Details for: UBASH3A

Gene ID: 53347

Symbol: UBASH3A

Ensembl ID: ENSG00000160185

Description: ubiquitin associated and SH3 domain containing A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 18.8370
    Cell Significance Index: -2.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.1430
    Cell Significance Index: -3.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.6244
    Cell Significance Index: -3.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.4305
    Cell Significance Index: -4.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.4007
    Cell Significance Index: -2.9600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 2.0692
    Cell Significance Index: 23.4300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.3344
    Cell Significance Index: 13.3800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.9702
    Cell Significance Index: -2.9800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8628
    Cell Significance Index: 25.3400
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.6103
    Cell Significance Index: 1.8600
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.5922
    Cell Significance Index: 6.1400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.5917
    Cell Significance Index: 1.5900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.2709
    Cell Significance Index: 4.6700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.2093
    Cell Significance Index: 3.0000
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.0595
    Cell Significance Index: 0.5200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0330
    Cell Significance Index: 0.1800
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.0250
    Cell Significance Index: 0.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0014
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0013
    Cell Significance Index: -2.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0018
    Cell Significance Index: -2.7100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0028
    Cell Significance Index: -1.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0043
    Cell Significance Index: -3.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0052
    Cell Significance Index: -3.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0053
    Cell Significance Index: -3.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -3.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0078
    Cell Significance Index: -1.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0081
    Cell Significance Index: -2.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0082
    Cell Significance Index: -3.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0110
    Cell Significance Index: -2.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0122
    Cell Significance Index: -3.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0167
    Cell Significance Index: -2.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0205
    Cell Significance Index: -3.7000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0206
    Cell Significance Index: -0.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0229
    Cell Significance Index: -3.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0254
    Cell Significance Index: -3.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0259
    Cell Significance Index: -3.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0266
    Cell Significance Index: -3.0500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0271
    Cell Significance Index: -0.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0273
    Cell Significance Index: -3.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0276
    Cell Significance Index: -2.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0282
    Cell Significance Index: -3.6400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0296
    Cell Significance Index: -0.3500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0301
    Cell Significance Index: -0.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0303
    Cell Significance Index: -1.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0308
    Cell Significance Index: -3.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0310
    Cell Significance Index: -3.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0318
    Cell Significance Index: -1.3000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0340
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0396
    Cell Significance Index: -0.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0397
    Cell Significance Index: -2.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0437
    Cell Significance Index: -0.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0445
    Cell Significance Index: -1.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0448
    Cell Significance Index: -3.4400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0471
    Cell Significance Index: -0.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0507
    Cell Significance Index: -3.7800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0528
    Cell Significance Index: -1.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0547
    Cell Significance Index: -1.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0551
    Cell Significance Index: -1.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0649
    Cell Significance Index: -4.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0652
    Cell Significance Index: -4.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0655
    Cell Significance Index: -3.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0674
    Cell Significance Index: -3.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0690
    Cell Significance Index: -2.2600
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0708
    Cell Significance Index: -0.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0710
    Cell Significance Index: -3.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0713
    Cell Significance Index: -2.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0737
    Cell Significance Index: -3.2600
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0770
    Cell Significance Index: -0.7300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0772
    Cell Significance Index: -1.5700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0778
    Cell Significance Index: -0.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0790
    Cell Significance Index: -2.0300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0793
    Cell Significance Index: -1.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0801
    Cell Significance Index: -4.1700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0842
    Cell Significance Index: -1.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0858
    Cell Significance Index: -3.2500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0902
    Cell Significance Index: -1.3500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0903
    Cell Significance Index: -2.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0918
    Cell Significance Index: -2.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0929
    Cell Significance Index: -2.4900
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: -0.0963
    Cell Significance Index: -0.7900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0973
    Cell Significance Index: -3.5700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1002
    Cell Significance Index: -1.5500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1021
    Cell Significance Index: -3.2300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1046
    Cell Significance Index: -2.2600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1054
    Cell Significance Index: -1.0700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1073
    Cell Significance Index: -2.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1104
    Cell Significance Index: -3.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1127
    Cell Significance Index: -1.9000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.1130
    Cell Significance Index: -1.0200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1139
    Cell Significance Index: -1.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1145
    Cell Significance Index: -3.0100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1147
    Cell Significance Index: -1.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1150
    Cell Significance Index: -2.4400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1161
    Cell Significance Index: -2.2900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1162
    Cell Significance Index: -1.1500
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.1165
    Cell Significance Index: -1.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBASH3A is a ubiquitin-associated protein that exhibits a unique combination of SH3 (Src homology 3) and ubiquitin-binding domains. This structural architecture enables it to interact with a wide range of proteins, including those involved in T-cell receptor signaling, cytokine production, and cell migration. The gene's expression profile is characterized by its significant presence in immune cells, including T cells, mast cells, and epithelial cells, which underscores its role in maintaining immune homeostasis. **Pathways and Functions:** UBASH3A is involved in several key pathways, including: 1. **Negative regulation of T-cell receptor signaling pathway**: UBASH3A acts as a negative regulator of T-cell receptor signaling, thereby modulating the immune response and preventing excessive inflammation. 2. **Regulation of cytokine production**: UBASH3A influences the production of cytokines, which are essential for coordinating the immune response and maintaining tissue homeostasis. 3. **Extracellular exosome-mediated communication**: UBASH3A is involved in the formation and secretion of exosomes, which facilitate intercellular communication and immune modulation. **Clinical Significance:** UBASH3A's dysregulation has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: UBASH3A's role in regulating T-cell receptor signaling and cytokine production makes it a potential target for the treatment of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: UBASH3A's involvement in cell migration and immune evasion mechanisms makes it a potential target for cancer therapy. 3. **Inflammatory bowel disease**: UBASH3A's dysregulation has been linked to the pathogenesis of inflammatory bowel disease, highlighting its potential as a therapeutic target. In conclusion, UBASH3A is a complex gene that plays a crucial role in regulating immune cell function and disease. Its dysregulation has been implicated in various immune-related disorders, making it a promising target for the development of novel therapeutic strategies. Further research is necessary to fully elucidate UBASH3A's mechanisms and to explore its potential as a therapeutic agent.

