositol-3-kinase activity
(GO:0016303)
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
(GO:0046934)
1-phosphatidylinositol-4-phosphate 3-kinase activity
(GO:0035005)
Atp binding
(GO:0005524)
Autophagy
(GO:0006914)
Cell surface receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Chemotaxis
(GO:0006935)
Endocytosis
(GO:0006897)
Endothelial cell proliferation
(GO:0001935)
G protein-coupled receptor signaling pathway
(GO:0007186)
Homophilic cell adhesion via plasma membrane adhesion molecules
(GO:0007156)
Insulin receptor substrate binding
(GO:0043560)
Intracellular calcium ion homeostasis
(GO:0006874)
Kinase activity
(GO:0016301)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of gene expression
(GO:0010628)
Protein binding
(GO:0005515)
Protein serine kinase activity
(GO:0106310)
Regulation of cell-matrix adhesion
(GO:0001952)
Response to ischemia
(GO:0002931)
Signal transduction
(GO:0007165)
Sphingosine-1-phosphate receptor signaling pathway
(GO:0003376)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 265.9034
Cell Significance Index: -41.3600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 162.2357
Cell Significance Index: -41.1500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 87.1123
Cell Significance Index: -35.3900
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 80.4844
Cell Significance Index: -41.4000
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 37.0990
Cell Significance Index: -35.4200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 34.0929
Cell Significance Index: -42.0400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.5887
Cell Significance Index: -41.7600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.5743
Cell Significance Index: -27.5200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.7323
Cell Significance Index: -42.3500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 4.6027
Cell Significance Index: 122.9000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0674
Cell Significance Index: 414.7200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.5733
Cell Significance Index: 105.7900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.5342
Cell Significance Index: 550.2800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.5053
Cell Significance Index: 57.0000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.4989
Cell Significance Index: 38.5300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4161
Cell Significance Index: 281.0300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.4048
Cell Significance Index: 39.2600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.3556
Cell Significance Index: 59.9600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.3367
Cell Significance Index: 102.5800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.1264
Cell Significance Index: 16.2000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1108
Cell Significance Index: 180.6600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0758
Cell Significance Index: 117.0100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9630
Cell Significance Index: 666.0800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.8657
Cell Significance Index: 21.6400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6933
Cell Significance Index: 15.0200
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.6293
Cell Significance Index: 3.9100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6272
Cell Significance Index: 18.0700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6228
Cell Significance Index: 34.9500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5499
Cell Significance Index: 33.8000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4389
Cell Significance Index: 396.3300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4310
Cell Significance Index: 42.6400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4303
Cell Significance Index: 19.5100
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.3630
Cell Significance Index: 8.7100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.3508
Cell Significance Index: 10.0100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3126
Cell Significance Index: 56.3600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2529
Cell Significance Index: 476.1100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2323
Cell Significance Index: 28.5600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2140
Cell Significance Index: 40.7200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1717
Cell Significance Index: 264.3300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1677
Cell Significance Index: 7.8200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1667
Cell Significance Index: 105.8800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1640
Cell Significance Index: 2.8100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1638
Cell Significance Index: 89.4800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1617
Cell Significance Index: 219.8400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1440
Cell Significance Index: 265.5000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1093
Cell Significance Index: 49.6200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1064
Cell Significance Index: 47.0600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0887
Cell Significance Index: 15.1400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0630
Cell Significance Index: 2.2200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0105
Cell Significance Index: -0.6600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0245
Cell Significance Index: -17.9600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0400
Cell Significance Index: -29.6100
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0427
Cell Significance Index: -0.6400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0496
Cell Significance Index: -37.5200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0649
Cell Significance Index: -36.5800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0772
Cell Significance Index: -48.2300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0792
Cell Significance Index: -1.0800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0883
Cell Significance Index: -1.8800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1261
Cell Significance Index: -12.8800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1295
Cell Significance Index: -37.2600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1355
Cell Significance Index: -19.6900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1444
Cell Significance Index: -16.8300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1675
Cell Significance Index: -19.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1927
Cell Significance Index: -26.4700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2058
Cell Significance Index: -10.7200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2138
Cell Significance Index: -45.0400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2215
Cell Significance Index: -10.4100
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2263
Cell Significance Index: -6.1600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2364
Cell Significance Index: -27.8800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2386
Cell Significance Index: -4.9500
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.2475
Cell Significance Index: -6.0400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2512
Cell Significance Index: -32.4500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2581
Cell Significance Index: -26.8700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2778
Cell Significance Index: -14.4300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.2829
Cell Significance Index: -36.2700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3178
Cell Significance Index: -6.7500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3466
Cell Significance Index: -7.5900
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3637
Cell Significance Index: -5.3700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3792
Cell Significance Index: -4.5200
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3820
Cell Significance Index: -6.4400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4001
Cell Significance Index: -29.8200
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4491
Cell Significance Index: -5.6000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4497
Cell Significance Index: -35.6200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4674
Cell Significance Index: -30.1600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4782
Cell Significance Index: -33.8200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5030
Cell Significance Index: -26.4100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.5055
Cell Significance Index: -6.2700
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.5163
Cell Significance Index: -7.6200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5221
Cell Significance Index: -11.1600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.5448
Cell Significance Index: -17.3500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5672
Cell Significance Index: -18.5700
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.5789
Cell Significance Index: -5.8400
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.5967
Cell Significance Index: -11.9800
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.6173
Cell Significance Index: -8.8700
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.6291
Cell Significance Index: -7.9400
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.6589
Cell Significance Index: -12.8600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.6735
Cell Significance Index: -9.6500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6797
Cell Significance Index: -21.7700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6848
Cell Significance Index: -41.9900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.6888
Cell Significance Index: -13.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Isoform**: The PIK3CB gene encodes for two isoforms, alpha and beta, which have distinct functions and tissue distributions. 2. **Cellular localization**: PIK3CB is primarily found in the plasma membrane, where it regulates signaling pathways. 3. **Kinase activity**: PIK3CB has intrinsic kinase activity, which phosphorylates phosphatidylinositol-4,5-bisphosphate (PIP2) to produce phosphatidylinositol-3,4,5-trisphosphate (PIP3). 4. **Signaling pathway**: PIK3CB is a key component of the PI3K signaling pathway, which regulates various cellular processes, including cell growth, differentiation, survival, and migration. **Pathways and Functions** 1. **Adaptive immune system**: PIK3CB regulates the activation and proliferation of immune cells, such as T cells and B cells. 2. **Neurological development**: PIK3CB plays a crucial role in the development and function of the nervous system, including the formation of synapses and the regulation of neuronal migration. 3. **Cancer**: PIK3CB is frequently mutated or overexpressed in various types of cancer, including breast, lung, and colon cancer, leading to uncontrolled cell growth and survival. 4. **Autophagy**: PIK3CB regulates autophagy, a process by which cells recycle damaged or dysfunctional components. 5. **Cell migration**: PIK3CB regulates cell migration, including the migration of immune cells and neurons. **Clinical Significance** 1. **Cancer**: PIK3CB mutations or overexpression are associated with poor prognosis and reduced response to therapy in various types of cancer. 2. **Autoimmune disorders**: PIK3CB dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and type 1 diabetes. 3. **Neurological disorders**: PIK3CB mutations or overexpression have been associated with neurological disorders, such as schizophrenia and autism spectrum disorder. 4. **Cardiovascular disease**: PIK3CB regulates vascular function and is involved in the development of cardiovascular disease. 5. **Immunotherapy**: PIK3CB inhibitors are being explored as a potential therapeutic strategy for cancer treatment. In conclusion, the PIK3CB gene plays a critical role in various cellular processes, including immune system function, neurological development, and cancer. Understanding the mechanisms of PIK3CB regulation and its clinical significance can lead to the development of novel therapeutic strategies for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
B4DER4_HUMAN

