Details for: PRKACB
Gene ID: 5567
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PRKACB
Ensembl ID: ENSG00000142875
Description: protein kinase cAMP-activated catalytic subunit beta
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 67.64rCSI 80.79%PRS 37.2
-
CSI 64.46rCSI 80.2%PRS 35.62
-
CSI 62.47rCSI 80.53%PRS 38.47
-
CSI 48.73rCSI 81.8%PRS 37.34
-
CSI 47.33rCSI 76.11%PRS 39.49
-
CSI 36.86rCSI 79.95%PRS 43.41
-
CSI 35.67rCSI 63%PRS 36.39
-
CSI 33.29rCSI 79.62%PRS 42.66
-
CSI 33.07rCSI 80.37%PRS 36.15
-
CSI 29.05rCSI 63.92%PRS 37.44
-
CSI 28.11rCSI 74.85%PRS 44.86
-
CSI 25.65rCSI 80.17%PRS 38.83
-
CSI 24.55rCSI 22.7%PRS 74.77
-
CSI 24.5rCSI 76.62%PRS 41.23
-
CSI 23.5rCSI 37.82%PRS 44.72
-
CSI 22.91rCSI 82.46%PRS 36.02
-
CSI 22.82rCSI 74.98%PRS 42.31
-
CSI 22.33rCSI 41.83%PRS 43.53
-
CSI 21.33rCSI 38.76%PRS 47.18
-
CSI 20.95rCSI 79.18%PRS 38.21
-
CSI 19.77rCSI 45.64%PRS 44.57
-
CSI 19.44rCSI 39.95%PRS 46.28
-
CSI 18.74rCSI 64.19%PRS 44.34
-
CSI 16.61rCSI 14.74%PRS 53.09
-
CSI 16.52rCSI 48.83%PRS 43.2
-
CSI 16.5rCSI 42.99%PRS 52.86
-
CSI 16.39rCSI 10.89%PRS 58.31
-
CSI 14.57rCSI 64.04%PRS 51.77
-
CSI 14.29rCSI 10.69%PRS 69.99
-
CSI 13.89rCSI 11.92%PRS 62.34
-
CSI 13.78rCSI 10.24%PRS 68.62
-
CSI 13.7rCSI 17.59%PRS 52.38
-
CSI 13.61rCSI 80.11%PRS 38.81
-
CSI 13.37rCSI 62.92%PRS 50.23
-
CSI 12.63rCSI 25.63%PRS 35.23
-
CSI 12.39rCSI 73.19%PRS 50.43
-
CSI 12.22rCSI 16.97%PRS 53.79
-
CSI 12.18rCSI 48.22%PRS 54.9
-
CSI 12.15rCSI 80.66%PRS 51.95
-
CSI 11.78rCSI 10.64%PRS 51.58
-
CSI 11.71rCSI 58.22%PRS 53.1
-
CSI 11.46rCSI 7.97%PRS 69.12
-
CSI 11.45rCSI 9.26%PRS 64.48
-
CSI 11.42rCSI 18.21%PRS 47.82
-
CSI 11.15rCSI 81.95%PRS 41.85
-
CSI 11rCSI 19.38%PRS 52.24
-
CSI 10.7rCSI 8.03%PRS 83.4
-
CSI 10.35rCSI 14.14%PRS 57
-
CSI 10.34rCSI 25.59%PRS 52.78
-
CSI 10.12rCSI 22.35%PRS 41.63
-
CSI 9.8rCSI 66.73%PRS 50.98
-
CSI 9.57rCSI 6.72%PRS 74.14
-
CSI 9.54rCSI 12.25%PRS 48.23
-
CSI 9.18rCSI 16.5%PRS 47.87
-
CSI 9.03rCSI 7.23%PRS 76.02
-
CSI 9.02rCSI 7.13%PRS 41.84
-
CSI 8.92rCSI 46.92%PRS 49.77
-
CSI 8.86rCSI 63.32%PRS 48.54
-
CSI 8.8rCSI 25.5%PRS 44.98
-
CSI 8.79rCSI 68.06%PRS 51.25
-
CSI 8.57rCSI 73.82%PRS 41.86
-