Genular Protein ID: 2196478491

Symbol: UBS3A_HUMAN

Name: Ubiquitin-associated and SH3 domain-containing protein A

UniProtKB Accession Codes:

P57075 G5E9E4 Q6HA34 Q6HA35 Q6ISI6 Q6ISK3 Q6ISS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11281453

Title: Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains.

PubMed ID: 11281453

DOI: 10.1007/s004390000453

PubMed ID: 15107835

Title: TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.

PubMed ID: 15107835

DOI: 10.1038/sj.onc.1207627

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15159412

Title: Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.

PubMed ID: 15159412

DOI: 10.1074/jbc.m403759200

PubMed ID: 17382318

Title: The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.

PubMed ID: 17382318

DOI: 10.1016/j.yexcr.2007.02.017

PubMed ID: 18189269

Title: TULA proteins regulate activity of the protein tyrosine kinase Syk.

PubMed ID: 18189269

DOI: 10.1002/jcb.21678

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 661
  • Mass: 74123
  • Checksum: 60DA2E0B8CE4ABFC
  • Sequence:
    • MAAGETQLYA KVSNKLKSRS SPSLLEPLLA MGFPVHTALK ALAATGRKTA EEALAWLHDH 
CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE 
DQKVECLYEA LKRAGDRLLG SFPTAVPLAL HSSISYLGFF VSGSPADVIR EFAMTFATEA 
SLLAGTSVSR FWIFSQVPGH GPNLRLSNLT RASFVSHYIL QKYCSVKPCT KQLHLTLAHK 
FYPHHQRTLE QLARAIPLGH SCQWTAALYS RDMRFVHYQT LRALFQYKPQ NVDELTLSPG 
DYIFVDPTQQ DEASEGWVIG ISQRTGCRGF LPENYTDRAS ESDTWVKHRM YTFSLATDLN 
SRKDGEASSR CSGEFLPQTA RSLSSLQALQ ATVARKSVLV VRHGERVDQI FGKAWLQQCS 
TPDGKYYRPD LNFPCSLPRR SRGIKDFEND PPLSSCGIFQ SRIAGDALLD SGIRISSVFA 
SPALRCVQTA KLILEELKLE KKIKIRVEPG IFEWTKWEAG KTTPTLMSLE ELKEANFNID 
TDYRPAFPLS ALMPAESYQE YMDRCTASMV QIVNTCPQDT GVILIVSHGS TLDSCTRPLL 
GLPPRECGDF AQLVRKIPSL GMCFCEENKE EGKWELVNPP VKTLTHGANA AFNWRNWISG 
N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.