Details for: POU3F2

Gene ID: 5454

Symbol: POU3F2

Ensembl ID: ENSG00000184486

Description: POU class 3 homeobox 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2630
    Cell Significance Index: 52.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1240
    Cell Significance Index: 85.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0460
    Cell Significance Index: 2.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0070
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0180
    Cell Significance Index: -33.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0244
    Cell Significance Index: -33.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0341
    Cell Significance Index: -25.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0392
    Cell Significance Index: -29.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0401
    Cell Significance Index: -25.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0412
    Cell Significance Index: -22.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0425
    Cell Significance Index: -23.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0543
    Cell Significance Index: -15.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0592
    Cell Significance Index: -26.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0601
    Cell Significance Index: -21.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1161
    Cell Significance Index: -23.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1214
    Cell Significance Index: -25.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1301
    Cell Significance Index: -23.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1400
    Cell Significance Index: -23.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1470
    Cell Significance Index: -17.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1694
    Cell Significance Index: -23.2600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1706
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1747
    Cell Significance Index: -25.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1920
    Cell Significance Index: -23.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2092
    Cell Significance Index: -11.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2094
    Cell Significance Index: -24.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2369
    Cell Significance Index: -24.2000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3397
    Cell Significance Index: -3.9600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3459
    Cell Significance Index: -5.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3966
    Cell Significance Index: -26.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4395
    Cell Significance Index: -10.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4417
    Cell Significance Index: -27.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4483
    Cell Significance Index: -20.3200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.4609
    Cell Significance Index: -4.1900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4791
    Cell Significance Index: -6.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5266
    Cell Significance Index: -27.6500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5342
    Cell Significance Index: -3.1700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.5359
    Cell Significance Index: -3.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5502
    Cell Significance Index: -25.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5575
    Cell Significance Index: -24.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5628
    Cell Significance Index: -15.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5688
    Cell Significance Index: -14.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5838
    Cell Significance Index: -14.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5848
    Cell Significance Index: -12.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5905
    Cell Significance Index: -22.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6551
    Cell Significance Index: -22.9500
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6632
    Cell Significance Index: -7.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6761
    Cell Significance Index: -21.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6949
    Cell Significance Index: -22.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7321
    Cell Significance Index: -25.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7437
    Cell Significance Index: -23.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7814
    Cell Significance Index: -22.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7955
    Cell Significance Index: -25.1600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.8617
    Cell Significance Index: -6.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8840
    Cell Significance Index: -32.4500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8930
    Cell Significance Index: -22.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9089
    Cell Significance Index: -26.7700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.9279
    Cell Significance Index: -12.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9408
    Cell Significance Index: -25.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9436
    Cell Significance Index: -16.1700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9494
    Cell Significance Index: -25.4400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.9663
    Cell Significance Index: -9.1600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.9666
    Cell Significance Index: -14.4600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9691
    Cell Significance Index: -21.2200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.9940
    Cell Significance Index: -16.3800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9982
    Cell Significance Index: -24.9000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0101
    Cell Significance Index: -27.0200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0271
    Cell Significance Index: -20.6200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0287
    Cell Significance Index: -27.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.0396
    Cell Significance Index: -22.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.0409
    Cell Significance Index: -48.5300
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -1.0430
    Cell Significance Index: -12.2900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0499
    Cell Significance Index: -26.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.0536
    Cell Significance Index: -53.2400
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -1.0663
    Cell Significance Index: -14.5000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -1.0770
    Cell Significance Index: -13.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.0851
    Cell Significance Index: -22.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0977
    Cell Significance Index: -31.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1188
    Cell Significance Index: -23.9200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -1.1319
    Cell Significance Index: -12.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1449
    Cell Significance Index: -24.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.1528
    Cell Significance Index: -24.0600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -1.1855
    Cell Significance Index: -11.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.1864
    Cell Significance Index: -23.3500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.1951
    Cell Significance Index: -13.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1951
    Cell Significance Index: -23.6300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -1.1951
    Cell Significance Index: -15.4400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.2423
    Cell Significance Index: -16.5600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.2636
    Cell Significance Index: -31.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2742
    Cell Significance Index: -31.0900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.2788
    Cell Significance Index: -25.5000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2855
    Cell Significance Index: -22.1600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -1.3088
    Cell Significance Index: -14.3400
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -1.3111
    Cell Significance Index: -15.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.3227
    Cell Significance Index: -14.3800
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -1.3320
    Cell Significance Index: -13.7800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -1.3441
    Cell Significance Index: -7.6400
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -1.3549
    Cell Significance Index: -13.9300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.3600
    Cell Significance Index: -15.4500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.3602
    Cell Significance Index: -21.5800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -1.3933
    Cell Significance Index: -15.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** POU3F2 is a member of the POU family of transcription factors, which are characterized by the presence of a POU domain. This domain is a conserved DNA-binding motif that allows POU3F2 to interact with specific DNA sequences and regulate gene expression. POU3F2 is primarily expressed in cells that are involved in neural development and function, including neurons, astrocytes, and blood vessel endothelial cells. Its expression is also detected in other cell types, such as goblet cells and cardiac endothelial cells. POU3F2 is a transcriptional activator, meaning that it regulates the expression of genes by binding to specific DNA sequences and recruiting other transcriptional co-factors. **Pathways and Functions:** POU3F2 is involved in several key pathways and processes, including: 1. **Neural Development:** POU3F2 is essential for the development of the nervous system, including the formation of neurons, astrocytes, and blood vessel endothelial cells. It regulates the expression of genes that are involved in neural differentiation and proliferation. 2. **Cell Proliferation:** POU3F2 is a positive regulator of cell proliferation, meaning that it promotes the growth and division of cells. It is involved in the regulation of the cell cycle and the expression of genes that are involved in cell growth and differentiation. 3. **Transcription Regulation:** POU3F2 is a transcriptional activator, meaning that it regulates the expression of genes by binding to specific DNA sequences and recruiting other transcriptional co-factors. It is involved in the regulation of the expression of genes that are involved in neural development, cell proliferation, and differentiation. 4. **Axonogenesis:** POU3F2 is involved in the regulation of axonogenesis, the process by which neurons extend axons. It regulates the expression of genes that are involved in axon growth and guidance. **Clinical Significance:** POU3F2 has been implicated in several diseases, including: 1. **Neurological Disorders:** POU3F2 has been implicated in the development of neurological disorders, including Parkinson's disease and amyotrophic lateral sclerosis (ALS). 2. **Cancer:** POU3F2 has been implicated in the development of certain types of cancer, including glioblastoma and breast cancer. 3. **Heart Disease:** POU3F2 has been implicated in the development of heart disease, including cardiac arrhythmias and cardiac hypertrophy. 4. **Kidney Disease:** POU3F2 has been implicated in the development of kidney disease, including chronic kidney disease and kidney failure. In conclusion, POU3F2 is a critical transcription factor that plays a pivotal role in neural development, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases, including neurological disorders, cancer, heart disease, and kidney disease. Further studies are needed to fully understand the role of POU3F2 in human disease and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 4046760082

