Details for: PPP3R1

Gene ID: 5534

Symbol: PPP3R1

Ensembl ID: ENSG00000221823

Description: protein phosphatase 3 regulatory subunit B, alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 225.3364
    Cell Significance Index: -35.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 144.6913
    Cell Significance Index: -36.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.9724
    Cell Significance Index: -36.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.0793
    Cell Significance Index: -40.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 72.4554
    Cell Significance Index: -37.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.1495
    Cell Significance Index: -35.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1350
    Cell Significance Index: -43.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.1291
    Cell Significance Index: -37.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7211
    Cell Significance Index: -38.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 4.0342
    Cell Significance Index: 254.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.2144
    Cell Significance Index: 142.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.0237
    Cell Significance Index: 114.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4843
    Cell Significance Index: 498.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0950
    Cell Significance Index: 117.5600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.9664
    Cell Significance Index: 24.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6488
    Cell Significance Index: 126.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5628
    Cell Significance Index: 560.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4031
    Cell Significance Index: 1266.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1141
    Cell Significance Index: 320.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9790
    Cell Significance Index: 106.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9516
    Cell Significance Index: 154.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8870
    Cell Significance Index: 54.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8305
    Cell Significance Index: 20.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5917
    Cell Significance Index: 15.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4995
    Cell Significance Index: 345.4900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4803
    Cell Significance Index: 11.5200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.4302
    Cell Significance Index: 4.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3548
    Cell Significance Index: 7.5900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3445
    Cell Significance Index: 4.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2999
    Cell Significance Index: 54.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2626
    Cell Significance Index: 16.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2562
    Cell Significance Index: 31.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2278
    Cell Significance Index: 31.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2155
    Cell Significance Index: 6.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1994
    Cell Significance Index: 108.8900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.1993
    Cell Significance Index: 2.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1622
    Cell Significance Index: 71.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0806
    Cell Significance Index: 15.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0678
    Cell Significance Index: 3.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0536
    Cell Significance Index: 2.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0410
    Cell Significance Index: 1.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0384
    Cell Significance Index: 4.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0236
    Cell Significance Index: 1.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0196
    Cell Significance Index: 0.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0064
    Cell Significance Index: 1.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0133
    Cell Significance Index: -0.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0188
    Cell Significance Index: -1.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0193
    Cell Significance Index: -36.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0215
    Cell Significance Index: -15.9300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0248
    Cell Significance Index: -0.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0268
    Cell Significance Index: -41.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0307
    Cell Significance Index: -41.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0337
    Cell Significance Index: -4.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0370
    Cell Significance Index: -28.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0387
    Cell Significance Index: -28.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0534
    Cell Significance Index: -33.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0552
    Cell Significance Index: -31.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0672
    Cell Significance Index: -42.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0825
    Cell Significance Index: -37.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1149
    Cell Significance Index: -1.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1249
    Cell Significance Index: -14.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1473
    Cell Significance Index: -3.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1582
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1667
    Cell Significance Index: -4.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1712
    Cell Significance Index: -17.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1807
    Cell Significance Index: -38.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1889
    Cell Significance Index: -24.4100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2223
    Cell Significance Index: -2.8500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2415
    Cell Significance Index: -4.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2430
    Cell Significance Index: -35.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2732
    Cell Significance Index: -31.3000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2791
    Cell Significance Index: -3.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2836
    Cell Significance Index: -20.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3203
    Cell Significance Index: -23.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3351
    Cell Significance Index: -7.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3416
    Cell Significance Index: -11.1900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3669
    Cell Significance Index: -11.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3689
    Cell Significance Index: -7.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3718
    Cell Significance Index: -38.7100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3752
    Cell Significance Index: -6.0200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3902
    Cell Significance Index: -10.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4062
    Cell Significance Index: -8.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4170
    Cell Significance Index: -3.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4258
    Cell Significance Index: -8.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4341
    Cell Significance Index: -34.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4531
    Cell Significance Index: -12.1200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4635
    Cell Significance Index: -5.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4826
    Cell Significance Index: -12.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5021
    Cell Significance Index: -10.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5179
    Cell Significance Index: -11.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5570
    Cell Significance Index: -7.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5630
    Cell Significance Index: -10.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5766
    Cell Significance Index: -9.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5929
    Cell Significance Index: -36.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6191
    Cell Significance Index: -19.8300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6453
    Cell Significance Index: -7.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6634
    Cell Significance Index: -23.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7164
    Cell Significance Index: -17.8700
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.7440
    Cell Significance Index: -7.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Regulatory Subunit of PP3**: PPP3R1 is a regulatory subunit of protein phosphatase 3, which is a critical enzyme involved in dephosphorylating and regulating various proteins. 2. **Calcium-Dependent Phosphatase**: PPP3R1 is a calcium-dependent protein serine/threonine phosphatase, which means it is activated by calcium ions and regulates various cellular processes. 3. **Involvement in Multiple Signaling Pathways**: PPP3R1 is involved in multiple signaling pathways, including calcineurin-mediated signaling, Wnt signaling, and GPCR signaling. 4. **Expression in Multiple Cell Types**: PPP3R1 is significantly expressed in multiple cell types, including GABAergic neurons, astrocytes, and inhibitory interneurons. **Pathways and Functions** 1. **Calcium-Dependent Protein Serine/Threonine Phosphatase Activity**: PPP3R1 regulates various cellular processes by dephosphorylating and activating proteins involved in calcium signaling. 2. **Calcineurin-Mediated Signaling**: PPP3R1 is involved in calcineurin-mediated signaling, which regulates various cellular processes, including immune responses and synaptic transmission. 3. **Wnt Signaling**: PPP3R1 is involved in Wnt signaling, which regulates various cellular processes, including cell proliferation, differentiation, and survival. 4. **GPCR Signaling**: PPP3R1 is involved in GPCR signaling, which regulates various cellular processes, including synaptic transmission and immune responses. 5. **Synaptic Transmission**: PPP3R1 regulates synaptic transmission by modulating the activity of ion channels and receptors involved in synaptic plasticity. 6. **Apoptosis**: PPP3R1 is involved in regulating apoptosis by modulating the activity of proteins involved in the intrinsic pathway. 7. **Immune System**: PPP3R1 is involved in regulating immune responses by modulating the activity of proteins involved in calcium signaling and immune cell activation. **Clinical Significance** 1. **Neurological Disorders**: Mutations in the PPP3R1 gene have been associated with various neurological disorders, including epilepsy and schizophrenia. 2. **Immune System Disorders**: PPP3R1 is involved in regulating immune responses, and mutations in the gene have been associated with various immune system disorders, including autoimmune diseases. 3. **Cancer**: PPP3R1 is involved in regulating cell proliferation and survival, and mutations in the gene have been associated with various types of cancer. 4. **Neurodevelopmental Disorders**: PPP3R1 is involved in regulating neural development and function, and mutations in the gene have been associated with various neurodevelopmental disorders, including autism spectrum disorder. In conclusion, the PPP3R1 gene plays a critical role in regulating various cellular processes, including synaptic transmission, apoptosis, and immune responses. Mutations in the gene have been associated with various neurological, immune system, and cancer disorders, highlighting the importance of PPP3R1 in maintaining cellular homeostasis.

