PRKACB | ENSG00000142875 | NCBI 5567

Details for: PRKACB

Gene ID: 5567

Symbol: PRKACB

Ensembl ID: ENSG00000142875

Description: protein kinase cAMP-activated catalytic subunit beta

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Axon guidance
(R-HSA-422475)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Cam pathway
(R-HSA-111997)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-HSA-442720)
Dag and ip3 signaling
(R-HSA-1489509)
Darpp-32 events
(R-HSA-180024)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (s) signalling events
(R-HSA-418555)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Gpcr downstream signalling
(R-HSA-388396)
Gper1 signaling
(R-HSA-9634597)
Hdl assembly
(R-HSA-8963896)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Metabolism of lipids
(R-HSA-556833)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Pka-mediated phosphorylation of key metabolic factors
(R-HSA-163358)
Pka activation
(R-HSA-163615)
Pka activation in glucagon signalling
(R-HSA-164378)
Plasma lipoprotein assembly
(R-HSA-8963898)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Rap1 signalling
(R-HSA-392517)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
(R-HSA-9634600)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Ret signaling
(R-HSA-8853659)
Robo receptors bind akap5
(R-HSA-9010642)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by robo receptors
(R-HSA-376176)
Signaling by vegf
(R-HSA-194138)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Triglyceride catabolism
(R-HSA-163560)
Triglyceride metabolism
(R-HSA-8979227)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Amp-activated protein kinase activity
(GO:0004679)
Atp binding
(GO:0005524)
Camp-dependent protein kinase activity
(GO:0004691)
High-density lipoprotein particle assembly
(GO:0034380)
Magnesium ion binding
(GO:0000287)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative regulation of torc1 signaling
(GO:1904262)
Neural tube closure
(GO:0001843)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of protein processing
(GO:0070613)
Renal water homeostasis
(GO:0003091)
Signal transduction
(GO:0007165)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 430.2929
Cell Significance Index: -66.9300
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 238.0902
Cell Significance Index: -60.3900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 142.9501
Cell Significance Index: -67.4900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 130.7792
Cell Significance Index: -53.1300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 121.2710
Cell Significance Index: -62.3800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 56.0779
Cell Significance Index: -53.5400
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 54.8763
Cell Significance Index: -67.6600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 22.9663
Cell Significance Index: -70.5400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 21.5166
Cell Significance Index: -57.6400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.2990
Cell Significance Index: -68.2600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.4836
Cell Significance Index: -29.5100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 3.8701
Cell Significance Index: 260.2300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.1206
Cell Significance Index: 138.0300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.0652
Cell Significance Index: 116.0700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.9388
Cell Significance Index: 1054.0900
Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.9171
Cell Significance Index: 69.9600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.9126
Cell Significance Index: 163.4400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.8699
Cell Significance Index: 575.7000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.8449
Cell Significance Index: 174.8600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.5041
Cell Significance Index: 71.4600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.8381
Cell Significance Index: 1271.2900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.4031
Cell Significance Index: 107.6800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2675
Cell Significance Index: 206.1500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.2147
Cell Significance Index: 25.8700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1176
Cell Significance Index: 221.7900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0856
Cell Significance Index: 118.0800
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.0083
Cell Significance Index: 17.2800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8515
Cell Significance Index: 39.7000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7771
Cell Significance Index: 22.3900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.6412
Cell Significance Index: 22.5300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.6201
Cell Significance Index: 32.5600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4517
Cell Significance Index: 31.2400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4514
Cell Significance Index: 849.9400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.4411
Cell Significance Index: 200.2200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3945
Cell Significance Index: 71.1200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2795
Cell Significance Index: 12.6700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.2624
Cell Significance Index: 166.6800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2524
Cell Significance Index: 6.3100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2309
Cell Significance Index: 28.3900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2264
Cell Significance Index: 14.2700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1667
Cell Significance Index: 16.4900
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.1049
Cell Significance Index: 1.3600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0761
Cell Significance Index: 117.1700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0556
Cell Significance Index: 102.4900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0514
Cell Significance Index: 9.7900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0353
Cell Significance Index: 19.2800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0065
Cell Significance Index: -0.7600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0090
Cell Significance Index: -1.2300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0137
Cell Significance Index: -18.6600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0143
Cell Significance Index: -0.3100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0209
Cell Significance Index: -2.4600
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0284
Cell Significance Index: -21.0700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0518
Cell Significance Index: -37.9500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0548
Cell Significance Index: -34.2300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0761
Cell Significance Index: -42.9400
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0809
Cell Significance Index: -35.7500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0955
Cell Significance Index: -72.3200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1466
Cell Significance Index: -25.0300
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1491
Cell Significance Index: -31.4000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1924
Cell Significance Index: -19.6500
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1927
Cell Significance Index: -28.0100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1982
Cell Significance Index: -3.9200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2009
Cell Significance Index: -57.8100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2516
Cell Significance Index: -16.2300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.2548
Cell Significance Index: -13.2700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2981
Cell Significance Index: -8.3300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3619
Cell Significance Index: -41.4700
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.3936
Cell Significance Index: -5.2500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4040
Cell Significance Index: -42.0700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.4536
Cell Significance Index: -58.6000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.4548
Cell Significance Index: -58.3000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4645
Cell Significance Index: -24.1300
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4941
Cell Significance Index: -5.8900
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.4961
Cell Significance Index: -9.9600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5077
Cell Significance Index: -57.9500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5771
Cell Significance Index: -12.3400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6049
Cell Significance Index: -19.8100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.6170
Cell Significance Index: -13.5100
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6450
Cell Significance Index: -13.6900
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.6705
Cell Significance Index: -21.3600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6782
Cell Significance Index: -53.7100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.7581
Cell Significance Index: -35.6300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.7737
Cell Significance Index: -57.6600
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.7954
Cell Significance Index: -23.3600
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.8179
Cell Significance Index: -8.5200
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.8215
Cell Significance Index: -8.9500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8221
Cell Significance Index: -50.4000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.8257
Cell Significance Index: -58.4000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.8920
Cell Significance Index: -17.4100
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.8997
Cell Significance Index: -8.5600
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -1.0890
Cell Significance Index: -15.6000
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.1877
Cell Significance Index: -25.6600
Cell Name: photoreceptor cell (CL0000210)
Fold Change: -1.2275
Cell Significance Index: -17.2400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.2611
Cell Significance Index: -44.1800
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.3066
Cell Significance Index: -19.2900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.3632
Cell Significance Index: -35.0400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.3881
Cell Significance Index: -20.8000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.3959
Cell Significance Index: -44.7100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.4015
Cell Significance Index: -48.7000
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.4056
Cell Significance Index: -36.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Gene structure**: PRKACB is a single-copy gene with a relatively small size, consisting of 6 exons and 5 introns. 2. **Protein function**: The encoded protein is a catalytic subunit of protein kinase A (PKA), which is activated by cAMP. PKA plays a central role in various signaling pathways, including those involved in immune responses, metabolic regulation, and cellular development. 3. **Cellular localization**: PRKACB is expressed in multiple cell types, including neurons, glial cells, and immune cells. 4. **Signaling pathways**: PRKACB is involved in numerous signaling pathways, including those related to immune responses, metabolic regulation, and cellular development. **Pathways and Functions** 1. **Immune responses**: PRKACB is involved in the regulation of immune responses, including the production of anti-inflammatory cytokines and the activation of NMDA receptors. 2. **Metabolic regulation**: PRKACB plays a crucial role in metabolic regulation, including the regulation of glycolysis and insulin secretion. 3. **Cellular development**: PRKACB is involved in the regulation of cellular development, including the development of neurons and glial cells. 4. **Adenylate cyclase-modulating G protein-coupled receptor signaling**: PRKACB is involved in the regulation of adenylate cyclase-modulating G protein-coupled receptor signaling pathways. 5. **Amp-activated protein kinase activity**: PRKACB is involved in the regulation of amp-activated protein kinase activity. **Clinical Significance** 1. **Disease association**: PRKACB has been implicated in several diseases, including diabetes, obesity, and immune disorders. 2. **Therapeutic targeting**: PRKACB is a potential target for therapeutic intervention in diseases related to its dysregulation. 3. **Neurological disorders**: PRKACB has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: PRKACB has been implicated in cancer, including the regulation of cell growth and survival. In conclusion, PRKACB is a multifunctional gene that plays a crucial role in various cellular processes, including immune responses, metabolic regulation, and cellular development. Its dysregulation has been implicated in several diseases, making it a potential target for therapeutic intervention. Further research is needed to fully understand the role of PRKACB in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 1141478992

