Details for: PPIC

Gene ID: 5480

Symbol: PPIC

Ensembl ID: ENSG00000168938

Description: peptidylprolyl isomerase C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 83.0688
    Cell Significance Index: -34.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 69.7912
    Cell Significance Index: -32.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.7834
    Cell Significance Index: -28.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.2070
    Cell Significance Index: -33.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.6834
    Cell Significance Index: -28.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.6546
    Cell Significance Index: -33.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8940
    Cell Significance Index: -31.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.5358
    Cell Significance Index: 21.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2102
    Cell Significance Index: 103.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1276
    Cell Significance Index: 24.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6751
    Cell Significance Index: 25.1000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.5953
    Cell Significance Index: 9.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5785
    Cell Significance Index: 33.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4852
    Cell Significance Index: 811.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3431
    Cell Significance Index: 132.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2661
    Cell Significance Index: 65.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0999
    Cell Significance Index: 135.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0732
    Cell Significance Index: 147.3800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0653
    Cell Significance Index: 18.8300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0548
    Cell Significance Index: 24.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9284
    Cell Significance Index: 25.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8204
    Cell Significance Index: 7.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7883
    Cell Significance Index: 101.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7581
    Cell Significance Index: 136.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7341
    Cell Significance Index: 54.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7178
    Cell Significance Index: 33.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6979
    Cell Significance Index: 630.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4795
    Cell Significance Index: 33.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4063
    Cell Significance Index: 18.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3769
    Cell Significance Index: 10.8100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3634
    Cell Significance Index: 160.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3112
    Cell Significance Index: 7.7800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.2518
    Cell Significance Index: 1.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2360
    Cell Significance Index: 40.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2244
    Cell Significance Index: 29.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1545
    Cell Significance Index: 4.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1285
    Cell Significance Index: 3.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0880
    Cell Significance Index: 17.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0848
    Cell Significance Index: 1.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0768
    Cell Significance Index: 14.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0570
    Cell Significance Index: 43.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0534
    Cell Significance Index: 2.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0144
    Cell Significance Index: 10.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0084
    Cell Significance Index: -15.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0141
    Cell Significance Index: -25.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0144
    Cell Significance Index: -9.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0157
    Cell Significance Index: -24.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0236
    Cell Significance Index: -32.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0238
    Cell Significance Index: -13.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0276
    Cell Significance Index: -17.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0314
    Cell Significance Index: -0.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0336
    Cell Significance Index: -3.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0478
    Cell Significance Index: -5.4800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0482
    Cell Significance Index: -0.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0634
    Cell Significance Index: -28.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0718
    Cell Significance Index: -8.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0826
    Cell Significance Index: -29.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0884
    Cell Significance Index: -25.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0968
    Cell Significance Index: -20.3900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1014
    Cell Significance Index: -0.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1175
    Cell Significance Index: -12.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1217
    Cell Significance Index: -3.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1258
    Cell Significance Index: -18.2800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1300
    Cell Significance Index: -0.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1382
    Cell Significance Index: -10.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1391
    Cell Significance Index: -27.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1397
