PRKAA2 | ENSG00000162409 | NCBI 5563

Details for: PRKAA2

Gene ID: 5563

Symbol: PRKAA2

Ensembl ID: ENSG00000162409

Description: protein kinase AMP-activated catalytic subunit alpha 2

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Activation of ppargc1a (pgc-1alpha) by phosphorylation
(R-HSA-2151209)
Ampk inhibits chrebp transcriptional activation activity
(R-HSA-163680)
Carnitine shuttle
(R-HSA-200425)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Energy dependent regulation of mtor by lkb1-ampk
(R-HSA-380972)
Fatty acid metabolism
(R-HSA-8978868)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Integration of energy metabolism
(R-HSA-163685)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Lipophagy
(R-HSA-9613354)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Mitochondrial biogenesis
(R-HSA-1592230)
Mtor signalling
(R-HSA-165159)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rna polymerase ii transcription
(R-HSA-73857)
Selective autophagy
(R-HSA-9663891)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Vesicle-mediated transport
(R-HSA-5653656)
Amp-activated protein kinase activity
(GO:0004679)
Atp binding
(GO:0005524)
Autophagy
(GO:0006914)
Cellular response to calcium ion
(GO:0071277)
Cellular response to glucose starvation
(GO:0042149)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to nutrient levels
(GO:0031669)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to prostaglandin e stimulus
(GO:0071380)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cholesterol biosynthetic process
(GO:0006695)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Energy homeostasis
(GO:0097009)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid homeostasis
(GO:0055089)
Glucose homeostasis
(GO:0042593)
Golgi apparatus
(GO:0005794)
Histone h2as1 kinase activity
(GO:0044024)
Histone h2bs36 kinase activity
(GO:0140823)
Lipid biosynthetic process
(GO:0008610)
Lipid droplet disassembly
(GO:1905691)
Metal ion binding
(GO:0046872)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of hepatocyte apoptotic process
(GO:1903944)
Negative regulation of torc1 signaling
(GO:1904262)
Negative regulation of tor signaling
(GO:0032007)
Negative regulation of tubulin deacetylation
(GO:1904428)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of glycolytic process
(GO:0045821)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of peptidyl-lysine acetylation
(GO:2000758)
Positive regulation of protein localization
(GO:1903829)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein localization to lipid droplet
(GO:1990044)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of circadian rhythm
(GO:0042752)
Regulation of macroautophagy
(GO:0016241)
Regulation of microtubule cytoskeleton organization
(GO:0070507)
Regulation of stress granule assembly
(GO:0062028)
Response to muscle activity
(GO:0014850)
Rhythmic process
(GO:0048511)
Signal transduction
(GO:0007165)
Wnt signaling pathway
(GO:0016055)
[hydroxymethylglutaryl-coa reductase (nadph)] kinase activity
(GO:0047322)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 147.5300
Cell Significance Index: -37.4200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 35.5855
Cell Significance Index: -33.9800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.2281
Cell Significance Index: -38.1200
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.3244
Cell Significance Index: -16.0300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 3.5796
Cell Significance Index: 225.6100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 3.1054
Cell Significance Index: 238.3000
Cell Name: type I muscle cell (CL0002211)
Fold Change: 2.4890
Cell Significance Index: 60.7300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.2190
Cell Significance Index: 445.1300
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.0477
Cell Significance Index: 24.4100
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.9167
Cell Significance Index: 380.3900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.7949
Cell Significance Index: 643.7900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.6717
Cell Significance Index: 42.9700
Cell Name: type II muscle cell (CL0002212)
Fold Change: 1.4355
Cell Significance Index: 23.1600
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 1.2016
Cell Significance Index: 17.7400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.9995
Cell Significance Index: 67.2100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.9657
Cell Significance Index: 36.5700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9648
Cell Significance Index: 95.4400
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.9307
Cell Significance Index: 20.3800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.9204
Cell Significance Index: 40.7100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.7998
Cell Significance Index: 44.8800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7032
Cell Significance Index: 43.2200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5818
Cell Significance Index: 26.3700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.5443
Cell Significance Index: 247.0400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4458
Cell Significance Index: 72.5000
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4166
Cell Significance Index: 288.1100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.3791
Cell Significance Index: 207.0100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3602
Cell Significance Index: 16.8000
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.3311
Cell Significance Index: 7.9400
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.3152
Cell Significance Index: 3.9100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2976
Cell Significance Index: 32.3700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2688
Cell Significance Index: 51.1500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2558
Cell Significance Index: 7.3000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2295
Cell Significance Index: 207.2400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1967
Cell Significance Index: 10.3300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1850
Cell Significance Index: 117.5100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1495
Cell Significance Index: 281.4800
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0887
Cell Significance Index: 163.5500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0822
Cell Significance Index: 14.8100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0795
Cell Significance Index: 58.3100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0646
Cell Significance Index: 99.3900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0411
Cell Significance Index: 7.0100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0359
Cell Significance Index: 48.8200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0007
Cell Significance Index: -0.0800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0073
Cell Significance Index: -0.2100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0096
Cell Significance Index: -7.1300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0097
Cell Significance Index: -4.2900
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0103
Cell Significance Index: -0.7100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0162
