Details for: BTBD1

Gene ID: 53339

Symbol: BTBD1

Ensembl ID: ENSG00000064726

Description: BTB domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 191.9056
    Cell Significance Index: -29.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 120.7601
    Cell Significance Index: -30.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.9818
    Cell Significance Index: -33.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.9927
    Cell Significance Index: -26.8100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.5468
    Cell Significance Index: -30.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.3218
    Cell Significance Index: -27.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 25.4429
    Cell Significance Index: -31.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9916
    Cell Significance Index: -29.4500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1925
    Cell Significance Index: -17.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0245
    Cell Significance Index: -31.6700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9412
    Cell Significance Index: 26.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3706
    Cell Significance Index: 274.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.2267
    Cell Significance Index: 26.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0251
    Cell Significance Index: 166.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9821
    Cell Significance Index: 75.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9460
    Cell Significance Index: 187.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6569
    Cell Significance Index: 454.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6461
    Cell Significance Index: 231.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5717
    Cell Significance Index: 14.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4943
    Cell Significance Index: 12.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4829
    Cell Significance Index: 87.0600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4731
    Cell Significance Index: 7.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4556
    Cell Significance Index: 9.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4395
    Cell Significance Index: 19.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3974
    Cell Significance Index: 48.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3561
    Cell Significance Index: 10.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3350
    Cell Significance Index: 18.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3022
    Cell Significance Index: 18.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2950
    Cell Significance Index: 15.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2945
    Cell Significance Index: 160.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2799
    Cell Significance Index: 33.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2394
    Cell Significance Index: 12.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2215
    Cell Significance Index: 3.2700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1932
    Cell Significance Index: 2.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1908
    Cell Significance Index: 18.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1861
    Cell Significance Index: 25.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1635
    Cell Significance Index: 301.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1587
    Cell Significance Index: 70.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1091
    Cell Significance Index: 3.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1035
    Cell Significance Index: 194.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0869
    Cell Significance Index: 55.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0620
    Cell Significance Index: 1.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0568
    Cell Significance Index: 87.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0495
    Cell Significance Index: 3.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0489
    Cell Significance Index: 22.2100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0378
    Cell Significance Index: 1.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0356
    Cell Significance Index: 0.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0321
    Cell Significance Index: 43.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0300
    Cell Significance Index: 5.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0239
    Cell Significance Index: 1.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0198
    Cell Significance Index: 0.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0083
    Cell Significance Index: 0.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0071
    Cell Significance Index: 0.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0075
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0084
    Cell Significance Index: -6.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0122
    Cell Significance Index: -11.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0155
    Cell Significance Index: -2.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0176
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0207
    Cell Significance Index: -15.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0353
    Cell Significance Index: -19.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0366
    Cell Significance Index: -27.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0385
    Cell Significance Index: -7.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0392
    Cell Significance Index: -5.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0472
    Cell Significance Index: -3.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0536
    Cell Significance Index: -5.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0697
    Cell Significance Index: -1.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0846
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0872
    Cell Significance Index: -18.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0940
    Cell Significance Index: -27.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1046
    Cell Significance Index: -11.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1086
    Cell Significance Index: -12.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1312
    Cell Significance Index: -3.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1489
    Cell Significance Index: -3.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1519
    Cell Significance Index: -2.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1594
    Cell Significance Index: -20.5900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1672
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1781
    Cell Significance Index: -20.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1809
    Cell Significance Index: -3.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1892
    Cell Significance Index: -5.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2101
    Cell Significance Index: -4.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2239
    Cell Significance Index: -6.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2278
    Cell Significance Index: -16.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2329
    Cell Significance Index: -24.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2510
    Cell Significance Index: -4.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2563
    Cell Significance Index: -3.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3194
    Cell Significance Index: -16.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3229
    Cell Significance Index: -25.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3497
    Cell Significance Index: -10.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3542
    Cell Significance Index: -12.3100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3728
    Cell Significance Index: -3.0400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4046
    Cell Significance Index: -5.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4368
    Cell Significance Index: -12.5200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.4425
    Cell Significance Index: -7.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4469
    Cell Significance Index: -11.7500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4698
    Cell Significance Index: -9.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5091
    Cell Significance Index: -5.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5185
    Cell Significance Index: -16.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5259
    Cell Significance Index: -16.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5343
    Cell Significance Index: -32.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The BTBD1 gene is characterized by its unique BTB/POZ domain, which confers specific protein-protein interactions and binding capabilities. This domain is essential for the protein's function in regulating protein ubiquitination and proteasome degradation. The BTBD1 protein is also involved in the regulation of protein binding, including interactions with Cullin family proteins, which are crucial for neddylation and ubiquitination processes. **Pathways and Functions:** The BTBD1 gene is involved in various cellular pathways, including: 1. **Adaptive Immune System:** BTBD1 plays a critical role in the adaptive immune response, particularly in antigen processing and presentation. This involves the interaction with Class I MHC molecules, which are essential for the presentation of antigens to CD8+ T cells. 2. **Antigen Processing: Ubiquitination & Proteasome Degradation:** BTBD1 regulates the ubiquitination and proteasome degradation of proteins, which is a crucial step in the processing of antigens for presentation to immune cells. 3. **Protein Modification:** BTBD1 is involved in the regulation of protein binding, including interactions with Cullin family proteins, which are essential for neddylation and ubiquitination processes. 4. **Metabolism of Proteins:** BTBD1 regulates the metabolism of proteins, including the ubiquitination and degradation of proteins. **Clinical Significance:** The BTBD1 gene has been studied in the context of various diseases, including: 1. **Autoimmune Disorders:** BTBD1 has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, where it is thought to play a role in the regulation of immune responses. 2. **Cancer:** BTBD1 has been studied in the context of cancer, where it is thought to play a role in the regulation of protein degradation and metabolism. 3. **Neurological Disorders:** BTBD1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it is thought to play a role in the regulation of protein degradation and metabolism. In conclusion, the BTBD1 gene is a complex and multifaceted gene that plays a crucial role in the regulation of immune responses, protein modification, and cellular regulation. Further studies are needed to fully understand the mechanisms by which BTBD1 functions and its clinical significance in various diseases.

