PRKCB | ENSG00000166501 | NCBI 5579

Details for: PRKCB

Gene ID: 5579

Symbol: PRKCB

Ensembl ID: ENSG00000166501

Description: protein kinase C beta

Associated with

Activation of nf-kappab in b cells
(R-HSA-1169091)
Adaptive immune system
(R-HSA-1280218)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Depolymerization of the nuclear lamina
(R-HSA-4419969)
Disinhibition of snare formation
(R-HSA-114516)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
G alpha (z) signalling events
(R-HSA-418597)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Mitotic prophase
(R-HSA-68875)
M phase
(R-HSA-68886)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear envelope breakdown
(R-HSA-2980766)
Pcp/ce pathway
(R-HSA-4086400)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate nadph oxidases
(R-HSA-5668599)
Rna polymerase ii transcription
(R-HSA-73857)
Runx1 regulates transcription of genes involved in differentiation of myeloid cells
(R-HSA-8939246)
Signaling by gpcr
(R-HSA-372790)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by vegf
(R-HSA-194138)
Signaling by wnt
(R-HSA-195721)
Trafficking of ampa receptors
(R-HSA-399719)
Trafficking of glur2-containing ampa receptors
(R-HSA-416993)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transmission across chemical synapses
(R-HSA-112315)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vegfr2 mediated cell proliferation
(R-HSA-5218921)
Wnt5a-dependent internalization of fzd4
(R-HSA-5099900)
Adaptive immune response
(GO:0002250)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
B cell activation
(GO:0042113)
B cell receptor signaling pathway
(GO:0050853)
Brush border membrane
(GO:0031526)
Calcium,diacylglycerol-dependent serine/threonine kinase activity
(GO:0004698)
Calcium channel regulator activity
(GO:0005246)
Calcium ion transport
(GO:0006816)
Cellular response to carbohydrate stimulus
(GO:0071322)
Centrosome
(GO:0005813)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Diacylglycerol-dependent serine/threonine kinase activity
(GO:0004697)
Dibenzo-p-dioxin metabolic process
(GO:0018894)
Histone binding
(GO:0042393)
Histone h3t6 kinase activity
(GO:0035403)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular signal transduction
(GO:0035556)
Lipoprotein transport
(GO:0042953)
Mitotic nuclear membrane disassembly
(GO:0007077)
Negative regulation of d-glucose transmembrane transport
(GO:0010829)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Nuclear androgen receptor binding
(GO:0050681)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of odontogenesis of dentin-containing tooth
(GO:0042488)
Positive regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030949)
Post-translational protein modification
(GO:0043687)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein binding
(GO:0005515)
Protein kinase c binding
(GO:0005080)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of d-glucose transmembrane transport
(GO:0010827)
Regulation of dopamine secretion
(GO:0014059)
Regulation of growth
(GO:0040008)
Regulation of synaptic vesicle exocytosis
(GO:2000300)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to ethanol
(GO:0045471)
Response to glucose
(GO:0009749)
Response to vitamin d
(GO:0033280)
Response to xenobiotic stimulus
(GO:0009410)
Signal transduction
(GO:0007165)
Spectrin
(GO:0008091)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 256.0027
Cell Significance Index: -39.8200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 128.1327
Cell Significance Index: -32.5000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 88.6877
Cell Significance Index: -36.0300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 80.0276
Cell Significance Index: -41.1700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 61.2349
Cell Significance Index: -41.0900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 32.4748
Cell Significance Index: -40.0400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.4166
Cell Significance Index: -38.6200
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.0943
Cell Significance Index: -43.2900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.3014
Cell Significance Index: -40.6500
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 9.1637
Cell Significance Index: 113.6600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 7.7538
Cell Significance Index: 342.9700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 7.1098
Cell Significance Index: 269.2300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 6.7520
Cell Significance Index: 115.7100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.6573
Cell Significance Index: -14.5700
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 5.3270
Cell Significance Index: 71.0600
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 5.2868
Cell Significance Index: 40.7500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 4.9729
Cell Significance Index: 141.9100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.4509
Cell Significance Index: 692.2500
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 2.8995
Cell Significance Index: 31.9900
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.2257
Cell Significance Index: 149.6600
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 2.1398
Cell Significance Index: 22.2900
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.0438
Cell Significance Index: 9.1400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.9745
Cell Significance Index: 1365.6400
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.5644
Cell Significance Index: 34.2600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.5143
Cell Significance Index: 97.7000
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.4616
Cell Significance Index: 11.2100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.3954
Cell Significance Index: 25.7900
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 1.3687
Cell Significance Index: 17.7500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.1607
Cell Significance Index: 220.8900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9627
Cell Significance Index: 345.2900
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.7907
Cell Significance Index: 1458.1600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.6354
Cell Significance Index: 74.9400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5237
Cell Significance Index: 51.8100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5085
Cell Significance Index: 459.1300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.4868
Cell Significance Index: 6.0700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4344
Cell Significance Index: 9.2900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4273
Cell Significance Index: 77.0300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2202
Cell Significance Index: 339.0000
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2063
Cell Significance Index: 33.5500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1942
Cell Significance Index: 10.2000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1904
Cell Significance Index: 20.7200
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.1686
Cell Significance Index: 1.9200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1232
Cell Significance Index: 55.9000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1144
Cell Significance Index: 7.0300
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.0931
Cell Significance Index: 0.8200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0230
Cell Significance Index: 2.8300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0182
Cell Significance Index: 34.2800
