Details for: PPP3CB

Gene ID: 5532

Symbol: PPP3CB

Ensembl ID: ENSG00000107758

Description: protein phosphatase 3 catalytic subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 355.1057
    Cell Significance Index: -55.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 221.4625
    Cell Significance Index: -56.1700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 120.0112
    Cell Significance Index: -56.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 112.0473
    Cell Significance Index: -45.5200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 100.8680
    Cell Significance Index: -51.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.9187
    Cell Significance Index: -45.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.6910
    Cell Significance Index: -56.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.9036
    Cell Significance Index: -50.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.5594
    Cell Significance Index: -47.7900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4423
    Cell Significance Index: -56.9900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.2316
    Cell Significance Index: -26.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.6402
    Cell Significance Index: 93.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4979
    Cell Significance Index: 501.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.1043
    Cell Significance Index: 41.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7417
    Cell Significance Index: 624.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4763
    Cell Significance Index: 90.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4517
    Cell Significance Index: 111.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4435
    Cell Significance Index: 81.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2352
    Cell Significance Index: 35.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2269
    Cell Significance Index: 82.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1150
    Cell Significance Index: 26.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0564
    Cell Significance Index: 209.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8986
    Cell Significance Index: 146.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8950
    Cell Significance Index: 39.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8924
    Cell Significance Index: 617.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8862
    Cell Significance Index: 96.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8765
    Cell Significance Index: 33.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7566
    Cell Significance Index: 21.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4519
    Cell Significance Index: 55.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4175
    Cell Significance Index: 75.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3892
    Cell Significance Index: 5.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3636
    Cell Significance Index: 19.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3317
    Cell Significance Index: 181.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3125
    Cell Significance Index: 42.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3064
    Cell Significance Index: 5.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3000
    Cell Significance Index: 6.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2846
    Cell Significance Index: 125.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2655
    Cell Significance Index: 12.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2236
    Cell Significance Index: 5.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1904
    Cell Significance Index: 358.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1731
    Cell Significance Index: 78.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1717
    Cell Significance Index: 109.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1479
    Cell Significance Index: 4.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1196
    Cell Significance Index: 108.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1111
    Cell Significance Index: 171.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0987
    Cell Significance Index: 182.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0623
    Cell Significance Index: 84.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0554
    Cell Significance Index: 1.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0465
    Cell Significance Index: 7.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0399
    Cell Significance Index: 4.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0337
    Cell Significance Index: 3.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0253
    Cell Significance Index: 1.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0171
    Cell Significance Index: 1.1100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0153
    Cell Significance Index: 0.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0194
    Cell Significance Index: -2.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0297
    Cell Significance Index: -21.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0326
    Cell Significance Index: -0.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0375
    Cell Significance Index: -27.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0457
    Cell Significance Index: -2.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0503
    Cell Significance Index: -9.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0516
    Cell Significance Index: -32.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0636
    Cell Significance Index: -35.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0658
    Cell Significance Index: -49.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0934
    Cell Significance Index: -4.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1144
    Cell Significance Index: -14.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1456
    Cell Significance Index: -30.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1518
    Cell Significance Index: -7.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1591
    Cell Significance Index: -3.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1666
    Cell Significance Index: -47.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1778
    Cell Significance Index: -25.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1781
    Cell Significance Index: -13.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1939
    Cell Significance Index: -13.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2048
    Cell Significance Index: -9.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2179
    Cell Significance Index: -25.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2410
    Cell Significance Index: -24.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2794
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2936
    Cell Significance Index: -33.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3305
    Cell Significance Index: -34.4100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.3365
    Cell Significance Index: -5.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3532
    Cell Significance Index: -4.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3879
    Cell Significance Index: -13.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4217
    Cell Significance Index: -8.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4308
    Cell Significance Index: -7.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4341
    Cell Significance Index: -49.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5070
    Cell Significance Index: -13.8000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5516
    Cell Significance Index: -43.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5879
    Cell Significance Index: -18.8300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6343
    Cell Significance Index: -7.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6731
    Cell Significance Index: -23.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6742
    Cell Significance Index: -14.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7546
    Cell Significance Index: -14.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7684
    Cell Significance Index: -20.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8060
    Cell Significance Index: -26.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8069
    Cell Significance Index: -25.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8084
    Cell Significance Index: -16.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8843
    Cell Significance Index: -25.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8844
    Cell Significance Index: -23.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8878
    Cell Significance Index: -54.4300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.8941
    Cell Significance Index: -11.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9513
    Cell Significance Index: -23.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** PPP3CB is predominantly expressed in skeletal muscle fibers, GABAergic cortical interneurons, and astrocytes, suggesting its specific role in these cell types. 2. **Protein phosphatase activity:** PPP3CB possesses protein phosphatase 2B (PP2B) activity, which enables it to dephosphorylate and regulate protein function. 3. **Regulation of signaling pathways:** PPP3CB is involved in various signaling pathways, including calcineurin-mediated signaling, Wnt signaling, and GPCR signaling, highlighting its role in regulating cellular responses. 4. **Cell-type specific expression:** The restricted expression of PPP3CB to specific cell types suggests its unique function in these cells. **Pathways and Functions:** 1. **Calcineurin-mediated signaling:** PPP3CB regulates calcineurin activity, which is crucial for T-cell activation, differentiation, and homeostasis. 2. **Wnt signaling:** PPP3CB modulates Wnt signaling, which is involved in developmental processes, including heart development and lymphangiogenesis. 3. **GPCR signaling:** PPP3CB regulates GPCR signaling, which is essential for various cellular responses, including immune response and synaptic plasticity. 4. **Regulation of protein localization:** PPP3CB regulates protein localization to the nucleus and cytosol, influencing cellular processes such as transcription and signaling. **Clinical Significance:** PPP3CB's dysregulation has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Altered PPP3CB expression has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Immunodeficiency disorders:** PPP3CB dysfunction has been associated with immunodeficiency disorders, such as X-linked lymphoproliferative disease. 3. **Neurological disorders:** PPP3CB's role in regulating GPCR signaling and Wnt signaling suggests its involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, PPP3CB plays a critical role in regulating various cellular processes, including immune response, development, and neurotransmission. Its unique cellular localization and function highlight the importance of PPP3CB in maintaining cellular homeostasis. Further research is necessary to elucidate the precise mechanisms underlying PPP3CB's functions and its clinical significance in immune-related disorders.

