Details for: SEPTIN5

Gene ID: 5413

Symbol: SEPTIN5

Ensembl ID: ENSG00000184702

Description: septin 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.6453
    Cell Significance Index: -5.7000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.3345
    Cell Significance Index: -5.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.0151
    Cell Significance Index: -6.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 12.1893
    Cell Significance Index: -6.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.3577
    Cell Significance Index: -6.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6474
    Cell Significance Index: -5.7300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.4736
    Cell Significance Index: 2.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3635
    Cell Significance Index: 22.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3607
    Cell Significance Index: 8.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2003
    Cell Significance Index: 8.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1875
    Cell Significance Index: 7.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1748
    Cell Significance Index: 50.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1511
    Cell Significance Index: 3.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1223
    Cell Significance Index: 43.8600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1169
    Cell Significance Index: 1.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0784
    Cell Significance Index: 1.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0630
    Cell Significance Index: 12.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0630
    Cell Significance Index: 3.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0616
    Cell Significance Index: 4.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0590
    Cell Significance Index: 2.9800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0421
    Cell Significance Index: 0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0267
    Cell Significance Index: 3.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0016
    Cell Significance Index: -0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -5.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0028
    Cell Significance Index: -1.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0040
    Cell Significance Index: -6.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0043
    Cell Significance Index: -5.8300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0045
    Cell Significance Index: -2.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0076
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0081
    Cell Significance Index: -5.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0092
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0107
    Cell Significance Index: -6.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0112
    Cell Significance Index: -1.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0145
    Cell Significance Index: -6.5700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0167
    Cell Significance Index: -0.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0175
    Cell Significance Index: -0.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0199
    Cell Significance Index: -2.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0300
    Cell Significance Index: -0.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0303
    Cell Significance Index: -5.4600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0311
    Cell Significance Index: -6.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0319
    Cell Significance Index: -6.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0335
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0401
    Cell Significance Index: -6.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0448
    Cell Significance Index: -4.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0460
    Cell Significance Index: -5.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0484
    Cell Significance Index: -0.8100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0523
    Cell Significance Index: -0.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0544
    Cell Significance Index: -5.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0548
    Cell Significance Index: -1.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0560
    Cell Significance Index: -6.4200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0605
    Cell Significance Index: -0.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0717
    Cell Significance Index: -8.4600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0718
    Cell Significance Index: -0.9200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0740
    Cell Significance Index: -3.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0741
    Cell Significance Index: -4.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0743
    Cell Significance Index: -3.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0745
    Cell Significance Index: -4.1800
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0760
    Cell Significance Index: -0.6900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0875
    Cell Significance Index: -0.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0878
    Cell Significance Index: -2.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0935
    Cell Significance Index: -4.3600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0992
    Cell Significance Index: -0.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0994
    Cell Significance Index: -2.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1025
    Cell Significance Index: -3.3600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1039
    Cell Significance Index: -4.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1058
    Cell Significance Index: -3.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1124
    Cell Significance Index: -5.2900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1161
    Cell Significance Index: -2.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1193
    Cell Significance Index: -4.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1219
    Cell Significance Index: -3.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1245
    Cell Significance Index: -2.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1295
    Cell Significance Index: -3.3300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1300
    Cell Significance Index: -1.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1308
    Cell Significance Index: -5.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1333
    Cell Significance Index: -2.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1340
    Cell Significance Index: -2.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1370
    Cell Significance Index: -2.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1423
    Cell Significance Index: -1.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1471
    Cell Significance Index: -5.4000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1545
    Cell Significance Index: -1.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1552
    Cell Significance Index: -3.7600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1614
    Cell Significance Index: -2.6600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1664
    Cell Significance Index: -1.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1672
    Cell Significance Index: -4.1700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1716
    Cell Significance Index: -2.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1729
    Cell Significance Index: -8.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1758
    Cell Significance Index: -6.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1847
    Cell Significance Index: -6.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1862
    Cell Significance Index: -3.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1897
    Cell Significance Index: -3.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1905
    Cell Significance Index: -5.6100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1909
    Cell Significance Index: -2.3800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1952
    Cell Significance Index: -1.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2003
    Cell Significance Index: -3.9100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2163
    Cell Significance Index: -1.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2197
    Cell Significance Index: -6.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2200
    Cell Significance Index: -5.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SEPT5 exhibits several distinct characteristics that distinguish it from other septin family members. These include: 1. **Septin ring formation**: SEPT5 is capable of forming ring structures, which are essential for regulating cytoskeleton dynamics and cell division. 2. **Microtubule cytoskeleton organization**: SEPT5 interacts with microtubules, influencing their organization and stability, which is crucial for maintaining cellular structure and function. 3. **Protein binding and interaction**: SEPT5 interacts with various proteins, including other septins, microtubules, and actin filaments, to regulate cellular processes. 4. **GTPase activity**: SEPT5 possesses GTPase activity, which is essential for regulating its own activity and interacting with other proteins. **Pathways and Functions** SEPT5 is involved in several key cellular pathways, including: 1. **Cytoskeleton-dependent cytokinesis**: SEPT5 plays a crucial role in regulating cell division by interacting with the actin cytoskeleton and microtubules. 2. **Regulation of synaptic vesicle exocytosis**: SEPT5 is involved in regulating the release of synaptic vesicles, which is essential for neuronal communication and learning. 3. **Regulation of exocytosis**: SEPT5 interacts with proteins involved in the regulation of exocytosis, influencing cellular signaling and response to external stimuli. 4. **Adult behavior and social behavior**: SEPT5 is expressed in brain regions involved in social behavior and learning, suggesting its role in regulating these processes. **Clinical Significance** Dysregulation of SEPT5 has been implicated in various diseases, including: 1. **Neurodevelopmental disorders**: Abnormalities in SEPT5 expression and function have been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Immune system dysfunction**: SEPT5 is expressed in immune cells, and its dysregulation may contribute to immune system dysfunction and autoimmune diseases. 3. **Cancer**: SEPT5 has been implicated in the regulation of cell division and cytoskeleton organization, which are critical processes in cancer development and progression. In conclusion, SEPT5 is a multifunctional protein that plays critical roles in regulating cellular processes, including cell division, cytoskeleton organization, and synaptic vesicle trafficking. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SEPT5 function and its clinical significance.