Symbol: KAPCB_HUMAN

Name: cAMP-dependent protein kinase catalytic subunit beta

UniProtKB Accession Codes:

P22694 B1APG4 B4DKB0 B4E2Q1 Q14VH1 Q59GC0 Q5BNE9 Q5BNF0 Q5BNF1 Q5BNF2 Q5BNF3 Q5CZ92 Q5T1K3 Q7Z3M1 Q8IYR5 Q8IZQ0 Q96B09

Database IDs:

Citations:

PubMed ID: 2342480

Title: Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.

PubMed ID: 2342480

DOI: 10.1210/mend-4-3-465

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11589697

Title: Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase.

PubMed ID: 11589697

DOI: 10.1046/j.0014-2956.2001.02429.x

PubMed ID: 12420224

Title: c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-CB) gene.

PubMed ID: 12420224

DOI: 10.1038/sj.onc.1205986

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21880142

Title: G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A.

PubMed ID: 21880142

DOI: 10.1186/1750-2187-6-10

PubMed ID: 21423175

Title: Control of PKA stability and signalling by the RING ligase praja2.

PubMed ID: 21423175

DOI: 10.1038/ncb2209

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 31112131

Title: GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.

PubMed ID: 31112131

DOI: 10.7554/elife.43038

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 33058759

Title: Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.

