Details for: PLXNA2

Gene ID: 5362

Symbol: PLXNA2

Ensembl ID: ENSG00000076356

Description: plexin A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 318.2997
    Cell Significance Index: -49.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 198.8619
    Cell Significance Index: -50.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.6290
    Cell Significance Index: -42.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.1061
    Cell Significance Index: -42.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.1555
    Cell Significance Index: -49.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.7356
    Cell Significance Index: -50.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.1957
    Cell Significance Index: -28.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7824
    Cell Significance Index: -50.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.4811
    Cell Significance Index: 64.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8893
    Cell Significance Index: 39.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.7889
    Cell Significance Index: 77.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.7587
    Cell Significance Index: 989.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4959
    Cell Significance Index: 500.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.8071
    Cell Significance Index: 81.9100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6898
    Cell Significance Index: 63.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4135
    Cell Significance Index: 86.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3617
    Cell Significance Index: 60.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3614
    Cell Significance Index: 221.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2926
    Cell Significance Index: 256.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2803
    Cell Significance Index: 1156.0500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1640
    Cell Significance Index: 27.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0800
    Cell Significance Index: 72.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0593
    Cell Significance Index: 732.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7184
    Cell Significance Index: 78.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6497
    Cell Significance Index: 18.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6369
    Cell Significance Index: 15.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6220
    Cell Significance Index: 37.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5691
    Cell Significance Index: 66.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5585
    Cell Significance Index: 68.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5331
    Cell Significance Index: 15.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5286
    Cell Significance Index: 52.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4946
    Cell Significance Index: 314.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4708
    Cell Significance Index: 26.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3915
    Cell Significance Index: 70.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3190
    Cell Significance Index: 22.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2953
    Cell Significance Index: 37.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2590
    Cell Significance Index: 9.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2392
    Cell Significance Index: 4.1000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1660
    Cell Significance Index: 2.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1611
    Cell Significance Index: 4.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1283
    Cell Significance Index: 9.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1272
    Cell Significance Index: 239.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1208
    Cell Significance Index: 54.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0820
    Cell Significance Index: 14.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0755
    Cell Significance Index: 14.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0679
    Cell Significance Index: 0.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0036
    Cell Significance Index: -1.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0081
    Cell Significance Index: -0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0129
    Cell Significance Index: -19.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0249
    Cell Significance Index: -45.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0251
    Cell Significance Index: -15.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0265
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0334
    Cell Significance Index: -24.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0408
    Cell Significance Index: -55.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0451
    Cell Significance Index: -33.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0451
    Cell Significance Index: -34.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0519
    Cell Significance Index: -29.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0576
    Cell Significance Index: -25.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1345
    Cell Significance Index: -28.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1549
    Cell Significance Index: -44.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1672
    Cell Significance Index: -3.5800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1702
    Cell Significance Index: -2.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2796
