Details for: PPARD

Gene ID: 5467

Symbol: PPARD

Ensembl ID: ENSG00000112033

Description: peroxisome proliferator activated receptor delta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 167.6040
    Cell Significance Index: -26.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 103.4523
    Cell Significance Index: -26.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.9436
    Cell Significance Index: -22.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.8598
    Cell Significance Index: -22.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.2822
    Cell Significance Index: -26.2400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9184
    Cell Significance Index: -26.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3439
    Cell Significance Index: -20.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.6548
    Cell Significance Index: -26.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.3999
    Cell Significance Index: 117.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6792
    Cell Significance Index: 87.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6696
    Cell Significance Index: 22.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5265
    Cell Significance Index: 177.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3173
    Cell Significance Index: 250.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0644
    Cell Significance Index: 213.5200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.9193
    Cell Significance Index: 22.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9039
    Cell Significance Index: 179.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7415
    Cell Significance Index: 19.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7007
    Cell Significance Index: 15.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6680
    Cell Significance Index: 603.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6383
    Cell Significance Index: 18.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6232
    Cell Significance Index: 61.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5703
    Cell Significance Index: 38.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4363
    Cell Significance Index: 33.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4282
    Cell Significance Index: 12.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4174
    Cell Significance Index: 149.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4144
    Cell Significance Index: 67.4000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.3511
    Cell Significance Index: 5.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3432
    Cell Significance Index: 37.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3187
    Cell Significance Index: 8.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2853
    Cell Significance Index: 10.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2737
    Cell Significance Index: 7.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2520
    Cell Significance Index: 6.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2156
    Cell Significance Index: 38.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2152
    Cell Significance Index: 12.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1925
    Cell Significance Index: 5.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1741
    Cell Significance Index: 21.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1538
    Cell Significance Index: 289.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1223
    Cell Significance Index: 8.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1209
    Cell Significance Index: 76.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1187
    Cell Significance Index: 5.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0948
    Cell Significance Index: 65.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0908
    Cell Significance Index: 139.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0788
    Cell Significance Index: 4.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0779
    Cell Significance Index: 3.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0684
    Cell Significance Index: 37.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0677
    Cell Significance Index: 1.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0583
    Cell Significance Index: 26.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0550
    Cell Significance Index: 101.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0526
    Cell Significance Index: 1.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0487
    Cell Significance Index: 21.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0460
    Cell Significance Index: 62.5400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0456
    Cell Significance Index: 0.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0256
    Cell Significance Index: 3.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0214
    Cell Significance Index: 1.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0200
    Cell Significance Index: 3.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0163
    Cell Significance Index: -12.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0216
    Cell Significance Index: -13.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0244
    Cell Significance Index: -13.7800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0261
    Cell Significance Index: -0.4400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0280
    Cell Significance Index: -20.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0292
    Cell Significance Index: -22.1300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0499
    Cell Significance Index: -0.3100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0545
    Cell Significance Index: -6.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0661
    Cell Significance Index: -13.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0743
    Cell Significance Index: -10.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0768
    Cell Significance Index: -22.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0831
    Cell Significance Index: -4.3300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0876
    Cell Significance Index: -8.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0931
    Cell Significance Index: -10.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1022
    Cell Significance Index: -11.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1058
    Cell Significance Index: -4.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1133
    Cell Significance Index: -12.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1189
    Cell Significance Index: -15.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1591
    Cell Significance Index: -1.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1688
    Cell Significance Index: -7.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1796
    Cell Significance Index: -18.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1891
    Cell Significance Index: -11.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1905
    Cell Significance Index: -2.7400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2093
    Cell Significance Index: -2.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2216
    Cell Significance Index: -15.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2392
    Cell Significance Index: -3.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2426
    Cell Significance Index: -18.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2569
    Cell Significance Index: -13.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2792
    Cell Significance Index: -17.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3032
    Cell Significance Index: -24.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3041
    Cell Significance Index: -9.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3125
    Cell Significance Index: -20.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3223
    Cell Significance Index: -16.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3304
    Cell Significance Index: -5.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3603
    Cell Significance Index: -6.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3972
    Cell Significance Index: -2.4000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4111
    Cell Significance Index: -6.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4508
    Cell Significance Index: -9.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4653
    Cell Significance Index: -14.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4727
    Cell Significance Index: -13.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4759
    Cell Significance Index: -15.5800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4793
    Cell Significance Index: -9.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5209
    Cell Significance Index: -7.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5269
    Cell Significance Index: -7.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5454
    Cell Significance Index: -14.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Activation by fatty acids and eicosanoids**: PPARD is activated by certain fatty acids and eicosanoids, which leads to the regulation of gene expression and cellular processes. 2. **Nuclear receptor activity**: PPARD is a nuclear receptor that binds to specific DNA sequences, regulating gene expression and transcription. 3. **Tissue-specific expression**: PPARD is significantly expressed in various tissues, including the brain, adipose tissue, and immune cells. 4. **Regulation of cell differentiation and proliferation**: PPARD regulates cell differentiation and proliferation in various cell types, including adipocytes, keratinocytes, and immune cells. **Pathways and Functions** 1. **Adipogenesis**: PPARD regulates adipogenesis by activating the expression of genes involved in fat cell formation and differentiation. 2. **Cell differentiation**: PPARD regulates cell differentiation in various cell types, including adipocytes, keratinocytes, and immune cells. 3. **Immune responses**: PPARD regulates immune responses by modulating the expression of genes involved in inflammation and immune cell function. 4. **Metabolic regulation**: PPARD regulates metabolic processes, including glucose and lipid metabolism, and energy homeostasis. 5. **Cancer regulation**: PPARD has been implicated in cancer development and progression, where it regulates cell proliferation, differentiation, and survival. **Clinical Significance** 1. **Obesity and metabolic disorders**: Dysregulation of PPARD has been implicated in obesity and metabolic disorders, such as type 2 diabetes and dyslipidemia. 2. **Cancer**: PPARD has been implicated in cancer development and progression, where it regulates cell proliferation, differentiation, and survival. 3. **Neurological disorders**: PPARD has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates neuronal function and survival. 4. **Immunological disorders**: PPARD regulates immune responses, and dysregulation of PPARD has been implicated in immunological disorders, such as autoimmune diseases and allergies. In conclusion, PPARD is a critical regulator of various physiological and pathological processes, including adipogenesis, cell differentiation, immune responses, and metabolic regulation. Dysregulation of PPARD has been implicated in several diseases, highlighting the importance of this gene in understanding human health and disease. Further research is needed to elucidate the mechanisms by which PPARD regulates gene expression and cellular processes, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3008187600

