Details for: ADAM22

Gene ID: 53616

Symbol: ADAM22

Ensembl ID: ENSG00000008277

Description: ADAM metallopeptidase domain 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 252.7239
    Cell Significance Index: -39.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 153.4832
    Cell Significance Index: -38.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 79.7250
    Cell Significance Index: -37.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.9233
    Cell Significance Index: -39.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9948
    Cell Significance Index: -39.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 9.3942
    Cell Significance Index: 160.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 4.9815
    Cell Significance Index: 334.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.7934
    Cell Significance Index: 47.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.6674
    Cell Significance Index: 1315.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 3.0319
    Cell Significance Index: 86.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.0264
    Cell Significance Index: 72.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9177
    Cell Significance Index: 129.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8266
    Cell Significance Index: 567.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.7248
    Cell Significance Index: 167.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.6910
    Cell Significance Index: 101.9000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.9856
    Cell Significance Index: 25.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.9381
    Cell Significance Index: 1340.4600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.5000
    Cell Significance Index: 20.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9721
    Cell Significance Index: 54.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8453
    Cell Significance Index: 18.5100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.6043
    Cell Significance Index: 6.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5476
    Cell Significance Index: 54.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4341
    Cell Significance Index: 391.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.3304
    Cell Significance Index: 4.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2920
    Cell Significance Index: 57.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2912
    Cell Significance Index: 132.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2852
    Cell Significance Index: 7.1300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2750
    Cell Significance Index: 2.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2724
    Cell Significance Index: 44.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2169
    Cell Significance Index: 9.8300
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.1383
    Cell Significance Index: 1.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1195
    Cell Significance Index: 6.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0778
    Cell Significance Index: 8.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0728
    Cell Significance Index: 112.0500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0678
    Cell Significance Index: 1.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0675
    Cell Significance Index: 12.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0484
    Cell Significance Index: 91.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0354
    Cell Significance Index: 1.0200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0309
    Cell Significance Index: 0.3900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0294
    Cell Significance Index: 0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0257
    Cell Significance Index: 34.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0147
    Cell Significance Index: 2.6500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0100
    Cell Significance Index: 0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0030
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0277
    Cell Significance Index: -17.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0285
    Cell Significance Index: -0.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0381
    Cell Significance Index: -0.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0443
    Cell Significance Index: -32.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0526
    Cell Significance Index: -38.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0553
    Cell Significance Index: -30.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0574
    Cell Significance Index: -43.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0711
    Cell Significance Index: -44.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0717
    Cell Significance Index: -40.4200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.0743
    Cell Significance Index: -0.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0977
    Cell Significance Index: -43.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1032
    Cell Significance Index: -2.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1064
    Cell Significance Index: -30.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1194
    Cell Significance Index: -1.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1564
    Cell Significance Index: -21.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1679
    Cell Significance Index: -20.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1728
    Cell Significance Index: -22.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1842
    Cell Significance Index: -26.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1917
    Cell Significance Index: -11.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1953
    Cell Significance Index: -6.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2023
    Cell Significance Index: -20.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2111
    Cell Significance Index: -5.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2126
    Cell Significance Index: -44.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2189
    Cell Significance Index: -16.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2352
    Cell Significance Index: -4.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2378
    Cell Significance Index: -14.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2443
    Cell Significance Index: -41.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2537
    Cell Significance Index: -13.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2550
    Cell Significance Index: -16.0700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2735
    Cell Significance Index: -5.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2858
    Cell Significance Index: -36.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2877
    Cell Significance Index: -9.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3053
    Cell Significance Index: -4.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3099
    Cell Significance Index: -32.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3176
    Cell Significance Index: -37.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3239
    Cell Significance Index: -38.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3261
    Cell Significance Index: -22.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3422
    Cell Significance Index: -39.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3598
    Cell Significance Index: -4.5400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3955
    Cell Significance Index: -4.7300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4097
    Cell Significance Index: -4.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4348
    Cell Significance Index: -9.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4411
    Cell Significance Index: -34.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4907
    Cell Significance Index: -36.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5027
    Cell Significance Index: -13.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5043
    Cell Significance Index: -10.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5095
    Cell Significance Index: -12.7100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5317
    Cell Significance Index: -5.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5474
    Cell Significance Index: -35.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5674
    Cell Significance Index: -29.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5822
    Cell Significance Index: -12.1500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5975
    Cell Significance Index: -20.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6336
    Cell Significance Index: -44.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7127
    Cell Significance Index: -33.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7468
    Cell Significance Index: -23.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADAM22 is a transmembrane protein that contains a disintegrin and metalloproteinase (MAD) domain, which is responsible for its proteolytic activity. The protein is characterized by its ability to bind to various ligands, including L1 cell adhesion molecule (L1CAM) and integrins, which are crucial for cell adhesion and migration. ADAM22 is also known to be involved in the regulation of axonal development and synaptic plasticity, particularly in the central nervous system. **Pathways and Functions:** ADAM22 is involved in several signaling pathways that regulate cell adhesion, migration, and development. These pathways include: 1. **Axon guidance:** ADAM22 is involved in the regulation of axon guidance and branching, particularly in the development of the central nervous system. 2. **Cell adhesion:** ADAM22 binds to L1CAM and integrins, which are crucial for cell adhesion and migration. 3. **Proteolysis:** ADAM22's proteolytic activity is involved in the regulation of various cellular processes, including cell adhesion, migration, and development. 4. **Synaptic plasticity:** ADAM22 is involved in the regulation of synaptic plasticity, particularly in the development of the central nervous system. **Clinical Significance:** ADAM22 has been implicated in several neurological disorders, including: 1. **Autism Spectrum Disorder (ASD):** Studies have shown that ADAM22 is significantly reduced in individuals with ASD, suggesting a potential link between ADAM22 dysfunction and ASD pathogenesis. 2. **Schizophrenia:** ADAM22 has been implicated in the regulation of synaptic plasticity and neuronal development, which are critical for the development of schizophrenia. 3. **Neurodegenerative diseases:** ADAM22 has been shown to be involved in the regulation of axonal development and synaptic plasticity, which are critical for the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's. In conclusion, ADAM22 is a key regulator of cell adhesion and axonal development in the central nervous system. Its dysregulation has been implicated in several neurological disorders, including ASD, schizophrenia, and neurodegenerative diseases. Further studies are needed to fully understand the role of ADAM22 in these disorders and to develop potential therapeutic strategies to target this protein.