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.0063
Cell Significance Index: 0.0800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0036
Cell Significance Index: 0.0900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0021
Cell Significance Index: 2.8900
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0092
Cell Significance Index: -0.1000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0198
Cell Significance Index: -2.8800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0271
Cell Significance Index: -17.2000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0410
Cell Significance Index: -1.4400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0540
Cell Significance Index: -39.5900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0545
Cell Significance Index: -1.1800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0553
Cell Significance Index: -41.8700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0572
Cell Significance Index: -42.3800
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0574
Cell Significance Index: -31.3600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0580
Cell Significance Index: -1.6700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0705
Cell Significance Index: -44.0500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0765
Cell Significance Index: -43.1200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0877
Cell Significance Index: -38.7900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0887
Cell Significance Index: -2.9100
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.0967
Cell Significance Index: -0.9200
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1027
Cell Significance Index: -20.3900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1185
Cell Significance Index: -34.1000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1187
Cell Significance Index: -8.2100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1219
Cell Significance Index: -3.2600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1375
Cell Significance Index: -4.3800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1399
Cell Significance Index: -2.9700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1401
Cell Significance Index: -6.3500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1449
Cell Significance Index: -2.9100
Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.1714
Cell Significance Index: -4.1100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2024
Cell Significance Index: -42.6300
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2191
Cell Significance Index: -37.4200
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2324
Cell Significance Index: -5.0200
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2499
Cell Significance Index: -10.8700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.2656
Cell Significance Index: -36.4800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.2744
Cell Significance Index: -7.0100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.3020
Cell Significance Index: -39.0200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3191
Cell Significance Index: -4.5700
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3406
Cell Significance Index: -34.7900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.3458
Cell Significance Index: -44.3300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.3594
Cell Significance Index: -20.1700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3765
Cell Significance Index: -39.2000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3806
Cell Significance Index: -43.6000
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -0.3886
Cell Significance Index: -4.7100
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.3969
Cell Significance Index: -9.9000
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.4036
Cell Significance Index: -7.9800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4073
Cell Significance Index: -21.1600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.4075
Cell Significance Index: -31.2700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4493
Cell Significance Index: -9.3200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4631
Cell Significance Index: -28.4000
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.5025
Cell Significance Index: -7.6500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5099
Cell Significance Index: -10.8600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.5292
Cell Significance Index: -39.4400
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5415
Cell Significance Index: -25.4500
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: -0.5543
Cell Significance Index: -6.8900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5606
Cell Significance Index: -19.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** PRKCB is a serine/threonine kinase enzyme, specifically a member of the PKC family. It is a tumor suppressor protein, with a molecular weight of approximately 55 kDa. PRKCB is highly expressed in various tissues, including the brain, immune cells, and epithelial tissues. It is also highly phosphorylated, which activates its kinase activity. **Pathways and Functions** PRKCB is involved in numerous signaling pathways, including: 1. **Adaptive Immune Response**: PRKCB regulates B cell activation, proliferation, and differentiation, playing a crucial role in the adaptive immune response. 2. **Neuronal Signaling**: PRKCB is involved in neuronal function, including synaptic plasticity, neurotransmitter release, and synaptic transmission. 3. **Cell Cycle Regulation**: PRKCB regulates cell cycle progression, acting as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. 4. **Apoptosis**: PRKCB is involved in the regulation of apoptosis, promoting programmed cell death in response to cellular stress. 5. **Metabolism**: PRKCB regulates glucose metabolism, insulin signaling, and lipid metabolism. **Clinical Significance** Dysregulation of PRKCB has been implicated in various diseases, including: 1. **Cancer**: PRKCB is a tumor suppressor, and its dysregulation can contribute to cancer development and progression. 2. **Neurodegenerative Diseases**: PRKCB is involved in neuronal function and signaling, and its dysregulation may contribute to neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Immune Disorders**: PRKCB regulates immune responses, and its dysregulation may contribute to immune disorders, such as autoimmune diseases and immunodeficiency. 4. **Metabolic Disorders**: PRKCB regulates glucose metabolism, and its dysregulation may contribute to metabolic disorders, such as diabetes and metabolic syndrome. In conclusion, PRKCB is a multifunctional enzyme involved in various cellular processes, including signal transduction, cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of PRKCB in maintaining cellular homeostasis and overall health. **References** * [Insert references to relevant scientific studies and reviews on PRKCB] **Future Directions** Further research is needed to fully understand the mechanisms of PRKCB in various diseases and to develop therapeutic strategies targeting this enzyme. Potential areas of investigation include: 1. **PRKCB inhibitors**: Develop inhibitors targeting PRKCB to treat diseases associated with its dysregulation. 2. **PRKCB activators**: Investigate the potential of PRKCB activators to enhance its therapeutic effects. 3. **PRKCB-targeted therapies**: Develop therapies targeting PRKCB to treat diseases, such as cancer, neurodegenerative diseases, and immune disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Protein kinase C beta type

