Details for: PRKAR2A

Gene ID: 5576

Symbol: PRKAR2A

Ensembl ID: ENSG00000114302

Description: protein kinase cAMP-dependent type II regulatory subunit alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 371.5318
    Cell Significance Index: -57.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 218.5746
    Cell Significance Index: -55.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 125.3911
    Cell Significance Index: -59.2000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 121.1548
    Cell Significance Index: -49.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 107.3903
    Cell Significance Index: -55.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 88.2683
    Cell Significance Index: -59.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 51.9197
    Cell Significance Index: -49.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.7734
    Cell Significance Index: -58.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4751
    Cell Significance Index: -54.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.3310
    Cell Significance Index: -50.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.9922
    Cell Significance Index: -59.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.8524
    Cell Significance Index: -25.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9899
    Cell Significance Index: 399.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.7140
    Cell Significance Index: 614.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6122
    Cell Significance Index: 175.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1368
    Cell Significance Index: 225.6100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0247
    Cell Significance Index: 13.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9675
    Cell Significance Index: 74.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9637
    Cell Significance Index: 666.5600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9552
    Cell Significance Index: 15.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8839
    Cell Significance Index: 22.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8700
    Cell Significance Index: 156.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.7879
    Cell Significance Index: 22.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7561
    Cell Significance Index: 92.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7052
    Cell Significance Index: 32.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6984
    Cell Significance Index: 39.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6638
    Cell Significance Index: 362.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6392
    Cell Significance Index: 87.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5590
    Cell Significance Index: 12.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5158
    Cell Significance Index: 98.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4836
    Cell Significance Index: 436.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3997
    Cell Significance Index: 11.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3812
    Cell Significance Index: 7.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3670
    Cell Significance Index: 36.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3015
    Cell Significance Index: 133.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2862
    Cell Significance Index: 19.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1931
    Cell Significance Index: 297.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1795
    Cell Significance Index: 11.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1293
    Cell Significance Index: 243.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1047
    Cell Significance Index: 193.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1029
    Cell Significance Index: 65.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0784
    Cell Significance Index: 13.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0762
    Cell Significance Index: 5.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0614
    Cell Significance Index: 27.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0561
    Cell Significance Index: 1.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0509
    Cell Significance Index: 6.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0363
    Cell Significance Index: 49.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0252
    Cell Significance Index: 0.6700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0058
    Cell Significance Index: -0.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0078
    Cell Significance Index: -0.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0366
    Cell Significance Index: -27.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0419
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0504
    Cell Significance Index: -37.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0794
    Cell Significance Index: -5.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0883
    Cell Significance Index: -5.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0905
    Cell Significance Index: -11.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0938
    Cell Significance Index: -52.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0972
    Cell Significance Index: -4.5700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0996
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1056
    Cell Significance Index: -65.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1296
    Cell Significance Index: -13.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1585
    Cell Significance Index: -18.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1772
    Cell Significance Index: -50.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1930
    Cell Significance Index: -28.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2051
    Cell Significance Index: -13.2400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2107
    Cell Significance Index: -5.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2284
    Cell Significance Index: -11.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2861
    Cell Significance Index: -21.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2967
    Cell Significance Index: -62.4900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2983
    Cell Significance Index: -4.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3397
    Cell Significance Index: -39.5900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3553
    Cell Significance Index: -7.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3703
    Cell Significance Index: -10.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3765
    Cell Significance Index: -43.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4143
    Cell Significance Index: -3.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4345
    Cell Significance Index: -6.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4808
    Cell Significance Index: -50.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5064
    Cell Significance Index: -22.9600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5652
    Cell Significance Index: -7.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5877
    Cell Significance Index: -46.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6065
    Cell Significance Index: -7.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6069
    Cell Significance Index: -17.3200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6631
    Cell Significance Index: -12.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6904
    Cell Significance Index: -35.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6932
    Cell Significance Index: -42.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7022
    Cell Significance Index: -16.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7166
    Cell Significance Index: -24.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7768
    Cell Significance Index: -13.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8029
    Cell Significance Index: -18.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8282
    Cell Significance Index: -23.7400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8854
    Cell Significance Index: -12.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8961
    Cell Significance Index: -15.1000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8999
    Cell Significance Index: -19.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9673
    Cell Significance Index: -20.6000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.9745
    Cell Significance Index: -28.6200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0296
    Cell Significance Index: -32.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0463
    Cell Significance Index: -26.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0867
    Cell Significance Index: -35.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1143
    Cell Significance Index: -35.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: PRKAR2A is a regulatory subunit of protein kinase A (PKA), which is a heterotrimeric enzyme composed of two catalytic subunits (R and C) and a regulatory subunit (R). 2. **Function**: PRKAR2A regulates the activity of PKA by binding to the catalytic subunits and modulating their activity. 3. **Expression**: PRKAR2A is expressed in various cell types, including neurons, muscle fibers, and epithelial cells. 4. **Signaling Pathways**: PRKAR2A is involved in numerous signaling pathways, including those related to glucose metabolism, insulin secretion, and neurotransmission. **Pathways and Functions** 1. **Glucagon Signaling**: PRKAR2A regulates glucagon signaling in metabolic regulation, including the activation of adenylate cyclase and the phosphorylation of CREB. 2. **Insulin Secretion**: PRKAR2A is involved in the regulation of insulin secretion, including the phosphorylation of DARPP-32 and the activation of adenylate cyclase. 3. **Neurotransmission**: PRKAR2A is involved in neurotransmission, including the regulation of NMDA receptors and postsynaptic events. 4. **Leishmania Infection**: PRKAR2A is involved in the regulation of Leishmania parasite growth and survival, including the production of anti-inflammatory cytokines. 5. **Cell Signaling**: PRKAR2A is involved in various cell signaling pathways, including those related to calcium-dependent events, calmodulin-induced events, and DAG/IP3 signaling. **Clinical Significance** 1. **Diabetes**: Mutations in the PRKAR2A gene have been associated with diabetes, including type 2 diabetes and gestational diabetes. 2. **Neurological Disorders**: PRKAR2A has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and schizophrenia. 3. **Infectious Diseases**: PRKAR2A is involved in the regulation of Leishmania parasite growth and survival, making it a potential target for the treatment of Leishmania infections. 4. **Cancer**: PRKAR2A has been implicated in the regulation of cell growth and survival, making it a potential target for the treatment of various cancers. In conclusion, the PRKAR2A gene plays a crucial role in various cellular processes, including signal transduction, metabolism, and gene expression. Its involvement in various signaling pathways and clinical disorders makes it a potential target for the treatment of various diseases. Further research is needed to fully understand the role of PRKAR2A in human disease and to explore its therapeutic potential.

