Details for: PRB4

Gene ID: 5545

Symbol: PRB4

Ensembl ID: ENSG00000230657

Description: proline rich protein BstNI subfamily 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 49.8717
    Cell Significance Index: 2325.2500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 2.1824
    Cell Significance Index: 21.8400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.1836
    Cell Significance Index: 28.6700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3897
    Cell Significance Index: 5.6800
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.1108
    Cell Significance Index: 0.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0963
    Cell Significance Index: 2.5800
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.0788
    Cell Significance Index: 0.6000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0651
    Cell Significance Index: 2.0600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.0550
    Cell Significance Index: 0.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.0537
    Cell Significance Index: 1.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0210
    Cell Significance Index: 0.3100
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.0178
    Cell Significance Index: 0.1700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0137
    Cell Significance Index: 0.1900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0132
    Cell Significance Index: 0.1600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0127
    Cell Significance Index: 0.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0095
    Cell Significance Index: 1.8900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.0072
    Cell Significance Index: 0.1500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0069
    Cell Significance Index: 0.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0059
    Cell Significance Index: 0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0011
    Cell Significance Index: 1.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0005
    Cell Significance Index: 0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: 0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0008
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0009
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0012
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0022
    Cell Significance Index: -0.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0024
    Cell Significance Index: -0.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0031
    Cell Significance Index: -0.5600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0044
    Cell Significance Index: -0.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0060
    Cell Significance Index: -0.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0064
    Cell Significance Index: -0.3600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0069
    Cell Significance Index: -0.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0069
    Cell Significance Index: -0.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0078
    Cell Significance Index: -0.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0080
    Cell Significance Index: -0.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0084
    Cell Significance Index: -0.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0084
    Cell Significance Index: -0.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0097
    Cell Significance Index: -0.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0103
    Cell Significance Index: -0.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0109
    Cell Significance Index: -0.6700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0109
    Cell Significance Index: -0.1000
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.0111
    Cell Significance Index: -0.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0113
    Cell Significance Index: -0.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0121
    Cell Significance Index: -0.3100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0132
    Cell Significance Index: -0.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0140
    Cell Significance Index: -0.6600
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: -0.0145
    Cell Significance Index: -0.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0151
    Cell Significance Index: -0.3900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0152
    Cell Significance Index: -0.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0153
    Cell Significance Index: -0.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0155
    Cell Significance Index: -0.2600
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0158
    Cell Significance Index: -0.1600
  • Cell Name: serous cell of epithelium of bronchus (CL1000331)
    Fold Change: -0.0168
    Cell Significance Index: -0.0700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0174
    Cell Significance Index: -0.2200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0175
    Cell Significance Index: -0.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0185
    Cell Significance Index: -0.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0187
    Cell Significance Index: -0.5000
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0192
    Cell Significance Index: -0.1700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0193
    Cell Significance Index: -0.1400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0195
    Cell Significance Index: -0.4900
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0198
    Cell Significance Index: -0.2200
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0202
    Cell Significance Index: -0.2800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0204
    Cell Significance Index: -0.2800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0212
    Cell Significance Index: -0.2100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0217
    Cell Significance Index: -0.5300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0217
    Cell Significance Index: -0.2100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0220
    Cell Significance Index: -0.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0222
    Cell Significance Index: -0.4800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0224
    Cell Significance Index: -0.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0226
    Cell Significance Index: -0.3100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0227
    Cell Significance Index: -0.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0229
    Cell Significance Index: -0.2500
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0238
    Cell Significance Index: -0.2700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0239
    Cell Significance Index: -0.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0240
    Cell Significance Index: -0.4800
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0240
    Cell Significance Index: -0.3200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0254
    Cell Significance Index: -0.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0261
    Cell Significance Index: -0.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0265
    Cell Significance Index: -0.7200
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: -0.0273
    Cell Significance Index: -0.2400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0275
    Cell Significance Index: -0.3700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0278
    Cell Significance Index: -0.4100
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0286
    Cell Significance Index: -0.3100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0289
    Cell Significance Index: -0.5000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0289
    Cell Significance Index: -0.3200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0290
    Cell Significance Index: -0.3500
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: -0.0291
    Cell Significance Index: -0.2600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.0302
    Cell Significance Index: -0.3300
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0308
    Cell Significance Index: -0.3600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0309
    Cell Significance Index: -0.4100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0309
    Cell Significance Index: -0.3600
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0313
    Cell Significance Index: -0.3800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0316
    Cell Significance Index: -0.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRB4 is a proline-rich protein, which implies its structural features are characterized by a high content of proline residues. This protein belongs to the BstNI subfamily, a group of proteins known for their involvement in cell signaling and adhesion. The expression of PRB4 is widespread, with significant expression in acinar cells of the salivary gland, duct epithelial cells, goblet cells, and various immune cells, including CD8-positive αβ T cells. This suggests that PRB4 plays a role in maintaining the integrity and function of epithelial tissues and immune cells. **Pathways and Functions:** PRB4 is involved in several cellular pathways, including: 1. **Cell Signaling:** PRB4 interacts with other proteins to regulate cell signaling pathways, including the MAPK/ERK pathway, which is involved in cell proliferation, differentiation, and survival. 2. **Adhesion:** PRB4 is involved in cell adhesion, particularly in the context of epithelial cells and immune cells. It interacts with integrins and other adhesion molecules to regulate cell-cell and cell-extracellular matrix interactions. 3. **Migration:** PRB4 is involved in cell migration, particularly in the context of immune cells and stem cells. It regulates the migration of these cells through interactions with the cytoskeleton and the extracellular matrix. **Clinical Significance:** The clinical significance of PRB4 is an area of ongoing research. However, its involvement in various diseases suggests that it may play a role in: 1. **Immunological Disorders:** PRB4 may be involved in autoimmune diseases, such as rheumatoid arthritis, where immune cells are dysregulated and contribute to tissue damage. 2. **Cancer:** PRB4 may be involved in cancer progression, particularly in the context of epithelial cancers, where cell signaling and adhesion pathways are dysregulated. 3. **Inflammatory Disorders:** PRB4 may be involved in inflammatory disorders, such as inflammatory bowel disease, where epithelial cells and immune cells are dysregulated and contribute to tissue damage. In conclusion, PRB4 is a multifunctional protein involved in various cellular pathways, including cell signaling, adhesion, and migration. Its expression in various cell types suggests its involvement in maintaining tissue homeostasis and immune function. Further research is needed to elucidate the clinical significance of PRB4 and its role in various diseases.