Genular Protein ID: 1985468291

Symbol: PK3CB_HUMAN

Name: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

UniProtKB Accession Codes:

P42338 D3DNF0 Q24JU2

Database IDs:

Citations:

PubMed ID: 8246984

Title: Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

PubMed ID: 8246984

DOI: 10.1128/mcb.13.12.7677-7688.1993

PubMed ID: 11016459

Title: Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes.

PubMed ID: 11016459

DOI: 10.2337/diabetes.49.10.1740

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12502714

Title: Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.

PubMed ID: 12502714

DOI: 10.1074/jbc.m210351200

PubMed ID: 15135396

Title: Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.

PubMed ID: 15135396

DOI: 10.1016/j.pep.2003.12.010

PubMed ID: 18594509

Title: Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.

PubMed ID: 18594509

DOI: 10.1038/nature07091

PubMed ID: 18755892

Title: PTEN-deficient cancers depend on PIK3CB.

PubMed ID: 18755892

DOI: 10.1073/pnas.0802655105

PubMed ID: 19635806

Title: p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.

PubMed ID: 19635806

DOI: 10.1128/mcb.01649-08

PubMed ID: 21030680

Title: A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.

PubMed ID: 21030680

DOI: 10.1073/pnas.1008739107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21383062

Title: Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival.

PubMed ID: 21383062

DOI: 10.1128/mcb.01313-10

PubMed ID: 21321382

Title: A beta version of life: p110beta takes center stage.

PubMed ID: 21321382

DOI: 10.18632/oncotarget.207

PubMed ID: 21035500

Title: Regulation and roles of PI3Kbeta, a major actor in platelet signaling and functions.

