Details for: PLD1

Gene ID: 5337

Symbol: PLD1

Ensembl ID: ENSG00000075651

Description: phospholipase D1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 183.7408
    Cell Significance Index: -28.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.5309
    Cell Significance Index: -29.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 76.9273
    Cell Significance Index: -31.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 57.0575
    Cell Significance Index: -23.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.6059
    Cell Significance Index: -29.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4023
    Cell Significance Index: -29.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.1782
    Cell Significance Index: 111.9600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.7193
    Cell Significance Index: 37.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.5169
    Cell Significance Index: 75.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.3755
    Cell Significance Index: 259.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.2310
    Cell Significance Index: 63.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.6527
    Cell Significance Index: 66.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.3348
    Cell Significance Index: 65.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.7021
    Cell Significance Index: 1080.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6399
    Cell Significance Index: 266.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.5805
    Cell Significance Index: 2975.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.2959
    Cell Significance Index: 65.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1773
    Cell Significance Index: 233.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1423
    Cell Significance Index: 68.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1310
    Cell Significance Index: 32.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0901
    Cell Significance Index: 73.3000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8955
    Cell Significance Index: 12.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7803
    Cell Significance Index: 35.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5665
    Cell Significance Index: 36.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5305
    Cell Significance Index: 721.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4733
    Cell Significance Index: 728.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4661
    Cell Significance Index: 93.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4444
    Cell Significance Index: 401.3000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.3858
    Cell Significance Index: 40.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3787
    Cell Significance Index: 19.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3507
    Cell Significance Index: 24.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3031
    Cell Significance Index: 14.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2907
    Cell Significance Index: 28.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2774
    Cell Significance Index: 50.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1935
    Cell Significance Index: 356.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1678
    Cell Significance Index: 76.1400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1457
    Cell Significance Index: 0.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1456
    Cell Significance Index: 2.1500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1177
    Cell Significance Index: 4.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0998
    Cell Significance Index: 18.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0740
    Cell Significance Index: 9.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0339
    Cell Significance Index: 18.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0172
    Cell Significance Index: 11.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0151
    Cell Significance Index: 6.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0039
    Cell Significance Index: 0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0101
    Cell Significance Index: -6.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0110
    Cell Significance Index: -0.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0119
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0119
    Cell Significance Index: -8.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0132
    Cell Significance Index: -2.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0285
    Cell Significance Index: -10.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0308
    Cell Significance Index: -17.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0333
    Cell Significance Index: -24.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0352
    Cell Significance Index: -4.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0402
    Cell Significance Index: -30.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0645
    Cell Significance Index: -0.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0657
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0697
    Cell Significance Index: -14.6800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0772
    Cell Significance Index: -22.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0786
    Cell Significance Index: -9.1600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0885
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1209
    Cell Significance Index: -13.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1413
    Cell Significance Index: -3.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1619
    Cell Significance Index: -20.7600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1753
