Details for: PPM1A

Gene ID: 5494

Symbol: PPM1A

Ensembl ID: ENSG00000100614

Description: protein phosphatase, Mg2+/Mn2+ dependent 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 271.1751
    Cell Significance Index: -42.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.6223
    Cell Significance Index: -45.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 102.8758
    Cell Significance Index: -48.5700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 98.5583
    Cell Significance Index: -40.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.7382
    Cell Significance Index: -46.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.2331
    Cell Significance Index: -48.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.0742
    Cell Significance Index: -40.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.1107
    Cell Significance Index: -43.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.7777
    Cell Significance Index: -44.9500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.7915
    Cell Significance Index: -42.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2325
    Cell Significance Index: -48.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7956
    Cell Significance Index: -19.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4524
    Cell Significance Index: 398.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3042
    Cell Significance Index: 129.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2923
    Cell Significance Index: 2069.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.2885
    Cell Significance Index: 266.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7855
    Cell Significance Index: 358.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5401
    Cell Significance Index: 167.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0689
    Cell Significance Index: 67.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0049
    Cell Significance Index: 25.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9872
    Cell Significance Index: 354.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9341
    Cell Significance Index: 71.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9049
    Cell Significance Index: 24.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8608
    Cell Significance Index: 170.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8332
    Cell Significance Index: 57.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8120
    Cell Significance Index: 37.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6906
    Cell Significance Index: 124.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5802
    Cell Significance Index: 71.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4492
    Cell Significance Index: 44.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4440
    Cell Significance Index: 60.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4397
    Cell Significance Index: 19.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4196
    Cell Significance Index: 12.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3863
    Cell Significance Index: 210.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3660
    Cell Significance Index: 16.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3648
    Cell Significance Index: 252.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3555
    Cell Significance Index: 13.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3501
    Cell Significance Index: 18.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3163
    Cell Significance Index: 139.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2742
    Cell Significance Index: 12.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2694
    Cell Significance Index: 20.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2694
    Cell Significance Index: 51.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2611
    Cell Significance Index: 13.6000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2517
    Cell Significance Index: 15.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2489
    Cell Significance Index: 42.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2009
    Cell Significance Index: 12.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1773
    Cell Significance Index: 11.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1312
    Cell Significance Index: 3.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1285
    Cell Significance Index: 3.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1173
    Cell Significance Index: 15.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1116
    Cell Significance Index: 3.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0952
    Cell Significance Index: 12.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0701
    Cell Significance Index: 44.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0635
    Cell Significance Index: 7.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0322
    Cell Significance Index: 60.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0317
    Cell Significance Index: 14.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0105
    Cell Significance Index: -0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0113
    Cell Significance Index: -17.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0115
    Cell Significance Index: -15.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0149
    Cell Significance Index: -27.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0220
    Cell Significance Index: -16.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0294
    Cell Significance Index: -18.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0325
    Cell Significance Index: -1.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0339
    Cell Significance Index: -19.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0418
    Cell Significance Index: -31.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0620
    Cell Significance Index: -1.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0875
    Cell Significance Index: -8.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1128
    Cell Significance Index: -23.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1151
    Cell Significance Index: -2.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1243
    Cell Significance Index: -2.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1453
    Cell Significance Index: -41.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1654
    Cell Significance Index: -24.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1789
    Cell Significance Index: -20.5000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1793
    Cell Significance Index: -3.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2261
    Cell Significance Index: -2.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2361
    Cell Significance Index: -16.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2409
    Cell Significance Index: -3.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2438
    Cell Significance Index: -4.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2564
    Cell Significance Index: -8.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2606
    Cell Significance Index: -29.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3038
    Cell Significance Index: -5.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3391
    Cell Significance Index: -8.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3407
    Cell Significance Index: -5.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4134
    Cell Significance Index: -5.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4259
    Cell Significance Index: -44.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4583
    Cell Significance Index: -14.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4716
    Cell Significance Index: -37.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5256
    Cell Significance Index: -15.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6779
    Cell Significance Index: -41.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6945
    Cell Significance Index: -14.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7184
    Cell Significance Index: -19.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7788
    Cell Significance Index: -11.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7911
    Cell Significance Index: -17.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8213
    Cell Significance Index: -26.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8295
    Cell Significance Index: -20.7400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8371
    Cell Significance Index: -26.6600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.8685
    Cell Significance Index: -13.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8785
    Cell Significance Index: -23.1000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.9012
    Cell Significance Index: -7.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mg2+/Mn2+ dependent phosphatase**: PPM1A is a magnesium (Mg2+) and manganese (Mn2+) dependent enzyme that catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues on target proteins. 2. **Cellular localization**: PPM1A is predominantly localized to the cytosol and nucleus, where it regulates various signaling pathways and transcriptional activities. 3. **Signaling pathways**: PPM1A has been implicated in numerous signaling pathways, including the TGF-β, BMP, NF-κB, and WNT pathways, as well as the regulation of the cell cycle and transcriptional activity. 4. **Regulation of protein dephosphorylation**: PPM1A plays a crucial role in the regulation of protein dephosphorylation, which is essential for maintaining cellular homeostasis and preventing aberrant signaling. **Pathways and Functions:** 1. **Calmodulin-dependent protein phosphatase activity**: PPM1A is involved in the regulation of calmodulin-dependent protein phosphatase activity, which is essential for maintaining calcium homeostasis and regulating cellular signaling. 2. **Cytosol and nucleus**: PPM1A is localized to both the cytosol and nucleus, where it regulates various signaling pathways and transcriptional activities. 3. **Dephosphorylation of smad2/3:smad4 heterotrimer**: PPM1A regulates the dephosphorylation of the smad2/3:smad4 heterotrimer, which is essential for TGF-β signaling. 4. **Energy-dependent regulation of mTOR by LKB1-AMPK**: PPM1A regulates the energy-dependent activation of mTOR by LKB1-AMPK, which is essential for regulating cell growth and metabolism. 5. **Gene expression (transcription)**: PPM1A regulates gene expression by dephosphorylating transcription factors and modifying chromatin structure. **Clinical Significance:** 1. **Cancer**: PPM1A has been implicated in various types of cancer, including breast, lung, and colon cancer, where it regulates cell cycle progression and transcriptional activity. 2. **Neurodegenerative disorders**: PPM1A has been implicated in neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it regulates protein dephosphorylation and transcriptional activity. 3. **Developmental disorders**: PPM1A has been implicated in developmental disorders, including autism and schizophrenia, where it regulates gene expression and transcriptional activity. 4. **Regulation of cell cycle**: PPM1A regulates cell cycle progression, which is essential for maintaining tissue homeostasis and preventing cancer. In conclusion, PPM1A is a crucial gene that regulates various cellular signaling pathways and transcriptional activities. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, and developmental disorders. Further research is needed to fully understand the role of PPM1A in human disease and to develop therapeutic strategies to target this gene.

