Details for: IL17D

Gene ID: 53342

Symbol: IL17D

Ensembl ID: ENSG00000172458

Description: interleukin 17D

Associated with

  • Cytokine activity
    (GO:0005125)
  • Extracellular space
    (GO:0005615)
  • Inflammatory response
    (GO:0006954)
  • Negative regulation of hemopoiesis
    (GO:1903707)
  • Positive regulation of cytokine production involved in inflammatory response
    (GO:1900017)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Protein homodimerization activity
    (GO:0042803)
  • Receptor ligand activity
    (GO:0048018)
  • Signal transduction
    (GO:0007165)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.7335
    Cell Significance Index: -11.6000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.6414
    Cell Significance Index: 40.0500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 1.1521
    Cell Significance Index: 16.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.9966
    Cell Significance Index: 61.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6430
    Cell Significance Index: 128.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4210
    Cell Significance Index: 18.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4057
    Cell Significance Index: 77.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3734
    Cell Significance Index: 14.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3297
    Cell Significance Index: 5.2300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.3089
    Cell Significance Index: 5.0900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2985
    Cell Significance Index: 7.2300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2377
    Cell Significance Index: 4.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2281
    Cell Significance Index: 81.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2250
    Cell Significance Index: 22.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1648
    Cell Significance Index: 148.8200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.1186
    Cell Significance Index: 2.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1186
    Cell Significance Index: 82.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1151
    Cell Significance Index: 18.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1130
    Cell Significance Index: 7.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1080
    Cell Significance Index: 6.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1079
    Cell Significance Index: 6.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1075
    Cell Significance Index: 11.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0676
    Cell Significance Index: 1.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0462
    Cell Significance Index: 6.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0387
    Cell Significance Index: 1.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0163
    Cell Significance Index: 1.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0121
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0074
    Cell Significance Index: 13.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0055
    Cell Significance Index: 0.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0012
    Cell Significance Index: 0.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0012
    Cell Significance Index: -0.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0016
    Cell Significance Index: -0.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0058
    Cell Significance Index: -8.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0060
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0084
    Cell Significance Index: -11.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0086
    Cell Significance Index: -4.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0133
    Cell Significance Index: -5.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0146
    Cell Significance Index: -9.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -12.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0164
    Cell Significance Index: -12.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0177
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0211
    Cell Significance Index: -13.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0223
    Cell Significance Index: -12.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0239
    Cell Significance Index: -10.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0272
    Cell Significance Index: -5.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0275
    Cell Significance Index: -4.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0323
    Cell Significance Index: -9.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0328
    Cell Significance Index: -1.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0415
    Cell Significance Index: -4.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0501
    Cell Significance Index: -6.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0571
    Cell Significance Index: -9.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0635
    Cell Significance Index: -13.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0760
    Cell Significance Index: -9.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0763
    Cell Significance Index: -1.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0834
    Cell Significance Index: -2.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0845
    Cell Significance Index: -1.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0862
    Cell Significance Index: -11.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0899
    Cell Significance Index: -2.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0972
    Cell Significance Index: -9.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1031
    Cell Significance Index: -10.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1070
    Cell Significance Index: -12.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1075
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1079
    Cell Significance Index: -12.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1149
    Cell Significance Index: -8.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1168
    Cell Significance Index: -3.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1192
    Cell Significance Index: -8.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1357