Symbol: PPARD_HUMAN

Name: Peroxisome proliferator-activated receptor delta

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1333051

Title: Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.

PubMed ID: 1333051

DOI: 10.1210/mend.6.10.1333051

PubMed ID: 10851270

Title: Characterization of the human peroxisome proliferator activated receptor delta gene and its expression.

PubMed ID: 10851270

DOI: 10.3892/ijmm.6.1.73

PubMed ID: 18619963

Title: DNA-binding profiling of human hormone nuclear receptors via fluorescence correlation spectroscopy in a cell-free system.

PubMed ID: 18619963

DOI: 10.1016/j.febslet.2008.07.003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15604518

Title: Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.

PubMed ID: 15604518

DOI: 10.1194/jlr.m400400-jlr200

PubMed ID: 35675826

Title: Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.

PubMed ID: 35675826

DOI: 10.1016/j.cmet.2022.05.005

PubMed ID: 10198642

Title: Molecular recognition of fatty acids by peroxisome proliferator-activated receptors.

PubMed ID: 10198642

DOI: 10.1016/s1097-2765(00)80467-0

PubMed ID: 10809235

Title: Alteration of a single amino acid in peroxisome proliferator-activated receptor-alpha (PPAR alpha) generates a PPAR delta phenotype.

PubMed ID: 10809235

DOI: 10.1210/mend.14.5.0456

PubMed ID: 16931011

Title: 3,4,5-trisubstituted isoxazoles as novel PPARdelta agonists. Part 2.

PubMed ID: 16931011

DOI: 10.1016/j.bmcl.2006.08.052

PubMed ID: 16405912

Title: Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.

PubMed ID: 16405912

DOI: 10.1016/j.jmb.2005.12.047

PubMed ID: 16387648

Title: Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form.

PubMed ID: 16387648

DOI: 10.1016/j.molcel.2005.12.001

PubMed ID: 17560785

Title: Design of a partial PPARdelta agonist.

PubMed ID: 17560785

DOI: 10.1016/j.bmcl.2007.05.079

PubMed ID: 18722772

Title: Discovery of a novel class of PPARdelta partial agonists.

PubMed ID: 18722772

DOI: 10.1016/j.bmcl.2008.08.011

PubMed ID: 19622862

Title: Adaptability and selectivity of human peroxisome proliferator-activated receptor (PPAR) pan agonists revealed from crystal structures.

PubMed ID: 19622862

DOI: 10.1107/s0907444909015935

PubMed ID: 19464171

Title: Identification of a PPARdelta agonist with partial agonistic activity on PPARgamma.

PubMed ID: 19464171

DOI: 10.1016/j.bmcl.2009.04.151

PubMed ID: 19116277

Title: Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.

PubMed ID: 19116277

DOI: 10.1073/pnas.0811325106

Sequence Information:

  • Length: 441
  • Mass: 49903
  • Checksum: 94FBB2A4B46521E8
  • Sequence:
  • MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS PPSLLDQLQM 
    GCDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERSCKIQKK 
    NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQYNP QVADLKAFSK 
    HIYNAYLKNF NMTKKKARSI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE 
    ISVHVFYRCQ CTTVETVREL TEFAKSIPSF SSLFLNDQVT LLKYGVHEAI FAMLASIVNK 
    DGLLVANGSG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGD 
    RPGLMNVPRV EAIQDTILRA LEFHLQANHP DAQYLFPKLL QKMADLRQLV TEHAQMMQRI 
    KKTETETSLH PLLQEIYKDM Y

Genular Protein ID: 2979614899

Symbol: F1D8S7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 361
  • Mass: 40406
  • Checksum: F97757AC266EF8BA
  • Sequence:
  • MEQPQEEAPE VREEEEKEEV AEAEGAPELN GGPQHALPSS SYTDLSRSSS PPSLLDQLQM 
    GCDGASCGSL NMECRVCGDK ASGFHYGVHA CEGCKGFFRR TIRMKLEYEK CERSCKIQKK 
    NRNKCQYCRF QKCLALGMSH NAIRFGRMPE AEKRKLVAGL TANEGSQYNP QVADLKAFSK 
    HIYNAYLKNF NMTKKKARSI LTGKASHTAP FVIHDIETLW QAEKGLVWKQ LVNGLPPYKE 
    ISVHVFYRCQ CTTVETVREL TEFAKSIPSF SSLFLNDQVT LLKYGVHEAI FAMLASIVNK 
    DGLLVANGSG FVTREFLRSL RKPFSDIIEP KFEFAVKFNA LELDDSDLAL FIAAIILCGG 
    E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.