    Cell Significance Index: -38.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3163
    Cell Significance Index: -36.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3198
    Cell Significance Index: -36.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3541
    Cell Significance Index: -45.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3637
    Cell Significance Index: -7.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3701
    Cell Significance Index: -37.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3927
    Cell Significance Index: -20.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3943
    Cell Significance Index: -41.0600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4018
    Cell Significance Index: -5.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4038
    Cell Significance Index: -8.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4270
    Cell Significance Index: -50.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4899
    Cell Significance Index: -13.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4991
    Cell Significance Index: -35.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5103
    Cell Significance Index: -10.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5159
    Cell Significance Index: -16.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5680
    Cell Significance Index: -18.0900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5806
    Cell Significance Index: -8.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5897
    Cell Significance Index: -46.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6404
    Cell Significance Index: -47.7300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6898
    Cell Significance Index: -9.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7076
    Cell Significance Index: -36.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7108
    Cell Significance Index: -43.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7208
    Cell Significance Index: -19.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.7608
    Cell Significance Index: -49.0800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8039
    Cell Significance Index: -13.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.8604
    Cell Significance Index: -40.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8822
    Cell Significance Index: -23.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9131
    Cell Significance Index: -57.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9428
    Cell Significance Index: -43.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0061
    Cell Significance Index: -34.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0522
    Cell Significance Index: -36.8600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0660
    Cell Significance Index: -26.0100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0678
    Cell Significance Index: -23.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0976
    Cell Significance Index: -18.3700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.0996
    Cell Significance Index: -11.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.1257
    Cell Significance Index: -21.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1521
    Cell Significance Index: -36.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.1675
    Cell Significance Index: -16.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PLXNA2 is a transmembrane receptor with a large extracellular domain that contains a semaphorin-binding site. The protein has two immunoglobulin-like domains and a fibronectin type III-like domain, which are involved in protein-protein interactions. PLXNA2 is a homodimer, meaning it forms a pair of identical subunits, which is essential for its function. The protein is expressed in various tissues, including the nervous system, and is involved in multiple signaling pathways, including the semaphorin-plexin signaling pathway. **Pathways and Functions** PLXNA2 is involved in several signaling pathways, including: 1. **Sema3a-plexin repulsion signaling**: PLXNA2 interacts with semaphorin 3A (Sema3A) to repel axons and regulate axon guidance. 2. **Sema3a-pak dependent axon repulsion**: PLXNA2 interacts with Sema3A and the Rho GTPase-activating protein (Pak) to regulate axon repulsion. 3. **Regulation of cell migration**: PLXNA2 regulates cell migration by modulating the activity of Rho GTPases. 4. **Regulation of cell adhesion**: PLXNA2 regulates cell adhesion by modulating the activity of integrins. 5. **Regulation of axonogenesis**: PLXNA2 regulates axonogenesis by modulating the activity of Rho GTPases. **Clinical Significance** Dysregulation of PLXNA2 has been implicated in various neurological disorders, including: 1. **Autism spectrum disorder**: PLXNA2 has been identified as a risk gene for autism spectrum disorder. 2. **Schizophrenia**: PLXNA2 has been implicated in the pathophysiology of schizophrenia. 3. **Neurodevelopmental disorders**: PLXNA2 has been implicated in various neurodevelopmental disorders, including Down syndrome and Fragile X syndrome. In addition, PLXNA2 has been identified as a potential therapeutic target for the treatment of various neurological disorders, including stroke and spinal cord injury. Further research is needed to fully understand the role of PLXNA2 in human disease and to develop effective therapeutic strategies. In conclusion, PLXNA2 is a critical component of the semaphorin-plexin signaling pathway, which plays a key role in axon guidance, neuronal migration, and development. Dysregulation of PLXNA2 has been implicated in various neurological disorders, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 1447129255