Genular Protein ID: 4021584693

Symbol: SEPT5_HUMAN

Name: Septin-5

UniProtKB Accession Codes:

Q99719 O15251 Q96MY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9022087

Title: Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence.

PubMed ID: 9022087

DOI: 10.1172/jci119188

PubMed ID: 9385360

Title: A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11.

PubMed ID: 9385360

DOI: 10.1007/s004390050576

PubMed ID: 9611266

Title: Structure and expression of the human septin gene HCDCREL-1.

PubMed ID: 9611266

DOI: 10.1016/s0378-1119(98)00146-2

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12023038

Title: Human septin-septin interaction: CDCrel-1 partners with KIAA0202.

PubMed ID: 12023038

DOI: 10.1016/s0014-5793(02)02749-7

PubMed ID: 11880646

Title: A prototypic platelet septin and its participation in secretion.

PubMed ID: 11880646

DOI: 10.1073/pnas.052715199

PubMed ID: 14530399

Title: Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1.

PubMed ID: 14530399

DOI: 10.1073/pnas.2132992100

PubMed ID: 15915442

Title: Expression profiling the human septin gene family.

PubMed ID: 15915442

DOI: 10.1002/path.1789

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 369
  • Mass: 42777
  • Checksum: 47054765DEA10D33
  • Sequence:
    • MSTGLRYKSK LATPEDKQDI DKQYVGFATL PNQVHRKSVK KGFDFTLMVA GESGLGKSTL 
VHSLFLTDLY KDRKLLSAEE RISQTVEILK HTVDIEEKGV KLKLTIVDTP GFGDAVNNTE 
CWKPITDYVD QQFEQYFRDE SGLNRKNIQD NRVHCCLYFI SPFGHGLRPV DVGFMKALHE 
KVNIVPLIAK ADCLVPSEIR KLKERIREEI DKFGIHVYQF PECDSDEDED FKQQDRELKE 
SAPFAVIGSN TVVEAKGQRV RGRLYPWGIV EVENQAHCDF VKLRNMLIRT HMHDLKDVTC 
DVHYENYRAH CIQQMTSKLT QDSRMESPIP ILPLPTPDAE TEKLIRMKDE ELRRMQEMLQ 
RMKQQMQDQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.