    Cell Significance Index: -1.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1782
    Cell Significance Index: -18.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2062
    Cell Significance Index: -26.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2071
    Cell Significance Index: -5.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2484
    Cell Significance Index: -29.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2498
    Cell Significance Index: -28.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2827
    Cell Significance Index: -13.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2872
    Cell Significance Index: -9.2000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2913
    Cell Significance Index: -4.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3189
    Cell Significance Index: -25.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3372
    Cell Significance Index: -20.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3440
    Cell Significance Index: -24.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3621
    Cell Significance Index: -26.9900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4055
    Cell Significance Index: -5.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4057
    Cell Significance Index: -11.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4100
    Cell Significance Index: -25.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4341
    Cell Significance Index: -22.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4433
    Cell Significance Index: -6.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.4571
    Cell Significance Index: -6.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4608
    Cell Significance Index: -4.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4804
    Cell Significance Index: -26.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4881
    Cell Significance Index: -4.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4921
    Cell Significance Index: -21.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4981
    Cell Significance Index: -26.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4999
    Cell Significance Index: -31.5100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.5028
    Cell Significance Index: -7.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5939
    Cell Significance Index: -8.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6132
    Cell Significance Index: -22.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6174
    Cell Significance Index: -23.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6354
    Cell Significance Index: -13.7700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6671
    Cell Significance Index: -21.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.7022
    Cell Significance Index: -11.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7046
    Cell Significance Index: -19.1800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7054
    Cell Significance Index: -10.1500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7115
    Cell Significance Index: -8.9800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.7240
    Cell Significance Index: -11.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Catalytic activity:** PLD1 is a phospholipase that hydrolyzes phosphatidylcholine and phosphatidylethanolamine to produce phosphatidic acid. 2. **Tissue expression:** PLD1 is highly expressed in cardiac myocytes, epithelial cells, oligodendrocytes, and smooth muscle cells. 3. **Cellular localization:** PLD1 is localized to the plasma membrane, Golgi apparatus, and endosomes. 4. **Subcellular localization:** PLD1 is also found in the perinuclear region of the cytoplasm and in intracellular membrane-bounded organelles. 5. **Regulatory mechanisms:** PLD1 is regulated by various signaling pathways, including the Cdc42 GTPase cycle, Rac1 GTPase cycle, and Rho GTPase cycle. **Pathways and Functions:** 1. **Glycerophospholipid biosynthesis:** PLD1 is involved in the biosynthesis of glycerophospholipids, including phosphatidic acid and phosphatidylinositol. 2. **Phospholipid metabolism:** PLD1 plays a key role in regulating phospholipid metabolism, including phospholipid catabolic processes and phospholipid metabolism. 3. **Signaling pathways:** PLD1 is involved in various signaling pathways, including the Cdc42 GTPase cycle, Rac1 GTPase cycle, Rho GTPase cycle, and Ras protein signal transduction. 4. **Immune response:** PLD1 is involved in regulating immune response, including neutrophil degranulation, Fcγ receptor-dependent phagocytosis, and chemotaxis. 5. **Vesicle-mediated transport:** PLD1 regulates vesicle-mediated transport, including endocytic vesicle, late endosome membrane, and lysosomal membrane. **Clinical Significance:** 1. **Cardiovascular disease:** PLD1 has been implicated in cardiovascular disease, including hypertension and cardiac arrhythmias. 2. **Neurological disorders:** PLD1 has been associated with various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer:** PLD1 has been implicated in cancer progression, including tumor growth, invasion, and metastasis. 4. **Infectious diseases:** PLD1 plays a role in regulating immune response to infectious diseases, including bacterial and viral infections. 5. **Neuroinflammation:** PLD1 has been implicated in neuroinflammation, including the regulation of microvillus assembly and synaptic vesicle cycle. In conclusion, PLD1 is a multifunctional enzyme involved in various cellular processes, including lipid metabolism, signaling pathways, and immune response. Its dysregulation has been implicated in various diseases, including cardiovascular disease, neurological disorders, cancer, and infectious diseases. Further research is needed to fully understand the role of PLD1 in human health and disease.

