Details for: PPT1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 265.4533
Cell Significance Index: -41.2900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 131.6021
Cell Significance Index: -33.3800 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 109.4314
Cell Significance Index: -45.0800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 98.3855
Cell Significance Index: -46.4500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 97.2783
Cell Significance Index: -39.5200 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 87.5803
Cell Significance Index: -45.0500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.6866
Cell Significance Index: -39.8000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 36.4003
Cell Significance Index: -44.8800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.7554
Cell Significance Index: -34.1700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.1311
Cell Significance Index: -37.2600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.6623
Cell Significance Index: -46.0200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.8218
Cell Significance Index: -14.9300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.3418
Cell Significance Index: 61.7700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.4314
Cell Significance Index: 49.7400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.3433
Cell Significance Index: 218.4800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.2740
Cell Significance Index: 94.9500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0401
Cell Significance Index: 939.1100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.9969
Cell Significance Index: 52.3400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.9606
Cell Significance Index: 111.9500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.9113
Cell Significance Index: 116.8200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8985
Cell Significance Index: 123.3900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8077
Cell Significance Index: 162.0200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6746
Cell Significance Index: 73.3800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5373
Cell Significance Index: 102.2600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4983
Cell Significance Index: 220.3000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4975
Cell Significance Index: 10.6000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4666
Cell Significance Index: 28.0100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4617
Cell Significance Index: 12.3500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4376
Cell Significance Index: 156.9800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4170
Cell Significance Index: 75.1700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4011
Cell Significance Index: 49.3200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3643
Cell Significance Index: 16.9900 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3626
Cell Significance Index: 7.5900 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.3609
Cell Significance Index: 9.4900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3062
Cell Significance Index: 211.7500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2925
Cell Significance Index: 37.8000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2317
Cell Significance Index: 126.5100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2114
Cell Significance Index: 41.9600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2078
Cell Significance Index: 14.3700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1916
Cell Significance Index: 5.2200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1643
Cell Significance Index: 11.6200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.1623
Cell Significance Index: 2.2200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.1570
Cell Significance Index: 4.6100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1501
Cell Significance Index: 14.8500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1313
Cell Significance Index: 6.8400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0525
Cell Significance Index: 8.9600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0465
Cell Significance Index: 2.1900 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0242
Cell Significance Index: 2.4700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0233
Cell Significance Index: 2.7500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0069
Cell Significance Index: 0.1500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0030
Cell Significance Index: -5.6000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0035
Cell Significance Index: -2.6600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0094
Cell Significance Index: -6.9100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0102
Cell Significance Index: -6.3500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0156
Cell Significance Index: -11.5700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0203
Cell Significance Index: -37.5000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0221
Cell Significance Index: -0.3700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0244
Cell Significance Index: -37.5700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0334
Cell Significance Index: -45.3800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0384
Cell Significance Index: -21.6800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0442
Cell Significance Index: -28.0900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0708
Cell Significance Index: -2.0400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0770
Cell Significance Index: -34.9600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0910
Cell Significance Index: -19.1800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1082
Cell Significance Index: -2.8900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1149
Cell Significance Index: -5.2100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1272
Cell Significance Index: -36.5900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1280
Cell Significance Index: -8.0700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.1752
Cell Significance Index: -4.3800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1894
Cell Significance Index: -12.2200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1919
Cell Significance Index: -21.9900 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.2116
Cell Significance Index: -2.3000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2306
Cell Significance Index: -11.9800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2408
Cell Significance Index: -35.0000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2634
Cell Significance Index: -17.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2999
Cell Significance Index: -16.8300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3135
Cell Significance Index: -19.2700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3170
Cell Significance Index: -11.1400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.3256
Cell Significance Index: -2.6600 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.3311
Cell Significance Index: -4.2400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3347
Cell Significance Index: -38.2100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3942
Cell Significance Index: -10.0700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4089
Cell Significance Index: -31.3800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4224
Cell Significance Index: -7.4700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4313
Cell Significance Index: -44.9100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4559
Cell Significance Index: -12.7400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4978
Cell Significance Index: -22.0200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5271
Cell Significance Index: -41.7500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5328
Cell Significance Index: -20.1800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5704
Cell Significance Index: -6.4800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5913
Cell Significance Index: -36.2500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.7183
Cell Significance Index: -10.9100 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.7619
Cell Significance Index: -8.1000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.7815
Cell Significance Index: -20.9400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8881
Cell Significance Index: -15.2200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9768
Cell Significance Index: -28.7700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.9785
Cell Significance Index: -34.2800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9820
Cell Significance Index: -32.1500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9897
Cell Significance Index: -25.4400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.0025
Cell Significance Index: -31.9300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3591285886
Symbol: PPT1_HUMAN
Name: Palmitoyl-protein thioesterase 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7637805
Title: Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis.
PubMed ID: 7637805
DOI: 10.1038/376584a0
PubMed ID: 8633062
Title: Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis.
PubMed ID: 8633062
PubMed ID: 8786130
Title: cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis.
PubMed ID: 8786130
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8816748
Title: Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase.
PubMed ID: 8816748
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 9425237
Title: Mutations in the palmitoyl-protein thioesterase gene (PPT; CLN1) causing juvenile neuronal ceroid lipofuscinosis with granular osmiophilic deposits.
PubMed ID: 9425237
DOI: 10.1093/hmg/7.2.291
PubMed ID: 9664077
Title: Molecular genetics of palmitoyl-protein thioesterase deficiency in the U.S.
PubMed ID: 9664077
DOI: 10.1172/jci3112
PubMed ID: 11506414
Title: Adult neuronal ceroid lipofuscinosis with palmitoyl-protein thioesterase deficiency: first adult-onset patients of a childhood disease.
PubMed ID: 11506414
DOI: 10.1002/ana.1103
PubMed ID: 19941651
Title: Novel interactions of CLN5 support molecular networking between neuronal ceroid lipofuscinosis proteins.
PubMed ID: 19941651
PubMed ID: 19201763
Title: Mutations in CLN7/MFSD8 are a common cause of variant late-infantile neuronal ceroid lipofuscinosis.
PubMed ID: 19201763
DOI: 10.1093/brain/awn366
PubMed ID: 21990111
Title: Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses.
PubMed ID: 21990111
DOI: 10.1002/humu.21624
Sequence Information:
- Length: 306
- Mass: 34193
- Checksum: 69F8083FD1C15E92
- Sequence:
MASPGCLWLL AVALLPWTCA SRALQHLDPP APLPLVIWHG MGDSCCNPLS MGAIKKMVEK KIPGIYVLSL EIGKTLMEDV ENSFFLNVNS QVTTVCQALA KDPKLQQGYN AMGFSQGGQF LRAVAQRCPS PPMINLISVG GQHQGVFGLP RCPGESSHIC DFIRKTLNAG AYSKVVQERL VQAEYWHDPI KEDVYRNHSI FLADINQERG INESYKKNLM ALKKFVMVKF LNDSIVDPVD SEWFGFYRSG QAKETIPLQE TSLYTQDRLG LKEMDNAGQL VFLATEGDHL QLSEEWFYAH IIPFLG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.