Details for: STX18

Gene ID: 53407

Symbol: STX18

Ensembl ID: ENSG00000168818

Description: syntaxin 18

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.6654
    Cell Significance Index: -36.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.5122
    Cell Significance Index: -35.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 98.9446
    Cell Significance Index: -40.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.4831
    Cell Significance Index: -38.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.3586
    Cell Significance Index: -32.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 71.2890
    Cell Significance Index: -36.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 57.3752
    Cell Significance Index: -38.5000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.3336
    Cell Significance Index: -37.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5356
    Cell Significance Index: -36.2600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9595
    Cell Significance Index: -30.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7008
    Cell Significance Index: -38.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.6357
    Cell Significance Index: -18.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.9470
    Cell Significance Index: 91.1900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2716
    Cell Significance Index: 36.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9471
    Cell Significance Index: 134.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6216
    Cell Significance Index: 885.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5103
    Cell Significance Index: 84.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4852
    Cell Significance Index: 297.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3509
    Cell Significance Index: 268.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2826
    Cell Significance Index: 1158.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0561
    Cell Significance Index: 39.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0250
    Cell Significance Index: 45.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0204
    Cell Significance Index: 27.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9850
    Cell Significance Index: 353.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9495
    Cell Significance Index: 57.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9244
    Cell Significance Index: 100.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9224
    Cell Significance Index: 118.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7848
    Cell Significance Index: 127.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6713
    Cell Significance Index: 464.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5225
    Cell Significance Index: 15.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4919
    Cell Significance Index: 9.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4807
    Cell Significance Index: 36.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4215
    Cell Significance Index: 9.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3626
    Cell Significance Index: 22.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3552
    Cell Significance Index: 9.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3363
    Cell Significance Index: 46.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3355
    Cell Significance Index: 41.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2697
    Cell Significance Index: 48.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2680
    Cell Significance Index: 7.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2423
    Cell Significance Index: 5.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1973
    Cell Significance Index: 13.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1602
    Cell Significance Index: 7.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1453
    Cell Significance Index: 3.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1390
    Cell Significance Index: 7.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1302
    Cell Significance Index: 82.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1273
    Cell Significance Index: 239.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1204
    Cell Significance Index: 4.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1064
    Cell Significance Index: 10.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1047
    Cell Significance Index: 46.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0856
    Cell Significance Index: 116.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0793
    Cell Significance Index: 146.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0787
    Cell Significance Index: 121.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0689
    Cell Significance Index: 31.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0682
    Cell Significance Index: 4.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0663
    Cell Significance Index: 12.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0088
    Cell Significance Index: 1.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0024
    Cell Significance Index: 0.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0094
    Cell Significance Index: -0.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0193
    Cell Significance Index: -2.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0353
    Cell Significance Index: -1.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0373
    Cell Significance Index: -2.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0383
    Cell Significance Index: -28.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0386
    Cell Significance Index: -29.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0397
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0410
    Cell Significance Index: -7.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0579
    Cell Significance Index: -7.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0641
    Cell Significance Index: -36.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0692
    Cell Significance Index: -43.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0711
    Cell Significance Index: -7.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0780
    Cell Significance Index: -5.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1118
    Cell Significance Index: -32.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1333
    Cell Significance Index: -6.0400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1705
    Cell Significance Index: -4.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1795
    Cell Significance Index: -20.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1827
    Cell Significance Index: -1.4900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1914
    Cell Significance Index: -22.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1942
    Cell Significance Index: -40.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2083
    Cell Significance Index: -14.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2258
    Cell Significance Index: -3.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2788
    Cell Significance Index: -7.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2822
    Cell Significance Index: -29.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2999
    Cell Significance Index: -3.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3397
    Cell Significance Index: -17.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3455
    Cell Significance Index: -27.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3459
    Cell Significance Index: -12.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3523
    Cell Significance Index: -4.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3640
    Cell Significance Index: -10.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3661
    Cell Significance Index: -19.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4021
    Cell Significance Index: -12.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4524
    Cell Significance Index: -7.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5051
    Cell Significance Index: -30.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5214
    Cell Significance Index: -13.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5570
    Cell Significance Index: -14.9000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5623
    Cell Significance Index: -8.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5627
    Cell Significance Index: -8.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5739
    Cell Significance Index: -12.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5944
    Cell Significance Index: -8.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6142
    Cell Significance Index: -20.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6324
    Cell Significance Index: -20.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** STX18 is a member of the syntaxin family, which consists of four distinct proteins: syntaxin 1, syntaxin 2, syntaxin 3, and syntaxin 18. These proteins share a similar structure, consisting of an N-terminal globular domain, a transmembrane region, and a C-terminal globular domain. The unique characteristics of STX18 include its ability to interact with other proteins, such as SNAP-25 and VAMP2, to facilitate membrane fusion and vesicle trafficking. Additionally, STX18 has been shown to be involved in the regulation of golgi organization and the positive regulation of ER-to-Golgi vesicle-mediated transport. **Pathways and Functions:** STX18 is involved in various cellular processes, including: 1. **Membrane Fusion and Vesicle Trafficking**: STX18 interacts with SNAP-25 and VAMP2 to facilitate the fusion of vesicles with the plasma membrane, playing a critical role in the regulation of membrane trafficking and synaptic transmission. 2. **Golgi Organization**: STX18 is involved in the regulation of golgi organization, ensuring the proper formation and function of the Golgi apparatus. 3. **ER-to-Golgi Vesicle-Mediated Transport**: STX18 is a positive regulator of ER-to-Golgi vesicle-mediated transport, facilitating the transport of proteins and lipids from the ER to the Golgi apparatus. 4. **Intracellular Protein Transport**: STX18 is involved in the regulation of intracellular protein transport, ensuring the proper distribution of proteins within the cell. **Clinical Significance:** STX18 has been implicated in various diseases, including: 1. **Immunodeficiency Disorders**: Mutations in STX18 have been associated with immunodeficiency disorders, such as X-linked immunodeficiency. 2. **Neurological Disorders**: STX18 has been implicated in neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer**: STX18 has been shown to be involved in cancer development and progression, particularly in hematological malignancies. 4. **Inflammatory Diseases**: STX18 has been implicated in inflammatory diseases, such as inflammatory bowel disease and rheumatoid arthritis. In conclusion, STX18 is a multifunctional protein that plays a critical role in various cellular processes, including membrane fusion, vesicle trafficking, and golgi organization. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of STX18 in immune cells and tissues. Further research is needed to elucidate the full extent of STX18's involvement in human disease and to develop therapeutic strategies for its manipulation.

Genular Protein ID: 3788122886

Symbol: STX18_HUMAN

Name: Syntaxin-18

UniProtKB Accession Codes:

Q9P2W9 Q596L3 Q5TZP5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10788491

Title: Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking.

PubMed ID: 10788491

DOI: 10.1074/jbc.275.18.13713

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15029241

Title: Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.

PubMed ID: 15029241

DOI: 10.1038/sj.emboj.7600135

PubMed ID: 15272311

Title: Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion.

PubMed ID: 15272311

DOI: 10.1038/sj.emboj.7600333

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 335
  • Mass: 38674
  • Checksum: D89B3B52407D77FF
  • Sequence:
    • MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS SRAREVISHI 
GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA QIFMRTCSEA IQQLRTEAHK 
EIHSQQVKEH RTAVLDFIED YLKRVCKLYS EQRAIRVKRV VDKKRLSKLE PEPNTKTRES 
TSSEKVSQSP SKDSEENPAT EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ 
RLIGEMNSLF DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE 
DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.