Details for: PLAGL2

Gene ID: 5326

Symbol: PLAGL2

Ensembl ID: ENSG00000126003

Description: PLAG1 like zinc finger 2

Associated with

  • Chylomicron assembly
    (GO:0034378)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Lipid metabolic process
    (GO:0006629)
  • Metal ion binding
    (GO:0046872)
  • Nucleus
    (GO:0005634)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Post-embryonic development
    (GO:0009791)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Sequence-specific dna binding
    (GO:0043565)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.2836
    Cell Significance Index: -11.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.4198
    Cell Significance Index: -12.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.8733
    Cell Significance Index: -11.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.6337
    Cell Significance Index: -13.7000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.2860
    Cell Significance Index: -11.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.5113
    Cell Significance Index: -12.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2672
    Cell Significance Index: -14.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3591
    Cell Significance Index: -13.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3985
    Cell Significance Index: 63.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3707
    Cell Significance Index: -3.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2375
    Cell Significance Index: 35.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2152
    Cell Significance Index: 16.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1776
    Cell Significance Index: 128.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1402
    Cell Significance Index: 59.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1370
    Cell Significance Index: 68.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0564
    Cell Significance Index: 171.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8235
    Cell Significance Index: 17.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7359
    Cell Significance Index: 46.3800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7041
    Cell Significance Index: 10.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6268
    Cell Significance Index: 43.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5952
    Cell Significance Index: 16.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5138
    Cell Significance Index: 11.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4449
    Cell Significance Index: 44.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3873
    Cell Significance Index: 76.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3301
    Cell Significance Index: 298.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3043
    Cell Significance Index: 6.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2844
    Cell Significance Index: 5.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2800
    Cell Significance Index: 56.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2518
    Cell Significance Index: 30.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2167
    Cell Significance Index: 39.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2146
    Cell Significance Index: 117.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2124
    Cell Significance Index: 93.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1937
    Cell Significance Index: 36.8600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1870
    Cell Significance Index: 2.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1096
    Cell Significance Index: 5.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0918
    Cell Significance Index: 2.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0798
    Cell Significance Index: 2.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0787
    Cell Significance Index: 28.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0692
    Cell Significance Index: 2.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0691
    Cell Significance Index: 1.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0672
    Cell Significance Index: 1.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0652
    Cell Significance Index: 5.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0651
    Cell Significance Index: 4.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0647
    Cell Significance Index: 8.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0633
    Cell Significance Index: 7.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0584
    Cell Significance Index: 0.6100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0561
    Cell Significance Index: 3.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0519
    Cell Significance Index: 0.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0452
    Cell Significance Index: 31.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0311
    Cell Significance Index: 1.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0126
    Cell Significance Index: 0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0124
    Cell Significance Index: 23.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0087
    Cell Significance Index: 0.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0086
    Cell Significance Index: 11.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0063
    Cell Significance Index: 0.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0035
    Cell Significance Index: -6.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0064
    Cell Significance Index: -4.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0079
    Cell Significance Index: -5.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0111
    Cell Significance Index: -8.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -10.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0178
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0182
    Cell Significance Index: -8.2400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0195
    Cell Significance Index: -2.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0226
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0242
    Cell Significance Index: -15.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0269
    Cell Significance Index: -4.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0290
    Cell Significance Index: -3.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0297
    Cell Significance Index: -8.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0306
    Cell Significance Index: -3.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0311