Cell Significance Index: -10.1400
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0276
Cell Significance Index: -0.6900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0398
Cell Significance Index: -22.4200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0526
Cell Significance Index: -39.8200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0533
Cell Significance Index: -3.9700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0572
Cell Significance Index: -1.2400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1036
Cell Significance Index: -21.8200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1058
Cell Significance Index: -30.4500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1133
Cell Significance Index: -16.4700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1290
Cell Significance Index: -13.1800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1633
Cell Significance Index: -18.7100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1637
Cell Significance Index: -22.4800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1653
Cell Significance Index: -5.8100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1752
Cell Significance Index: -18.2400
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1793
Cell Significance Index: -22.9900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2022
Cell Significance Index: -23.5600
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2200
Cell Significance Index: -3.7700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2272
Cell Significance Index: -13.9300
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.2309
Cell Significance Index: -3.0000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2472
Cell Significance Index: -31.9400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2914
Cell Significance Index: -15.1400
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3129
Cell Significance Index: -6.6400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3153
Cell Significance Index: -6.5400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3182
Cell Significance Index: -25.2000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3242
Cell Significance Index: -37.0100
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3768
Cell Significance Index: -26.6500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4053
Cell Significance Index: -5.5300
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4124
Cell Significance Index: -8.2800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4398
Cell Significance Index: -20.6700
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4405
Cell Significance Index: -14.0300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4623
Cell Significance Index: -12.9200
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4813
Cell Significance Index: -10.2500
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.5165
Cell Significance Index: -6.4400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5370
Cell Significance Index: -17.5800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5461
Cell Significance Index: -14.3600
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.5690
Cell Significance Index: -11.2500
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5698
Cell Significance Index: -12.3100
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.5942
Cell Significance Index: -7.6200
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.6020
Cell Significance Index: -4.6400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6385
Cell Significance Index: -17.3800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.6495
Cell Significance Index: -33.8300
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.6814
Cell Significance Index: -8.6000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6974
Cell Significance Index: -24.4300
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.6994
Cell Significance Index: -6.6600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7087
Cell Significance Index: -22.7000
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.7238
Cell Significance Index: -7.5400
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.7328
Cell Significance Index: -18.2800
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8107
Cell Significance Index: -28.1700
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.8385
Cell Significance Index: -6.4100
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8386
Cell Significance Index: -22.4700
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8399
Cell Significance Index: -24.7400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.8443
Cell Significance Index: -31.0000
Cell Name: peg cell (CL4033014)
Fold Change: -0.8960
Cell Significance Index: -20.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **AMP-activated protein kinase complex**: PRKAA2 is a subunit of the AMPK complex, which is activated in response to low energy levels within the cell. 2. **Phosphorylation activity**: PRKAA2 exhibits phosphorylation activity, which is essential for its regulation of downstream targets. 3. **Multiple cellular responses**: PRKAA2 regulates various cellular responses, including autophagy, fatty acid metabolism, and glucose homeostasis. 4. **Significant expression in multiple cell types**: PRKAA2 is expressed in various cell types, including cardiac myocytes, skeletal muscle cells, and renal epithelial cells. **Pathways and Functions:** 1. **Energy homeostasis**: PRKAA2 plays a critical role in regulating energy homeostasis by phosphorylating and regulating downstream targets involved in energy metabolism. 2. **Autophagy**: PRKAA2 is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. 3. **Fatty acid metabolism**: PRKAA2 regulates fatty acid metabolism by phosphorylating and activating key enzymes involved in fatty acid synthesis and degradation. 4. **Glucose homeostasis**: PRKAA2 is involved in regulating glucose homeostasis by phosphorylating and activating key enzymes involved in glucose metabolism. 5. **Cellular stress response**: PRKAA2 regulates the cellular stress response by phosphorylating and activating key transcription factors involved in stress response pathways. **Clinical Significance:** 1. **Metabolic disorders**: PRKAA2 mutations have been associated with metabolic disorders, such as type 2 diabetes and obesity. 2. **Cardiovascular disease**: PRKAA2 is involved in regulating cardiac energy metabolism, and mutations in PRKAA2 have been associated with cardiovascular disease. 3. **Neurological disorders**: PRKAA2 is involved in regulating neuronal energy metabolism, and mutations in PRKAA2 have been associated with neurological disorders, such as Parkinson's disease. 4. **Cancer**: PRKAA2 is involved in regulating cancer cell metabolism, and its dysregulation has been associated with cancer progression. In conclusion, PRKAA2 is a critical gene involved in regulating energy homeostasis and cellular stress response. Its dysregulation has been associated with various diseases, including metabolic disorders, cardiovascular disease, neurological disorders, and cancer. Further research is needed to fully understand the role of PRKAA2 in human disease and to develop therapeutic strategies to target this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

