Details for: PITPNA

Gene ID: 5306

Symbol: PITPNA

Ensembl ID: ENSG00000174238

Description: phosphatidylinositol transfer protein alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 243.9805
    Cell Significance Index: -37.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.6265
    Cell Significance Index: -39.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.2533
    Cell Significance Index: -40.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.7493
    Cell Significance Index: -34.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 74.2634
    Cell Significance Index: -38.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.2477
    Cell Significance Index: -39.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2859
    Cell Significance Index: -38.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.1579
    Cell Significance Index: -24.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0208
    Cell Significance Index: -33.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2077
    Cell Significance Index: -40.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.4371
    Cell Significance Index: 91.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5858
    Cell Significance Index: 35.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0961
    Cell Significance Index: 58.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6091
    Cell Significance Index: 322.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4646
    Cell Significance Index: 144.8800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3622
    Cell Significance Index: 63.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3331
    Cell Significance Index: 216.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3300
    Cell Significance Index: 1200.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2763
    Cell Significance Index: 76.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0358
    Cell Significance Index: 112.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0084
    Cell Significance Index: 200.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8532
    Cell Significance Index: 306.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7435
    Cell Significance Index: 91.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7358
    Cell Significance Index: 508.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7203
    Cell Significance Index: 393.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6549
    Cell Significance Index: 15.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5964
    Cell Significance Index: 107.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5612
    Cell Significance Index: 29.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.5168
    Cell Significance Index: 322.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3619
    Cell Significance Index: 20.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3428
    Cell Significance Index: 26.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3240
    Cell Significance Index: 9.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2709
    Cell Significance Index: 37.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2553
    Cell Significance Index: 6.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2350
    Cell Significance Index: 10.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2252
    Cell Significance Index: 99.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1959
    Cell Significance Index: 13.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1694
    Cell Significance Index: 7.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1595
    Cell Significance Index: 3.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1301
    Cell Significance Index: 200.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1297
    Cell Significance Index: 244.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1181
    Cell Significance Index: 3.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1173
    Cell Significance Index: 7.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1062
    Cell Significance Index: 195.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1002
    Cell Significance Index: 3.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0932
    Cell Significance Index: 15.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0901
    Cell Significance Index: 6.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0765
    Cell Significance Index: 48.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0350
    Cell Significance Index: 15.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0292
    Cell Significance Index: 0.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0092
    Cell Significance Index: 12.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0138
    Cell Significance Index: -10.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0285
    Cell Significance Index: -21.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0344
    Cell Significance Index: -19.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0635
    Cell Significance Index: -4.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0721
    Cell Significance Index: -3.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0740
    Cell Significance Index: -9.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0764
    Cell Significance Index: -9.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0931
    Cell Significance Index: -2.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0953
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1128
    Cell Significance Index: -23.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1156
    Cell Significance Index: -11.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1161
    Cell Significance Index: -33.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1254
    Cell Significance Index: -23.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1364
    Cell Significance Index: -16.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1400
    Cell Significance Index: -15.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1466
    Cell Significance Index: -17.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1468
    Cell Significance Index: -7.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1535
    Cell Significance Index: -3.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1737
    Cell Significance Index: -1.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1880
    Cell Significance Index: -7.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2027
    Cell Significance Index: -15.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2131
    Cell Significance Index: -6.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2285
    Cell Significance Index: -26.1800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2317
    Cell Significance Index: -1.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2370
    Cell Significance Index: -5.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2544
    Cell Significance Index: -4.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2641
    Cell Significance Index: -16.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2739
    Cell Significance Index: -28.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3804
    Cell Significance Index: -7.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3875
    Cell Significance Index: -30.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4495
    Cell Significance Index: -9.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4535
    Cell Significance Index: -15.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4805
    Cell Significance Index: -8.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4888
    Cell Significance Index: -10.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5105
    Cell Significance Index: -8.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5117
    Cell Significance Index: -31.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5480
    Cell Significance Index: -12.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5541
    Cell Significance Index: -28.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6154
    Cell Significance Index: -14.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6364
    Cell Significance Index: -6.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6411
    Cell Significance Index: -16.4800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6591
    Cell Significance Index: -8.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6950
    Cell Significance Index: -10.2600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6981
    Cell Significance Index: -10.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7066
    Cell Significance Index: -22.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7303
    Cell Significance Index: -23.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7651
    Cell Significance Index: -25.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PITPNA is a member of the phosphatidylinositol transfer protein family, which is characterized by its ability to facilitate the transfer of PI between phospholipids. The alpha isoform of PITPNA (PIPNA_HUMAN) is specifically expressed in various cell types, including basal epithelial cells, dopaminergic neurons, and GABAergic cortical interneurons. This isoform is distinct from the beta isoform, which is predominantly expressed in immune cells. **Pathways and Functions:** PITPNA is involved in multiple signaling pathways, including: 1. **Cytokine signaling in the immune system:** PITPNA plays a crucial role in the transfer of PI from membrane-bound receptors to signaling molecules, facilitating the activation of immune responses. 2. **Axon guidance and axonogenesis:** PITPNA is involved in the regulation of axon growth and guidance, suggesting a potential role in neuronal development and function. 3. **Lipid metabolic process:** PITPNA is involved in the transfer of PI between phospholipids, regulating lipid metabolism and cell membrane dynamics. 4. **Interleukin-12 signaling:** PITPNA is required for the proper functioning of the IL-12 signaling pathway, which is essential for the activation of immune responses. **Clinical Significance:** Dysregulation of PITPNA has been implicated in various diseases, including: 1. **Autoimmune disorders:** Alterations in PITPNA expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Neurodevelopmental disorders:** PITPNA dysregulation has been suggested to contribute to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer:** PITPNA has been implicated in the regulation of lipid metabolism and cell membrane dynamics, suggesting a potential role in cancer progression. **Conclusion:** PITPNA is a critical enzyme involved in various cellular processes, including cytokine signaling, axon guidance, and lipid metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of PITPNA in maintaining immune homeostasis and neuronal function. Further research is necessary to fully understand the mechanisms by which PITPNA regulates these processes and to explore its potential as a therapeutic target for various diseases. **Recommendations:** 1. **Further research on PITPNA expression and function:** Investigating the expression and function of PITPNA in different cell types and tissues will provide a better understanding of its role in immune response and neurodevelopment. 2. **Investigation of PITPNA's role in disease:** Exploring the relationship between PITPNA dysregulation and various diseases, including autoimmune disorders and neurodevelopmental disorders, will provide insights into its potential as a therapeutic target. 3. **Development of PITPNA-based therapies:** Designing therapies that target PITPNA may provide new avenues for treating diseases associated with its dysregulation. By continuing to explore the functions and significance of PITPNA, we can gain a deeper understanding of its role in maintaining immune homeostasis and neuronal function, ultimately leading to the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 636717793