CSI 8.5rCSI 6.47%PRS 67.41
-
CSI 8.5rCSI 13.43%PRS 56.36
-
CSI 8.43rCSI 8.28%PRS 70.6
-
CSI 8.3rCSI 16.66%PRS 43.97
-
CSI 8.25rCSI 5.76%PRS 57.44
-
CSI 8.22rCSI 5.9%PRS 68.75
-
CSI 8.21rCSI 14.2%PRS 44.9
-
CSI 8.2rCSI 18.71%PRS 47.07
-
CSI 8.1rCSI 9.36%PRS 48.43
-
CSI 8.01rCSI 26.84%PRS 41.04
-
CSI 7.94rCSI 18.17%PRS 54.24
-
CSI 7.86rCSI 5.46%PRS 65.15
-
CSI 7.76rCSI 10.97%PRS 61.31
-
CSI 7.6rCSI 6.92%PRS 69.1
-
CSI 7.4rCSI 5.53%PRS 72.46
-
CSI 7.33rCSI 5.55%PRS 68.43
-
CSI 7.22rCSI 14.33%PRS 52.82
-
CSI 7.1rCSI 6.61%PRS 54.68
-
CSI 7.06rCSI 17.25%PRS 48.9
-
CSI 7.02rCSI 26.49%PRS 42.83
-
CSI 7.01rCSI 10.71%PRS 55.41
-
CSI 6.99rCSI 27.83%PRS 68.92
-
CSI 6.99rCSI 18.23%PRS 54.04
-
CSI 6.98rCSI 5.78%PRS 56.45
-
CSI 6.97rCSI 61.35%PRS 41.47
-
CSI 6.89rCSI 10.12%PRS 48.91
-
CSI 6.88rCSI 13.39%PRS 57.28
-
CSI 6.81rCSI 5.29%PRS 72.57
-
CSI 6.69rCSI 5.03%PRS 59.51
-
CSI 6.67rCSI 50.14%PRS 48.71
-
CSI 6.64rCSI 17.53%PRS 63.34
-
CSI 6.57rCSI 9.31%PRS 51.1
-
CSI 6.5rCSI 9.99%PRS 63.2
-
CSI 6.43rCSI 73.61%PRS 46.08
-
CSI 6.41rCSI 6.06%PRS 54.7
-
CSI 6.33rCSI 5.33%PRS 72.56
-
CSI 6.32rCSI 6.21%PRS 78.21
-
CSI 6.31rCSI 20.32%PRS 53.34
-
CSI 6.27rCSI 5.45%PRS 65.45
-
CSI 0.1rCSI 1.9%PRS 88.0%
-
CSI 0.2rCSI 1.8%PRS 76.6%
-
CSI 0.3rCSI 1.9%PRS 65.3%
-
CSI 0.4rCSI 2.5%PRS 65.1%
-
CSI 0.6rCSI 1.2%PRS 52.5%
-
CSI 0.6rCSI 6.3%PRS 53.9%
-
CSI 0.9rCSI 3.3%PRS 75.3%
-
CSI 0.9rCSI 0.7%PRS 54.5%
-
CSI 0.9rCSI 3.0%PRS 61.0%
-
CSI 1.0rCSI 3.0%PRS 68.2%
-
CSI 1.1rCSI 1.5%PRS 57.4%
-
CSI 1.1rCSI 2.7%PRS 63.1%
-
CSI 1.1rCSI 3.6%PRS 55.9%
-
CSI 1.2rCSI 1.8%PRS 59.3%
-
CSI 1.2rCSI 1.4%PRS 44.8%
-
CSI 1.2rCSI 4.8%PRS 66.0%
-
CSI 1.2rCSI 1.3%PRS 58.0%
-
CSI 1.3rCSI 7.8%PRS 37.7%
-
CSI 1.3rCSI 6.9%PRS 66.3%
-
CSI 1.3rCSI 3.3%PRS 81.8%
-
CSI 1.4rCSI 6.6%PRS 75.0%
-
CSI 1.4rCSI 2.0%PRS 63.0%
-
CSI 1.5rCSI 3.1%PRS 73.5%
-
CSI 1.5rCSI 12.5%PRS 47.6%
-
CSI 1.5rCSI 3.8%PRS 55.1%
-
CSI 1.6rCSI 11.7%PRS 72.6%
-
CSI 1.6rCSI 2.0%PRS 50.8%
-
CSI 1.6rCSI 2.6%PRS 65.9%
-
CSI 1.7rCSI 1.5%PRS 59.5%
-
CSI 1.7rCSI 10.4%PRS 71.7%
-
CSI 1.7rCSI 8.6%PRS 67.2%
-
CSI 1.8rCSI 1.4%PRS 56.0%
-
CSI 1.8rCSI 4.7%PRS 82.2%
-
CSI 1.8rCSI 4.4%PRS 73.3%
-
CSI 1.8rCSI 3.3%PRS 53.6%
-