Symbol: PO3F2_HUMAN

Name: POU domain, class 3, transcription factor 2

UniProtKB Accession Codes:

P20265 Q14960 Q86V54 Q9UJL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8441633

Title: cDNA cloning of human N-Oct3, a nervous-system specific POU domain transcription factor binding to the octamer DNA motif.

PubMed ID: 8441633

DOI: 10.1093/nar/21.2.253

PubMed ID: 7651733

Title: The brn-2 gene regulates the melanocytic phenotype and tumorigenic potential of human melanoma cells.

PubMed ID: 7651733

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2739723

Title: Expression of a large family of POU-domain regulatory genes in mammalian brain development.

PubMed ID: 2739723

DOI: 10.1038/340035a0

PubMed ID: 10332029

Title: PQBP-1, a novel polyglutamine tract binding protein, inhibits transcription activation by Brn-2 and affects cell survival.

PubMed ID: 10332029

DOI: 10.1093/hmg/8.6.977

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 443
  • Mass: 46893
  • Checksum: D470360894D788C6
  • Sequence:
    • MATAASNHYS LLTSSASIVH AEPPGGMQQG AGGYREAQSL VQGDYGALQS NGHPLSHAHQ 
WITALSHGGG GGGGGGGGGG GGGGGGGGDG SPWSTSPLGQ PDIKPSVVVQ QGGRGDELHG 
PGALQQQHQQ QQQQQQQQQQ QQQQQQQQQR PPHLVHHAAN HHPGPGAWRS AAAAAHLPPS 
MGASNGGLLY SQPSFTVNGM LGAGGQPAGL HHHGLRDAHD EPHHADHHPH PHSHPHQQPP 
PPPPPQGPPG HPGAHHDPHS DEDTPTSDDL EQFAKQFKQR RIKLGFTQAD VGLALGTLYG 
NVFSQTTICR FEALQLSFKN MCKLKPLLNK WLEEADSSSG SPTSIDKIAA QGRKRKKRTS 
IEVSVKGALE SHFLKCPKPS AQEITSLADS LQLEKEVVRV WFCNRRQKEK RMTPPGGTLP 
GAEDVYGGSR DTPPHHGVQT PVQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.