Genular Protein ID: 1517894827

Symbol: KPCB_HUMAN

Name: Protein kinase C beta type

UniProtKB Accession Codes:

P05771 C5IFJ8 D3DWF5 O43744 P05127 Q15138 Q93060 Q9UE49 Q9UE50 Q9UEH8 Q9UJ30 Q9UJ33

Database IDs:

Citations:

PubMed ID: 3755548

Title: Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.

PubMed ID: 3755548

DOI: 10.1126/science.3755548

PubMed ID: 3666134

Title: Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences.

PubMed ID: 3666134

DOI: 10.1016/0014-5793(87)80524-0

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7880442

Title: Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells.

PubMed ID: 7880442

DOI: 10.1089/dna.1995.14.213

PubMed ID: 1556124

Title: Positive and negative regulation of the transcription of the human protein kinase C beta gene.

PubMed ID: 1556124

DOI: 10.1016/s0021-9258(18)42675-0

PubMed ID: 1400396

Title: Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters.

PubMed ID: 1400396

DOI: 10.1016/s0021-9258(19)36758-4

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 3677994

Title: Alternative splicing increases the diversity of the human protein kinase C family.

PubMed ID: 3677994

DOI: 10.1089/dna.1987.6.389

PubMed ID: 3658678

Title: Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta-I/beta-II.