Genular Protein ID: 2893225297

Symbol: PLD1_HUMAN

Name: Choline phosphatase 1

UniProtKB Accession Codes:

Q13393

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CORUM 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 27 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 8 RefSeq 4 Rhea 6 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530346

Title: Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family.

PubMed ID: 8530346

DOI: 10.1074/jbc.270.50.29640

PubMed ID: 9013646

Title: Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha.

PubMed ID: 9013646

DOI: 10.1074/jbc.272.6.3860

PubMed ID: 9761774

Title: Characterization of human PLD2 and the analysis of PLD isoform splice variants.

PubMed ID: 9761774

DOI: 10.1096/fasebj.12.13.1309

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582313

Title: Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2.

PubMed ID: 9582313

DOI: 10.1074/jbc.273.21.12846

PubMed ID: 11032811

Title: Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity.

PubMed ID: 11032811

DOI: 10.1093/emboj/19.20.5440

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25936805

Title: Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.

PubMed ID: 25936805

DOI: 10.1016/j.molcel.2015.03.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27799408

Title: Congenital valvular defects associated with deleterious mutations in the PLD1 gene.

PubMed ID: 27799408

DOI: 10.1136/jmedgenet-2016-104259

Sequence Information:

  • Length: 1074
  • Mass: 124184
  • Checksum: 734F285790A0BF7A
  • Sequence:
    • MSLKNEPRVN TSALQKIAAD MSNIIENLDT RELHFEGEEV DYDVSPSDPK IQEVYIPFSA 
IYNTQGFKEP NIQTYLSGCP IKAQVLEVER FTSTTRVPSI NLYTIELTHG EFKWQVKRKF 
KHFQEFHREL LKYKAFIRIP IPTRRHTFRR QNVREEPREM PSLPRSSENM IREEQFLGRR 
KQLEDYLTKI LKMPMYRNYH ATTEFLDISQ LSFIHDLGPK GIEGMIMKRS GGHRIPGLNC 
CGQGRACYRW SKRWLIVKDS FLLYMKPDSG AIAFVLLVDK EFKIKVGKKE TETKYGIRID 
NLSRTLILKC NSYRHARWWG GAIEEFIQKH GTNFLKDHRF GSYAAIQENA LAKWYVNAKG 
YFEDVANAME EANEEIFITD WWLSPEIFLK RPVVEGNRWR LDCILKRKAQ QGVRIFIMLY 
KEVELALGIN SEYTKRTLMR LHPNIKVMRH PDHVSSTVYL WAHHEKLVII DQSVAFVGGI 
DLAYGRWDDN EHRLTDVGSV KRVTSGPSLG SLPPAAMESM ESLRLKDKNE PVQNLPIQKS 
IDDVDSKLKG IGKPRKFSKF SLYKQLHRHH LHDADSISSI DSTSSYFNHY RSHHNLIHGL 
KPHFKLFHPS SESEQGLTRP HADTGSIRSL QTGVGELHGE TRFWHGKDYC NFVFKDWVQL 
DKPFADFIDR YSTPRMPWHD IASAVHGKAA RDVARHFIQR WNFTKIMKSK YRSLSYPFLL 
PKSQTTAHEL RYQVPGSVHA NVQLLRSAAD WSAGIKYHEE SIHAAYVHVI ENSRHYIYIE 
NQFFISCADD KVVFNKIGDA IAQRILKAHR ENQKYRVYVV IPLLPGFEGD ISTGGGNALQ 
AIMHFNYRTM CRGENSILGQ LKAELGNQWI NYISFCGLRT HAELEGNLVT ELIYVHSKLL 
IADDNTVIIG SANINDRSML GKRDSEMAVI VQDTETVPSV MDGKEYQAGR FARGLRLQCF 
RVVLGYLDDP SEDIQDPVSD KFFKEVWVST AARNATIYDK VFRCLPNDEV HNLIQLRDFI 
NKPVLAKEDP IRAEEELKKI RGFLVQFPFY FLSEESLLPS VGTKEAIVPM EVWT

Genular Protein ID: 3890378875

Symbol: Q59EA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EA4

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 3 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 4 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 2 SMART 3 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 1059
  • Mass: 122009
  • Checksum: BC5A4072C54AC053
  • Sequence:
    • ANAQVLAAPS PCSPFAFTLS KVNMSLKNEP RVNTSALQKI AADMSNIIEN LDTRELHFEG 
EEVDYDVSPS DPKIQEVYIP FSAIYNTQGF KEPNIQTYLS GCPIKAQVLE VERFTSTTRV 
PSINLYTIEL THGEFKWQVK RKFKHFQEFH RELLKYKAFI RIPIPTRRHT FRRQNVREEP 
REMPSLPRSS ENMIREEQFL GRRKQLEDYL TKILKMPMYR NYHATTEFLD ISQLSFIHDL 
GPKGIEGMIM KRSGGHRIPG LNCCGQGRAC YRWSKRWLIV KDSFLLYMKP DSGAIAFVLL 
VDKEFKIKVG KKETETKYGI RIDNLSRTLI LKCNSYRHAR WWGGAIEEFI QKHGTNFLKD 
HRFGSYAAIQ ENALAKWYVN AKGYFEDVAN AMEEANEEIF ITDWWLSPEI FLKRPVVEGN 
RWRLDCILKR KAQQGVRIFI MLYKEVELAL GINSEYTKRT LMRLHPNIKV MRHPDHVSST 
VYLWAHHEKL VIIDQSVAFV GGIDLAYGRW DDNEHRLTDV GSVKRVTSGP SLGSLPPAAM 
ESMESLRLKD KNEPVQNLPI QKSIDDVDSK LKGIGKPRKF SKFSLYKQLH RHHLHDADSI 
SSIDSTSNTG SIRSLQTGVG ELHGETRFWH GKDYCNFVFK DWVQLDKPFA DFIDRYSTPR 
MPWHDIASAV HGKAARDVAR HFIQRWNFTK IMKSKYRSLS YPFLLPKSQT TAHELRYQVP 
GSVHANVQLL RSAADWSAGI KYHEESIHAA YVHVIENSRH YIYIENQFFI SCADDKVVFN 
KIGDAIAQRI LKAHRENQKY RVYVVIPLLP GFEGDISTGG GNALQAIMHF NYRTMCRGEN 
SILGQLKAEL GNQWINYISF CGLRTHAELE GNLVTELIYV HSKLLIADDN TVIIGSANIN 
DRSMLGKRDS EMAVIVQDTE TVPSVMDGKE YQAGRFARGL RLQCFRVVLG YLDDPSEDIQ 
DPVSDKFFKE VWVSTAARNA TIYDKVFRCL PNDEVHNLIQ LRDFINKPVL AKEDPIRAEE 
ELKKIRGFLV QFPFYFLSEE SLLPSVGTKE AIVPMEVWT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.