Genular Protein ID: 3219121319

Symbol: PPM1A_HUMAN

Name: Protein phosphatase 1A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1311954

Title: Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences.

PubMed ID: 1311954

DOI: 10.1016/0167-4781(92)90471-b

PubMed ID: 9707433

Title: Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways.

PubMed ID: 9707433

DOI: 10.1093/emboj/17.16.4744

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16751101

Title: PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.

PubMed ID: 16751101

DOI: 10.1016/j.cell.2006.03.044

PubMed ID: 18930133

Title: PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.

PubMed ID: 18930133

DOI: 10.1016/j.cellsig.2008.09.012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 30267671

Title: The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis.

PubMed ID: 30267671

DOI: 10.1016/j.bbabio.2018.09.369

PubMed ID: 9003755

Title: Crystal structure of the protein serine/threonine phosphatase 2C at 2.0-A resolution.

PubMed ID: 9003755

DOI: 10.1002/j.1460-2075.1996.tb01071.x

Sequence Information:

  • Length: 382
  • Mass: 42448
  • Checksum: D48EF508B4A76687
  • Sequence:
  • MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD 
    GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH 
    GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 
    SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG 
    IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILIC FPNAPKVSPE 
    AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA 
    VYNRLNPYKN DDTDSTSTDD MW

Genular Protein ID: 975967689

Symbol: B2R8E4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 382
  • Mass: 42434
  • Checksum: 4CB576A324B98999
  • Sequence:
  • MGAFLDKPKM EKHNAQGQGN GLRYGLSSMQ GWRVEMEDAH TAVIGLPSGL ESWSFFAVYD 
    GHAGSQVAKY CCEHLLDHIT NNQDFKGSAG APSVENVKNG IRTGFLEIDE HMRVMSEKKH 
    GADRSGSTAV GVLISPQHTY FINCGDSRGL LCRNRKVHFF TQDHKPSNPL EKERIQNAGG 
    SVMIQRVNGS LAVSRALGDF DYKCVHGKGP TEQLVSPEPE VHDIERSEED DQFIILACDG 
    IWDVMGNEEL CDFVRSRLEV TDDLEKVCNE VVDTCLYKGS RDNMSVILVC FPNAPKVSPE 
    AVKKEAELDK YLECRVEEII KKQGEGVPDL VHVMRTLASE NIPSLPPGGE LASKRNVIEA 
    VYNRLNPYKN DDTDSTSTDD MW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.