Symbol: PIPNA_HUMAN

Name: Phosphatidylinositol transfer protein alpha isoform

UniProtKB Accession Codes:

Q00169

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8194769

Title: Sequence of a human cDNA encoding phosphatidylinositol transfer protein and occurrence of a related sequence in widely divergent eukaryotes.

PubMed ID: 8194769

DOI: 10.1016/0378-1119(94)90279-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10531358

Title: Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta.

PubMed ID: 10531358

DOI: 10.1074/jbc.274.44.31553

PubMed ID: 15522822

Title: Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha.

PubMed ID: 15522822

DOI: 10.1016/j.bbalip.2004.08.003

PubMed ID: 18636990

Title: Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells.

PubMed ID: 18636990

DOI: 10.1111/j.1600-0854.2008.00794.x

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22822086

Title: Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid.

PubMed ID: 22822086

DOI: 10.1074/jbc.m112.375840

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 14962392

Title: Structure-function analysis of human phosphatidylinositol transfer protein alpha bound to phosphatidylinositol.

PubMed ID: 14962392

DOI: 10.1016/j.str.2004.01.013

Sequence Information:

  • Length: 270
  • Mass: 31806
  • Checksum: 4531E6E38697C93B
  • Sequence:
    • MVLLKEYRVI LPVSVDEYQV GQLYSVAEAS KNETGGGEGV EVLVNEPYEK DGEKGQYTHK 
IYHLQSKVPT FVRMLAPEGA LNIHEKAWNA YPYCRTVITN EYMKEDFLIK IETWHKPDLG 
TQENVHKLEP EAWKHVEAVY IDIADRSQVL SKDYKAEEDP AKFKSIKTGR GPLGPNWKQE 
LVNQKDCPYM CAYKLVTVKF KWWGLQNKVE NFIHKQERRL FTNFHRQLFC WLDKWVDLTM 
DDIRRMEEET KRQLDEMRQK DPVKGMTADD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.