Symbol: PLXA2_HUMAN

Name: Plexin-A2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9455484

Title: Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

PubMed ID: 9455484

DOI: 10.1093/dnares/4.5.345

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8570614

Title: A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.

PubMed ID: 8570614

DOI: 10.1073/pnas.93.2.674

PubMed ID: 10520995

Title: Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates.

PubMed ID: 10520995

DOI: 10.1016/s0092-8674(00)80063-x

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1894
  • Mass: 211104
  • Checksum: DFC3DE5BCBB40357
  • Sequence:
  • MEQRRPWPRA LEVDSRSVVL LSVVWVLLAP PAAGMPQFST FHSENRDWTF NHLTVHQGTG 
    AVYVGAINRV YKLTGNLTIQ VAHKTGPEED NKSCYPPLIV QPCSEVLTLT NNVNKLLIID 
    YSENRLLACG SLYQGVCKLL RLDDLFILVE PSHKKEHYLS SVNKTGTMYG VIVRSEGEDG 
    KLFIGTAVDG KQDYFPTLSS RKLPRDPESS AMLDYELHSD FVSSLIKIPS DTLALVSHFD 
    IFYIYGFASG GFVYFLTVQP ETPEGVAINS AGDLFYTSRI VRLCKDDPKF HSYVSLPFGC 
    TRAGVEYRLL QAAYLAKPGD SLAQAFNITS QDDVLFAIFS KGQKQYHHPP DDSALCAFPI 
    RAINLQIKER LQSCYQGEGN LELNWLLGKD VQCTKAPVPI DDNFCGLDIN QPLGGSTPVE 
    GLTLYTTSRD RMTSVASYVY NGYSVVFVGT KSGKLKKIRA DGPPHGGVQY EMVSVLKDGS 
    PILRDMAFSI DQRYLYVMSE RQVTRVPVES CEQYTTCGEC LSSGDPHCGW CALHNMCSRR 
    DKCQQAWEPN RFAASISQCV SLAVHPSSIS VSEHSRLLSL VVSDAPDLSA GIACAFGNLT 
    EVEGQVSGSQ VICISPGPKD VPVIPLDQDW FGLELQLRSK ETGKIFVSTE FKFYNCSAHQ 
    LCLSCVNSAF RCHWCKYRNL CTHDPTTCSF QEGRINISED CPQLVPTEEI LIPVGEVKPI 
    TLKARNLPQP QSGQRGYECV LNIQGAIHRV PALRFNSSSV QCQNSSYQYD GMDISNLAVD 
    FAVVWNGNFI IDNPQDLKVH LYKCAAQRES CGLCLKADRK FECGWCSGER RCTLHQHCTS 
    PSSPWLDWSS HNVKCSNPQI TEILTVSGPP EGGTRVTIHG VNLGLDFSEI AHHVQVAGVP 
    CTPLPGEYII AEQIVCEMGH ALVGTTSGPV RLCIGECKPE FMTKSHQQYT FVNPSVLSLN 
    PIRGPESGGT MVTITGHYLG AGSSVAVYLG NQTCEFYGRS MSEIVCVSPP SSNGLGPVPV 
    SVSVDRAHVD SNLQFEYIDD PRVQRIEPEW SIASGHTPLT ITGFNLDVIQ EPRIRVKFNG 
    KESVNVCKVV NTTTLTCLAP SLTTDYRPGL DTVERPDEFG FVFNNVQSLL IYNDTKFIYY 
    PNPTFELLSP TGVLDQKPGS PIILKGKNLC PPASGGAKLN YTVLIGETPC AVTVSETQLL 
    CEPPNLTGQH KVMVHVGGMV FSPGSVSVIS DSLLTLPAIV SIAAGGSLLL IIVIIVLIAY 
    KRKSRENDLT LKRLQMQMDN LESRVALECK EAFAELQTDI NELTSDLDRS GIPYLDYRTY 
    AMRVLFPGIE DHPVLRELEV QGNGQQHVEK ALKLFAQLIN NKVFLLTFIR TLELQRSFSM 
    RDRGNVASLI MTGLQGRLEY ATDVLKQLLS DLIDKNLENK NHPKLLLRRT ESVAEKMLTN 
    WFAFLLHKFL KECAGEPLFM LYCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIEYKTL 
    ILNCVNPDNE NSPEIPVKVL NCDTITQVKE KILDAVYKNV PYSQRPRAVD MDLEWRQGRI 
    ARVVLQDEDI TTKIEGDWKR LNTLMHYQVS DRSVVALVPK QTSSYNIPAS ASISRTSISR 
    YDSSFRYTGS PDSLRSRAPM ITPDLESGVK VWHLVKNHDH GDQKEGDRGS KMVSEIYLTR 
    LLATKGTLQK FVDDLFETLF STVHRGSALP LAIKYMFDFL DEQADRHSIH DTDVRHTWKS 
    NCLPLRFWVN VIKNPQFVFD IHKGSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY 
    AKDIPSYKSW VERYYADIAK LPAISDQDMN AYLAEQSRLH AVEFNMLSAL NEIYSYVSKY 
    SEELIGALEQ DEQARRQRLA YKVEQLINAM SIES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.