Details for: PPARD
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 167.6040
Cell Significance Index: -26.0700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 103.4523
Cell Significance Index: -26.2400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 55.9436
Cell Significance Index: -22.7300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 23.8598
Cell Significance Index: -22.7800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 21.2822
Cell Significance Index: -26.2400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.9184
Cell Significance Index: -26.5700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.3439
Cell Significance Index: -20.4500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.6548
Cell Significance Index: -26.2600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 4.3999
Cell Significance Index: 117.4900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.6792
Cell Significance Index: 87.2300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.6696
Cell Significance Index: 22.7800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.5265
Cell Significance Index: 177.9000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3173
Cell Significance Index: 250.6900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0644
Cell Significance Index: 213.5200 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.9193
Cell Significance Index: 22.4300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9039
Cell Significance Index: 179.3800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.7415
Cell Significance Index: 19.0600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7007
Cell Significance Index: 15.1800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6680
Cell Significance Index: 603.1200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6383
Cell Significance Index: 18.3900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6232
Cell Significance Index: 61.6500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5703
Cell Significance Index: 38.3500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.4363
Cell Significance Index: 33.4800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.4282
Cell Significance Index: 12.2200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4174
Cell Significance Index: 149.7000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4144
Cell Significance Index: 67.4000 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.3511
Cell Significance Index: 5.6700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3432
Cell Significance Index: 37.3300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3187
Cell Significance Index: 8.5400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2853
Cell Significance Index: 10.0300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2737
Cell Significance Index: 7.4500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2520
Cell Significance Index: 6.3000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2156
Cell Significance Index: 38.8700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2152
Cell Significance Index: 12.9200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1925
Cell Significance Index: 5.3800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1741
Cell Significance Index: 21.4100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1538
Cell Significance Index: 289.5300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1223
Cell Significance Index: 8.4600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1209
Cell Significance Index: 76.8000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1187
Cell Significance Index: 5.2500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0948
Cell Significance Index: 65.5700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0908
Cell Significance Index: 139.7200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0788
Cell Significance Index: 4.4200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0779
Cell Significance Index: 3.5300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0684
Cell Significance Index: 37.3400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0677
Cell Significance Index: 1.1600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0583
Cell Significance Index: 26.4400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0550
Cell Significance Index: 101.5100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0526
Cell Significance Index: 1.9900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0487
Cell Significance Index: 21.5100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0460
Cell Significance Index: 62.5400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.0456
Cell Significance Index: 0.5700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0256
Cell Significance Index: 3.5200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0214
Cell Significance Index: 1.3500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0200
Cell Significance Index: 3.4200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0163
Cell Significance Index: -12.1100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0216
Cell Significance Index: -13.4900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0244
Cell Significance Index: -13.7800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0261
Cell Significance Index: -0.4400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0280
Cell Significance Index: -20.5100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0292
Cell Significance Index: -22.1300 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.0499
Cell Significance Index: -0.3100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0545
Cell Significance Index: -6.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0661
Cell Significance Index: -13.9300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0743
Cell Significance Index: -10.8000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0768
Cell Significance Index: -22.1000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0831
Cell Significance Index: -4.3300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0876
Cell Significance Index: -8.9500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0931
Cell Significance Index: -10.9800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1022
Cell Significance Index: -11.6700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1058
Cell Significance Index: -4.9400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1133
Cell Significance Index: -12.9900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1189
Cell Significance Index: -15.3600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1591
Cell Significance Index: -1.4700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1688
Cell Significance Index: -7.9400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1796
Cell Significance Index: -18.7000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1891
Cell Significance Index: -11.6200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.1905
Cell Significance Index: -2.7400 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2093
Cell Significance Index: -2.9800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2216
Cell Significance Index: -15.6700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2392
Cell Significance Index: -3.5300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2426
Cell Significance Index: -18.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2569
Cell Significance Index: -13.4900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2792
Cell Significance Index: -17.1200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3032
Cell Significance Index: -24.0200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3041
Cell Significance Index: -9.7400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3125
Cell Significance Index: -20.1600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3223
Cell Significance Index: -16.2900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3304
Cell Significance Index: -5.5300 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.3603
Cell Significance Index: -6.0600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3972
Cell Significance Index: -2.4000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4111
Cell Significance Index: -6.1600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4508
Cell Significance Index: -9.6000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4653
Cell Significance Index: -14.8200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4727
Cell Significance Index: -13.5500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4759
Cell Significance Index: -15.5800 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4793
Cell Significance Index: -9.3600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5209
Cell Significance Index: -7.6900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.5269
Cell Significance Index: -7.9400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5454
Cell Significance Index: -14.3400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3008187600
Symbol: PPARD_HUMAN
Name: Peroxisome proliferator-activated receptor delta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1333051
Title: Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.
PubMed ID: 1333051
PubMed ID: 10851270
Title: Characterization of the human peroxisome proliferator activated receptor delta gene and its expression.
PubMed ID: 10851270
DOI: 10.3892/ijmm.6.1.73
PubMed ID: 18619963
Title: DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system.
PubMed ID: 18619963
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15604518
Title: Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.
PubMed ID: 15604518
PubMed ID: 35675826
Title: Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.
PubMed ID: 35675826
PubMed ID: 10198642
Title: Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.
PubMed ID: 10198642
PubMed ID: 10809235
Title: Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype.
PubMed ID: 10809235
PubMed ID: 16931011
Title: 3,4,5-trisubstituted isoxazoles as novel PPARdelta agonists. Part 2.
PubMed ID: 16931011
PubMed ID: 16405912
Title: Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.
PubMed ID: 16405912
PubMed ID: 16387648
Title: Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form.
PubMed ID: 16387648
PubMed ID: 17560785
PubMed ID: 18722772
Title: Discovery of a novel class of PPARdelta partial agonists.
PubMed ID: 18722772
PubMed ID: 19622862
Title: Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures.
PubMed ID: 19622862
PubMed ID: 19464171
Title: Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.
PubMed ID: 19464171
PubMed ID: 19116277
Title: Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.
PubMed ID: 19116277
Sequence Information:
- Length: 441
- Mass: 49903
- Checksum: 94FBB2A4B46521E8
- Sequence:
MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS PPSLLDQLQM GCDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERSCKIQKK NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQYNP QVADLKAFSK HIYNAYLKNF NMTKKKARSI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE ISVHVFYRCQ CTTVETVREL TEFAKSIPSF SSLFLNDQVT LLKYGVHEAI FAMLASIVNK DGLLVANGSG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGD RPGLMNVPRV EAIQDTILRA LEFHLQANHP DAQYLFPKLL QKMADLRQLV TEHAQMMQRI KKTETETSLH PLLQEIYKDM Y
Genular Protein ID: 2979614899
Symbol: F1D8S7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 361
- Mass: 40406
- Checksum: F97757AC266EF8BA
- Sequence:
MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS PPSLLDQLQM GCDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERSCKIQKK NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQYNP QVADLKAFSK HIYNAYLKNF NMTKKKARSI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE ISVHVFYRCQ CTTVETVREL TEFAKSIPSF SSLFLNDQVT LLKYGVHEAI FAMLASIVNK DGLLVANGSG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGG E
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.