CSI 1.8rCSI 4.8%PRS 58.7%
-
CSI 1.8rCSI 8.2%PRS 39.3%
-
CSI 1.9rCSI 3.7%PRS 65.3%
-
CSI 2.0rCSI 3.9%PRS 82.1%
-
CSI 2.1rCSI 5.0%PRS 56.0%
-
CSI 2.1rCSI 3.0%PRS 70.8%
-
CSI 2.1rCSI 39.1%PRS 85.7%
-
CSI 2.2rCSI 5.3%PRS 67.4%
-
CSI 2.2rCSI 8.7%PRS 70.3%
-
CSI 2.2rCSI 45.6%PRS 47.3%
-
CSI 2.3rCSI 2.4%PRS 51.5%
-
CSI 2.4rCSI 6.9%PRS 79.4%
-
CSI 2.4rCSI 55.5%PRS 76.0%
-
CSI 2.4rCSI 49.4%PRS 45.9%
-
CSI 2.4rCSI 3.6%PRS 58.7%
-
CSI 2.5rCSI 6.9%PRS 52.5%
-
CSI 2.5rCSI 4.4%PRS 78.5%
-
CSI 2.5rCSI 12.7%PRS 77.5%
-
CSI 2.5rCSI 10.7%PRS 69.2%
-
CSI 2.5rCSI 10.7%PRS 49.0%
-
CSI 2.6rCSI 6.9%PRS 46.3%
-
CSI 2.6rCSI 3.2%PRS 67.5%
-
CSI 2.6rCSI 8.0%PRS 64.9%
-
CSI 2.7rCSI 12.8%PRS 53.9%
-
CSI 2.7rCSI 4.7%PRS 63.2%
-
CSI 2.7rCSI 6.8%PRS 44.5%
-
CSI 2.7rCSI 4.0%PRS 66.4%
-
CSI 2.8rCSI 10.6%PRS 46.4%
-
CSI 2.8rCSI 2.7%PRS 78.0%
-
CSI 2.8rCSI 29.2%PRS 47.3%
-
CSI 3.0rCSI 2.4%PRS 76.9%
-
CSI 3.0rCSI 6.8%PRS 62.3%
-
CSI 3.1rCSI 17.5%PRS 40.3%
-
CSI 3.2rCSI 13.9%PRS 46.4%
-
CSI 3.2rCSI 7.6%PRS 65.1%
-
CSI 3.2rCSI 77.4%PRS 37.6%
-
CSI 3.2rCSI 77.6%PRS 36.7%
-
CSI 3.3rCSI 3.4%PRS 53.4%
-
CSI 3.3rCSI 8.5%PRS 49.9%
-
CSI 3.3rCSI 3.2%PRS 57.2%
-
CSI 3.3rCSI 3.9%PRS 57.8%
-
CSI 3.4rCSI 4.0%PRS 74.8%
-
CSI 3.4rCSI 9.3%PRS 50.6%
-
CSI 3.4rCSI 7.9%PRS 68.9%
-
CSI 3.4rCSI 48.5%PRS 46.3%
-
CSI 3.5rCSI 15.3%PRS 53.9%
-
CSI 3.5rCSI 5.0%PRS 45.0%
-
CSI 3.5rCSI 5.0%PRS 64.6%
-
CSI 3.5rCSI 4.2%PRS 63.2%
-
CSI 3.5rCSI 8.9%PRS 63.2%
-
CSI 3.6rCSI 4.3%PRS 53.0%
-
CSI 3.6rCSI 3.9%PRS 53.5%
-
CSI 3.6rCSI 5.6%PRS 80.2%
-
CSI 3.7rCSI 17.6%PRS 54.3%
-
CSI 3.7rCSI 5.0%PRS 49.1%
-
CSI 3.7rCSI 23.2%PRS 46.7%
-
CSI 3.7rCSI 4.3%PRS 75.6%
-
CSI 3.7rCSI 24.0%PRS 57.8%
-
CSI 3.8rCSI 8.5%PRS 38.1%
-
CSI 3.9rCSI 4.3%PRS 71.3%
-
CSI 3.9rCSI 6.7%PRS 74.0%
-
CSI 4.0rCSI 6.1%PRS 69.7%
-
CSI 4.1rCSI 16.4%PRS 53.3%
-
CSI 4.1rCSI 33.3%PRS 48.0%
-
CSI 4.1rCSI 2.8%PRS 67.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1141478992
Symbol: KAPCB_HUMAN
Name: cAMP-dependent protein kinase catalytic subunit beta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2342480
Title: Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis -- representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.