Genular Protein ID: 3684860242

Symbol: KAP2_HUMAN

Name: cAMP-dependent protein kinase type II-alpha regulatory subunit

UniProtKB Accession Codes:

P13861 Q16823 Q9BUB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 8 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 12 RefSeq 5 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2540040

Title: Human testis cDNA for the regulatory subunit RII alpha of cAMP-dependent protein kinase encodes an alternate amino-terminal region.

PubMed ID: 2540040

DOI: 10.1016/0014-5793(89)80253-4

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9003463

Title: Molecular cloning, upstream sequence and promoter studies of the human gene for the regulatory subunit RII alpha of cAMP-dependent protein kinase.

PubMed ID: 9003463

DOI: 10.1016/s0167-4781(96)00152-2

PubMed ID: 11823486

Title: Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes.

PubMed ID: 11823486

DOI: 10.4049/jimmunol.168.4.1590

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16807684

Title: Phosphoproteomic analysis of the human pituitary.

PubMed ID: 16807684

DOI: 10.1007/s11102-006-8916-x

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17827149

Title: MyRIP anchors protein kinase A to the exocyst complex.

PubMed ID: 17827149

DOI: 10.1074/jbc.m705167200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21423175

Title: Control of PKA stability and signalling by the RING ligase praja2.

PubMed ID: 21423175

DOI: 10.1038/ncb2209

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22976297

Title: A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex.

PubMed ID: 22976297

DOI: 10.1242/jcs.111427

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27484798

Title: The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3beta Interaction Protein (GSKIP) Regulates beta-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3beta.

PubMed ID: 27484798

DOI: 10.1074/jbc.m116.738047

Sequence Information:

  • Length: 404
  • Mass: 45518
  • Checksum: C7D6E8E476E1DB65
  • Sequence:
    • MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG 
HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH 
PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE 
RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI 
IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QGEKADSFYI 
IESGEVSILI RSRTKSNKDG GNQEVEIARC HKGQYFGELA LVTNKPRAAS AYAVGDVKCL 
VMDVQAFERL LGPCMDIMKR NISHYEEQLV KMFGSSVDLG NLGQ

Genular Protein ID: 3581448225

Symbol: A0A9L9PY56_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PY56

Database IDs:

ARBA 10 CDD 2 CTD 1 EMBL 2 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 376
  • Mass: 42182
  • Checksum: DC6DFA2204B8DD6A
  • Sequence:
    • MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG 
HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPREQL 
SQVLDAMFER IVKADEHVID QGDDGDNFYV IERGTYDILV TKDNQTRSVG QYDNRGSFGE 
LALMYNTPRA ATIVATSEGS LWGLDRVTFR RIIVKNNAKK RKMFESFIES VPLLKSLEVS 
ERMKIVDVIG EKIYKDGERI ITQGEKADSF YIIESGEVSI LIRSRTKSNK DGGNQEVEIA 
RCHKGQYFGE LALVTNKPRA ASAYAVGDVK CLVMDVQAFE RLLGPCMDIM KRNISHYEEQ 
LVKMFGSSVD LGNLGQ

Genular Protein ID: 2855424831

Symbol: A0A0S2Z472_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z472

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 6 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 2 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 382
  • Mass: 43067
  • Checksum: 87D6AC1A5CE9E300
  • Sequence:
    • MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG 
HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH 
PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE 
RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI 
IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QTKSNKDGGN 
QEVEIARCHK GQYFGELALV TNKPRAASAY AVGDVKCLVM DVQAFERLLG PCMDIMKRNI 
SHYEEQLVKM FGSSVDLGNL GQ

Genular Protein ID: 3548067583

Symbol: A8KAH7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8KAH7

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 4 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 404
  • Mass: 45504
  • Checksum: 3387ADF026F4DACF
  • Sequence:
    • MSHIQIPPGL TELLQGYTVE VLRQQPPDLV EFAVEYFTRL REARAPASVL PAATPRQSLG 
HPPPEPGPDR VADAKGDSES EEDEDLEVPV PSRFNRRVSV CAETYNPDEE EEDTDPRVIH 
PKTDEQRCRL QEACKDILLF KNLDQEQLSQ VLDAMFERIV KADEHVIDQG DDGDNFYVIE 
RGTYDILVTK DNQTRSVGQY DNRGSFGELA LMYNTPRAAT IVATSEGSLW GLDRVTFRRI 
IVKNNAKKRK MFESFIESVP LLKSLEVSER MKIVDVIGEK IYKDGERIIT QGEKADSFYI 
IDSGEVSILI RSRTKSNKDG GNQEVEIARC HKGQYFGELA LVTNKPRAAS AYAVGDVKCL 
VMDVQAFERL LGPCMDIMKR NISHYEEQLV KMFGSSVDLG NLGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.