Details for: PPP3R2

Gene ID: 5535

Symbol: PPP3R2

Ensembl ID: ENSG00000188386

Description: protein phosphatase 3 regulatory subunit B, beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.2310
    Cell Significance Index: 2.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1924
    Cell Significance Index: 2.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1328
    Cell Significance Index: 38.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0836
    Cell Significance Index: 1.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0595
    Cell Significance Index: 21.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0493
    Cell Significance Index: 1.0800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0201
    Cell Significance Index: 0.4200
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.0104
    Cell Significance Index: 0.0900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0093
    Cell Significance Index: 0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0040
    Cell Significance Index: 0.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0010
    Cell Significance Index: -0.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0019
    Cell Significance Index: -1.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0049
    Cell Significance Index: -0.3000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0050
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0053
    Cell Significance Index: -1.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0058
    Cell Significance Index: -0.8000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0063
    Cell Significance Index: -0.0800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0071
    Cell Significance Index: -0.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0084
    Cell Significance Index: -0.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0090
    Cell Significance Index: -0.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0091
    Cell Significance Index: -0.3200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0099
    Cell Significance Index: -0.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0116
    Cell Significance Index: -0.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0124
    Cell Significance Index: -0.5800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0125
    Cell Significance Index: -0.3000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0137
    Cell Significance Index: -0.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0142
    Cell Significance Index: -0.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0142
    Cell Significance Index: -1.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0149
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0161
    Cell Significance Index: -1.8500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0184
    Cell Significance Index: -0.2000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0191
    Cell Significance Index: -0.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0209
    Cell Significance Index: -0.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0220
    Cell Significance Index: -0.7000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0237
    Cell Significance Index: -0.3100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -0.0248
    Cell Significance Index: -0.2000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0356
    Cell Significance Index: -0.7100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0357
    Cell Significance Index: -0.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0391
    Cell Significance Index: -1.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0410
    Cell Significance Index: -1.6800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0416
    Cell Significance Index: -0.4300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0416
    Cell Significance Index: -0.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0422
    Cell Significance Index: -1.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0428
    Cell Significance Index: -1.0900
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.0445
    Cell Significance Index: -0.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0446
    Cell Significance Index: -0.6600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0463
    Cell Significance Index: -0.5400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0466
    Cell Significance Index: -0.5200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0468
    Cell Significance Index: -0.7000
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0474
    Cell Significance Index: -0.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0478
    Cell Significance Index: -1.0000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0486
    Cell Significance Index: -0.6100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0487
    Cell Significance Index: -0.6300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0488
    Cell Significance Index: -0.6400
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.0489
    Cell Significance Index: -0.4600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0505
    Cell Significance Index: -0.6400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0530
    Cell Significance Index: -0.6400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0535
    Cell Significance Index: -0.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0550
    Cell Significance Index: -1.0800
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.0557
    Cell Significance Index: -0.6000
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0566
    Cell Significance Index: -0.7700
  • Cell Name: immature B cell (CL0000816)
    Fold Change: -0.0592
    Cell Significance Index: -0.5600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0604
    Cell Significance Index: -0.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0618
    Cell Significance Index: -1.0400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0619
    Cell Significance Index: -0.6700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0623
    Cell Significance Index: -1.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0625
    Cell Significance Index: -1.0800