    Cell Significance Index: -0.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0342
    Cell Significance Index: -3.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0384
    Cell Significance Index: -4.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0610
    Cell Significance Index: -4.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0663
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0668
    Cell Significance Index: -14.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0668
    Cell Significance Index: -2.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0717
    Cell Significance Index: -1.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1030
    Cell Significance Index: -0.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1091
    Cell Significance Index: -3.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1102
    Cell Significance Index: -3.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1104
    Cell Significance Index: -4.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1139
    Cell Significance Index: -11.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1143
    Cell Significance Index: -7.0100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1149
    Cell Significance Index: -1.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1229
    Cell Significance Index: -6.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1284
    Cell Significance Index: -7.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1542
    Cell Significance Index: -12.2100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1719
    Cell Significance Index: -2.5900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1906
    Cell Significance Index: -1.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1976
    Cell Significance Index: -5.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2006
    Cell Significance Index: -5.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2014
    Cell Significance Index: -4.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2085
    Cell Significance Index: -10.9500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2204
    Cell Significance Index: -9.0300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2220
    Cell Significance Index: -3.0800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2340
    Cell Significance Index: -8.5900
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2553
    Cell Significance Index: -1.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PLAGL2 is a 1,144-amino acid protein that belongs to the PLAG1 family, which is characterized by the presence of a zinc finger domain. This domain is essential for the protein's ability to bind to specific DNA sequences, thereby regulating gene expression. PLAGL2 is predominantly expressed in cells of the nervous system, kidney, and gastrointestinal tract. Its expression is regulated by various transcription factors, including the PPARγ coactivator PGC-1α, which suggests a complex interplay between PLAGL2 and other transcriptional regulators. **Pathways and Functions:** PLAGL2 is involved in several biological pathways, including: 1. **Chylomicron assembly**: PLAGL2 regulates the expression of genes involved in lipid metabolism, including those involved in chylomicron assembly and transport. 2. **DNA-binding transcription activator activity**: PLAGL2 acts as a transcriptional activator, modulating the expression of genes involved in cell growth, differentiation, and survival. 3. **Positive regulation of intrinsic apoptotic signaling pathway**: PLAGL2 can regulate the expression of genes involved in apoptosis, thereby influencing cell survival and death. 4. **Lipid metabolic process**: PLAGL2 is involved in the regulation of lipid metabolism, including the synthesis and degradation of lipids. **Functions:** PLAGL2's functions can be broadly categorized into the following: 1. **Transcriptional regulation**: PLAGL2 regulates the expression of genes involved in various cellular processes, including development, metabolism, and apoptosis. 2. **Cell growth and differentiation**: PLAGL2 modulates the expression of genes involved in cell growth and differentiation, influencing the development of various tissues and organs. 3. **Apoptosis regulation**: PLAGL2 regulates the expression of genes involved in apoptosis, influencing cell survival and death. **Clinical Significance:** PLAGL2 has been implicated in various human diseases, including: 1. **Obesity and metabolic disorders**: PLAGL2 has been shown to regulate lipid metabolism and energy homeostasis, making it a potential target for the treatment of obesity and metabolic disorders. 2. **Neurodegenerative diseases**: PLAGL2 has been implicated in the regulation of neuronal survival and death, making it a potential target for the treatment of neurodegenerative diseases such as Alzheimer's and Parkinson's. 3. **Cancer**: PLAGL2 has been shown to regulate the expression of genes involved in cell growth and apoptosis, making it a potential target for the treatment of various types of cancer. In conclusion, PLAGL2 is a multifunctional protein that plays a crucial role in various cellular processes, including transcriptional regulation, cell growth and differentiation, and apoptosis regulation. Its dysregulation has been implicated in various human diseases, making it a potential target for the development of new therapeutic strategies.

Genular Protein ID: 548775206

Symbol: PLAL2_HUMAN

Name: Zinc finger protein PLAGL2

UniProtKB Accession Codes:

Q9UPG8 A8K8T5 E1P5M3 Q92584

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9722527

Title: Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.

PubMed ID: 9722527

DOI: 10.1074/jbc.273.36.23026

PubMed ID: 8724849

Title: Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 8724849

DOI: 10.1093/dnares/3.1.17

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 496
  • Mass: 54584
  • Checksum: 20F5E7A28EF60603
  • Sequence:
    • MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS NGEKLRPHSL 
PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC MYCDKMFHRK DHLRNHLQTH 
DPNKEALHCS ECGKNYNTKL GYRRHLAMHA ASSGDLSCKV CLQTFESTQA LLEHLKAHSR 
RVAGGAKEKK HPCDHCDRRF YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK 
SHSQELLKIK TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA 
HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL PDKLPKVEVD 
SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP ANLSEALCAA NVDFSHLLGF 
LPLNLPPCNP PGATGGLVMG YSQAEAQPLL TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT 
SGLSSTTLPR FHQAFQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.