Genular Protein ID: 1064589237

Symbol: PP2BB_HUMAN

Name: Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

UniProtKB Accession Codes:

P16298 P16299 Q5F2F9 Q8N1F0 Q8N3W4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DEPOD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 8 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 5 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2556704

Title: Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

PubMed ID: 2556704

DOI: 10.1073/pnas.86.23.9183

PubMed ID: 1848109

Title: Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta.

PubMed ID: 1848109

DOI: 10.1016/0167-4781(91)90069-x

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19154138

Title: The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding.

PubMed ID: 19154138

DOI: 10.1021/bi8019355

PubMed ID: 25720963

Title: Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.

PubMed ID: 25720963

DOI: 10.1038/ncb3114

PubMed ID: 32753672

Title: Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens.

PubMed ID: 32753672

DOI: 10.1038/s41556-020-0549-1

PubMed ID: 34446558

Title: SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PubMed ID: 34446558

DOI: 10.1073/pnas.2106673118

PubMed ID: 26794871

Title: Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.

PubMed ID: 26794871

DOI: 10.1038/cr.2016.14

Sequence Information:

  • Length: 524
  • Mass: 59024
  • Checksum: 7661183F3C2362C8
  • Sequence:
    • MAAPEPARAA PPPPPPPPPP PGADRVVKAV PFPPTHRLTS EEVFDLDGIP RVDVLKNHLV 
KEGRVDEEIA LRIINEGAAI LRREKTMIEV EAPITVCGDI HGQFFDLMKL FEVGGSPANT 
RYLFLGDYVD RGYFSIECVL YLWVLKILYP STLFLLRGNH ECRHLTEYFT FKQECKIKYS 
ERVYEACMEA FDSLPLAALL NQQFLCVHGG LSPEIHTLDD IRRLDRFKEP PAFGPMCDLL 
WSDPSEDFGN EKSQEHFSHN TVRGCSYFYN YPAVCEFLQN NNLLSIIRAH EAQDAGYRMY 
RKSQTTGFPS LITIFSAPNY LDVYNNKAAV LKYENNVMNI RQFNCSPHPY WLPNFMDVFT 
WSLPFVGEKV TEMLVNVLSI CSDDELMTEG EDQFDGSAAA RKEIIRNKIR AIGKMARVFS 
VLREESESVL TLKGLTPTGM LPSGVLAGGR QTLQSATVEA IEAEKAIRGF SPPHRICSFE 
EAKGLDRINE RMPPRKDAVQ QDGFNSLNTA HATENHGTGN HTAQ

Genular Protein ID: 2759096847

Symbol: B7Z781_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z781

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 7 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 Rhea 6 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 411
  • Mass: 46757
  • Checksum: 0B24098616542265
  • Sequence:
    • MIEVEAPITV CGDIHGQFFD LMKLFEVGGS PANTRYLFLG DYVDRGYFSI ECVLYLWVLK 
ILYPSTLFLL RGNHECRHLT EYFTFKQECK IKYSERVYEA CMEAFDSLPL AALLNQQFLC 
VHGGLSPEIH TLDDIRRLDR FKEPPAFGPM CDLLWSDPSE DFGNEKSQEH FSHNTVRGCS 
YFYNYPAVCE FLQNNNLLSI IRAPEAQDAG YRMYRKSQTT GFPSLITIFS APNYLDVYNN 
KAAVLKYENN VMNIRQFNCS PHPYWLPNFM DVFTWSLPFV GEKVTEMLVN VLSICSDDEL 
MTEGEDQFDV GSAAARKEII RNKIRAIGKM ARVFSVLREE SESVLTLKGL TPTGMLPSGV 
LAGGRQTLQS GNDVMQLAVP QMDWGTPHSF ANNSHNACRE FLLFFSSCLS S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.