Details for: PPM1A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 271.1751
Cell Significance Index: -42.1800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 179.6223
Cell Significance Index: -45.5600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 102.8758
Cell Significance Index: -48.5700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 98.5583
Cell Significance Index: -40.0400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 89.7382
Cell Significance Index: -46.1600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 72.2331
Cell Significance Index: -48.4700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 42.0742
Cell Significance Index: -40.1700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 35.1107
Cell Significance Index: -43.2900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.7777
Cell Significance Index: -44.9500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.7915
Cell Significance Index: -42.3600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.2325
Cell Significance Index: -48.2700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.7956
Cell Significance Index: -19.2500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.4524
Cell Significance Index: 398.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.3042
Cell Significance Index: 129.3000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 2.2923
Cell Significance Index: 2069.7600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.2885
Cell Significance Index: 266.7000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7855
Cell Significance Index: 358.1600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5401
Cell Significance Index: 167.5200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.0689
Cell Significance Index: 67.3700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.0049
Cell Significance Index: 25.8300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9872
Cell Significance Index: 354.1100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9341
Cell Significance Index: 71.6800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.9049
Cell Significance Index: 24.6300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8608
Cell Significance Index: 170.8200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.8332
Cell Significance Index: 57.6200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8120
Cell Significance Index: 37.8600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6906
Cell Significance Index: 124.5000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.5802
Cell Significance Index: 71.3400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4492
Cell Significance Index: 44.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4440
Cell Significance Index: 60.9800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.4397
Cell Significance Index: 19.9300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4196
Cell Significance Index: 12.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3863
Cell Significance Index: 210.9900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3660
Cell Significance Index: 16.1900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3648
Cell Significance Index: 252.2800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3555
Cell Significance Index: 13.4600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3501
Cell Significance Index: 18.3800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3163
Cell Significance Index: 139.8300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2742
Cell Significance Index: 12.8900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2694
Cell Significance Index: 20.0800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2694
Cell Significance Index: 51.2700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2611
Cell Significance Index: 13.6000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2517
Cell Significance Index: 15.4700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2489
Cell Significance Index: 42.5000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.2009
Cell Significance Index: 12.9600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1773
Cell Significance Index: 11.9200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1312
Cell Significance Index: 3.7600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1285
Cell Significance Index: 3.5900 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.1173
Cell Significance Index: 15.1600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1116
Cell Significance Index: 3.9200 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0952
Cell Significance Index: 12.2100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0701
Cell Significance Index: 44.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0635
Cell Significance Index: 7.4900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0322
Cell Significance Index: 60.6800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0317
Cell Significance Index: 14.3800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0082
Cell Significance Index: 0.2200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0082
Cell Significance Index: -6.0500 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.0105
Cell Significance Index: -0.1300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0113
Cell Significance Index: -17.4700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0115
Cell Significance Index: -15.6700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0149
Cell Significance Index: -27.4700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0220
Cell Significance Index: -16.1400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0294
Cell Significance Index: -18.3700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0325
Cell Significance Index: -1.6900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0339
Cell Significance Index: -19.1400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0418
Cell Significance Index: -31.6500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0620
Cell Significance Index: -1.3200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0875
Cell Significance Index: -8.9400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1128
Cell Significance Index: -23.7500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1151
Cell Significance Index: -2.7600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1243
Cell Significance Index: -2.1300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1453
Cell Significance Index: -41.8200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1654
Cell Significance Index: -24.0500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1789
Cell Significance Index: -20.5000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.1793
Cell Significance Index: -3.0200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2261
Cell Significance Index: -2.6900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2361
Cell Significance Index: -16.7000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.2409
Cell Significance Index: -3.6100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2438
Cell Significance Index: -4.0800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2564
Cell Significance Index: -8.9100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2606
Cell Significance Index: -29.7500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3038
Cell Significance Index: -5.9300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3391
Cell Significance Index: -8.2800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.3407
Cell Significance Index: -5.0300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4134
Cell Significance Index: -5.6400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4259
Cell Significance Index: -44.3500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4583
Cell Significance Index: -14.6800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4716
Cell Significance Index: -37.3500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5256
Cell Significance Index: -15.0000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6779
Cell Significance Index: -41.5600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6945
Cell Significance Index: -14.7400 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.7184
Cell Significance Index: -19.2500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.7788
Cell Significance Index: -11.5000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.7911
Cell Significance Index: -17.1400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8213
Cell Significance Index: -26.8900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8295
Cell Significance Index: -20.7400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8371
Cell Significance Index: -26.6600 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.8685
Cell Significance Index: -13.1900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.8785
Cell Significance Index: -23.1000 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.9012
Cell Significance Index: -7.6600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3219121319
Symbol: PPM1A_HUMAN
Name: Protein phosphatase 1A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1311954
Title: Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences.
PubMed ID: 1311954
PubMed ID: 9707433
Title: Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways.
PubMed ID: 9707433
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 19054851
Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
PubMed ID: 19054851
DOI: 10.1038/nmeth.1273
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16751101
Title: PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.
PubMed ID: 16751101
PubMed ID: 18930133
Title: PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
PubMed ID: 18930133
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20213681
Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.
PubMed ID: 20213681
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22781750
Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
PubMed ID: 22781750
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 30267671
Title: The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis.
PubMed ID: 30267671
PubMed ID: 9003755
Title: Crystal structure of the protein serine/threonine phosphatase 2C at 2.0-A resolution.
PubMed ID: 9003755
Sequence Information:
- Length: 382
- Mass: 42448
- Checksum: D48EF508B4A76687
- Sequence:
MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA VYNRLNPYKN DDTDSTSTDD MW
Genular Protein ID: 975967689
Symbol: B2R8E4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 382
- Mass: 42434
- Checksum: 4CB576A324B98999
- Sequence:
MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILVC FPNAPKVSPE AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA VYNRLNPYKN DDTDSTSTDD MW
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.