PubMed ID: 33058759

DOI: 10.1016/j.ajhg.2020.09.005

Sequence Information:

Length: 351
Mass: 40623
Checksum: 5C7443FBBA1C9BEC
Sequence:

MGNAATAKKG SEVESVKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL GTGSFGRVML 
VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVRLEYA FKDNSNLYMV 
MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY 
IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF 
ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT 
TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE F

Genular Protein ID: 2683019269

Symbol: B1APF9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B1APF9

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 245
Mass: 28550
Checksum: 72ABC48F946516DF
Sequence:

MGLLKEFLAK AKEDFLKKWE NPTQNNAGLE DFERKKTLGT GSFGRVMLVK HKATEQYYAM 
KILDKQKVVK LKQIEHTLNE KRILQAVNFP FLVRLEYAFK DNSNLYMVME YVPGGEMFSH 
LRRIGRFSEP HARFYAAQIV LTFEYLHSLD LIYRDLKPEN LLIDHQGYIQ VTDFGFAKRV 
KGRTWTLCGT PEYLAPEIIL SKGYNKAVDW WALGVLIYEM AAGYPPFFAD QPIQIYEKIV 
SGKNF

Genular Protein ID: 4149090957

Symbol: B1APG3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B1APG3

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

Length: 264
Mass: 30498
Checksum: 181CA0A6367836DB
Sequence:

MSARKSSDAS ACSSSEISDS FVKEFLAKAK EDFLKKWENP TQNNAGLEDF ERKKTLGTGS 
FGRVMLVKHK ATEQYYAMKI LDKQKVVKLK QIEHTLNEKR ILQAVNFPFL VRLEYAFKDN 
SNLYMVMEYV PGGEMFSHLR RIGRFSEPHA RFYAAQIVLT FEYLHSLDLI YRDLKPENLL 
IDHQGYIQVT DFGFAKRVKG RTWTLCGTPE YLAPEIILSK GYNKAVDWWA LGVLIYEMAA 
GYPPFFADQP IQIYEKIVSG KQNF

Genular Protein ID: 167440886

Symbol: B7ZA00_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZA00

Database IDs:

Sequence Information:

Length: 314
Mass: 36479
Checksum: F56E02B8C211B94A
Sequence:

MPDLKILKGK KTLGTGSFGR VMLVKHKATE QYYAMKILDK QKVVKLKQIE HTLNEKRILQ 
AVNFPFLVRL EYAFKDNSNL YMVMEYVPGG EMFSHLRRIG RFSEPHARFY AAQIVLTFEY 
LHSLDLIYRD LKPENLLIDH QGYIQVTDFG FAKRVKGRTW TLCGTPEYLA PEIILSKGYN 
KAVDWWALGV LIYEMAAGYP PFFADQPIQI YEKIVSGKVR FPSHFSSDLK DLLRNLLQVD 
LTKRFGNLKN GVSDIKTHKW FATTDWIAIY QRKVEAPFIP KFRGSGDTSN FDDYEEEDIR 
VSITEKCAKE FGEF

Genular Protein ID: 3202147629

Symbol: A0A087WVC4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WVC4

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 338
Mass: 39236
Checksum: EE93AE7F31AB12E5
Sequence:

MLLLSSSISL YKDRNEARLI SSQNNAGLED FERKKTLGTG SFGRVMLVKH KATEQYYAMK 
ILDKQKVVKL KQIEHTLNEK RILQAVNFPF LVRLEYAFKD NSNLYMVMEY VPGGEMFSHL 
RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL IYRDLKPENL LIDHQGYIQV TDFGFAKRVK 
GRTWTLCGTP EYLAPEIILS KGYNKAVDWW ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS 
GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG NLKNGVSDIK THKWFATTDW IAIYQRKVEA 
PFIPKFRGSG DTSNFDDYEE EDIRVSITEK CAKEFGEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKACB

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. PubMed ID: 2342480

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. PubMed ID: 11589697

c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-CB) gene. PubMed ID: 12420224

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. PubMed ID: 21880142

Control of PKA stability and signalling by the RING ligase praja2. PubMed ID: 21423175

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. PubMed ID: 25255805

GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. PubMed ID: 31112131

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. PubMed ID: 33058759

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Initial characterization of the human central proteome. PubMed ID: 21269460

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Initial characterization of the human central proteome. PubMed ID: 21269460

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Database document:

PubMed ID: 2342480

PubMed ID: 17974005

PubMed ID: 14702039

PubMed ID: 16710414

PubMed ID: 15489334

PubMed ID: 11589697

PubMed ID: 12420224

PubMed ID: 19690332

PubMed ID: 21269460

PubMed ID: 21880142

PubMed ID: 21423175

PubMed ID: 24275569

PubMed ID: 25255805

PubMed ID: 31112131

PubMed ID: 17344846

PubMed ID: 33058759

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 21269460

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 21269460

PubMed ID: 11237011

PubMed ID: 15496913

PubMed ID: 16710414

PubMed ID: 19690332

PubMed ID: 21269460

PubMed ID: 24275569