PubMed ID: 21035500

DOI: 10.1016/j.advenzreg.2010.09.011

Sequence Information:

Length: 1070
Mass: 122762
Checksum: 81135FE93452C00E
Sequence:

MCFSFIMPPA MADILDIWAV DSQIASDGSI PVDFLLPTGI YIQLEVPREA TISYIKQMLW 
KQVHNYPMFN LLMDIDSYMF ACVNQTAVYE ELEDETRRLC DVRPFLPVLK LVTRSCDPGE 
KLDSKIGVLI GKGLHEFDSL KDPEVNEFRR KMRKFSEEKI LSLVGLSWMD WLKQTYPPEH 
EPSIPENLED KLYGGKLIVA VHFENCQDVF SFQVSPNMNP IKVNELAIQK RLTIHGKEDE 
VSPYDYVLQV SGRVEYVFGD HPLIQFQYIR NCVMNRALPH FILVECCKIK KMYEQEMIAI 
EAAINRNSSN LPLPLPPKKT RIISHVWENN NPFQIVLVKG NKLNTEETVK VHVRAGLFHG 
TELLCKTIVS SEVSGKNDHI WNEPLEFDIN ICDLPRMARL CFAVYAVLDK VKTKKSTKTI 
NPSKYQTIRK AGKVHYPVAW VNTMVFDFKG QLRTGDIILH SWSSFPDELE EMLNPMGTVQ 
TNPYTENATA LHVKFPENKK QPYYYPPFDK IIEKAAEIAS SDSANVSSRG GKKFLPVLKE 
ILDRDPLSQL CENEMDLIWT LRQDCREIFP QSLPKLLLSI KWNKLEDVAQ LQALLQIWPK 
LPPREALELL DFNYPDQYVR EYAVGCLRQM SDEELSQYLL QLVQVLKYEP FLDCALSRFL 
LERALGNRRI GQFLFWHLRS EVHIPAVSVQ FGVILEAYCR GSVGHMKVLS KQVEALNKLK 
TLNSLIKLNA VKLNRAKGKE AMHTCLKQSA YREALSDLQS PLNPCVILSE LYVEKCKYMD 
SKMKPLWLVY NNKVFGEDSV GVIFKNGDDL RQDMLTLQML RLMDLLWKEA GLDLRMLPYG 
CLATGDRSGL IEVVSTSETI ADIQLNSSNV AAAAAFNKDA LLNWLKEYNS GDDLDRAIEE 
FTLSCAGYCV ASYVLGIGDR HSDNIMVKKT GQLFHIDFGH ILGNFKSKFG IKRERVPFIL 
TYDFIHVIQQ GKTGNTEKFG RFRQCCEDAY LILRRHGNLF ITLFALMLTA GLPELTSVKD 
IQYLKDSLAL GKSEEEALKQ FKQKFDEALR ESWTTKVNWM AHTVRKDYRS

Genular Protein ID: 3557323277

Symbol: B4DER4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DER4

Database IDs:

Sequence Information:

Length: 582
Mass: 66800
Checksum: 08A2202DE0785851
Sequence:

MLNPMGTVQT NPYTENATAL HVKFPENKKQ PYYYPPLDKS RGGKKFLPVL KEILDRDPLS 
QLCENEMDLI WTLRQDCREI FPQSLPKLLL SIKWNKLEDV AQLQALLQIW PKLPPREALE 
LLDFNYPDQY VREYAVGCLR QMSDEELSQY LLQLVQVLKY EPFLDCALSR FLLERALGNR 
RIGQFLFWHL RSEVHIPAVS VQFGVILEAY CRGSVGHMKV LSKQVEALNK LKTLNSLIKL 
NAVKLNRAKG KEAMHTCLKQ SAYREALSDL QSPLNPCVIL SELYVEKCKY MDSKMKPLWL 
VYNNKVFGED SVGVIFKNGD DLRQDMLTLQ MLRLMDLLWK EAGLDLRMLP YGCLATGDRS 
GLIEVVSTSE TIADIQLNSS NVAAAAAFNK DALLNWLKEY NSGDDLDRAI EEFTLSCAGY 
CVASYVLGIG DRHSDNIMVK KTGQLFHIDF GHILGNFKSK FGIKRERVPF ILTYDFIHVI 
QQGKTGNTEK FGRFRQCCED AYLILRRHGN LFITLFALML TAGLPELTSV KDIQYLKDSL 
ALGKSEEEAL KQFKQKFDEA LRESWTTKVN WMAHTVRKDY RS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PIK3CB

Associated with

Cells (max top 100)

Other Information

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. PubMed ID: 8246984

Gene encoding the catalytic subunit p110beta of human phosphatidylinositol 3-kinase: cloning, genomic structure, and screening for variants in patients with type 2 diabetes. PubMed ID: 11016459

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma. PubMed ID: 12502714

Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms. PubMed ID: 15135396

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. PubMed ID: 18594509

PTEN-deficient cancers depend on PIK3CB. PubMed ID: 18755892

p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. PubMed ID: 19635806

A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase. PubMed ID: 21030680

Initial characterization of the human central proteome. PubMed ID: 21269460

Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival. PubMed ID: 21383062

A beta version of life: p110beta takes center stage. PubMed ID: 21321382

Regulation and roles of PI3Kbeta, a major actor in platelet signaling and functions. PubMed ID: 21035500