PubMed ID: 3658678

DOI: 10.1093/nar/15.17.7179

PubMed ID: 11598012

Title: PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.

PubMed ID: 11598012

DOI: 10.1093/emboj/20.20.5692

PubMed ID: 16103100

Title: The protein kinase Cbeta-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.

PubMed ID: 16103100

DOI: 10.1158/0008-5472.can-05-0071

PubMed ID: 18162466

Title: The phosphatase PHLPP controls the cellular levels of protein kinase C.

PubMed ID: 18162466

DOI: 10.1074/jbc.m707319200

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 19176525

Title: Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription.

PubMed ID: 19176525

DOI: 10.1074/jbc.m808719200

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20228790

Title: Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.

PubMed ID: 20228790

DOI: 10.1038/nature08839

PubMed ID: 12417015

Title: Protein kinase C beta (PKC beta): normal functions and diseases.

PubMed ID: 12417015

DOI: 10.1093/oxfordjournals.jbchem.a003273

PubMed ID: 20186491

Title: Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications.

PubMed ID: 20186491

DOI: 10.1007/s11154-010-9134-4

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25313067

Title: Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.

PubMed ID: 25313067

DOI: 10.1073/pnas.1418342111

PubMed ID: 25982116

Title: A protein kinase C phosphorylation motif in GLUT1 affects glucose transport and is mutated in GLUT1 deficiency syndrome.

PubMed ID: 25982116

DOI: 10.1016/j.molcel.2015.04.015

PubMed ID: 36040231

Title: PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

PubMed ID: 36040231

DOI: 10.1042/bcj20220308

PubMed ID: 17115692

Title: Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor.

PubMed ID: 17115692

DOI: 10.1021/bi061128h

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 671
Mass: 76869
Checksum: 3937E7B667108C68
Sequence:

MADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC SHCTDFIWGF 
GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS 
LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIQAHIDR DVLIVLVRDA 
KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL 
SVEIWDWDLT SRNDFMGSLS FGISELQKAS VDGWFKLLSQ EEGEYFNVPV PPEGSEANEE 
LRQKFERAKI SQGTKVPEEK TTNTVSKFDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE 
RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM 
EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI 
KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP 
FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF 
RYIDWEKLER KEIQPPYKPK ARDKRDTSNF DKEFTRQPVE LTPTDKLFIM NLDQNEFAGF 
SYTNPEFVIN V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PRKCB

Associated with

Cells (max top 100)

Other Information

Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. PubMed ID: 3755548

Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences. PubMed ID: 3666134

Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. PubMed ID: 10493829

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Autoregulation of cloned human protein kinase C beta and gamma gene promoters in U937 cells. PubMed ID: 7880442

Positive and negative regulation of the transcription of the human protein kinase C beta gene. PubMed ID: 1556124

Cloning and characterization of the major promoter of the human protein kinase C beta gene. Regulation by phorbol esters. PubMed ID: 1400396

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Alternative splicing increases the diversity of the human protein kinase C family. PubMed ID: 3677994

Nucleotide sequence of the 3' portion of a human gene for protein kinase C beta-I/beta-II. PubMed ID: 3658678

PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization. PubMed ID: 11598012

The protein kinase Cbeta-selective inhibitor, enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. PubMed ID: 16103100

The phosphatase PHLPP controls the cellular levels of protein kinase C. PubMed ID: 18162466

Phosphoproteome of resting human platelets. PubMed ID: 18088087

Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription. PubMed ID: 19176525

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. PubMed ID: 20228790

Protein kinase C beta (PKC beta): normal functions and diseases. PubMed ID: 12417015

Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. PubMed ID: 20186491

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. PubMed ID: 25313067

A protein kinase C phosphorylation motif in GLUT1 affects glucose transport and is mutated in GLUT1 deficiency syndrome. PubMed ID: 25982116

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain. PubMed ID: 36040231

Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor. PubMed ID: 17115692

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846