Genular Protein ID: 1865680413

Symbol: CANB1_HUMAN

Name: Calcineurin subunit B type 1

UniProtKB Accession Codes:

P63098 B2RC10 B5MDU4 P06705 P15117 Q08044 Q53SL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 ComplexPortal 6 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 DrugCentral 1 ELM 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2558868

Title: Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase.

PubMed ID: 2558868

DOI: 10.1089/dna.1.1989.8.675

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12809556

Title: Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

PubMed ID: 12809556

DOI: 10.1042/bj20030267

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 34446558

Title: SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PubMed ID: 34446558

DOI: 10.1073/pnas.2106673118

PubMed ID: 8524402

Title: Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

PubMed ID: 8524402

DOI: 10.1038/378641a0

PubMed ID: 12218175

Title: Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.

PubMed ID: 12218175

DOI: 10.1073/pnas.192206699

PubMed ID: 12357034

Title: Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

PubMed ID: 12357034

DOI: 10.1073/pnas.212504399

PubMed ID: 17498738

Title: Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction.

PubMed ID: 17498738

DOI: 10.1016/j.jmb.2007.04.032

PubMed ID: 22343722

Title: Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

PubMed ID: 22343722

DOI: 10.1038/nsmb.2238

PubMed ID: 23468591

Title: The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.

PubMed ID: 23468591

DOI: 10.1371/journal.pbio.1001492

PubMed ID: 26794871

Title: Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.

PubMed ID: 26794871

DOI: 10.1038/cr.2016.14

PubMed ID: 27974827

Title: Investigating the human Calcineurin Interaction Network using the piLxVP SLiM.

PubMed ID: 27974827

DOI: 10.1038/srep38920

PubMed ID: 31375679

Title: Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin.

PubMed ID: 31375679

DOI: 10.1038/s41467-019-11391-7

Sequence Information:

  • Length: 170
  • Mass: 19300
  • Checksum: C904715DC0386056
  • Sequence:
    • MGNEASYPLE MCSHFDADEI KRLGKRFKKL DLDNSGSLSV EEFMSLPELQ QNPLVQRVID 
IFDTDGNGEV DFKEFIEGVS QFSVKGDKEQ KLRFAFRIYD MDKDGYISNG ELFQVLKMMV 
GNNLKDTQLQ QIVDKTIINA DKDGDGRISF EEFCAVVGGL DIHKKMVVDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.