5'-AMP-activated protein kinase catalytic subunit alpha-2

Genular Protein ID: 1023372013

Symbol: AAPK2_HUMAN

Name: 5'-AMP-activated protein kinase catalytic subunit alpha-2

UniProtKB Accession Codes:

P54646 Q9H1E8 Q9UD43

Database IDs:

Citations:

PubMed ID: 7959015

Title: Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals.

PubMed ID: 7959015

DOI: 10.1016/0378-1119(94)90174-0

PubMed ID: 7988703

Title: Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase.

PubMed ID: 7988703

DOI: 10.1016/0014-5793(94)01247-4

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11554766

Title: Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line.

PubMed ID: 11554766

DOI: 10.1006/bbrc.2001.5627

PubMed ID: 11518699

Title: Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors.

PubMed ID: 11518699

DOI: 10.1074/jbc.c100316200

PubMed ID: 11602624

Title: Role of AMP-activated protein kinase in mechanism of metformin action.

PubMed ID: 11602624

DOI: 10.1172/jci13505

PubMed ID: 12519745

Title: Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells.

PubMed ID: 12519745

DOI: 10.1152/ajpcell.00227.2002

PubMed ID: 14651849

Title: TSC2 mediates cellular energy response to control cell growth and survival.

PubMed ID: 14651849

DOI: 10.1016/s0092-8674(03)00929-2

PubMed ID: 15980064

Title: The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.

PubMed ID: 15980064

DOI: 10.1074/jbc.m503824200

PubMed ID: 15866171

Title: AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

PubMed ID: 15866171

DOI: 10.1016/j.molcel.2005.03.027

PubMed ID: 17711846

Title: The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor.

PubMed ID: 17711846

DOI: 10.1074/jbc.m705325200

PubMed ID: 17486097

Title: Energy-dependent regulation of cell structure by AMP-activated protein kinase.

PubMed ID: 17486097

DOI: 10.1038/nature05828

PubMed ID: 18184930

Title: AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5.

PubMed ID: 18184930

DOI: 10.2337/db07-0843

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20074060

Title: Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.

PubMed ID: 20074060

DOI: 10.1042/bst0380205

PubMed ID: 20160076

Title: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.

PubMed ID: 20160076

DOI: 10.1073/pnas.0913860107

PubMed ID: 21460634

Title: Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

PubMed ID: 21460634

DOI: 10.4161/auto.7.7.15451

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21205641

Title: Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy.

PubMed ID: 21205641

DOI: 10.1126/science.1196371

PubMed ID: 17307971

Title: AMP-activated protein kinase in metabolic control and insulin signaling.

PubMed ID: 17307971

DOI: 10.1161/01.res.0000256090.42690.05

PubMed ID: 17712357

Title: AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

PubMed ID: 17712357

DOI: 10.1038/nrm2249

PubMed ID: 22517326

Title: The ancient drug salicylate directly activates AMP-activated protein kinase.

PubMed ID: 22517326

DOI: 10.1126/science.1215327

PubMed ID: 23088624

Title: N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells.

PubMed ID: 23088624

DOI: 10.1042/bj20121201

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24767988

Title: A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.

PubMed ID: 24767988

DOI: 10.1016/j.celrep.2014.03.065

PubMed ID: 25687571

Title: The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network.

PubMed ID: 25687571

DOI: 10.1074/mcp.m114.047159

PubMed ID: 28552616

Title: Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.