Genular Protein ID: 1457327962

Symbol: BTBD1_HUMAN

Name: BTB/POZ domain-containing protein 1

UniProtKB Accession Codes:

Q9H0C5 A6NMI8 Q9BX71 Q9NWN4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11179693

Title: Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24.

PubMed ID: 11179693

DOI: 10.1016/s0378-1119(00)00513-8

PubMed ID: 11818025

Title: Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with topoisomerase I.

PubMed ID: 11818025

DOI: 10.1186/1471-2164-3-1

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12878161

Title: BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.

PubMed ID: 12878161

DOI: 10.1016/s0014-4827(03)00187-3

PubMed ID: 14528312

Title: Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.

PubMed ID: 14528312

DOI: 10.1038/ncb1056

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 482
  • Mass: 52771
  • Checksum: 525A49E01728AFF0
  • Sequence:
    • MASLGPAAAG EQASGAEAEP GPAGPPPPPS PSSLGPLLPL QREPLYNWQA TKASLKERFA 
FLFNSELLSD VRFVLGKGRG AAAAGGPQRI PAHRFVLAAG SAVFDAMFNG GMATTSAEIE 
LPDVEPAAFL ALLRFLYSDE VQIGPETVMT TLYTAKKYAV PALEAHCVEF LTKHLRADNA 
FMLLTQARLF DEPQLASLCL DTIDKSTMDA ISAEGFTDID IDTLCAVLER DTLSIRESRL 
FGAVVRWAEA ECQRQQLPVT FGNKQKVLGK ALSLIRFPLM TIEEFAAGPA QSGILSDREV 
VNLFLHFTVN PKPRVEYIDR PRCCLRGKEC CINRFQQVES RWGYSGTSDR IRFTVNRRIS 
IVGFGLYGSI HGPTDYQVNI QIIEYEKKQT LGQNDTGFSC DGTANTFRVM FKEPIEILPN 
VCYTACATLK GPDSHYGTKG LKKVVHETPA ASKTVFFFFS SPGNNNGTSI EDGQIPEIIF 
YT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.