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0636
    Cell Significance Index: -0.6700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0637
    Cell Significance Index: -0.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0640
    Cell Significance Index: -0.9200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0644
    Cell Significance Index: -0.6700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0655
    Cell Significance Index: -0.8200
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0655
    Cell Significance Index: -0.7800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0664
    Cell Significance Index: -0.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0674
    Cell Significance Index: -1.2500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0683
    Cell Significance Index: -0.7800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0705
    Cell Significance Index: -0.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0727
    Cell Significance Index: -0.7900
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: -0.0731
    Cell Significance Index: -0.6900
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0742
    Cell Significance Index: -0.7500
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0754
    Cell Significance Index: -0.8900
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0760
    Cell Significance Index: -0.8200
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.0763
    Cell Significance Index: -0.8200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0784
    Cell Significance Index: -0.9900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0788
    Cell Significance Index: -1.0500
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0801
    Cell Significance Index: -1.1000
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0813
    Cell Significance Index: -0.9900
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0814
    Cell Significance Index: -0.7900
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0816
    Cell Significance Index: -1.1000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0827
    Cell Significance Index: -1.0600
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0829
    Cell Significance Index: -0.5500
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.0835
    Cell Significance Index: -1.0400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0835
    Cell Significance Index: -1.1100
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.0851
    Cell Significance Index: -1.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0857
    Cell Significance Index: -0.7200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0858
    Cell Significance Index: -1.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0858
    Cell Significance Index: -1.0700
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0869
    Cell Significance Index: -1.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** PPP3R2 shares significant structural homology with the alpha and beta subunits of calcineurin, highlighting its functional importance in calcium-dependent signaling pathways. 2. **Calcium-Binding Properties:** PPP3R2 exhibits calcium-binding capabilities, which regulate its activity and interactions with other proteins. 3. **Regulatory Subunit:** As a regulatory subunit, PPP3R2 modulates the activity of calcineurin, a calcium-dependent protein serine/threonine phosphatase. 4. **Cellular Expression:** PPP3R2 is significantly expressed in various cell types, including progenitor cells, endothelial cells, T cells, and plasma cells, underscoring its role in tissue development and immune response. **Pathways and Functions:** 1. **Calcineurin-Mediated Signaling:** PPP3R2 is integral to the calcineurin complex, which regulates various signaling pathways, including the calcineurin-NFAT (nuclear factor of activated T cells) cascade. 2. **Calcium Ion Binding:** Calcium ions bind to PPP3R2, modulating its activity and interactions with other proteins, including calcineurin and NFAT. 3. **Protein Phosphatase Complex:** PPP3R2 forms a protein serine/threonine phosphatase complex with calcineurin, facilitating the dephosphorylation of target proteins. 4. **Sperm Mitochondrial Sheath:** PPP3R2 is also involved in the regulation of sperm mitochondrial sheath formation, highlighting its role in reproductive biology. **Clinical Significance:** 1. **Immunological Disorders:** PPP3R2 dysregulation has been implicated in various immunological disorders, including autoimmune diseases and immunodeficiency syndromes. 2. **Cancer:** Alterations in PPP3R2 expression have been observed in certain types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 3. **Neurological Disorders:** PPP3R2 has been linked to neurological disorders, such as epilepsy and Alzheimer's disease, highlighting its involvement in neuronal development and function. 4. **Reproductive Biology:** PPP3R2 plays a crucial role in reproductive biology, including sperm mitochondrial sheath formation and female fertility. In conclusion, PPP3R2 is a multifunctional protein that regulates calcium-dependent signaling pathways, modulating various cellular processes. Its dysregulation has been implicated in various diseases, emphasizing the need for further research into its role in human health and disease.

Genular Protein ID: 3854289542

Symbol: CANB2_HUMAN

Name: Calcineurin subunit B type 2

UniProtKB Accession Codes:

Q96LZ3 Q5VTR4 Q7Z4V8 Q8WYJ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 20 ComplexPortal 6 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15865209

Title: Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis.

PubMed ID: 15865209

DOI: 10.1007/s11033-004-4250-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 34446558

Title: SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

PubMed ID: 34446558

DOI: 10.1073/pnas.2106673118

Sequence Information:

  • Length: 170
  • Mass: 19533
  • Checksum: 322F9CA4123BA2C3
  • Sequence:
    • MGNEASYPAE MCSHFDNDEI KRLGRRFKKL DLDKSGSLSV EEFMSLPELR HNPLVRRVID 
VFDTDGDGEV DFKEFILGTS QFSVKGDEEQ KLRFAFSIYD MDKDGYISNG ELFQVLKMMV 
GNNLTDWQLQ QLVDKTIIIL DKDGDGKISF EEFSAVVRDL EIHKKLVLIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.