Genular Protein ID: 825379041

Symbol: E7EXA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EXA8

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 4 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 178
  • Mass: 18011
  • Checksum: 74EC20B20F6F7B08
  • Sequence:
    • MLLILLSVAL LALSSAESSS EDVSQEESLF LISGKPEGRR PQGGNQPQRP PPPPGKPQGP 
PPQGGNQSQG PPPPPGKPEG RPPQGGNQSQ GPPPHPGKPE RPPPQGGNQS QGKPQGPPQQ 
EGNKPQGPPP PGKPQGPPPA GGNPQQPQAP PAGKPQGPPP PPQGGRPPRP AQGQQPPQ

Genular Protein ID: 1352825079

Symbol: E9PAL0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PAL0

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 4 GeneTree 1 HGNC 1 InterPro 1 MANE-Select 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 2 SMART 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 247
  • Mass: 25064
  • Checksum: 6A1943E4351346C4
  • Sequence:
    • MLLILLSVAL LALSSAESSS EDVSQEESLF LISGKPEGRR PQGGNQPQRP PPPPGKPQGP 
PPQGGNQSQG PPPPPGKPEG RPPQGGNQSQ GPPPHPGKPE RPPPQGGNQS QGTPPPPGKP 
ERPPPQGGNQ SHRPPPPPGK PERPPPQGGN QSQGPPPHPG KPEGPPPQEG NKSRSARSPP 
GKPQGPPQQE GNKPQGPPPP GKPQGPPPAG GNPQQPQAPP AGKPQGPPPP PQGGRPPRPA 
QGQQPPQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.