    Cell Significance Index: -7.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1368
    Cell Significance Index: -3.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1388
    Cell Significance Index: -3.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1418
    Cell Significance Index: -3.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1579
    Cell Significance Index: -11.7700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1589
    Cell Significance Index: -2.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1663
    Cell Significance Index: -10.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1786
    Cell Significance Index: -3.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1842
    Cell Significance Index: -9.6700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1878
    Cell Significance Index: -3.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1909
    Cell Significance Index: -6.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2032
    Cell Significance Index: -9.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2079
    Cell Significance Index: -10.8300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2095
    Cell Significance Index: -2.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2115
    Cell Significance Index: -7.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2119
    Cell Significance Index: -9.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2143
    Cell Significance Index: -5.9900
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.2218
    Cell Significance Index: -2.4700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2285
    Cell Significance Index: -5.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2462
    Cell Significance Index: -4.1200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2559
    Cell Significance Index: -5.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2585
    Cell Significance Index: -5.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2605
    Cell Significance Index: -5.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2790
    Cell Significance Index: -5.8400
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2837
    Cell Significance Index: -3.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2987
    Cell Significance Index: -10.3800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3048
    Cell Significance Index: -4.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3125
    Cell Significance Index: -6.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3225
    Cell Significance Index: -8.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3370
    Cell Significance Index: -12.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3483
    Cell Significance Index: -10.2600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3591
    Cell Significance Index: -4.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure and Function:** IL17D is a secreted protein that belongs to the IL-17 family of cytokines, which are characterized by the presence of a conserved cysteine-rich domain. IL17D has been shown to interact with the IL-17 receptor A (IL-17RA) and IL-17 receptor C (IL-17RC) to mediate its biological effects. 2. **Expression Patterns:** IL17D is expressed in various cell types, including hematopoietic oligopotent progenitor cells, type I muscle cells, hippocampal astrocytes, intestinal tuft cells, and epithelial cells of the pancreas. 3. **Regulatory Role:** IL17D has been shown to regulate the production of various cytokines, including granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-6 (IL-6), and interleukin-8 (IL-8), which are involved in the inflammatory response. 4. **Cellular Interactions:** IL17D has been shown to interact with various immune cells, including T cells, B cells, and dendritic cells, to regulate their activation and differentiation. **Pathways and Functions:** 1. **Inflammatory Response:** IL17D has been shown to play a key role in the regulation of the inflammatory response by inducing the production of pro-inflammatory cytokines, such as IL-6 and IL-8. 2. **Cytokine Production:** IL17D has been shown to regulate the production of various cytokines, including GM-CSF, which is involved in the differentiation and activation of immune cells. 3. **Immune Cell Activation:** IL17D has been shown to activate immune cells, including T cells and dendritic cells, to regulate their activation and differentiation. 4. **Regulation of Hemopoiesis:** IL17D has been shown to regulate the production of hematopoietic cells by interacting with hematopoietic oligopotent progenitor cells. **Clinical Significance:** 1. **Inflammatory Disorders:** IL17D has been implicated in the pathogenesis of various inflammatory disorders, including rheumatoid arthritis, psoriasis, and inflammatory bowel disease. 2. **Cancer:** IL17D has been shown to play a role in the regulation of the immune response in cancer, and its dysregulation has been implicated in the development of various types of cancer. 3. **Neurological Disorders:** IL17D has been implicated in the regulation of the immune response in neurological disorders, including multiple sclerosis and Alzheimer's disease. 4. **Immunotherapy:** IL17D has been shown to be a potential target for immunotherapy, particularly in the context of cancer and autoimmune disorders. In conclusion, IL17D is a key effector molecule involved in the regulation of immune responses, particularly in the context of inflammation. Its dysregulation has been implicated in various diseases, including inflammatory disorders, cancer, and neurological disorders. Further research is needed to fully understand the role of IL17D in these diseases and to develop effective therapeutic strategies.

Genular Protein ID: 940811117

Symbol: IL17D_HUMAN

Name: Interleukin-17D

UniProtKB Accession Codes:

Q8TAD2 B1AM69

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12097364

Title: Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis.

PubMed ID: 12097364

DOI: 10.4049/jimmunol.169.2.642

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 202
  • Mass: 21893
  • Checksum: D171C5FB2DD039C3
  • Sequence:
    • MLVAGFLLAL PPSWAAGAPR AGRRPARPRG CADRPEELLE QLYGRLAAGV LSAFHHTLQL 
GPREQARNAS CPAGGRPADR RFRPPTNLRS VSPWAYRISY DPARYPRYLP EAYCLCRGCL 
TGLFGEEDVR FRSAPVYMPT VVLRRTPACA GGRSVYTEAY VTIPVGCTCV PEPEKDADSI 
NSSIDKQGAK LLLGPNDAPA GP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.