PubMed ID: 2342480
DOI: 10.1210/mend-4-3-465
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11589697
Title: Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase.
PubMed ID: 11589697
PubMed ID: 12420224
Title: c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-CB) gene.
PubMed ID: 12420224
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21880142
Title: G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A.
PubMed ID: 21880142
PubMed ID: 21423175
Title: Control of PKA stability and signalling by the RING ligase praja2.
PubMed ID: 21423175
DOI: 10.1038/ncb2209
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25255805
Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.
PubMed ID: 25255805
DOI: 10.1038/ncomms5919
PubMed ID: 31112131
Title: GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor.
PubMed ID: 31112131
DOI: 10.7554/elife.43038
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 33058759
Title: Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome.
PubMed ID: 33058759
Sequence Information:
- Length: 351
- Mass: 40623
- Checksum: 5C7443FBBA1C9BEC
- Sequence:
MGNAATAKKG SEVESVKEFL AKAKEDFLKK WENPTQNNAG LEDFERKKTL GTGSFGRVML VKHKATEQYY AMKILDKQKV VKLKQIEHTL NEKRILQAVN FPFLVRLEYA FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ IVLTFEYLHS LDLIYRDLKP ENLLIDHQGY IQVTDFGFAK RVKGRTWTLC GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVS DIKTHKWFAT TDWIAIYQRK VEAPFIPKFR GSGDTSNFDD YEEEDIRVSI TEKCAKEFGE F
Genular Protein ID: 2683019269
Symbol: B1APF9_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 245
- Mass: 28550
- Checksum: 72ABC48F946516DF
- Sequence:
MGLLKEFLAK AKEDFLKKWE NPTQNNAGLE DFERKKTLGT GSFGRVMLVK HKATEQYYAM KILDKQKVVK LKQIEHTLNE KRILQAVNFP FLVRLEYAFK DNSNLYMVME YVPGGEMFSH LRRIGRFSEP HARFYAAQIV LTFEYLHSLD LIYRDLKPEN LLIDHQGYIQ VTDFGFAKRV KGRTWTLCGT PEYLAPEIIL SKGYNKAVDW WALGVLIYEM AAGYPPFFAD QPIQIYEKIV SGKNF
Genular Protein ID: 4149090957
Symbol: B1APG3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
Sequence Information:
- Length: 264
- Mass: 30498
- Checksum: 181CA0A6367836DB
- Sequence:
MSARKSSDAS ACSSSEISDS FVKEFLAKAK EDFLKKWENP TQNNAGLEDF ERKKTLGTGS FGRVMLVKHK ATEQYYAMKI LDKQKVVKLK QIEHTLNEKR ILQAVNFPFL VRLEYAFKDN SNLYMVMEYV PGGEMFSHLR RIGRFSEPHA RFYAAQIVLT FEYLHSLDLI YRDLKPENLL IDHQGYIQVT DFGFAKRVKG RTWTLCGTPE YLAPEIILSK GYNKAVDWWA LGVLIYEMAA GYPPFFADQP IQIYEKIVSG KQNF
Genular Protein ID: 167440886
Symbol: B7ZA00_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 314
- Mass: 36479
- Checksum: F56E02B8C211B94A
- Sequence:
MPDLKILKGK KTLGTGSFGR VMLVKHKATE QYYAMKILDK QKVVKLKQIE HTLNEKRILQ AVNFPFLVRL EYAFKDNSNL YMVMEYVPGG EMFSHLRRIG RFSEPHARFY AAQIVLTFEY LHSLDLIYRD LKPENLLIDH QGYIQVTDFG FAKRVKGRTW TLCGTPEYLA PEIILSKGYN KAVDWWALGV LIYEMAAGYP PFFADQPIQI YEKIVSGKVR FPSHFSSDLK DLLRNLLQVD LTKRFGNLKN GVSDIKTHKW FATTDWIAIY QRKVEAPFIP KFRGSGDTSN FDDYEEEDIR VSITEKCAKE FGEF
Genular Protein ID: 3202147629
Symbol: A0A087WVC4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 338
- Mass: 39236
- Checksum: EE93AE7F31AB12E5
- Sequence:
MLLLSSSISL YKDRNEARLI SSQNNAGLED FERKKTLGTG SFGRVMLVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF LVRLEYAFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL IYRDLKPENL LIDHQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRFG NLKNGVSDIK THKWFATTDW IAIYQRKVEA PFIPKFRGSG DTSNFDDYEE EDIRVSITEK CAKEFGEF