Details for: TM6SF1

Gene ID: 53346

Symbol: TM6SF1

Ensembl ID: ENSG00000136404

Description: transmembrane 6 superfamily member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 83.8984
    Cell Significance Index: -13.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 51.6867
    Cell Significance Index: -13.1100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.0180
    Cell Significance Index: -10.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.5843
    Cell Significance Index: -13.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4385
    Cell Significance Index: -11.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6136
    Cell Significance Index: -5.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.6131
    Cell Significance Index: 234.4800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4740
    Cell Significance Index: 95.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4071
    Cell Significance Index: 3.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3454
    Cell Significance Index: 238.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3117
    Cell Significance Index: 19.1600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.2272
    Cell Significance Index: 2.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2252
    Cell Significance Index: 5.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2120
    Cell Significance Index: 2.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1096
    Cell Significance Index: 202.1900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1049
    Cell Significance Index: 2.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1033
    Cell Significance Index: 1.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0740
    Cell Significance Index: 26.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0288
    Cell Significance Index: 44.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0141
    Cell Significance Index: 1.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0120
    Cell Significance Index: 16.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0088
    Cell Significance Index: 1.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0059
    Cell Significance Index: 11.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0006
    Cell Significance Index: 0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0143
    Cell Significance Index: -6.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0157
    Cell Significance Index: -11.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0179
    Cell Significance Index: -13.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0180
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0184
    Cell Significance Index: -13.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0200
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0241
    Cell Significance Index: -15.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0262
    Cell Significance Index: -14.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0332
    Cell Significance Index: -6.5800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0365
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0368
    Cell Significance Index: -10.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0390
    Cell Significance Index: -4.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0415
    Cell Significance Index: -0.8800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0461
    Cell Significance Index: -0.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0500
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0705
    Cell Significance Index: -14.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0829
    Cell Significance Index: -6.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0836
    Cell Significance Index: -2.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0836
    Cell Significance Index: -10.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0853
    Cell Significance Index: -14.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0919
    Cell Significance Index: -12.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0924
    Cell Significance Index: -11.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0930
    Cell Significance Index: -10.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1017
    Cell Significance Index: -5.3000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1036
    Cell Significance Index: -1.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1124
    Cell Significance Index: -6.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1196
    Cell Significance Index: -2.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1198
    Cell Significance Index: -12.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1234
    Cell Significance Index: -2.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1262
    Cell Significance Index: -5.9300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1282
    Cell Significance Index: -1.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1295
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1300
    Cell Significance Index: -14.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1306
    Cell Significance Index: -9.2400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1424
    Cell Significance Index: -6.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1452
    Cell Significance Index: -11.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1572
    Cell Significance Index: -0.9500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1596
    Cell Significance Index: -1.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1598
    Cell Significance Index: -11.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1610
    Cell Significance Index: -10.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1712
    Cell Significance Index: -8.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1802
    Cell Significance Index: -5.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1852
    Cell Significance Index: -8.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1918
    Cell Significance Index: -6.1100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1942
    Cell Significance Index: -2.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2029
    Cell Significance Index: -12.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2050
    Cell Significance Index: -6.0200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2065
    Cell Significance Index: -5.1500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2101
    Cell Significance Index: -4.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2152
    Cell Significance Index: -7.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2197
    Cell Significance Index: -8.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2211
    Cell Significance Index: -6.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2239
    Cell Significance Index: -11.6300
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.2240
    Cell Significance Index: -2.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2262
    Cell Significance Index: -13.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2400
    Cell Significance Index: -11.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2508
    Cell Significance Index: -6.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2683
    Cell Significance Index: -3.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2784
    Cell Significance Index: -12.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2895
    Cell Significance Index: -7.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3040
    Cell Significance Index: -6.3500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.3060
    Cell Significance Index: -4.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3182
    Cell Significance Index: -8.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3287
    Cell Significance Index: -6.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3289
    Cell Significance Index: -11.4300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3304
    Cell Significance Index: -4.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3310
    Cell Significance Index: -12.1500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3339
    Cell Significance Index: -10.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3653
    Cell Significance Index: -7.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3743
    Cell Significance Index: -10.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3796
    Cell Significance Index: -11.1800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3810
    Cell Significance Index: -4.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3847
    Cell Significance Index: -4.3700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3857
    Cell Significance Index: -5.4900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3906
    Cell Significance Index: -8.4400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4054
    Cell Significance Index: -8.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TM6SF1 is a transmembrane protein belonging to the transmembrane 6 superfamily, which is characterized by its six transmembrane domains. The gene is approximately 12 kb in length and contains 11 exons. TM6SF1 is primarily expressed in cells of hematopoietic origin, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and mucosal type mast cells. Its expression pattern is also observed in other cell types, such as epidermal Langerhans cells, pigmented ciliary epithelial cells, and neurons. **Pathways and Functions:** TM6SF1 is involved in various cellular processes, including immune regulation, cellular development, and signal transduction. Its functional roles are mediated through its interactions with other proteins, such as receptors and ligands, which are involved in the regulation of immune responses. Specifically, TM6SF1 has been shown to interact with the CD8-alpha-beta receptor, which is involved in the regulation of T cell responses. Additionally, TM6SF1 has been implicated in the regulation of mast cell degranulation and the release of cytokines. **Clinical Significance:** TM6SF1 has been associated with various immune-related disorders, including autoimmune diseases and immunodeficiencies. For instance, studies have shown that TM6SF1 is overexpressed in patients with rheumatoid arthritis and systemic lupus erythematosus. Furthermore, TM6SF1 has been implicated in the regulation of the immune response in patients with multiple sclerosis. Additionally, TM6SF1 has been identified as a potential therapeutic target for the treatment of immunodeficiencies and autoimmune diseases. In conclusion, TM6SF1 is a complex gene that plays a crucial role in modulating immune responses and maintaining tissue homeostasis. Its unique expression pattern and functional roles suggest that TM6SF1 is a key regulator of immune-related processes, and further research is needed to fully elucidate its role in human disease. **Future Directions:** Further research is needed to fully elucidate the functional roles of TM6SF1 in immune regulation and cellular development. Specifically, studies should focus on the interactions between TM6SF1 and other proteins, as well as its involvement in the regulation of immune responses in different disease contexts. Additionally, TM6SF1 may serve as a potential therapeutic target for the treatment of immunodeficiencies and autoimmune diseases.