    Cell Significance Index: -15.9500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1435
    Cell Significance Index: -1.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1612
    Cell Significance Index: -6.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1666
    Cell Significance Index: -8.6800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1860
    Cell Significance Index: -0.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2261
    Cell Significance Index: -3.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2662
    Cell Significance Index: -5.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2667
    Cell Significance Index: -9.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2914
    Cell Significance Index: -34.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2981
    Cell Significance Index: -31.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3508
    Cell Significance Index: -7.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3727
    Cell Significance Index: -29.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3854
    Cell Significance Index: -11.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4037
    Cell Significance Index: -24.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4214
    Cell Significance Index: -26.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4928
    Cell Significance Index: -33.1400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5140
    Cell Significance Index: -31.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5217
    Cell Significance Index: -33.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5446
    Cell Significance Index: -8.0400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.5630
    Cell Significance Index: -5.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6294
    Cell Significance Index: -18.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6394
    Cell Significance Index: -35.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7250
    Cell Significance Index: -15.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7284
    Cell Significance Index: -32.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7380
    Cell Significance Index: -18.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7459
    Cell Significance Index: -39.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7503
    Cell Significance Index: -19.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7663
    Cell Significance Index: -28.1300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.7811
    Cell Significance Index: -4.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7825
    Cell Significance Index: -27.1900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7879
    Cell Significance Index: -19.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8047
    Cell Significance Index: -28.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Catalytic Activity:** PPIC exhibits peptidyl-prolyl cis-trans isomerase activity, enabling it to catalyze the isomerization of peptidyl-prolyl bonds in proteins. 2. **Expression Patterns:** PPIC is significantly expressed in various cell types, including decidual cells, stratified epithelial cells, bronchus fibroblasts, and keratinocytes, suggesting its involvement in immune regulation and cell signaling. 3. **Protein Binding:** PPIC interacts with various proteins, including cyclosporin A, which may modulate its activity and function. 4. **Organ-Specific Expression:** PPIC is expressed in specific organs, such as the kidney, lung, and esophagus, indicating its role in organ-specific functions. **Pathways and Functions:** 1. **Protein Folding:** PPIC facilitates proper protein folding by catalyzing the cis-trans isomerization of peptidyl-prolyl bonds, ensuring the correct conformation of proteins. 2. **Immune Regulation:** PPIC is expressed in immune cells, such as decidual cells and keratinocytes, suggesting its involvement in immune regulation and cell signaling. 3. **Cell Signaling:** PPIC interacts with various proteins, including cyclosporin A, which may modulate its activity and function in cell signaling pathways. 4. **Extracellular Exosome:** PPIC is also involved in the regulation of extracellular exosome function, which is critical for cell communication and immune regulation. **Clinical Significance:** 1. **Immune Disorders:** PPIC dysregulation may contribute to immune disorders, such as autoimmune diseases and immunodeficiency disorders. 2. **Cancer:** PPIC expression has been linked to cancer progression, suggesting its potential role as a prognostic marker or therapeutic target. 3. **Organ Dysfunction:** PPIC expression in specific organs may contribute to organ dysfunction, such as kidney disease or lung fibrosis. 4. **Cyclosporin A Therapy:** PPIC interacts with cyclosporin A, a widely used immunosuppressant, suggesting its potential role in modulating cyclosporin A activity and function. In conclusion, PPIC is a crucial enzyme that plays a vital role in protein folding, immune regulation, and cell signaling pathways. Further studies are necessary to elucidate the mechanisms underlying PPIC function and its clinical significance in various diseases.

Genular Protein ID: 4095156038

Symbol: PPIC_HUMAN

Name: Rotamase C

UniProtKB Accession Codes:

P45877 A4LBB5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8031755

Title: Human cyclophilin C: primary structure, tissue distribution, and determination of binding specificity for cyclosporins.

PubMed ID: 8031755

DOI: 10.1021/bi00193a007

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20676357

Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

PubMed ID: 20676357

DOI: 10.1371/journal.pbio.1000439

Sequence Information:

  • Length: 212
  • Mass: 22763
  • Checksum: 6F3DB547A2AE581B
  • Sequence:
    • MGPGPRLLLP LVLCVGLGAL VFSSGAEGFR KRGPSVTAKV FFDVRIGDKD VGRIVIGLFG 
KVVPKTVENF VALATGEKGY GYKGSKFHRV IKDFMIQGGD ITTGDGTGGV SIYGETFPDE 
NFKLKHYGIG WVSMANAGPD TNGSQFFITL TKPTWLDGKH VVFGKVIDGM TVVHSIELQA 
TDGHDRPLTN CSIINSGKID VKTPFVVEIA DW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.