Genular Protein ID: 662934439

Symbol: ADA22_HUMAN

Name: Disintegrin and metalloproteinase domain-containing protein 22

UniProtKB Accession Codes:

Q9P0K1 O75075 O75076 Q9P0K2 Q9UIA1 Q9UKK2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693107

Title: Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain.

PubMed ID: 9693107

DOI: 10.1042/bj3340093

PubMed ID: 11050470

Title: The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene in brain tissues and gliomas.

PubMed ID: 11050470

DOI: 10.1111/j.1349-7006.2000.tb00877.x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 10524237

Title: The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries.

PubMed ID: 10524237

DOI: 10.1016/s0378-1119(99)00302-9

PubMed ID: 12589811

Title: The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading.

PubMed ID: 12589811

DOI: 10.1016/s0006-291x(03)00056-1

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 15882968

Title: ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3.

PubMed ID: 15882968

DOI: 10.1016/j.bbrc.2005.03.229

PubMed ID: 16385342

Title: ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain.

PubMed ID: 16385342

DOI: 10.1227/01.neu.0000192363.84287.8b

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 27066583

Title: Dysfunctional ADAM22 implicated in progressive encephalopathy with cortical atrophy and epilepsy.

PubMed ID: 27066583

DOI: 10.1212/nxg.0000000000000046

PubMed ID: 19692335

Title: Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function.

PubMed ID: 19692335

DOI: 10.1074/jbc.m109.014258

Sequence Information:

  • Length: 906
  • Mass: 100433
  • Checksum: 265ECCD0FA6C088B
  • Sequence:
    • MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 
GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 
EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 
DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 
IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 
ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 
GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 
EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 
QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 
ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 
GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 
MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 
AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRQLP QGDYVKKPGD 
GDSFYSDIPP GVSTNSASSS KKRSNGLSHS WSERIPDTKH ISDICENGRP RSNSWQGNLG 
GNKKKIRGKR FRPRSNSTET LSPAKSPSSS TGSIASSRKY PYPMPPLPDE DKKVNRQSAR 
LWETSI

Genular Protein ID: 3894698123

Symbol: H7C3I4_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7C3I4

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 10 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 3 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

  • Length: 964
  • Mass: 107325
  • Checksum: AEA00DF8A028C268
  • Sequence:
    • MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 
GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 
EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 
DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 
IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 
ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 
GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 
EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 
QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 
ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 
GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 
MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 
AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRQLP QGDYVKKPGD 
GDSFYSDIPP GVSTNSASSS KKRSAFLSHF QISTCSITHY SISQNISLFC SRSNGLSHSW 
SERIPDTKHI SDICENGRPR SNSWQGNLGG NKKKIRGKRF RPRSNSTEYL NPWFKRDYNV 
AKWVEDVNKN TEGPYFRTLS PAKSPSSSTG SIASSRKYPY PMPPLPDEDK KVNRQSARLW 
ETSI

Genular Protein ID: 1821187995

Symbol: Q08AL8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q08AL8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 GO 3 Gene3D 3 InterPro 10 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 SAM 3 SMART 2 SUPFAM 2 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 870
  • Mass: 96696
  • Checksum: 3BDF8E14213F860E
  • Sequence:
    • MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 
GEDESRHDAL DTRVRGDLGG RQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 
EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 
DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 
IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 
ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 
GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 
EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 
QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 
ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 
GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 
MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 
AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRSNG LSHSWSERIP 
DTKHISDICE NGRPRSNSWQ GNLGGNKKKI RGKRFRPRSN STETLSPAKS PSSSTGSIAS 
SRKYPYPMPP LPDEDKKVNR QSARLWETSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.