Genular Protein ID: 1752360032

Symbol: TM6S1_HUMAN

Name: Transmembrane 6 superfamily member 1

UniProtKB Accession Codes:

Q9BZW5 A8K7T5 H3BU56 Q4U0U5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11124529

Title: Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-q26 and 19p13.3-p12.

PubMed ID: 11124529

DOI: 10.1159/000056784

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 25566323

Title: TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease.

PubMed ID: 25566323

DOI: 10.3389/fgene.2014.00439

Sequence Information:

  • Length: 370
  • Mass: 41636
  • Checksum: 57E0BC11BBF16D68
  • Sequence:
    • MSASAATGVF VLSLSAIPVT YVFNHLAAQH DSWTIVGVAA LILFLVALLA RVLVKRKPPR 
DPLFYVYAVF GFTSVVNLII GLEQDGIIDG FMTHYLREGE PYLNTAYGHM ICYWDGSAHY 
LMYLVMVAAI AWEETYRTIG LYWVGSIIMS VVVFVPGNIV GKYGTRICPA FFLSIPYTCL 
PVWAGFRIYN QPSENYNYPS KVIQEAQAKD LLRRPFDLML VVCLLLATGF CLFRGLIALD 
CPSELCRLYT QFQEPYLKDP AAYPKIQMLA YMFYSVPYFV TALYGLVVPG CSWMPDITLI 
HAGGLAQAQF SHIGASLHAR TAYVYRVPEE AKILFLALNI AYGVLPQLLA YRCIYKPEFF 
IKTKAEEKVE

Genular Protein ID: 2138401171

Symbol: Q6P4D7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P4D7

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Proteomes 2 RefSeq 4 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 188
  • Mass: 20868
  • Checksum: 225C8363FC1F76CC
  • Sequence:
    • MSASAATGVF VLSLSAIPVT YVFNHLAAQH DSWTIVGVAA LILFLVALLA RVLVKRKPPR 
DPLFYVYAVF GFTSVVNLII GLEQDGIIDG FMTHYLREGE PYLNTAYGHM ICYWDGSAHY 
LMYLVMVAAI AWEETYRTIG LYWVGSIIMS VVVFVPGNIV DAGIYVLFCS LLCDCTVWLS 
GSWMFLDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.