PubMed ID: 28552616

DOI: 10.1016/j.molcel.2017.04.026

PubMed ID: 28561066

Title: WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

PubMed ID: 28561066

DOI: 10.1038/ncomms15637

PubMed ID: 32029622

Title: An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

PubMed ID: 32029622

DOI: 10.1126/science.aay0542

PubMed ID: 34077757

Title: Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

PubMed ID: 34077757

DOI: 10.1016/j.molcel.2021.05.005

PubMed ID: 36732624

Title: AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation.

PubMed ID: 36732624

DOI: 10.1038/s42255-022-00732-4

PubMed ID: 37079666

Title: Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.

PubMed ID: 37079666

DOI: 10.1126/science.abj5559

PubMed ID: 36017701

Title: AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation.

PubMed ID: 36017701

DOI: 10.1242/jcs.259609

PubMed ID: 36367943

Title: AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology.

PubMed ID: 36367943

DOI: 10.1126/sciadv.abo7956

PubMed ID: 20124709

Title: A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation.

PubMed ID: 20124709

DOI: 10.1107/s1744309109052543

PubMed ID: 21543851

Title: Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha2 subunit kinase domain.

PubMed ID: 21543851

DOI: 10.1107/s0907444911010201

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 552
Mass: 62320
Checksum: C46AAFC1D5104975
Sequence:

MAEKQKHDGR VKIGHYVLGD TLGVGTFGKV KIGEHQLTGH KVAVKILNRQ KIRSLDVVGK 
IKREIQNLKL FRHPHIIKLY QVISTPTDFF MVMEYVSGGE LFDYICKHGR VEEMEARRLF 
QQILSAVDYC HRHMVVHRDL KPENVLLDAH MNAKIADFGL SNMMSDGEFL RTSCGSPNYA 
APEVISGRLY AGPEVDIWSC GVILYALLCG TLPFDDEHVP TLFKKIRGGV FYIPEYLNRS 
VATLLMHMLQ VDPLKRATIK DIREHEWFKQ DLPSYLFPED PSYDANVIDD EAVKEVCEKF 
ECTESEVMNS LYSGDPQDQL AVAYHLIIDN RRIMNQASEF YLASSPPSGS FMDDSAMHIP 
PGLKPHPERM PPLIADSPKA RCPLDALNTT KPKSLAVKKA KWHLGIRSQS KPYDIMAEVY 
RAMKQLDFEW KVVNAYHLRV RRKNPVTGNY VKMSLQLYLV DNRSYLLDFK SIDDEVVEQR 
SGSSTPQRSC SAAGLHRPRS SFDSTTAESH SLSGSLTGSL TGSTLSSVSP RLGSHTMDFF 
EMCASLITTL AR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKAA2

Associated with

Cells (max top 100)

Other Information

Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals. PubMed ID: 7959015

Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase. PubMed ID: 7988703

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. PubMed ID: 11554766

Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors. PubMed ID: 11518699

Role of AMP-activated protein kinase in mechanism of metformin action. PubMed ID: 11602624

Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. PubMed ID: 12519745

TSC2 mediates cellular energy response to control cell growth and survival. PubMed ID: 14651849

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. PubMed ID: 15980064

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. PubMed ID: 15866171

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. PubMed ID: 17711846

Energy-dependent regulation of cell structure by AMP-activated protein kinase. PubMed ID: 17486097

AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. PubMed ID: 18184930

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement. PubMed ID: 20074060

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. PubMed ID: 20160076

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. PubMed ID: 21460634

Initial characterization of the human central proteome. PubMed ID: 21269460

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. PubMed ID: 21205641

AMP-activated protein kinase in metabolic control and insulin signaling. PubMed ID: 17307971

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. PubMed ID: 17712357

The ancient drug salicylate directly activates AMP-activated protein kinase. PubMed ID: 22517326

N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells. PubMed ID: 23088624

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels. PubMed ID: 24767988

The last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein network. PubMed ID: 25687571

Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. PubMed ID: 28552616

WIPI3 and WIPI4 beta-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. PubMed ID: 28561066

An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. PubMed ID: 32029622

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets. PubMed ID: 34077757

AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activation. PubMed ID: 36732624

Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1. PubMed ID: 37079666

AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation. PubMed ID: 36017701

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. PubMed ID: 36367943

A conserved mechanism of autoinhibition for the AMPK kinase domain: ATP-binding site and catalytic loop refolding as a means of regulation. PubMed ID: 20124709

Structural basis for compound C inhibition of the human AMP-activated protein kinase alpha2 subunit kinase domain. PubMed ID: 21543851

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846